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Invitrogen
Human ZNHIT2 (aa 188-264) Control Fragment Recombinant Protein
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Product Details
RP-99907
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
CTPVVPTRIPAIVSLSRGPVSPLVRFQLPNVLFAYAHTLALYHGGDDALLSDFCATLLGVSGALGAQQVFASAEEAL
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (82%), Rat (82%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63517. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The ZNHIT2 gene, located on chromosome 7, encodes a zinc-finger HIT-type containing protein crucial for various cellular processes, such as chromatin remodeling and gene transcription regulation. Knockout studies in mice reveal that ZNHIT2, alongside ZNHIT1, is essential during early development, with deficits leading to embryonic lethality during peri-implantation stages due to reduced proportions of pluripotent inner cell mass cells and aberrant expression of key developmental genes like NANOG and SOX17. This gene's relevance extends to its involvement in protein-protein and protein-nucleic acid interactions that are fundamental in cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein FON; Zinc finger HIT domain-containing protein 2; zinc finger, HIT domain containing 2; zinc finger, HIT type 2; zinc finger, HIT-type containing 2
Gene Aliases: C11orf5; FON; ZNHIT2
UniProt ID: (Human) Q9UHR6
Entrez Gene ID: (Human) 741
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