Product References
The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias.
Cell reports. Medicine
Fan Y,Huang S,Li S,Wu B,Zhao Q,Huang L,Zheng Z,Xie X,Liu J,Huang W,Sun J,Zhu X,Zhu J,Xiang AP,Li W
450-01 was used in In vitro experiments to show that adipocyte-derived leptin activates sympathetic neurons and increases the release of neuropeptide Y (NPY), which in turn triggers arrhythmia in cardiomyocytes by interacting with the Y1 receptor (Y1R) and subsequently enhancing the activity of the Na+/Ca2+ exchanger (NCX) and calcium/calmodulin-dependent protein kinase II (CaMKII).
Tue May 21 00:00:00 UTC 2024
Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity.
Biomaterials science
Dutta D,Pirolli NH,Levy D,Tsao J,Seecharan N,Wang Z,Xu X,Jia X,Jay SM
450-01 was used in In vitro experiments to assess whether oligodendrocyte precursor cells and immature oligodendrocytes, which are further differentiated than neural progenitor/stem cells (NPSCs) and which both give rise to mature myelinating oligodendrocytes, could yield extracellular vesicles with neurotherapeutic properties comparable or superior to those from NPSCs.
Tue Aug 08 00:00:00 UTC 2023
Glioma synapses recruit mechanisms of adaptive plasticity.
Nature
Taylor KR,Barron T,Hui A,Spitzer A,Yalçin B,Ivec AE,Geraghty AC,Hartmann GG,Arzt M,Gillespie SM,Kim YS,Maleki Jahan S,Zhang H,Shamardani K,Su M,Ni L,Du PP,Woo PJ,Silva-Torres A,Venkatesh HS,Mancusi R,Ponnuswami A,Mulinyawe S,Keough MB,Chau I,Aziz-Bose R,Tirosh I,Suvà ML,Monje M
450-01 was used in Cell Culture to indicate that brain-derived neurotrophic factor1-3-TrkB signalling promotes malignant synaptic plasticity and augments tumour progression.
Wed Nov 01 00:00:00 UTC 2023
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Molecular psychiatry
Albornoz EA,Amarilla AA,Modhiran N,Parker S,Li XX,Wijesundara DK,Aguado J,Zamora AP,McMillan CLD,Liang B,Peng NYG,Sng JDJ,Saima FT,Fung JN,Lee JD,Paramitha D,Parry R,Avumegah MS,Isaacs A,Lo MW,Miranda-Chacon Z,Bradshaw D,Salinas-Rebolledo C,Rajapakse NW,Wolvetang EJ,Munro TP,Rojas-Fernandez A,Young PR,Stacey KJ,Khromykh AA,Chappell KJ,Watterson D,Woodruff TM
450-01 was used in Cell Culture to support a possible mechanism of microglial innate immune activation by SARS-CoV-2, which could explain the increased vulnerability to developing neurological symptoms akin to Parkinson's disease in COVID-19 infected individuals, and a potential therapeutic avenue for intervention.
Sat Jul 01 00:00:00 UTC 2023
Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation.
Nature communications
Li Z,Lui KN,Lau ST,Lai FP,Li P,Chung PH,Wong KK,Tam PK,Garica-Barcelo MM,Hui CC,Sham PC,Ngan ES
450-01 was used in In vitro experiments to define various factors associated with Hirschsprung pathogenesis and demonstrate the implications of oxidative phosphorylation in enteric neural crest development.
Sat Apr 15 00:00:00 UTC 2023
Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.
The Journal of clinical investigation
Li Z,Duan H,Jia Y,Zhao C,Li W,Wang X,Gong Y,Dong C,Ma B,Dou S,Zhang B,Li D,Cao Y,Xie L,Zhou Q,Shi W
Tue Jan 04 00:00:00 UTC 2022
A cryo-ET survey of microtubules and intracellular compartments in mammalian axons.
The Journal of cell biology
Foster HE,Ventura Santos C,Carter AP
Mon Feb 07 00:00:00 UTC 2022
Nerve bundle formation during the promotion of peripheral nerve regeneration: collagen VI-neural cell adhesion molecule 1 interaction.
Neural regeneration research
Sun JH,Huang M,Fang Z,Li TX,Wu TT,Chen Y,Quan DP,Xu YY,Wang YM,Yang Y,Zou JL
450-01 was used in Tissue/organ culture to study how the extracellular matrix (ECM) microenvironment affects the formation of nerve bundles, which is partially regulated by neural cell adhesion molecule 1 (NCAM1), and is important for neural network organization during peripheral nerve regeneration.
Sun May 01 00:00:00 UTC 2022
Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models.
Nature communications
Wu HF,Yu W,Saito-Diaz K,Huang CW,Carey J,Lefcort F,Hart GW,Liu HX,Zeltner N
450-01 was used in In vivo experiments to find that candidate drugs lowered hyperactivity independent of ELP1 modulation.
Thu Nov 17 00:00:00 UTC 2022
A Cd9+Cd271+ stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation.
Cell reports
Fan C,Zhao Y,Chen Y,Qin T,Lin J,Han S,Yan R,Lei T,Xie Y,Wang T,Gu S,Ouyang H,Shen W,Yin Z,Chen X
450-01 was used in Cell Culture to integrate the structural, mechanical, and molecular properties of tendon maturation to show that post-natal days 7-14 are the crucial transitional stage for mouse tendon maturation.
Tue Apr 26 00:00:00 UTC 2022
Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
Neural development
Bollmann C,Schöning S,Kotschnew K,Grosse J,Heitzig N,Fischer von Mollard G
450-01 was used in Sample Preparation to show the importance of vti1a or vti1b for two pathways of neurite elongation.
Tue Nov 22 00:00:00 UTC 2022
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Cell
Casarotto PC,Girych M,Fred SM,Kovaleva V,Moliner R,Enkavi G,Biojone C,Cannarozzo C,Sahu MP,Kaurinkoski K,Brunello CA,Steinzeig A,Winkel F,Patil S,Vestring S,Serchov T,Diniz CRAF,Laukkanen L,Cardon I,Antila H,Rog T,Piepponen TP,Bramham CR,Normann C,Lauri SE,Saarma M,Vattulainen I,Castrén E
Thu Mar 04 00:00:00 UTC 2021
DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons.
ACS central science
McGhee CE,Yang Z,Guo W,Wu Y,Lyu M,DeLong CJ,Hong S,Ma Y,McInnis MG,O'Shea KS,Lu Y
450-01 was used in Cell Culture to investigate lithium ion distribution in bipolar disorder.
Wed Nov 24 00:00:00 UTC 2021
Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment.
Advanced healthcare materials
Vedaraman S,Perez-Tirado A,Haraszti T,Gerardo-Nava J,Nishiguchi A,De Laporte L
Fri Oct 01 00:00:00 UTC 2021
NGF Signaling Interacts With the Hippo/YAP Pathway to Regulate Cervical Cancer Progression.
Frontiers in oncology
Wang L,Li J,Wang R,Chen H,Wang R,Wang W,Yang X
450-01 was used in Cell Culture to indicate that combined targeting of the NGF signaling and the Hippo pathway represents a novel therapeutic strategy for treatment of cervical cancer.
Tue Nov 02 00:00:00 UTC 2021
IGF-I and NGFβ enhance in vitro progressive motility and vitality of human spermatozoa.
Reproductive medicine and biology
Asimakopoulos B,Tiptiri-Kourpeti A,Metallinou C
Thu Jul 01 00:00:00 UTC 2021
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Cell reports
Ghosh S,Nataraj NB,Noronha A,Patkar S,Sekar A,Mukherjee S,Winograd-Katz S,Kramarski L,Verma A,Lindzen M,Garcia DD,Green J,Eisenberg G,Gil-Henn H,Basu A,Lender Y,Weiss S,Oren M,Lotem M,Geiger B,Ruppin E,Yarden Y
Tue May 25 00:00:00 UTC 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
Mon May 10 00:00:00 UTC 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
Mon May 10 00:00:00 UTC 2021
Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction.
Cells
Dahlström M,Madjid N,Nordvall G,Halldin MM,Vazquez-Juarez E,Lindskog M,Sandin J,Winblad B,Eriksdotter M,Forsell P
450-01 was used in In vitro experiments to identify small molecules with stimulatory effects on the signaling of two neurotrophins, the nerve growth factor (NGF) and the brain derived neurotrophic factor (BDNF).
Fri Jul 23 00:00:00 UTC 2021
Towards a bioengineered uterus: bioactive sheep uterus scaffolds are effectively recellularized by enzymatic preconditioning.
NPJ Regenerative medicine
Padma AM,Carrière L,Krokström Karlsson F,Sehic E,Bandstein S,Tiemann TT,Oltean M,Song MJ,Brännström M,Hellström M
Fri May 21 00:00:00 UTC 2021
SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells.
Cell death & disease
Lai X,Liu J,Zou Z,Wang Y,Wang Y,Liu X,Huang W,Ma Y,Chen Q,Li F,Wu G,Li W,Wang W,Yuan Y,Jiang B
Fri Aug 27 00:00:00 UTC 2021
An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions.
Cell reports. Medicine
Clark AJ,Kugathasan U,Baskozos G,Priestman DA,Fugger N,Lone MA,Othman A,Chu KH,Blesneac I,Wilson ER,Laurà M,Kalmar B,Greensmith L,Hornemann T,Platt FM,Reilly MM,Bennett DL
Tue Jul 20 00:00:00 UTC 2021
High-Throughput Screening and Hierarchical Topography-Mediated Neural Differentiation of Mesenchymal Stem Cells.
Advanced healthcare materials
Yang L,Jurczak KM,Ge L,van Rijn P
Mon Jun 01 00:00:00 UTC 2020
Odontogenesis and neuronal differentiation characteristics of periodontal ligament stem cells from beagle dog.
Journal of cellular and molecular medicine
Li X,Liao D,Sun G,Chu H
Fri May 01 00:00:00 UTC 2020
Small-Molecule Ligands that Bind the RET Receptor Activate Neuroprotective Signals Independent of but Modulated by Coreceptor GFRα1.
Molecular pharmacology
Jmaeff S,Sidorova Y,Lippiatt H,Barcelona PF,Nedev H,Saragovi LM,Hancock MA,Saarma M,Saragovi HU
450-01 was used in Cell Culture to validate RET receptor as a druggable therapeutic target and provide for potential leads to evaluate in neurodegenerative states.
Wed Jul 01 00:00:00 UTC 2020
Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.
Cell reports
Black JB,McCutcheon SR,Dube S,Barrera A,Klann TS,Rice GA,Adkar SS,Soderling SH,Reddy TE,Gersbach CA
450-01 was used in Cell Culture to systematically map human neuronal cell fate regulators, using high-throughput pooled CRISPR activation (CRISPRa) screens.
Tue Dec 01 00:00:00 UTC 2020
Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency.
Nature communications
Ouwendijk WJD,Depledge DP,Rajbhandari L,Lenac Rovis T,Jonjic S,Breuer J,Venkatesan A,Verjans GMGM,Sadaoka T
Thu Dec 10 00:00:00 UTC 2020
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.
Nature communications
OʼShea TM,Wollenberg AL,Kim JH,Ao Y,Deming TJ,Sofroniew MV
Fri Dec 04 00:00:00 UTC 2020
An Elvitegravir Nanoformulation Crosses the Blood-Brain Barrier and Suppresses HIV-1 Replication in Microglia.
Viruses
Gong Y,Zhi K,Nagesh PKB,Sinha N,Chowdhury P,Chen H,Gorantla S,Yallapu MM,Kumar S
450-01 was used in In vitro experiments to investigate ART treatment of HIV-1.
Wed May 20 00:00:00 UTC 2020
Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.
Nature communications
Sun J,Huang Y,Gong J,Wang J,Fan Y,Cai J,Wang Y,Qiu Y,Wei Y,Xiong C,Chen J,Wang B,Ma Y,Huang L,Chen X,Zheng S,Huang W,Ke Q,Wang T,Li X,Zhang W,Xiang AP,Li W
Thu Oct 15 00:00:00 UTC 2020
3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kajtez J,Buchmann S,Vasudevan S,Birtele M,Rocchetti S,Pless CJ,Heiskanen A,Barker RA,Martínez-Serrano A,Parmar M,Lind JU,Emnéus J
Sat Aug 01 00:00:00 UTC 2020
Neurotrophic effects of GM1 ganglioside, NGF, and FGF2 on canine dorsal root ganglia neurons in vitro.
Scientific reports
Schwarz S,Lehmbecker A,Tongtako W,Hahn K,Wang Y,Felmy F,Zdora I,Brogden G,Branitzki-Heinemann K,von Köckritz-Blickwede M,Baumgärtner W,Gerhauser I
Wed Mar 25 00:00:00 UTC 2020
Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors.
The Journal of biological chemistry
Jmaeff S,Sidorova Y,Nedev H,Saarma M,Saragovi HU
Fri May 08 00:00:00 UTC 2020
Coiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth.
Scientific reports
Min JS,Halder D,Yoon JY,Jeon SJ,Jun SY,Lee JR,Lee JJ,Choi MH,Jung CR,Lee D,Kim BJ,Kim NS
Fri Dec 04 00:00:00 UTC 2020
Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion.
Scientific reports
Rivera KO,Russo F,Boileau RM,Tomlinson RE,Miclau T,Marcucio RS,Desai TA,Bahney CS
Thu Dec 17 00:00:00 UTC 2020
Modelling human CNS injury with human neural stem cells in 2- and 3-Dimensional cultures.
Scientific reports
Vagaska B,Gillham O,Ferretti P
Wed Apr 22 00:00:00 UTC 2020
Defining the Functional Role of NaV1.7 in Human Nociception.
Neuron
McDermott LA,Weir GA,Themistocleous AC,Segerdahl AR,Blesneac I,Baskozos G,Clark AJ,Millar V,Peck LJ,Ebner D,Tracey I,Serra J,Bennett DL
Wed Mar 06 00:00:00 UTC 2019
Defining the Functional Role of NaV1.7 in Human Nociception.
Neuron
McDermott LA,Weir GA,Themistocleous AC,Segerdahl AR,Blesneac I,Baskozos G,Clark AJ,Millar V,Peck LJ,Ebner D,Tracey I,Serra J,Bennett DL
Wed Mar 06 00:00:00 UTC 2019
The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony-Forming Efficiency, and the Limbal Stem Cell Phenotype.
Stem cells (Dayton, Ohio)
Kolli S,Bojic S,Ghareeb AE,Kurzawa-Akanbi M,Figueiredo FC,Lako M
Tue Jan 01 00:00:00 UTC 2019
Ion current and action potential alterations in peripheral neurons subject to uniaxial strain.
Journal of neuroscience research
Bianchi F,Malboubi M,George JH,Jerusalem A,Thompson MS,Ye H
Mon Jul 01 00:00:00 UTC 2019
Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons.
The European journal of neuroscience
Dahlström M,Nordvall G,Sundström E,Åkesson E,Tegerstedt G,Eriksdotter M,Forsell P
Fri Nov 01 00:00:00 UTC 2019
Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons.
The European journal of neuroscience
Dahlström M,Nordvall G,Sundström E,Åkesson E,Tegerstedt G,Eriksdotter M,Forsell P
Fri Nov 01 00:00:00 UTC 2019
Nystagmus-related FRMD7 gene influences the maturation and complexities of neuronal processes in human neurons.
Brain and behavior
Pu J,Dai S,Gao T,Hu J,Fang Y,Zheng R,Jin C,Zhang B
Sun Dec 01 00:00:00 UTC 2019
Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
Current protocols in stem cell biology
Frith TJR,Tsakiridis A
450-01 was used in Cell Culture to describe a detailed protocol for the efficient in vitro generation of trunk neural crest (NC) cells and their derivatives from human pluripotent stem cells (hPSCs).
Sat Jun 01 00:00:00 UTC 2019
Nerve modulation therapy in gouty arthritis: targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage.
Theranostics
Mei J,Zhou F,Qiao H,Li H,Tang T
450-01 was used in Cell Culture to investigate the significance of sensory neuron neuropeptides and chemokine signals on inflammation-induced macrophages polarization during gouty arthritis.
Mon Sep 14 00:00:00 UTC 2020
Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents.
Nature communications
Zou T,Gao L,Zeng Y,Li Q,Li Y,Chen S,Hu X,Chen X,Fu C,Xu H,Yin ZQ
Thu Mar 14 00:00:00 UTC 2019
Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang N,Milbreta U,Chin JS,Pinese C,Lin J,Shirahama H,Jiang W,Liu H,Mi R,Hoke A,Wu W,Chew SY
Fri May 03 00:00:00 UTC 2019
Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition.
PloS one
Li Q,Huang Q
450-01 was used in Cell Culture to show that the process of epithelial-to-mesenchymal transition, which is inherent to the process of definitive endoderm differentiation, was also disrupted upon Repsox treatment. Our findings may provide a new approach to produce neural progenitors.
Wed Mar 11 00:00:00 UTC 2020
TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane.
Scientific reports
Kanda A,Noda K,Hirose I,Ishida S
Thu Jan 24 00:00:00 UTC 2019
β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.
Cancer cell
Renz BW,Takahashi R,Tanaka T,Macchini M,Hayakawa Y,Dantes Z,Maurer HC,Chen X,Jiang Z,Westphalen CB,Ilmer M,Valenti G,Mohanta SK,Habenicht AJR,Middelhoff M,Chu T,Nagar K,Tailor Y,Casadei R,Di Marco M,Kleespies A,Friedman RA,Remotti H,Reichert M,Worthley DL,Neumann J,Werner J,Iuga AC,Olive KP,Wang TC
Mon Jan 08 00:00:00 UTC 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 UTC 2018
Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection.
Proceedings of the National Academy of Sciences of the United States of America
Zimmer B,Ewaleifoh O,Harschnitz O,Lee YS,Peneau C,McAlpine JL,Liu B,Tchieu J,Steinbeck JA,Lafaille F,Volpi S,Notarangelo LD,Casanova JL,Zhang SY,Smith GA,Studer L
Tue Sep 11 00:00:00 UTC 2018
Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.
Stem cell research & therapy
Zhang W,Chu W,Liu Q,Coates D,Shang Y,Li C
450-01 was used in Cell Culture to report the expression, functions, and molecular interactions of deer thymosin beta 10 (TMSB10) in tissue and cells in antler growth.
Tue Jun 19 00:00:00 UTC 2018
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells.
Scientific reports
Alshawaf AJ,Viventi S,Qiu W,D'Abaco G,Nayagam B,Erlichster M,Chana G,Everall I,Ivanusic J,Skafidas E,Dottori M
Fri Jan 12 00:00:00 UTC 2018
Oxaliplatin induces pH acidification in dorsal root ganglia neurons.
Scientific reports
Riva B,Dionisi M,Potenzieri A,Chiorazzi A,Cordero-Sanchez C,Rigolio R,Carozzi VA,Lim D,Cavaletti G,Marmiroli P,Distasi C,Genazzani AA
Wed Oct 10 00:00:00 UTC 2018
SiO2 nanoparticles modulate the electrical activity of neuroendocrine cells without exerting genomic effects.
Scientific reports
Distasi C,Ruffinatti FA,Dionisi M,Antoniotti S,Gilardino A,Croci G,Riva B,Bassino E,Alberto G,Castroflorio E,Incarnato D,Morandi E,Martra G,Oliviero S,Munaron L,Lovisolo D
Fri Feb 09 00:00:00 UTC 2018
Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.
Neuron
Pease-Raissi SE,Pazyra-Murphy MF,Li Y,Wachter F,Fukuda Y,Fenstermacher SJ,Barclay LA,Bird GH,Walensky LD,Segal RA
Wed Oct 11 00:00:00 UTC 2017
Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation.
The Journal of experimental medicine
Peng T,Chanthaphavong RS,Sun S,Trigilio JA,Phasouk K,Jin L,Layton ED,Li AZ,Correnti CE,De van der Schueren W,Vazquez J,O'Day DR,Glass IA,Knipe DM,Wald A,Corey L,Zhu J
Mon Aug 07 00:00:00 UTC 2017
A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA.
Scientific reports
Pignataro D,Francia S,Zanetta F,Brenna G,Brandini S,Olivieri A,Torroni A,Biamonti G,Montecucco A
Fri Aug 25 00:00:00 UTC 2017
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Nature medicine
Zeltner N,Fattahi F,Dubois NC,Saurat N,Lafaille F,Shang L,Zimmer B,Tchieu J,Soliman MA,Lee G,Casanova JL,Studer L
450-01 was used in Cell Culture to study disease-related phenotypes in human pluripotent stem cells (PSCs) that capture familial dysautonomia (FD) severity and demonstrate that PSC-based modeling is sensitive in recapitulating disease severity, which presents an important step toward personalized medicine.
Thu Dec 01 00:00:00 UTC 2016
MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNγ-independent fashion and during development.
Scientific reports
Vagaska B,New SE,Alvarez-Gonzalez C,D'Acquisto F,Gomez SG,Bulstrode NW,Madrigal A,Ferretti P
Fri Apr 15 00:00:00 UTC 2016
Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Chambers SM,Mica Y,Lee G,Studer L,Tomishima MJ
450-01 was used in In vitro experiments to provide methods to direct NC into two different terminal fates: melanocytes and sensory neurons.
Mon May 16 00:00:00 UTC 2016
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.
Nature communications
Jiang H,Xu Z,Zhong P,Ren Y,Liang G,Schilling HA,Hu Z,Zhang Y,Wang X,Chen S,Yan Z,Feng J
Mon Dec 07 00:00:00 UTC 2015
The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells.
Scientific reports
Boisvert EM,Engle SJ,Hallowell SE,Liu P,Wang ZW,Li XJ
Thu Nov 19 00:00:00 UTC 2015
Computer-assisted quantification of motile and invasive capabilities of cancer cells.
Scientific reports
Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M
Wed Oct 21 00:00:00 UTC 2015
Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling.
Cell death & disease
Secq V,Leca J,Bressy C,Guillaumond F,Skrobuk P,Nigri J,Lac S,Lavaut MN,Bui TT,Thakur AK,Callizot N,Steinschneider R,Berthezene P,Dusetti N,Ouaissi M,Moutardier V,Calvo E,Bousquet C,Garcia S,Bidaut G,Vasseur S,Iovanna JL,Tomasini R
Thu Jan 15 00:00:00 UTC 2015
Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses.
The Journal of biological chemistry
Sparta B,Pargett M,Minguet M,Distor K,Bell G,Albeck JG
Fri Oct 09 00:00:00 UTC 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 UTC 2015
Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
The Journal of clinical investigation
Westphalen CB,Asfaha S,Hayakawa Y,Takemoto Y,Lukin DJ,Nuber AH,Brandtner A,Setlik W,Remotti H,Muley A,Chen X,May R,Houchen CW,Fox JG,Gershon MD,Quante M,Wang TC
Sat Mar 01 00:00:00 UTC 2014
Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone.
Stem cells (Dayton, Ohio)
Scardigli R,Capelli P,Vignone D,Brandi R,Ceci M,La Regina F,Piras E,Cintoli S,Berardi N,Capsoni S,Cattaneo A
Mon Sep 01 00:00:00 UTC 2014
Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.
The Journal of biological chemistry
Liu X,Obianyo O,Chan CB,Huang J,Xue S,Yang JJ,Zeng F,Goodman M,Ye K
Fri Oct 03 00:00:00 UTC 2014
Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.
The Journal of biological chemistry
Liu X,Obianyo O,Chan CB,Huang J,Xue S,Yang JJ,Zeng F,Goodman M,Ye K
Fri Oct 03 00:00:00 UTC 2014
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 UTC 2013
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America
Baeza-Raja B,Li P,Le Moan N,Sachs BD,Schachtrup C,Davalos D,Vagena E,Bridges D,Kim C,Saltiel AR,Olefsky JM,Akassoglou K
Tue Apr 10 00:00:00 UTC 2012
Microfibrous substrate geometry as a critical trigger for organization, self-renewal, and differentiation of human embryonic stem cells within synthetic 3-dimensional microenvironments.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Carlson AL,Florek CA,Kim JJ,Neubauer T,Moore JC,Cohen RI,Kohn J,Grumet M,Moghe PV
Wed Aug 01 00:00:00 UTC 2012
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons.
PloS one
Park TI,Monzo H,Mee EW,Bergin PS,Teoh HH,Montgomery JM,Faull RL,Curtis MA,Dragunow M
Thu Oct 11 00:00:00 UTC 2012
Stepwise optimization of the procedure for assessment of circulating progenitor cells in patients with myocardial infarction.
PloS one
Cui YX,Johnson T,Baumbach A,Reeves BC,Rogers CA,Angelini GD,Marsden D,Madeddu P
Mon Jun 11 00:00:00 UTC 2012
Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion.
The Journal of biological chemistry
Li XZ,Yan J,Huang SH,Zhao L,Wang J,Chen ZY
Fri Jan 13 00:00:00 UTC 2012
Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability.
PloS one
Pristerà A,Baker MD,Okuse K
Tue Feb 19 00:00:00 UTC 2013
The nerve growth factor reduces APOBEC3G synthesis and enhances HIV-1 transcription and replication in human primary macrophages.
Blood
Souza TM,Rodrigues DQ,Passaes CP,Barreto-de-Souza V,Aguiar RS,Temerozo JR,Morgado MG,Fontes CF,Araujo EG,Bou-Habib DC
Thu Mar 10 00:00:00 UTC 2011
Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice.
The Journal of clinical investigation
Cazorla M,Prémont J,Mann A,Girard N,Kellendonk C,Rognan D
Sun May 01 00:00:00 UTC 2011
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis.
BMC genomics
Dutta P,Koch A,Breyer B,Schneider H,Dittrich-Breiholz O,Kracht M,Tamura T
Mon Apr 18 00:00:00 UTC 2011
ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America
Lebrun-Julien F,Bertrand MJ,De Backer O,Stellwagen D,Morales CR,Di Polo A,Barker PA
Tue Feb 23 00:00:00 UTC 2010
Normalization with genes encoding ribosomal proteins but not GAPDH provides an accurate quantification of gene expressions in neuronal differentiation of PC12 cells.
BMC genomics
Zhou L,Lim QE,Wan G,Too HP
Fri Jan 29 00:00:00 UTC 2010
Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.
Molecular pain
Chen T,Koga K,Li XY,Zhuo M
Fri Apr 09 00:00:00 UTC 2010
Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
Blood
Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA
Sat Nov 01 00:00:00 UTC 2008
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect.
Proceedings of the National Academy of Sciences of the United States of America
Jeanneteau F,Garabedian MJ,Chao MV
Tue Mar 25 00:00:00 UTC 2008
Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice.
BMC developmental biology
Stewart AL,Anderson RB,Kobayashi K,Young HM
Fri Jul 25 00:00:00 UTC 2008
Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.
Mechanisms of development
Kettunen P,Spencer-Dene B,Furmanek T,Kvinnsland IH,Dickson C,Thesleff I,Luukko K
Wed Mar 19 00:00:00 UTC 2008
Neurotrophins mediate human embryonic stem cell survival.
Nature biotechnology
Pyle AD,Lock LF,Donovan PJ
Wed Mar 01 00:00:00 UTC 2006
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
Blood
Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M
Thu Jul 01 00:00:00 UTC 2004
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
Blood
Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M
Thu Jul 01 00:00:00 UTC 2004
Cloning and characterization of a novel transcription factor involved in cellular proliferation arrest: PATF.
Oncogene
Crisanti P,Raguenez G,Blancher C,Neron B,Mamoune A,Omri B
450-01 was used in Cell Culture to indicate that PATF could be a new molecular signal implicated in the final neuronal cell cycle withdrawal.
Thu Sep 06 00:00:00 UTC 2001
Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.
Neuron
Rossi J,Luukko K,Poteryaev D,Laurikainen A,Sun YF,Laakso T,Eerikäinen S,Tuominen R,Lakso M,Rauvala H,Arumäe U,Pasternack M,Saarma M,Airaksinen MS
Mon Feb 01 00:00:00 UTC 1999
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA
Tue Sep 15 00:00:00 UTC 1998
