Product References
NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.
iScience
Valadares DG,Clay OS,Chen Y,Scorza BM,Cassel SL,Sutterwala FS,Wilson ME
250-27B was used in In vitro experiments to hypothesize that Nlrp12-expressing DCs are required for efficient dissemination and immune clearance of L. infantum from the site of initial infection.
Fri Mar 17 00:00:00 UTC 2023
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer.
Cancer immunology research
Celus W,Oliveira AI,Rivis S,Van Acker HH,Landeloos E,Serneels J,Cafarello ST,Van Herck Y,Mastrantonio R,Köhler A,Garg AD,Flamand V,Tamagnone L,Marine JC,Di Matteo M,Costa BM,Bechter O,Mazzone M
250-27B was used in In vitro experiments to show that expression of the axon guidance molecule Plexin-A4 (Plxna4) in cytotoxic T cells (CTLs), especially in effector/memory CD8+ T cells, is induced upon T-cell activation, sustained in the circulation, but reduced when entering the tumor bed and that upon deletion of Plxna4, CTLs acquire improved homing capacity to the lymph nodes and to the tumor.
Sat Jan 01 00:00:00 UTC 2022
Exposure to Systemic Immunosuppressive Ultraviolet Radiation Alters T Cell Recirculation through Sphingosine-1-Phosphate.
Journal of immunology (Baltimore, Md. : 1950)
Tse BCY,Ireland RA,Lee JY,Marsh-Wakefield F,Kok LF,Don AS,Byrne SN
Mon Nov 01 00:00:00 UTC 2021
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
iScience
Lai JH,Wu DW,Wu CH,Hung LF,Huang CY,Ka SM,Chen A,Chang ZF,Ho LJ
250-27B was used in In vitro experiments to conclude that CMPK2 is a critical factor in DENV-induced immune responses to determine innate immunity.
Fri Jun 25 00:00:00 UTC 2021
Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.
Science advances
Alcaraz-Serna A,Bustos-Morán E,Fernández-Delgado I,Calzada-Fraile D,Torralba D,Marina-Zárate E,Lorenzo-Vivas E,Vázquez E,Barreto de Albuquerque J,Ruef N,Gómez MJ,Sánchez-Cabo F,Dopazo A,Stein JV,Ramiro A,Sánchez-Madrid F
250-27B was used in Sample Preparation (FC/FACS) to describe a previously unknown DC population whose transcriptomics, epigenomics, and migratory capacity change in response to their cognate contact with T cells.
Mon Feb 01 00:00:00 UTC 2021
Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress.
The Journal of experimental medicine
Du X,Zeng H,Liu S,Guy C,Dhungana Y,Neale G,Bergo MO,Chi H
Mon Feb 03 00:00:00 UTC 2020
Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood.
Journal of immunology (Baltimore, Md. : 1950)
Cain DW,Bortner CD,Diaz-Jimenez D,Petrillo MG,Gruver-Yates A,Cidlowski JA
Sat Aug 01 00:00:00 UTC 2020
Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Qin T,Ma S,Miao X,Tang Y,Huangfu D,Wang J,Jiang J,Xu N,Yin Y,Chen S,Liu X,Yin Y,Peng D,Gao L
Tue Sep 01 00:00:00 UTC 2020
PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity.
Cell reports
Lucas ED,Schafer JB,Matsuda J,Kraus M,Burchill MA,Tamburini BAJ
250-27B was used in In vitro experiments to identify a TSS signaling motif within the intracellular domain of PD-L1.
Tue Oct 13 00:00:00 UTC 2020
Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.
Cell stem cell
Chen M,Reed RR,Lane AP
250-27B was used in Neutralization experiments to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.
Thu Oct 03 00:00:00 UTC 2019
Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.
Cell stem cell
Chen M,Reed RR,Lane AP
250-27B was used in Neutralization experiments to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.
Thu Oct 03 00:00:00 UTC 2019
Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.
Cell stem cell
Chen M,Reed RR,Lane AP
250-27B was used in Neutralization experiments to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.
Thu Oct 03 00:00:00 UTC 2019
A simple 3D cellular chemotaxis assay and analysis workflow suitable for a wide range of migrating cells.
MethodsX
Visweshwaran SP,Maritzen T
250-27B was used in In vitro experiments to produce a method for construction of a chemotaxis assay for analysis of large cell numbers, validated by analyzing the 3D chemotaxis of highly migratory primary dendritic cells and the invasive MDA-MB-231 cancer cells.
Thu Oct 01 00:00:00 UTC 2020
CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults.
Scientific reports
Joutoku Z,Onodera T,Matsuoka M,Homan K,Momma D,Baba R,Hontani K,Hamasaki M,Matsubara S,Hishimura R,Iwasaki N
Tue Mar 26 00:00:00 UTC 2019
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.
The Journal of experimental medicine
Moalli F,Ficht X,Germann P,Vladymyrov M,Stolp B,de Vries I,Lyck R,Balmer J,Fiocchi A,Kreutzfeldt M,Merkler D,Iannacone M,Ariga A,Stoffel MH,Sharpe J,Bähler M,Sixt M,Diz-Muñoz A,Stein JV
Mon Jul 02 00:00:00 UTC 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
250-27B was used in In vitro experiments to show that apolipoprotein E deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells, resulting in enhanced MHC-II-dependent antigen presentation and CD4+ T-cell activation.
Mon Aug 06 00:00:00 UTC 2018
Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.
SLAS discovery : advancing life sciences R & D
Hull-Ryde EA,Porter MA,Fowler KA,Kireev D,Li K,Simpson CD,Sassano MF,Suto MJ,Pearce KH,Janzen W,Coghill JM
250-27B was used in In vitro experiments to unravel and validate cosalane as a CCR7 antagosnist, that inhibits the respective chemokine receptors in rodents and humans both.
Sat Dec 01 00:00:00 UTC 2018
Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.
SLAS discovery : advancing life sciences R & D
Hull-Ryde EA,Porter MA,Fowler KA,Kireev D,Li K,Simpson CD,Sassano MF,Suto MJ,Pearce KH,Janzen W,Coghill JM
250-27B was used in In vitro experiments to unravel and validate cosalane as a CCR7 antagosnist, that inhibits the respective chemokine receptors in rodents and humans both.
Sat Dec 01 00:00:00 UTC 2018
An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Clay GM,Valadares DG,Graff JW,Ulland TK,Davis RE,Scorza BM,Zhanbolat BS,Chen Y,Sutterwala FS,Wilson ME
Sun Oct 15 00:00:00 UTC 2017
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
Scientific reports
Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW
Wed Nov 22 00:00:00 UTC 2017
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Scientific reports
Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S
Tue Jun 27 00:00:00 UTC 2017
Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.
Cell research
Zhang Y,Xu Y,Liu S,Guo X,Cen D,Xu J,Li H,Li K,Zeng C,Lu L,Zhou Y,Shen H,Cheng H,Zhang X,Ke Y
Tue Nov 01 00:00:00 UTC 2016
Peripheral tolerance can be modified by altering KLF2-regulated Treg migration.
Proceedings of the National Academy of Sciences of the United States of America
Pabbisetty SK,Rabacal W,Volanakis EJ,Parekh VV,Olivares-Villagómez D,Cendron D,Boyd KL,Van Kaer L,Sebzda E
Tue Aug 09 00:00:00 UTC 2016
Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
Xu X,Wang X,Todd EM,Jaeger ER,Vella JL,Mooren OL,Feng Y,Hu J,Cooper JA,Morley SC,Huang YH
Thu Sep 01 00:00:00 UTC 2016
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release.
Immunity
Komarowska I,Coe D,Wang G,Haas R,Mauro C,Kishore M,Cooper D,Nadkarni S,Fu H,Steinbruchel DA,Pitzalis C,Anderson G,Bucy P,Lombardi G,Breckenridge R,Marelli-Berg FM
Tue Jun 16 00:00:00 UTC 2015
FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes.
Journal of immunology (Baltimore, Md. : 1950)
Han Y,Li X,Zhou Q,Jie H,Lao X,Han J,He J,Liu X,Gu D,He Y,Sun E
Sun Nov 01 00:00:00 UTC 2015
CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs.
Journal of immunology (Baltimore, Md. : 1950)
Rubtsov AV,Rubtsova K,Kappler JW,Jacobelli J,Friedman RS,Marrack P
Wed Jul 01 00:00:00 UTC 2015
FOXO1 regulates dendritic cell activity through ICAM-1 and CCR7.
Journal of immunology (Baltimore, Md. : 1950)
Dong G,Wang Y,Xiao W,Pacios Pujado S,Xu F,Tian C,Xiao E,Choi Y,Graves DT
Wed Apr 15 00:00:00 UTC 2015
A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
The Journal of biological chemistry
López-Cotarelo P,Escribano-Díaz C,González-Bethencourt IL,Gómez-Moreira C,Deguiz ML,Torres-Bacete J,Gómez-Cabañas L,Fernández-Barrera J,Delgado-Martín C,Mellado M,Regueiro JR,Miranda-Carús ME,Rodríguez-Fernández JL
Fri Jan 09 00:00:00 UTC 2015
CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.
Journal of immunology (Baltimore, Md. : 1950)
Chauhan SK,Saban DR,Dohlman TH,Dana R
Wed Jan 15 00:00:00 UTC 2014
Essential role of Elmo1 in Dock2-dependent lymphocyte migration.
Journal of immunology (Baltimore, Md. : 1950)
Stevenson C,de la Rosa G,Anderson CS,Murphy PS,Capece T,Kim M,Elliott MR
Sun Jun 15 00:00:00 UTC 2014
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
Fri Mar 14 00:00:00 UTC 2014
CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Srivatsan S,Swiecki M,Otero K,Cella M,Shaw AS
Sun Dec 15 00:00:00 UTC 2013
Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration.
Journal of immunology (Baltimore, Md. : 1950)
Zhang F,Wei W,Chai H,Xie X
Fri Feb 01 00:00:00 UTC 2013
Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.
Journal of immunology (Baltimore, Md. : 1950)
Al-Shami A,Crisostomo J,Wilkins C,Xu N,Humphries J,Chang WC,Anderson SJ,Oravecz T
Tue Oct 01 00:00:00 UTC 2013
Programmed downregulation of CCR6 is important for establishment of epidermal γδT cells by regulating their thymic egress and epidermal location.
Journal of immunology (Baltimore, Md. : 1950)
Hu S,Xiong N
Mon Apr 01 00:00:00 UTC 2013
Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.
PloS one
Atorrasagasti C,Peixoto E,Aquino JB,Kippes N,Malvicini M,Alaniz L,Garcia M,Piccioni F,Fiore EJ,Bayo J,Bataller R,Guruceaga E,Corrales F,Podhajcer O,Mazzolini G
Fri Sep 06 00:00:00 UTC 2013
T cells become licensed in the lung to enter the central nervous system.
Nature
Odoardi F,Sie C,Streyl K,Ulaganathan VK,Schläger C,Lodygin D,Heckelsmiller K,Nietfeld W,Ellwart J,Klinkert WE,Lottaz C,Nosov M,Brinkmann V,Spang R,Lehrach H,Vingron M,Wekerle H,Flügel-Koch C,Flügel A
Thu Aug 30 00:00:00 UTC 2012
Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.
Blood
Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D
Thu Nov 01 00:00:00 UTC 2012
Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine.
Journal of immunology (Baltimore, Md. : 1950)
Subramanian H,Grailer JJ,Ohlrich KC,Rymaszewski AL,Loppnow JJ,Kodera M,Conway RM,Steeber DA
Sun Apr 01 00:00:00 UTC 2012
The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
Journal of immunology (Baltimore, Md. : 1950)
Baek JH,Birchmeier C,Zenke M,Hieronymus T
Wed Aug 15 00:00:00 UTC 2012
Fluorescent magnetic nanoparticle-labeled mesenchymal stem cells for targeted imaging and hyperthermia therapy of in vivo gastric cancer.
Nanoscale research letters
Ruan J,Ji J,Song H,Qian Q,Wang K,Wang C,Cui D
Mon Jun 18 00:00:00 UTC 2012
Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch.
PloS one
Wang C,Lee JH,Kim CH
Mon Jun 04 00:00:00 UTC 2012
Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31.
PloS one
Kishore M,Ma L,Cornish G,Nourshargh S,Marelli-Berg FM
Wed Dec 12 00:00:00 UTC 2012
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.
Blood
Reijmers RM,Groen RW,Kuil A,Weijer K,Kimberley FC,Medema JP,van Kuppevelt TH,Li JP,Spaargaren M,Pals ST
Thu Jun 09 00:00:00 UTC 2011
Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4.
Journal of immunology (Baltimore, Md. : 1950)
Ricart BG,John B,Lee D,Hunter CA,Hammer DA
Sat Jan 01 00:00:00 UTC 2011
Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis.
International journal of biological sciences
Liu C,Lin J,Zhao L,Yang Y,Gao F,Li B,Cui J,Cai J
Mon Feb 14 00:00:00 UTC 2011
Activated local immunity by CC chemokine ligand 19-transduced embryonic endothelial progenitor cells suppresses metastasis of murine ovarian cancer.
Stem cells (Dayton, Ohio)
Hamanishi J,Mandai M,Matsumura N,Baba T,Yamaguchi K,Fujii S,Konishi I
Fri Jan 01 00:00:00 UTC 2010
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950)
Arthur JC,Lich JD,Ye Z,Allen IC,Gris D,Wilson JE,Schneider M,Roney KE,O'Connor BP,Moore CB,Morrison A,Sutterwala FS,Bertin J,Koller BH,Liu Z,Ting JP
Fri Oct 15 00:00:00 UTC 2010
Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Buatois V,Fagète S,Magistrelli G,Chatel L,Fischer N,Kosco-Vilbois MH,Ferlin WG
Sun Aug 15 00:00:00 UTC 2010
IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.
Journal of immunology (Baltimore, Md. : 1950)
Yen JH,Kong W,Ganea D
Thu Apr 01 00:00:00 UTC 2010
IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity.
Journal of immunology (Baltimore, Md. : 1950)
Turnis ME,Song XT,Bear A,Foster AE,Gottschalk S,Brenner MK,Chen SY,Rooney CM
Fri Oct 01 00:00:00 UTC 2010
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Nature
Buonamici S,Trimarchi T,Ruocco MG,Reavie L,Cathelin S,Mar BG,Klinakis A,Lukyanov Y,Tseng JC,Sen F,Gehrie E,Li M,Newcomb E,Zavadil J,Meruelo D,Lipp M,Ibrahim S,Efstratiadis A,Zagzag D,Bromberg JS,Dustin ML,Aifantis I
Thu Jun 18 00:00:00 UTC 2009
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Nature
Buonamici S,Trimarchi T,Ruocco MG,Reavie L,Cathelin S,Mar BG,Klinakis A,Lukyanov Y,Tseng JC,Sen F,Gehrie E,Li M,Newcomb E,Zavadil J,Meruelo D,Lipp M,Ibrahim S,Efstratiadis A,Zagzag D,Bromberg JS,Dustin ML,Aifantis I
Thu Jun 18 00:00:00 UTC 2009
Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.
Immunity
Herroeder S,Reichardt P,Sassmann A,Zimmermann B,Jaeneke D,Hoeckner J,Hollmann MW,Fischer KD,Vogt S,Grosse R,Hogg N,Gunzer M,Offermanns S,Wettschureck N
Fri May 01 00:00:00 UTC 2009
The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration.
PLoS pathogens
McLaughlin LM,Govoni GR,Gerke C,Gopinath S,Peng K,Laidlaw G,Chien YH,Jeong HW,Li Z,Brown MD,Sacks DB,Monack D
Sun Nov 01 00:00:00 UTC 2009
A cell-intrinsic role for Mst1 in regulating thymocyte egress.
Journal of immunology (Baltimore, Md. : 1950)
Dong Y,Du X,Ye J,Han M,Xu T,Zhuang Y,Tao W
Tue Sep 15 00:00:00 UTC 2009
A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.
Journal of immunology (Baltimore, Md. : 1950)
Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N
Wed Jul 01 00:00:00 UTC 2009
Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Shao Z,Makinde TO,McGee HS,Wang X,Agrawal DK
Tue Dec 01 00:00:00 UTC 2009
CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta.
Journal of immunology (Baltimore, Md. : 1950)
Escribano C,Delgado-Martín C,Rodríguez-Fernández JL
Sun Nov 15 00:00:00 UTC 2009
Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
The Journal of biological chemistry
Wang Z,Kumamoto Y,Wang P,Gan X,Lehmann D,Smrcka AV,Cohn L,Iwasaki A,Li L,Wu D
Fri Oct 16 00:00:00 UTC 2009
Structure and function of A41, a vaccinia virus chemokine binding protein.
PLoS pathogens
Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM
Tue Jan 01 00:00:00 UTC 2008
Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Britschgi MR,Link A,Lissandrin TK,Luther SA
Mon Dec 01 00:00:00 UTC 2008
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.
The Journal of biological chemistry
Thompson BD,Jin Y,Wu KH,Colvin RA,Luster AD,Birnbaumer L,Wu MX
Fri Mar 30 00:00:00 UTC 2007
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
The Journal of experimental medicine
Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ
Mon Jun 20 00:00:00 UTC 2005
