Product References
An Adaptable Protocol to Generate a Murine Enteroid-Macrophage Co-Culture System.
International journal of molecular sciences
Hentschel V,Govindarajan D,Seufferlein T,Armacki M
315-09 was used in Cell Culture to provide step-by-step instructions on how to set up a murine enteroid-macrophage co-culture by culturing cellular elements in proximity separated by a porous membrane.
Sat Jul 20 00:00:00 UTC 2024
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
315-09 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
315-09 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
315-09 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus.
Allergy
Doyle AD,Masuda MY,Pyon GC,Luo H,Putikova A,LeSuer WE,Flashner S,Rank MA,Nakagawa H,Kita H,Wright BL
315-09 was used in Cell Culture to determine whether detergent exposure decreases epithelial barrier function and induces esophageal inflammation.
Sun Jan 01 00:00:00 UTC 2023
Engineering Adenoviral Vectors with Improved GBM Selectivity.
Viruses
Bates EA,Lovatt C,Plein AR,Davies JA,Siebzehnrubl FA,Parker AL
315-09 was used in Cell Culture to demonstrate tight Glioblastoma (GBM)-specific transgene expression using these constructs, indicating that the combination of pseudotyping and tumour-specific promoter approaches may enable the development of efficacious therapies better suited to GBM.
Fri Apr 28 00:00:00 UTC 2023
IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury.
Inflammation and regeneration
Wang J,Xu L,Peng D,Zhu Y,Gu Z,Yao Y,Li H,Cao X,Fu CY,Zheng M,Song X,Ding Y,Shen Y,Zhong J,Chen YY,Hu J,Wang LL
315-09 was used in Cell Culture to identify INF-γ as a critical mediator of CD8+ T-cell-NSC cross talk and a potential node for therapeutic intervention in spinal cord injury.
Mon Feb 13 00:00:00 UTC 2023
Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis.
Nature communications
Fankhaenel M,Hashemi FSG,Mourao L,Lucas E,Hosawi MM,Skipp P,Morin X,Scheele CLGJ,Elias S
315-09 was used in Cell Culture to establish Annexin A1 as an upstream cortical cue that regulates LGN to direct planar cell divisions during mammalian epithelial morphogenesis.
Wed Jan 11 00:00:00 UTC 2023
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity.
Cellular and molecular gastroenterology and hepatology
Rivera KR,Bliton RJ,Burclaff J,Czerwinski MJ,Liu J,Trueblood JM,Hinesley CM,Breau KA,Deal HE,Joshi S,Pozdin VA,Yao M,Ziegler AL,Blikslager AT,Daniele MA,Magness ST
315-09 was used in In vitro experiments to present a new microphysiological system (MPS) to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolonged hypoxia modulates how hISCs respond to inflammation-associated interleukins (ILs).
Mon Oct 23 00:00:00 UTC 2023
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche.
Nature communications
Manieri E,Tie G,Malagola E,Seruggia D,Madha S,Maglieri A,Huang K,Fujiwara Y,Zhang K,Orkin SH,Wang TC,He R,McCarthy N,Shivdasani RA
315-09 was used in Cell Culture to shed light on spatial, molecular, and functional organization of gastric mesenchyme and the spectrum of signaling sources for epithelial support.
Sat Dec 02 00:00:00 UTC 2023
Epithelial colonization by gut dendritic cells promotes their functional diversification.
Immunity
Rivera CA,Randrian V,Richer W,Gerber-Ferder Y,Delgado MG,Chikina AS,Frede A,Sorini C,Maurin M,Kammoun-Chaari H,Parigi SM,Goudot C,Cabeza-Cabrerizo M,Baulande S,Lameiras S,Guermonprez P,Reis e Sousa C,Lecuit M,Moreau HD,Helft J,Vignjevic DM,Villablanca EJ,Lennon-Duménil AM
315-09 was used in Tissue/organ culture to investigate How tissue-specific cues orchestrate Dendritic cells diversification.
Tue Jan 11 00:00:00 UTC 2022
The preference for sugar over sweetener depends on a gut sensor cell.
Nature neuroscience
Buchanan KL,Rupprecht LE,Kaelberer MM,Sahasrabudhe A,Klein ME,Villalobos JA,Liu WW,Yang A,Gelman J,Park S,Anikeeva P,Bohórquez DV
Tue Feb 01 00:00:00 UTC 2022
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
Cell stem cell
Gadomski S,Fielding C,García-García A,Korn C,Kapeni C,Ashraf S,Villadiego J,Toro RD,Domingues O,Skepper JN,Michel T,Zimmer J,Sendtner R,Dillon S,Poole KES,Holdsworth G,Sendtner M,Toledo-Aral JJ,De Bari C,McCaskie AW,Robey PG,Méndez-Ferrer S
315-09 was used in Cell Culture to uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.
Thu Apr 07 00:00:00 UTC 2022
ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease.
Hepatology (Baltimore, Md.)
Cai H,Cheng X,Wang XP
Sat Oct 01 00:00:00 UTC 2022
Different responses to DNA damage determine ageing differences between organs.
Aging cell
Vougioukalaki M,Demmers J,Vermeij WP,Baar M,Bruens S,Magaraki A,Kuijk E,Jager M,Merzouk S,Brandt RMC,Kouwenberg J,van Boxtel R,Cuppen E,Pothof J,Hoeijmakers JHJ
Fri Apr 01 00:00:00 UTC 2022
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Mucosal immunology
Spalinger MR,Crawford M,Bobardt SD,Li J,Sayoc-Becerra A,Santos AN,Shawki A,Chatterjee P,Nair MG,McCole DF
Sat Jan 01 00:00:00 UTC 2022
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips.
Lab on a chip
Grant J,Lee E,Almeida M,Kim S,LoGrande N,Goyal G,Sesay AM,Breault DT,Prantil-Baun R,Ingber DE
315-09 was used in Cell Culture to describe a simple strategy which recapitulates in vivo functionality to achieve physiologically relevant oxygen tension in a two-channel human small intestine-on-a-chip (Intestine Chip) lined with primary human duodenal epithelium and intestinal microvascular endothelium in parallel channels separated by a porous membrane while both channels are perfused with oxygenated medium.
Tue Apr 12 00:00:00 UTC 2022
The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness.
Frontiers in oncology
Schäfer A,Evers L,Meier L,Schlomann U,Bopp MHA,Dreizner GL,Lassmann O,Ben Bacha A,Benescu AC,Pojskic M,Preußer C,von Strandmann EP,Carl B,Nimsky C,Bartsch JW
315-09 was used in In vitro experiments to study whether microRNA (miRNA) expression levels could be regulators of MMP9 expression in glioblastoma (GBM) cells expressing ADAM8.
Tue Apr 05 00:00:00 UTC 2022
A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity.
Journal of immunology research
Zhang L,Du J,Song Q,Zhang C,Wu X
315-09 was used in Cell Culture to study the synergistic antitumour effect of combining intralesional Rose Bengal (RB) with immature dendritic cells (DCs) (RB-iDCs) to reveal that the RB-iDC vaccine can synergistically destroy the primary tumour, inhibit distant metastasis, and prevent tumour relapse in a lung cancer mouse model, which provides important preclinical data for the development of a novel combinatorial immunotherapy.
Tue Mar 29 00:00:00 UTC 2022
Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.
Nature communications
Igarashi N,Miyata K,Loo TM,Chiba M,Hanyu A,Nishio M,Kawasaki H,Zheng H,Toyokuni S,Kon S,Moriyama K,Fujita Y,Takahashi A
315-09 was used in Cell Culture to provide evidence that cellular senescence inhibits cell competition-mediated elimination of oncogenic cells through HGF signaling, suggesting that it may lead to cancer incidence during aging.
Mon Jul 18 00:00:00 UTC 2022
Exosomes-Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Fan L,Liu C,Chen X,Zheng L,Zou Y,Wen H,Guan P,Lu F,Luo Y,Tan G,Yu P,Chen D,Deng C,Sun Y,Zhou L,Ning C
Sun May 01 00:00:00 UTC 2022
Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.
Molecular cell
He D,Feng H,Sundberg B,Yang J,Powers J,Christian AH,Wilkinson JE,Monnin C,Avizonis D,Thomas CJ,Friedman RA,Kluger MD,Hollingsworth MA,Grandgenett PM,Klute KA,Toste FD,Chang CJ,Chio IIC
315-09 was used in Tissue/organ culture to demonstrate that methionine residues can act as reversible redox switches governing distinct signaling outcomes and that the MSRA-PKM2 axis serves as a regulatory nexus between redox biology and cancer metabolism to control tumor metastasis.
Thu Aug 18 00:00:00 UTC 2022
Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.
Molecular cell
He D,Feng H,Sundberg B,Yang J,Powers J,Christian AH,Wilkinson JE,Monnin C,Avizonis D,Thomas CJ,Friedman RA,Kluger MD,Hollingsworth MA,Grandgenett PM,Klute KA,Toste FD,Chang CJ,Chio IIC
315-09 was used in Tissue/organ culture to demonstrate that methionine residues can act as reversible redox switches governing distinct signaling outcomes and that the MSRA-PKM2 axis serves as a regulatory nexus between redox biology and cancer metabolism to control tumor metastasis.
Thu Aug 18 00:00:00 UTC 2022
Establishing transgenic murine esophageal organoids.
STAR protocols
Ko KP,Zhang J,Park JI
315-09 was used in Cell Culture to provide guidelines on establishing transgenic esophageal organoids.
Fri Jun 17 00:00:00 UTC 2022
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
JCI insight
Borza CM,Bolas G,Bock F,Zhang X,Akabogu FC,Zhang MZ,de Caestecker M,Yang M,Yang H,Lee E,Gewin L,Fogo AB,McDonald WH,Zent R,Pozzi A
315-09 was used in Cell Culture to conclude that DDR1 contributes to acute and chronic kidney injury by regulating BCR and STAT3 phosphorylation and in turn the production of MCP-1 and TGF-β.
Tue Feb 08 00:00:00 UTC 2022
Ultrasound-targeted microbubbles destruction assists dual delivery of beta-amyloid antibody and neural stem cells to restore neural function in transgenic mice of Alzheimer's disease.
Medical physics
Zhu Q,Xu X,Chen B,Liao Y,Guan X,He Y,Cui H,Rong Y,Liu Z,Xu Y
315-09 was used in Cell Culture to evaluate the usability of UTMD assisted dual delivery of beta-amyloid antibodies to treat Alzheimer's disease.
Tue Mar 01 00:00:00 UTC 2022
Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma.
Nature communications
Aubin RG,Troisi EC,Montelongo J,Alghalith AN,Nasrallah MP,Santi M,Camara PG
315-09 was used in Cell Culture to investigate gene expression of ependymoma tumorigenic mechanisms to discover potential treatments.
Fri Jul 08 00:00:00 UTC 2022
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice.
Nature communications
Zhou T,Li Y,Li X,Zeng F,Rao Y,He Y,Wang Y,Liu M,Li D,Xu Z,Zhou X,Du S,Niu F,Peng J,Mei X,Ji SJ,Shu Y,Lu W,Guo F,Wu T,Yuan TF,Mao Y,Peng B
315-09 was used in Cell Culture to elucidate that removal of micropglial debris is astrocyte-depnedant, involving C4b opsonization followed by RUBICON-dependent LC3-associated phagocytosis (LAP) of engulfed fragments in a form of noncanonical autophagy.
Mon Oct 24 00:00:00 UTC 2022
ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.
Cancer letters
Lorenzoni M,De Felice D,Beccaceci G,Di Donato G,Foletto V,Genovesi S,Bertossi A,Cambuli F,Lorenzin F,Savino A,Avalle L,Cimadamore A,Montironi R,Weber V,Carbone FG,Barbareschi M,Demichelis F,Romanel A,Poli V,Del Sal G,Julio MK,Gaspari M,Alaimo A,Lunardi A
315-09 was used in In vitro experiments to highlight previously unrecognized functions of ETS-related gene in undermining adult prostate progenitor niche through cell autonomous and non-autonomous mechanisms.
Sat May 28 00:00:00 UTC 2022
The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.
eLife
Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ
315-09 was used in Cell Culture to show that the N6-methyladenosine (m6A) reader YTHDF2 is highly expressed in mouse retinal ganglion cells.
Fri Feb 18 00:00:00 UTC 2022
Lrig1 regulates the balance between proliferation and quiescence in glioblastoma stem cells.
Frontiers in cell and developmental biology
Ferguson KM,Blin C,Alfazema N,Gangoso E,Pollard SM,Marques-Torrejon MA
315-09 was used in In vitro experiments to highlight important roles for Lrig1 in controlling responsiveness to both epidermal growth factor receptor and BMPR signalling, and hence the proportions of quiescent and proliferative subpopulations in GBMs.
Sat Feb 10 00:00:00 UTC 2024
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.
Nature communications
Graf M,Interlandi M,Moreno N,Holdhof D,Göbel C,Melcher V,Mertins J,Albert TK,Kastrati D,Alfert A,Holsten T,de Faria F,Meisterernst M,Rossig C,Warmuth-Metz M,Nowak J,Meyer Zu Hörste G,Mayère C,Nef S,Johann P,Frühwald MC,Dugas M,Schüller U,Kerl K
315-09 was used in Cell Culture to determine epigenetic intertumoral heterogeneity of Rhabdoid tumors.
Tue Mar 22 00:00:00 UTC 2022
Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target.
Nature communications
Abdelfattah N,Kumar P,Wang C,Leu JS,Flynn WF,Gao R,Baskin DS,Pichumani K,Ijare OB,Wood SL,Powell SZ,Haviland DL,Parker Kerrigan BC,Lang FF,Prabhu SS,Huntoon KM,Jiang W,Kim BYS,George J,Yun K
315-09 was used in Cell Culture to identify molecular signatures for nine distinct myeloid cell subtypes, of which five are independent prognostic indicators of glioma patient survival.
Wed Feb 09 00:00:00 UTC 2022
Microencapsulation and nanowarming enables vitrification cryopreservation of mouse preantral follicles.
Nature communications
Tian C,Shen L,Gong C,Cao Y,Shi Q,Zhao G
315-09 was used in Cell Culture to provide a step towards nontoxic vitrification by utilizing the synergistic cryoprotection effect of microencapsulation and nanowarming.
Thu Dec 15 00:00:00 UTC 2022
Methods for Assessing Circadian Rhythms and Cell Cycle in Intestinal Enteroids.
Methods in molecular biology (Clifton, N.J.)
Park M,Cao Y,Hong CI
315-09 was used in In vitro experiments to establish procedures to assess circadian rhythms and cell cycle dynamics in enteroids through time course sample collection methods and assay techniques including immunofluorescence, live cell confocal microscopy, and bioluminescence.
Thu May 26 00:00:00 UTC 2022
Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation.
Inflammation and regeneration
Kobayashi S,Ogasawara N,Watanabe S,Yoneyama Y,Kirino S,Hiraguri Y,Inoue M,Nagata S,Okamoto-Uchida Y,Kofuji S,Shimizu H,Ito G,Mizutani T,Yamauchi S,Kinugasa Y,Kano Y,Nemoto Y,Watanabe M,Tsuchiya K,Nishina H,Okamoto R,Yui S
315-09 was used in Cell Culture to reveal that the remodeling of mesenchyme with collagen fibril induces YAP/TAZ-dependent fate conversion of intestinal/colonic epithelial cells covering the wound bed towards fetal-like progenitors.
Mon Nov 28 00:00:00 UTC 2022
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
Thu Apr 29 00:00:00 UTC 2021
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
Thu Apr 29 00:00:00 UTC 2021
Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
Immunity
Yan Y,Ramanan D,Rozenberg M,McGovern K,Rastelli D,Vijaykumar B,Yaghi O,Voisin T,Mosaheb M,Chiu I,Itzkovitz S,Rao M,Mathis D,Benoist C
Tue Mar 09 00:00:00 UTC 2021
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.
Immunity
Saxton RA,Henneberg LT,Calafiore M,Su L,Jude KM,Hanash AM,Garcia KC
Tue Apr 13 00:00:00 UTC 2021
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
Cell stem cell
Leimkühler NB,Gleitz HFE,Ronghui L,Snoeren IAM,Fuchs SNR,Nagai JS,Banjanin B,Lam KH,Vogl T,Kuppe C,Stalmann USA,Büsche G,Kreipe H,Gütgemann I,Krebs P,Banz Y,Boor P,Tai EW,Brümmendorf TH,Koschmieder S,Crysandt M,Bindels E,Kramann R,Costa IG,Schneider RK
Thu Apr 01 00:00:00 UTC 2021
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Cell stem cell
Bressan RB,Southgate B,Ferguson KM,Blin C,Grant V,Alfazema N,Wills JC,Marques-Torrejon MA,Morrison GM,Ashmore J,Robertson F,Williams CAC,Bradley L,von Kriegsheim A,Anderson RA,Tomlinson SR,Pollard SM
Thu May 06 00:00:00 UTC 2021
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.
Molecular cell
Cieśla M,Ngoc PCT,Cordero E,Martinez ÁS,Morsing M,Muthukumar S,Beneventi G,Madej M,Munita R,Jönsson T,Lövgren K,Ebbesson A,Nodin B,Hedenfalk I,Jirström K,Vallon-Christersson J,Honeth G,Staaf J,Incarnato D,Pietras K,Bosch A,Bellodi C
Thu Apr 01 00:00:00 UTC 2021
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.
Molecular cell
Cieśla M,Ngoc PCT,Cordero E,Martinez ÁS,Morsing M,Muthukumar S,Beneventi G,Madej M,Munita R,Jönsson T,Lövgren K,Ebbesson A,Nodin B,Hedenfalk I,Jirström K,Vallon-Christersson J,Honeth G,Staaf J,Incarnato D,Pietras K,Bosch A,Bellodi C
Thu Apr 01 00:00:00 UTC 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Mon Apr 05 00:00:00 UTC 2021
The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis.
Molecular psychiatry
Kerloch T,Farrugia F,Bouit L,Maître M,Terral G,Koehl M,Mortessagne P,Heng JI,Blanchard M,Doat H,Leste-Lasserre T,Goron A,Gonzales D,Perrais D,Guillemot F,Abrous DN,Pacary E
Wed Dec 01 00:00:00 UTC 2021
A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Murakami K,Terakado Y,Saito K,Jomen Y,Takeda H,Oshima M,Barker N
Tue Jan 26 00:00:00 UTC 2021
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.
Proceedings of the National Academy of Sciences of the United States of America
Tien JC,Chugh S,Goodrum AE,Cheng Y,Mannan R,Zhang Y,Wang L,Dommeti VL,Wang X,Xu A,Hon J,Kenum C,Su F,Wang R,Cao X,Shankar S,Chinnaiyan AM
Tue May 18 00:00:00 UTC 2021
Deciphering the signaling network of breast cancer improves drug sensitivity prediction.
Cell systems
Tognetti M,Gabor A,Yang M,Cappelletti V,Windhager J,Rueda OM,Charmpi K,Esmaeilishirazifard E,Bruna A,de Souza N,Caldas C,Beyer A,Picotti P,Saez-Rodriguez J,Bodenmiller B
Wed May 19 00:00:00 UTC 2021
Comparison of RNA m6A and DNA methylation profiles between mouse female germline stem cells and STO cells.
Molecular therapy. Nucleic acids
Zhao X,Tian GG,Fang Q,Pei X,Wang Z,Wu J
Fri Mar 05 00:00:00 UTC 2021
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Oncogene
Lindzen M,Ghosh S,Noronha A,Drago D,Nataraj NB,Leitner O,Carvalho S,Zmora E,Sapoznik S,Shany KB,Levanon K,Aderka D,Ramírez BS,Dahlhoff M,McNeish I,Yarden Y
Sat May 01 00:00:00 UTC 2021
NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
Development (Cambridge, England)
Brischetto C,Krieger K,Klotz C,Krahn I,Kunz S,Kolesnichenko M,Mucka P,Heuberger J,Scheidereit C,Schmidt-Ullrich R
315-09 was used in Sample Preparation (FC/FACS) to study the physiological function of NF-κB in sustaining intestinal epithelial homeostasis beyond inflammation to suggest that NF-κB is important for intestinal epithelial self-renewal.
Mon Nov 01 00:00:00 UTC 2021
Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition.
Oncogenesis
Maru Y,Tanaka N,Tatsumi Y,Nakamura Y,Itami M,Hippo Y
Fri Jun 25 00:00:00 UTC 2021
Heat-stable enterotoxin inhibits intestinal stem cell expansion to disrupt the intestinal integrity by downregulating the Wnt/β-catenin pathway.
Stem cells (Dayton, Ohio)
Zhou JY,Huang DG,Gao CQ,Yan HC,Zou SG,Wang XQ
Thu Apr 01 00:00:00 UTC 2021
GDF-5 induces epidermal stem cell migration via RhoA-MMP9 signalling.
Journal of cellular and molecular medicine
Li X,Wang F,Lan Y,Bian R,Wang Y,Zhang X,Guo Y,Xiao L,Ni W,Zhao X,Luo G,Zhan R
Mon Feb 01 00:00:00 UTC 2021
Different Neurogenic Potential in the Subnuclei of the Postnatal Rat Cochlear Nucleus.
Stem cells international
Voelker J,Engert J,Voelker C,Bieniussa L,Schendzielorz P,Hagen R,Rak K
Thu Apr 22 00:00:00 UTC 2021
Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.
Journal of neuro-oncology
Crotty EE,Smith SMC,Brasel K,Pakiam F,Girard EJ,Connor YD,Zindy F,Mhyre AJ,Roussel MF,Olson JM
315-09 was used in Cell Culture to investigate the role of tumour-associated macrophage infiltration in cancer progression.
Tue Jun 01 00:00:00 UTC 2021
Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.
Cell adhesion & migration
Roncato F,Regev O,Yadav SK,Alon R
315-09 was used in In vitro experiments to investigate microtubule turnover in epithelial barriers.
Wed Dec 01 00:00:00 UTC 2021
Locus specific epigenetic modalities of random allelic expression imbalance.
Nature communications
Marion-Poll L,Forêt B,Zielinski D,Massip F,Attia M,Carter AC,Syx L,Chang HY,Gendrel AV,Heard E
Thu Sep 09 00:00:00 UTC 2021
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma.
Nature communications
Vinel C,Rosser G,Guglielmi L,Constantinou M,Pomella N,Zhang X,Boot JR,Jones TA,Millner TO,Dumas AA,Rakyan V,Rees J,Thompson JL,Vuononvirta J,Nadkarni S,El Assan T,Aley N,Lin YY,Liu P,Nelander S,Sheer D,Merry CLR,Marelli-Berg F,Brandner S,Marino S
Thu Oct 21 00:00:00 UTC 2021
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Cell reports
Schild T,McReynolds MR,Shea C,Low V,Schaffer BE,Asara JM,Piskounova E,Dephoure N,Rabinowitz JD,Gomes AP,Blenis J
Tue Jun 15 00:00:00 UTC 2021
CTCF is a barrier for 2C-like reprogramming.
Nature communications
Olbrich T,Vega-Sendino M,Tillo D,Wu W,Zolnerowich N,Pavani R,Tran AD,Domingo CN,Franco M,Markiewicz-Potoczny M,Pegoraro G,FitzGerald PC,Kruhlak MJ,Lazzerini-Denchi E,Nora EP,Nussenzweig A,Ruiz S
Wed Aug 11 00:00:00 UTC 2021
CREPT is required for murine stem cell maintenance during intestinal regeneration.
Nature communications
Yang L,Yang H,Chu Y,Song Y,Ding L,Zhu B,Zhai W,Wang X,Kuang Y,Ren F,Jia B,Wu W,Ye X,Wang Y,Chang Z
Mon Jan 11 00:00:00 UTC 2021
A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells.
iScience
Welte T,Mai J,Zhang Z,Tian S,Zhang G,Xu Y,Zhang L,Chen SS,Wang T,Shen H
315-09 was used in Cell Culture to study how thioaptamer probe (T1) binds to myeloid-derived suppressor cells (MDSC) subsets in colorectal and pancreatic tumors with high specificity to uncover heparan-sulfate-dependent MDSC modulation in the tumor microenvironment and identify T1 as tool preferentially targeting tumor-promoting myeloid cell subsets.
Fri Nov 19 00:00:00 UTC 2021
Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells.
Communications biology
Rore H,Owen N,Piña-Aguilar RE,Docherty K,Sekido R
Mon Jun 28 00:00:00 UTC 2021
Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation.
Nature communications
Kurashima Y,Kigoshi T,Murasaki S,Arai F,Shimada K,Seki N,Kim YG,Hase K,Ohno H,Kawano K,Ashida H,Suzuki T,Morimoto M,Saito Y,Sasou A,Goda Y,Yuki Y,Inagaki Y,Iijima H,Suda W,Hattori M,Kiyono H
Tue Feb 16 00:00:00 UTC 2021
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response.
Nature communications
Yen YT,Chien M,Wu PY,Ho CC,Ho CT,Huang KC,Chiang SF,Chao KSC,Chen WT,Hung SC
Wed Dec 15 00:00:00 UTC 2021
Active elimination of intestinal cells drives oncogenic growth in organoids.
Cell reports
Krotenberg Garcia A,Fumagalli A,Le HQ,Jackstadt R,Lannagan TRM,Sansom OJ,van Rheenen J,Suijkerbuijk SJE
Tue Jul 06 00:00:00 UTC 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
Mon May 10 00:00:00 UTC 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
Mon May 10 00:00:00 UTC 2021
Microglial ASD-related genes are involved in oligodendrocyte differentiation.
Scientific reports
Takanezawa Y,Tanabe S,Kato D,Ozeki R,Komoda M,Suzuki T,Baba H,Muramatsu R
Wed Sep 08 00:00:00 UTC 2021
Dynamic integration of enteric neural stem cells in ex vivo organotypic colon cultures.
Scientific reports
Navoly G,McCann CJ
Thu Aug 05 00:00:00 UTC 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
Fri Feb 05 00:00:00 UTC 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
Fri Feb 05 00:00:00 UTC 2021
Rapid Prototyping of Multilayer Microphysiological Systems.
ACS biomaterials science & engineering
Hosic S,Bindas AJ,Puzan ML,Lake W,Soucy JR,Zhou F,Koppes RA,Breault DT,Murthy SK,Koppes AN
315-09 was used in Cell Culture to present a compelling fabrication technique for developing organs-on-chips of various geometries to study multicellular tissues.
Mon Jul 12 00:00:00 UTC 2021
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture.
Nature communications
Lattke M,Goldstone R,Ellis JK,Boeing S,Jurado-Arjona J,Marichal N,MacRae JI,Berninger B,Guillemot F
Thu Jul 15 00:00:00 UTC 2021
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
Cell
Raghavan S,Winter PS,Navia AW,Williams HL,DenAdel A,Lowder KE,Galvez-Reyes J,Kalekar RL,Mulugeta N,Kapner KS,Raghavan MS,Borah AA,Liu N,Väyrynen SA,Costa AD,Ng RWS,Wang J,Hill EK,Ragon DY,Brais LK,Jaeger AM,Spurr LF,Li YY,Cherniack AD,Booker MA,Cohen EF,Tolstorukov MY,Wakiro I,Rotem A,Johnson BE,McFarland JM,Sicinska ET,Jacks TE,Sullivan RJ,Shapiro GI,Clancy TE,Perez K,Rubinson DA,Ng K,Cleary JM,Crawford L,Manalis SR,Nowak JA,Wolpin BM,Hahn WC,Aguirre AJ,Shalek AK
315-09 was used in In vitro experiments to study distinct site and state-specific tumour microevironments in pancreatic cancer.
Thu Dec 09 00:00:00 UTC 2021
Targeting Smyd3 by next-generation antisense oligonucleotides suppresses liver tumor growth.
iScience
Kontaki H,Koukaki M,Vasilarou M,Giakountis A,Deligianni E,Luo X,Kim Y,Talianidis I
Fri May 21 00:00:00 UTC 2021
Targeting Smyd3 by next-generation antisense oligonucleotides suppresses liver tumor growth.
iScience
Kontaki H,Koukaki M,Vasilarou M,Giakountis A,Deligianni E,Luo X,Kim Y,Talianidis I
Fri May 21 00:00:00 UTC 2021
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells.
Nature communications
Marqués-Torrejón MÁ,Williams CAC,Southgate B,Alfazema N,Clements MP,Garcia-Diaz C,Blin C,Arranz-Emparan N,Fraser J,Gammoh N,Parrinello S,Pollard SM
Mon May 10 00:00:00 UTC 2021
Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease.
Med (New York, N.Y.)
Matei DE,Menon M,Alber DG,Smith AM,Nedjat-Shokouhi B,Fasano A,Magill L,Duhlin A,Bitoun S,Gleizes A,Hacein-Bey-Abina S,Manson JJ,Rosser EC,Klein N,Blair PA,Mauri C
315-09 was used in Tissue/organ culture to analyze changes in markers of gut permeability, damage, and inflammation in peripheral blood and serum of rheumatoid arthritis patients, as well as relevant organs in engineered arthritic mice.
Fri Jul 09 00:00:00 UTC 2021
Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors.
Communications biology
Gao Y,Duque-Wilckens N,Aljazi MB,Wu Y,Moeser AJ,Mias GI,Robison AJ,He J
Fri Jun 18 00:00:00 UTC 2021
Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis.
Cell death & disease
Gudiño V,Cammareri P,Billard CV,Myant KB
Sat Sep 25 00:00:00 UTC 2021
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
JCI insight
Jana S,Deo R,Hough RP,Liu Y,Horn JL,Wright JL,Lam HM,Webster KR,Chiang GG,Sonenberg N,Hsieh AC
315-09 was used in Tissue/organ culture to study candidate gene analysis for translation regulators implicated in dependency of protein synthesis for efficient urothelial cancer formation and growth to discover that phosphorylation of the translation initiation factor eIF4E at serine 209 is increased in both murine and human bladder cancer, and this phosphorylation corresponds with an increase in de novo protein synthesis.
Tue Jun 08 00:00:00 UTC 2021
Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cui F,Pan Q,Wang S,Zhao F,Wang R,Zhang T,Song Y,He J,Zhang H,Weng Q,Jin Y,Xia W,Li Y,Yang GY,De Vos WH,Timmermans JP,Xu S,Tang Y,Sheng X
Wed Dec 01 00:00:00 UTC 2021
B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells.
bioRxiv : the preprint server for biology
Yu B,Qi Y,Li R,Shi Q,Satpathy A,Chang HY
Tue Jan 05 00:00:00 UTC 2021
Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation.
Cell death & disease
Meier S,Cantilena S,Niklison Chirou MV,Anderson J,Hargrave D,Salomoni P,de Boer J,Michod D
Wed Aug 11 00:00:00 UTC 2021
Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function.
eLife
Haward F,Maslon MM,Yeyati PL,Bellora N,Hansen JN,Aitken S,Lawson J,von Kriegsheim A,Wachten D,Mill P,Adams IR,Caceres JF
315-09 was used in Cell Culture to study the physiological significance of the role of SR family protein regulation of RNA splicing in the nucleus and SRSF1 shuttling between the nucleus and cytoplasm for post-splicing processes.
Mon Aug 02 00:00:00 UTC 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
Thu Jul 22 00:00:00 UTC 2021
Protocol for mouse adult neural stem cell isolation and culture.
STAR protocols
Ahmed AKMA,Isaksen TJ,Yamashita T
Fri Jun 18 00:00:00 UTC 2021
Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells.
Cell death & disease
An H,Heo JS,Kim P,Lian Z,Lee S,Park J,Hong E,Pang K,Park Y,Ooshima A,Lee J,Son M,Park H,Wu Z,Park KS,Kim SJ,Bae I,Yang KM
Mon Feb 08 00:00:00 UTC 2021
Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development.
Cell stem cell
Avgustinova A,Laudanna C,Pascual-García M,Rovira Q,Djurec M,Castellanos A,Urdiroz-Urricelqui U,Marchese D,Prats N,Van Keymeulen A,Heyn H,Vaquerizas JM,Benitah SA
315-09 was used in Cell Culture to conclude that altering the chromatin accessibility of retroviral elements disrupts mammary gland development and stem cell activity through both cell-autonomous and non-autonomous mechanisms.
Thu Oct 07 00:00:00 UTC 2021
Self-assembling peptide scaffolds in the clinic.
NPJ Regenerative medicine
Gelain F,Luo Z,Rioult M,Zhang S
Wed Feb 17 00:00:00 UTC 2021
Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo.
Cell reports
Dignum T,Varnum-Finney B,Srivatsan SR,Dozono S,Waltner O,Heck AM,Ishida T,Nourigat-McKay C,Jackson DL,Rafii S,Trapnell C,Bernstein ID,Hadland B
Tue Sep 14 00:00:00 UTC 2021
Anti-tumor effects of an ID antagonist with no observed acquired resistance.
NPJ breast cancer
Wojnarowicz PM,Escolano MG,Huang YH,Desai B,Chin Y,Shah R,Xu S,Yadav S,Yaklichkin S,Ouerfelli O,Soni RK,Philip J,Montrose DC,Healey JH,Rajasekhar VK,Garland WA,Ratiu J,Zhuang Y,Norton L,Rosen N,Hendrickson RC,Zhou XK,Iavarone A,Massague J,Dannenberg AJ,Lasorella A,Benezra R
Mon May 24 00:00:00 UTC 2021
miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine.
Nature communications
Goga A,Yagabasan B,Herrmanns K,Godbersen S,Silva PN,Denzler R,Zünd M,Furter M,Schwank G,Sunagawa S,Hardt WD,Stoffel M
Mon Jun 07 00:00:00 UTC 2021
Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells.
Journal of visualized experiments : JoVE
Shechtman LA,Piarowski CM,Scott JK,Golden EJ,Gaillard D,Barlow LA
315-09 was used in In vitro experiments to adapt previously published protocols and a standardized method for generating taste organoids from taste progenitor cells isolated from the circumvallate papilla (CVP) of adult mice is presented.
Mon Apr 05 00:00:00 UTC 2021
mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.
Cell reports
Li K,Wu H,Wang A,Charron J,Mishina Y,Habib SL,Liu H,Li B
Tue May 04 00:00:00 UTC 2021
Setd4 controlled quiescent c-Kit+ cells contribute to cardiac neovascularization of capillaries beyond activation.
Scientific reports
Xing S,Tian JZ,Yang SH,Huang XT,Ding YF,Lu QY,Yang JS,Yang WJ
Wed Jun 02 00:00:00 UTC 2021
A RAC-GEF network critical for early intestinal tumourigenesis.
Nature communications
Pickering KA,Gilroy K,Cassidy JW,Fey SK,Najumudeen AK,Zeiger LB,Vincent DF,Gay DM,Johansson J,Fordham RP,Miller B,Clark W,Hedley A,Unal EB,Kiel C,McGhee E,Machesky LM,Nixon C,Johnsson AE,Bain M,Strathdee D,van Hoof SR,Medema JP,Anderson KI,Brachmann SM,Stucke VM,Malliri A,Drysdale M,Turner M,Serrano L,Myant K,Campbell AD,Sansom OJ
Mon Jan 04 00:00:00 UTC 2021
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.
Nature communications
Gudiño V,Pohl SÖ,Billard CV,Cammareri P,Bolado A,Aitken S,Stevenson D,Hall AE,Agostino M,Cassidy J,Nixon C,von Kriegsheim A,Freile P,Popplewell L,Dickson G,Murphy L,Wheeler A,Dunlop M,Din F,Strathdee D,Sansom OJ,Myant KB
Tue Apr 20 00:00:00 UTC 2021
HES1 protein oscillations are necessary for neural stem cells to exit from quiescence.
iScience
Marinopoulou E,Biga V,Sabherwal N,Miller A,Desai J,Adamson AD,Papalopulu N
Fri Oct 22 00:00:00 UTC 2021
Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations.
Cell reports
Chen Z,Wu J,Liu B,Zhang G,Wang Z,Zhang L,Wang K,Fan Z,Zhu P
Tue Jul 27 00:00:00 UTC 2021
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity.
Cell reports
Mana MD,Hussey AM,Tzouanas CN,Imada S,Barrera Millan Y,Bahceci D,Saiz DR,Webb AT,Lewis CA,Carmeliet P,Mihaylova MM,Shalek AK,Yilmaz ÖH
Tue Jun 08 00:00:00 UTC 2021
Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice.
BMC complementary medicine and therapies
Wang XF,Xiao HH,Wu YT,Kong L,Chen JC,Yang JX,Hu XL
315-09 was used in Cell Culture to investigate the effects of three active constituents [3,6'-disinapoyl sucrose (DISS), onjisaponin B (OB) and tenuifolin (TEN)] of Polygala tenuifolia (PT) on the proliferation and differentiation of neural stem cells (NSCs) to identify the potential active constituent of PT promoting hippocampal neurogenesis.
Mon Oct 25 00:00:00 UTC 2021
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 UTC 2020
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Cell
Lai NY,Musser MA,Pinho-Ribeiro FA,Baral P,Jacobson A,Ma P,Potts DE,Chen Z,Paik D,Soualhi S,Yan Y,Misra A,Goldstein K,Lagomarsino VN,Nordstrom A,Sivanathan KN,Wallrapp A,Kuchroo VK,Nowarski R,Starnbach MN,Shi H,Surana NK,An D,Wu C,Huh JR,Rao M,Chiu IM
Thu Jan 09 00:00:00 UTC 2020
Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity.
Immunity
McGinty JW,Ting HA,Billipp TE,Nadjsombati MS,Khan DM,Barrett NA,Liang HE,Matsumoto I,von Moltke J
Tue Mar 17 00:00:00 UTC 2020
The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling.
Gastroenterology
Chen B,Dragomir MP,Fabris L,Bayraktar R,Knutsen E,Liu X,Tang C,Li Y,Shimura T,Ivkovic TC,De Los Santos MC,Anfossi S,Shimizu M,Shah MY,Ling H,Shen P,Multani AS,Pardini B,Burks JK,Katayama H,Reineke LC,Huo L,Syed M,Song S,Ferracin M,Oki E,Fromm B,Ivan C,Bhuvaneshwar K,Gusev Y,Mimori K,Menter D,Sen S,Matsuyama T,Uetake H,Vasilescu C,Kopetz S,Parker-Thornburg J,Taguchi A,Hanash SM,Girnita L,Slaby O,Goel A,Varani G,Gagea M,Li C,Ajani JA,Calin GA
315-09 was used in Cell Culture to study the relationship between the colon cancer-associated transcript 2 gene encoded long noncoding RNA and the development of chromosomal instability.
Tue Dec 01 00:00:00 UTC 2020
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Cell metabolism
Bensard CL,Wisidagama DR,Olson KA,Berg JA,Krah NM,Schell JC,Nowinski SM,Fogarty S,Bott AJ,Wei P,Dove KK,Tanner JM,Panic V,Cluntun A,Lettlova S,Earl CS,Namnath DF,Vázquez-Arreguín K,Villanueva CJ,Tantin D,Murtaugh LC,Evason KJ,Ducker GS,Thummel CS,Rutter J
315-09 was used in Cell Culture to study how the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (MPC), which couples glycolysis and glucose oxidation through mitochondrial pyruvate import, suggetsing that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation.
Tue Feb 04 00:00:00 UTC 2020
Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages.
Nature cell biology
Sato T,Ishikawa S,Asano J,Yamamoto H,Fujii M,Sato T,Yamamoto K,Kitagaki K,Akashi T,Okamoto R,Ohteki T
Sat Aug 01 00:00:00 UTC 2020
Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Cell stem cell
Li Q,Sun Y,Jarugumilli GK,Liu S,Dang K,Cotton JL,Xiol J,Chan PY,DeRan M,Ma L,Li R,Zhu LJ,Li JH,Leiter AB,Ip YT,Camargo FD,Luo X,Johnson RL,Wu X,Mao J
315-09 was used in Tissue/organ culture to demonstrate if Lats1/2, the core Hippo kinases, are essential to maintain Wnt pathway activity and intestinal stem cells.
Thu May 07 00:00:00 UTC 2020
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.
Cell stem cell
Miao ZF,Adkins-Threats M,Burclaff JR,Osaki LH,Sun JX,Kefalov Y,He Z,Wang ZN,Mills JC
315-09 was used in Tissue/organ culture to show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation.
Thu Jun 04 00:00:00 UTC 2020
Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma.
The Journal of clinical investigation
Moon BS,Cai M,Lee G,Zhao T,Song X,Giannotta SL,Attenello FJ,Yu M,Lu W
Mon Nov 02 00:00:00 UTC 2020
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
The Journal of clinical investigation
Hyun J,Sun Z,Ahmadi AR,Bangru S,Chembazhi UV,Du K,Chen T,Tsukamoto H,Rusyn I,Kalsotra A,Diehl AM
Wed Apr 01 00:00:00 UTC 2020
Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.
The EMBO journal
Dumas AA,Pomella N,Rosser G,Guglielmi L,Vinel C,Millner TO,Rees J,Aley N,Sheer D,Wei J,Marisetty A,Heimberger AB,Bowman RL,Brandner S,Joyce JA,Marino S
315-09 was used in Cell Culture to show that GBM-initiating cells induce mTOR signalling in the microglia but not bone marrow-derived macrophages in both in vitro and in vivo GBM mouse models.
Mon Aug 03 00:00:00 UTC 2020
AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.
Developmental cell
Marneros AG
315-09 was used in In vivo experiments to show that the transcription factor AP-2β is required for the differentiation of distal tubule precursors into early stage distal convoluted tubules during nephrogenesis.
Mon Aug 10 00:00:00 UTC 2020
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.
Cell death and differentiation
Nguyen PM,Dagley LF,Preaudet A,Lam N,Giam M,Fung KY,Aizel K,van Duijneveldt G,Tan CW,Hirokawa Y,Yip HYK,Love CG,Poh AR,Cruz A,Burstroem C,Feltham R,Abdirahman SM,Meiselbach K,Low RRJ,Palmieri M,Ernst M,Webb AI,Burgess T,Sieber OM,Bouillet P,Putoczki TL
Sat Feb 01 00:00:00 UTC 2020
Impaired adult neurogenesis is an early event in Alzheimer's disease neurodegeneration, mediated by intracellular Aβ oligomers.
Cell death and differentiation
Scopa C,Marrocco F,Latina V,Ruggeri F,Corvaglia V,La Regina F,Ammassari-Teule M,Middei S,Amadoro G,Meli G,Scardigli R,Cattaneo A
Sun Mar 01 00:00:00 UTC 2020
LGR5 controls extracellular matrix production by stem cells in the developing intestine.
EMBO reports
Fernandez Vallone V,Leprovots M,Ribatallada-Soriano D,Gerbier R,Lefort A,Libert F,Vassart G,Garcia MI
Fri Jul 03 00:00:00 UTC 2020
MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium.
EMBO reports
Pereira B,Amaral AL,Dias A,Mendes N,Muncan V,Silva AR,Thibert C,Radu AG,David L,Máximo V,van den Brink GR,Billaud M,Almeida R
Fri Apr 03 00:00:00 UTC 2020
Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.
Clinical and translational medicine
Qin T,Yuan Z,Yu J,Fu X,Deng X,Fu Q,Ma Z,Ma S
Tue Dec 01 00:00:00 UTC 2020
Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury.
CNS neuroscience & therapeutics
Huang X,Wang C,Zhou X,Wang J,Xia K,Yang B,Gong Z,Ying L,Yu C,Shi K,Shu J,Cheng F,Han B,Liang C,Li F,Chen Q
Tue Sep 01 00:00:00 UTC 2020
3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis.
Frontiers in cell and developmental biology
Rabata A,Fedr R,Soucek K,Hampl A,Koledova Z
315-09 was used in Cell Culture to present lung 3D cell culture models as useful tools to study the role and interplay of signaling pathways in postnatal lung development and homeostasis, and we reveal distinct roles for FGF ligands in regulation of mouse lung morphogenesis and differentiation ex vivo.
Wed Jul 31 00:00:00 UTC 2024
Aldosterone controls primary cilium length and cell size in renal collecting duct principal cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Komarynets O,Chassot A,Bernabeu E,Czogalla J,Roth I,Liaudet N,Prodon F,Loffing J,Feraille E
Sat Feb 01 00:00:00 UTC 2020
Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Li X,Song J,Yan B,Rock SA,Jia J,Liu J,Wang C,Weiss T,Weiss HL,Gao T,Alam A,Evers BM
Mon Jun 01 00:00:00 UTC 2020
Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Naruse C,Abe K,Yoshihara T,Kato T,Nishiuchi T,Asano M
Sun Mar 01 00:00:00 UTC 2020
New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mao ZF,Ouyang SH,Zhang QY,Wu YP,Wang GE,Tu LF,Luo Z,Li WX,Kurihara H,Li YF,He RR
Sat Aug 01 00:00:00 UTC 2020
Regulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hou Q,Dong Y,Yu Q,Wang B,Le S,Guo Y,Zhang B
Sat Aug 01 00:00:00 UTC 2020
Prolyl-hydroxyproline, a collagen-derived dipeptide, enhances hippocampal cell proliferation, which leads to antidepressant-like effects in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nogimura D,Mizushige T,Taga Y,Nagai A,Shoji S,Azuma N,Kusubata M,Adachi SI,Yoshizawa F,Kabuyama Y
Wed Apr 01 00:00:00 UTC 2020
Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas.
Laboratory investigation; a journal of technical methods and pathology
Felsenstein M,Trujillo MA,Huang B,Nanda N,Jiang Z,Jeong YJ,Pflüger M,Goggins MG,Hruban RH,Thompson ED,Heaphy CM,Roberts NJ,Wood LD
315-09 was used in Cell Culture to study the generation as well as the characterization of cell line from a human pancreatic ITPN.
Wed Jul 01 00:00:00 UTC 2020
Role of the ESCRT-III complex in controlling integrity of the Salmonella-containing vacuole.
Cellular microbiology
Göser V,Kehl A,Röder J,Hensel M
Mon Jun 01 00:00:00 UTC 2020
A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells.
Genesis (New York, N.Y. : 2000)
van de Moosdijk AAA,van de Grift YBC,de Man SMA,Zeeman AL,van Amerongen R
Tue Sep 01 00:00:00 UTC 2020
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms.
Scientific reports
Engel DF,Bobbo VCD,Solon CS,Nogueira GA,Moura-Assis A,Mendes NF,Zanesco AM,Papangelis A,Ulven T,Velloso LA
Mon Jul 06 00:00:00 UTC 2020
Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron.
Cell death & disease
Seiwert N,Wecklein S,Demuth P,Hasselwander S,Kemper TA,Schwerdtle T,Brunner T,Fahrer J
Wed Sep 23 00:00:00 UTC 2020
TIGAR/AP-1 axis accelerates the division of Lgr5- reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation.
Cell death & disease
Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C
Mon Jul 06 00:00:00 UTC 2020
A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses.
Redox biology
Okkelman IA,Neto N,Papkovsky DB,Monaghan MG,Dmitriev RI
315-09 was used in Tissue/organ culture to study the redox metabolism of Lgr5-GFP intestinal organoids by combined analysis of fluorescence-based FLIM for NAD(P)H and organoid oxygenation by phosphorescence-based PLIM,.
Sat Feb 01 00:00:00 UTC 2020
TFEB regulates murine liver cell fate during development and regeneration.
Nature communications
Pastore N,Huynh T,Herz NJ,Calcagni' A,Klisch TJ,Brunetti L,Kim KH,De Giorgi M,Hurley A,Carissimo A,Mutarelli M,Aleksieva N,D'Orsi L,Lagor WR,Moore DD,Settembre C,Finegold MJ,Forbes SJ,Ballabio A
Mon May 18 00:00:00 UTC 2020
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Nature communications
Sun X,Peng X,Cao Y,Zhou Y,Sun Y
Fri Jun 12 00:00:00 UTC 2020
Fate and functional roles of Prominin 1+ cells in liver injury and cancer.
Scientific reports
Wu R,Pan S,Chen Y,Nakano Y,Li M,Balog S,Tsukamoto H
Tue Nov 10 00:00:00 UTC 2020
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.
Cellular and molecular gastroenterology and hepatology
Sontheimer-Phelps A,Chou DB,Tovaglieri A,Ferrante TC,Duckworth T,Fadel C,Frismantas V,Sutherland AD,Jalili-Firoozinezhad S,Kasendra M,Stas E,Weaver JC,Richmond CA,Levy O,Prantil-Baun R,Breault DT,Ingber DE
315-09 was used in In vitro experiments to develop a colon-on-a-chip microfluidic device modelling human colon mucus physiology in vitro, that helps visualise its accumulation in living cultures noninvasively.
Mon May 03 00:00:00 UTC 2021
IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.
Scientific reports
Minamide K,Sato T,Nakanishi Y,Ohno H,Kato T,Asano J,Ohteki T
Tue Sep 08 00:00:00 UTC 2020
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.
Nature communications
Lõhmussaar K,Kopper O,Korving J,Begthel H,Vreuls CPH,van Es JH,Clevers H
Wed May 27 00:00:00 UTC 2020
Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK Activation.
Cellular and molecular gastroenterology and hepatology
Sheng W,Malagola E,Nienhüser H,Zhang Z,Kim W,Zamechek L,Sepulveda A,Hata M,Hayakawa Y,Zhao CM,Chen D,Wang TC
315-09 was used in Cell Culture to study the genes involved in the mechanisms that lead to hypergastrinemia in enterochromaffin-like cells.
Fri Jul 09 00:00:00 UTC 2021
MicroRNA-674-5p induced by HIF-1α targets XBP-1 in intestinal epithelial cell injury during endotoxemia.
Cell death discovery
Liu Z,Jiang J,Dai W,Wei H,Zhang X,Yang Z,Xiong Y
Tue Sep 26 00:00:00 UTC 2023
Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway.
Frontiers in pharmacology
Sun L,Zhang H,Wang W,Chen Z,Wang S,Li J,Li G,Gao C,Sun X
315-09 was used in Sample Preparation (Western Blotting) to study Astragaloside IV (As IV) stimulation of hippocampal neurogenesis after stroke which potentially facilitates the brain to remodel and repair by downregulating IL-17 expression via Wnt pathway.
Thu Apr 14 00:00:00 UTC 2022
Molecular basis of CTCF binding polarity in genome folding.
Nature communications
Nora EP,Caccianini L,Fudenberg G,So K,Kameswaran V,Nagle A,Uebersohn A,Hajj B,Saux AL,Coulon A,Mirny LA,Pollard KS,Dahan M,Bruneau BG
Thu Nov 05 00:00:00 UTC 2020
Mechano-modulatory synthetic niches for liver organoid derivation.
Nature communications
Sorrentino G,Rezakhani S,Yildiz E,Nuciforo S,Heim MH,Lutolf MP,Schoonjans K
Fri Jul 10 00:00:00 UTC 2020
Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells.
Nature communications
Fu DJ,Wang L,Chouairi FK,Rose IM,Abetov DA,Miller AD,Yamulla RJ,Schimenti JC,Flesken-Nikitin A,Nikitin AY
Fri Jan 03 00:00:00 UTC 2020
Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer.
NPJ precision oncology
Duffy C,Sorolla A,Wang E,Golden E,Woodward E,Davern K,Ho D,Johnstone E,Pfleger K,Redfern A,Iyer KS,Baer B,Blancafort P
Sat Apr 02 00:00:00 UTC 2022
Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway.
Cell death discovery
Sun L,Han R,Guo F,Chen H,Wang W,Chen Z,Liu W,Sun X,Gao C
Tue Sep 26 00:00:00 UTC 2023
Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway.
Cell death discovery
Sun L,Han R,Guo F,Chen H,Wang W,Chen Z,Liu W,Sun X,Gao C
Tue Sep 26 00:00:00 UTC 2023
Engineered Plant-Based Nanocellulose Hydrogel for Small Intestinal Organoid Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Curvello R,Kerr G,Micati DJ,Chan WH,Raghuwanshi VS,Rosenbluh J,Abud HE,Garnier G
Wed Jan 01 00:00:00 UTC 2020
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Nature communications
Obraztsova K,Basil MC,Rue R,Sivakumar A,Lin SM,Mukhitov AR,Gritsiuta AI,Evans JF,Kopp M,Katzen J,Robichaud A,Atochina-Vasserman EN,Li S,Carl J,Babu A,Morley MP,Cantu E,Beers MF,Frank DB,Morrisey EE,Krymskaya VP
Fri Nov 06 00:00:00 UTC 2020
The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma.
Scientific reports
Sarić N,Selby M,Ramaswamy V,Kool M,Stockinger B,Hogstrand C,Williamson D,Marino S,Taylor MD,Clifford SC,Basson MA
Fri Jan 10 00:00:00 UTC 2020
Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation.
Scientific reports
Matsumura S,Kurashima Y,Murasaki S,Morimoto M,Arai F,Saito Y,Katayama N,Kim D,Inagaki Y,Kudo T,Ernst PB,Shimizu T,Kiyono H
Tue Oct 27 00:00:00 UTC 2020
Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation.
Scientific reports
Matsumura S,Kurashima Y,Murasaki S,Morimoto M,Arai F,Saito Y,Katayama N,Kim D,Inagaki Y,Kudo T,Ernst PB,Shimizu T,Kiyono H
Tue Oct 27 00:00:00 UTC 2020
LGR5 marks targetable tumor-initiating cells in mouse liver cancer.
Nature communications
Cao W,Li M,Liu J,Zhang S,Noordam L,Verstegen MMA,Wang L,Ma B,Li S,Wang W,Bolkestein M,Doukas M,Chen K,Ma Z,Bruno M,Sprengers D,Kwekkeboom J,van der Laan LJW,Smits R,Peppelenbosch MP,Pan Q
Thu Apr 23 00:00:00 UTC 2020
Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.
Cancers
Holokai L,Chakrabarti J,Lundy J,Croagh D,Adhikary P,Richards SS,Woodson C,Steele N,Kuester R,Scott A,Khreiss M,Frankel T,Merchant J,Jenkins BJ,Wang J,Shroff RT,Ahmad SA,Zavros Y
315-09 was used in Cell Culture to develop a clinically relevant in vitro organoid model to specifically target mechanisms that deplete myeloid-derived suppressor cells as a therapeutic strategy for pancreatic ductal adenocarcinoma.
Thu Dec 17 00:00:00 UTC 2020
Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine.
Scientific reports
Sato T,Sase M,Ishikawa S,Kajita M,Asano J,Sato T,Mori Y,Ohteki T
Fri May 22 00:00:00 UTC 2020
Alcohol abrogates human norovirus infectivity in a pH-dependent manner.
Scientific reports
Sato S,Matsumoto N,Hisaie K,Uematsu S
Mon Sep 28 00:00:00 UTC 2020
12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling.
Scientific reports
Radaszkiewicz KA,Beckerová D,Woloszczuková L,Radaszkiewicz TW,Lesáková P,Blanářová OV,Kubala L,Humpolíček P,Pachernik J
Mon Sep 28 00:00:00 UTC 2020
Three-dimensional culture of dental pulp pluripotent-like stem cells (DPPSCs) enhances Nanog expression and provides a serum-free condition for exosome isolation.
FASEB bioAdvances
Faruqu FN,Zhou S,Sami N,Gheidari F,Lu H,Al-Jamal KT
Wed Jul 01 00:00:00 UTC 2020
Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.
Cell
Cheng CW,Biton M,Haber AL,Gunduz N,Eng G,Gaynor LT,Tripathi S,Calibasi-Kocal G,Rickelt S,Butty VL,Moreno-Serrano M,Iqbal AM,Bauer-Rowe KE,Imada S,Ulutas MS,Mylonas C,Whary MT,Levine SS,Basbinar Y,Hynes RO,Mino-Kenudson M,Deshpande V,Boyer LA,Fox JG,Terranova C,Rai K,Piwnica-Worms H,Mihaylova MM,Regev A,Yilmaz ÖH
Thu Aug 22 00:00:00 UTC 2019
Physical Principles of Membrane Shape Regulation by the Glycocalyx.
Cell
Shurer CR,Kuo JC,Roberts LM,Gandhi JG,Colville MJ,Enoki TA,Pan H,Su J,Noble JM,Hollander MJ,O'Donnell JP,Yin R,Pedram K,Möckl L,Kourkoutis LF,Moerner WE,Bertozzi CR,Feigenson GW,Reesink HL,Paszek MJ
Thu Jun 13 00:00:00 UTC 2019
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Immunity
Hoyer FF,Naxerova K,Schloss MJ,Hulsmans M,Nair AV,Dutta P,Calcagno DM,Herisson F,Anzai A,Sun Y,Wojtkiewicz G,Rohde D,Frodermann V,Vandoorne K,Courties G,Iwamoto Y,Garris CS,Williams DL,Breton S,Brown D,Whalen M,Libby P,Pittet MJ,King KR,Weissleder R,Swirski FK,Nahrendorf M
Tue Nov 19 00:00:00 UTC 2019
Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1.
Cell host & microbe
Liang S,Guo XK,Ou J,Huang R,Xue Q,Zhang B,Chung Y,Wu W,Dong C,Yang X,Hu X
315-09 was used in Cell Culture to uncover a regulatory circuit that couples host nutrient status to epithelial antimicrobial immunity.
Wed May 08 00:00:00 UTC 2019
Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.
Cell stem cell
Chen M,Reed RR,Lane AP
315-09 was used in Cell Culture to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.
Thu Oct 03 00:00:00 UTC 2019
Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.
The Journal of clinical investigation
Meir M,Burkard N,Ungewiß H,Diefenbacher M,Flemming S,Kannapin F,Germer CT,Schweinlin M,Metzger M,Waschke J,Schlegel N
Mon Jun 17 00:00:00 UTC 2019
A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes.
The EMBO journal
Maslon MM,Braunschweig U,Aitken S,Mann AR,Kilanowski F,Hunter CJ,Blencowe BJ,Kornblihtt AR,Adams IR,Cáceres JF
Thu May 02 00:00:00 UTC 2019
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification.
Cell death and differentiation
Nicklas S,Hillje AL,Okawa S,Rudolph IM,Collmann FM,van Wuellen T,Del Sol A,Schwamborn JC
Fri Mar 01 00:00:00 UTC 2019
Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.
Aging cell
Yue S,Zheng X,Zheng Y
Thu Aug 01 00:00:00 UTC 2019
Comparison of different in vitro differentiation conditions for murine female germline stem cells.
Cell proliferation
Zou K,Wang J,Bi H,Zhang Y,Tian X,Tian N,Ma W,Wu J
Tue Jan 01 00:00:00 UTC 2019
Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis.
Mucosal immunology
Lin Y,Li B,Yang X,Liu T,Shi T,Deng B,Zhang Y,Jia L,Jiang Z,He R
Fri Nov 01 00:00:00 UTC 2019
Low sulfated heparins target multiple proteins for central nervous system repair.
Glia
McCanney GA,McGrath MA,Otto TD,Burchmore R,Yates EA,Bavington CD,Willison HJ,Turnbull JE,Barnett SC
Mon Apr 01 00:00:00 UTC 2019
Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases.
Glia
Suo N,Guo YE,He B,Gu H,Xie X
Mon Jul 01 00:00:00 UTC 2019
DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells.
Journal of lipid research
van Rijn JM,van Hoesel M,de Heus C,van Vugt AHM,Klumperman J,Nieuwenhuis EES,Houwen RHJ,Middendorp S
Tue Oct 01 00:00:00 UTC 2019
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
International journal of oncology
Wen N,Guo B,Zheng H,Xu L,Liang H,Wang Q,Wang D,Chen X,Zhang S,Li Y,Zhang L
315-09 was used in Cell Culture to explore the underlying mechanisms of the anti-tumour effects of Brd4 and the bromodomain inhibitor JQ1 on glioma stem cells.
Tue Oct 01 00:00:00 UTC 2019
Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice.
Stem cells (Dayton, Ohio)
Yanagawa T,Sumiyoshi H,Higashi K,Nakao S,Higashiyama R,Fukumitsu H,Minakawa K,Chiba Y,Suzuki Y,Sumida K,Saito K,Kamiya A,Inagaki Y
Tue Jan 01 00:00:00 UTC 2019
AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
Stem cells (Dayton, Ohio)
Zhang X,Wei R,Sun Y,Xia Q,Xie W,Song H,Wang W,Zou K
Thu Aug 01 00:00:00 UTC 2019
ProNGF Is a Cell-Type-Specific Mitogen for Adult Hippocampal and for Induced Neural Stem Cells.
Stem cells (Dayton, Ohio)
Corvaglia V,Cilli D,Scopa C,Brandi R,Arisi I,Malerba F,La Regina F,Scardigli R,Cattaneo A
Sun Sep 01 00:00:00 UTC 2019
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.
Journal of cellular and molecular medicine
Jin M,Li Q,Gu Y,Wan B,Huang J,Xu X,Huang R,Zhang Y
Fri Feb 01 00:00:00 UTC 2019
Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11.
American journal of physiology. Cell physiology
Katsumi T,Guicciardi ME,Azad A,Bronk SF,Krishnan A,Gores GJ
Tue Oct 01 00:00:00 UTC 2019
Changes of Metabolic Phenotype of Cardiac Progenitor Cells During Differentiation: Neutral Effect of Stimulation of AMP-Activated Protein Kinase.
Stem cells and development
André E,De Pauw A,Verdoy R,Brusa D,Bouzin C,Timmermans A,Bertrand L,Balligand JL
315-09 was used in Cell Culture to investigate the pharmacological modulation involved in the metabolic shift of cardiac progenitor cells.
Fri Nov 15 00:00:00 UTC 2019
Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.
Cell death & disease
Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S
Thu Sep 26 00:00:00 UTC 2019
Direct reprogramming of epidermal cells toward sweat gland-like cells by defined factors.
Cell death & disease
Yao B,Xie J,Liu N,Hu T,Song W,Huang S,Fu X
Wed Mar 20 00:00:00 UTC 2019
CIC protein instability contributes to tumorigenesis in glioblastoma.
Nature communications
Bunda S,Heir P,Metcalf J,Li ASC,Agnihotri S,Pusch S,Yasin M,Li M,Burrell K,Mansouri S,Singh O,Wilson M,Alamsahebpour A,Nejad R,Choi B,Kim D,von Deimling A,Zadeh G,Aldape K
Fri Feb 08 00:00:00 UTC 2019
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell.
Cell death discovery
Wang S,Du L,Peng G,Li W
Thu Oct 01 00:00:00 UTC 2020
RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury.
Nature communications
Zhu X,Yan J,Bregere C,Zelmer A,Goerne T,Kapfhammer JP,Guzman R,Wellmann S
Wed Sep 04 00:00:00 UTC 2019
BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration.
Nature communications
Liu M,Sun T,Li N,Peng J,Fu D,Li W,Li L,Gao WQ
Thu Oct 10 00:00:00 UTC 2019
Ex Vivo Hepatocyte Reprograming Promotes Homology-Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation.
Hepatology communications
VanLith CJ,Guthman RM,Nicolas CT,Allen KL,Liu Y,Chilton JA,Tritz ZP,Nyberg SL,Kaiser RA,Lillegard JB,Hickey RD
Mon Apr 01 00:00:00 UTC 2019
Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.
Nature communications
Gay DM,Ridgway RA,Müller M,Hodder MC,Hedley A,Clark W,Leach JD,Jackstadt R,Nixon C,Huels DJ,Campbell AD,Bird TG,Sansom OJ
Wed Feb 13 00:00:00 UTC 2019
PKCγ promotes axonal remodeling in the cortico-spinal tract via GSK3β/β-catenin signaling after traumatic brain injury.
Scientific reports
Zhang B,Li Z,Zhang R,Hu Y,Jiang Y,Cao T,Wang J,Gong L,Ji L,Mu H,Yang X,Dai Y,Jiang C,Yin Y,Zou J
Tue Nov 19 00:00:00 UTC 2019
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms.
Cell death & disease
Priem D,Devos M,Druwé S,Martens A,Slowicka K,Ting AT,Pasparakis M,Declercq W,Vandenabeele P,van Loo G,Bertrand MJM
Wed Sep 18 00:00:00 UTC 2019
Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.
Scientific reports
Kang HM,Lim JH,Noh KH,Park D,Cho HS,Susztak K,Jung CR
Tue Nov 26 00:00:00 UTC 2019
Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids.
Scientific reports
Yokoi Y,Nakamura K,Yoneda T,Kikuchi M,Sugimoto R,Shimizu Y,Ayabe T
Mon Feb 25 00:00:00 UTC 2019
Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
Cellular and molecular gastroenterology and hepatology
Jones JC,Brindley CD,Elder NH,Myers MG,Rajala MW,Dekaney CM,McNamee EN,Frey MR,Shroyer NF,Dempsey PJ
315-09 was used in In vitro experiments to show that Defa4Cre-expressing Paneth cells possess cellular plasticity, can dedifferentiate into multipotent stem cells upon Notch activation, and can contribute to intestinal regeneration in an acute injury model.
Tue Jun 04 00:00:00 UTC 2019
Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.
Nature communications
Zurkirchen L,Varum S,Giger S,Klug A,Häusel J,Bossart R,Zemke M,Cantù C,Atak ZK,Zamboni N,Basler K,Sommer L
Thu May 16 00:00:00 UTC 2019
Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro.
Nature communications
Feldman A,Mukha D,Maor II,Sedov E,Koren E,Yosefzon Y,Shlomi T,Fuchs Y
Tue May 28 00:00:00 UTC 2019
N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration.
eLife
Kon E,Calvo-Jiménez E,Cossard A,Na Y,Cooper JA,Jossin Y
315-09 was used in Cell Culture to reveal novel functions for FGFRs in cortical projection neuron migration, suggest a physiological role for FGFR and N-Cadherin interaction in vivo and identify Reelin as an extracellular upstream regulator and Erk1/2 as downstream effectors of FGFRs during neuron migration.
Wed Oct 02 00:00:00 UTC 2019
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
Nature communications
Soutto M,Chen Z,Bhat AA,Wang L,Zhu S,Gomaa A,Bates A,Bhat NS,Peng D,Belkhiri A,Piazuelo MB,Washington MK,Steven XC,Peek R,El-Rifai W
Wed Jul 10 00:00:00 UTC 2019
Evaluation of Neurosecretome from Mesenchymal Stem Cells Encapsulated in Silk Fibroin Hydrogels.
Scientific reports
Martín-Martín Y,Fernández-García L,Sanchez-Rebato MH,Marí-Buyé N,Rojo FJ,Pérez-Rigueiro J,Ramos M,Guinea GV,Panetsos F,González-Nieto D
Wed Jun 19 00:00:00 UTC 2019
Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors.
Nature communications
Ahmad ST,Rogers AD,Chen MJ,Dixit R,Adnani L,Frankiw LS,Lawn SO,Blough MD,Alshehri M,Wu W,Marra MA,Robbins SM,Cairncross JG,Schuurmans C,Chan JA
Wed May 01 00:00:00 UTC 2019
Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.
Stem cell research & therapy
I T,Sumita Y,Yoshida T,Honma R,Iwatake M,Raudales JLM,Shizuno T,Kuroshima S,Masuda H,Seki M,Tran SD,Asahara T,Asahina I
315-09 was used in Cell Culture to investigate methods conditioning peripheral blood mononuclear cells to regenerate salivary gland following head and neck cancer treatment.
Thu Oct 17 00:00:00 UTC 2019
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Nature communications
Chan K,Robert F,Oertlin C,Kapeller-Libermann D,Avizonis D,Gutierrez J,Handly-Santana A,Doubrovin M,Park J,Schoepfer C,Da Silva B,Yao M,Gorton F,Shi J,Thomas CJ,Brown LE,Porco JA,Pollak M,Larsson O,Pelletier J,Chio IIC
Wed Nov 13 00:00:00 UTC 2019
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Nature communications
Chan K,Robert F,Oertlin C,Kapeller-Libermann D,Avizonis D,Gutierrez J,Handly-Santana A,Doubrovin M,Park J,Schoepfer C,Da Silva B,Yao M,Gorton F,Shi J,Thomas CJ,Brown LE,Porco JA,Pollak M,Larsson O,Pelletier J,Chio IIC
Wed Nov 13 00:00:00 UTC 2019
Effects of insulin signaling on mouse taste cell proliferation.
PloS one
Takai S,Watanabe Y,Sanematsu K,Yoshida R,Margolskee RF,Jiang P,Atsuta I,Koyano K,Ninomiya Y,Shigemura N
315-09 was used in Cell Culture to demonstrate the important role of insulin in taste cell differentiation and proliferation, and show how it triggers the mTOR signaling pathway.
Mon Mar 23 00:00:00 UTC 2020
Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.
NPJ Regenerative medicine
Weiner AI,Jackson SR,Zhao G,Quansah KK,Farshchian JN,Neupauer KM,Littauer EQ,Paris AJ,Liberti DC,Scott Worthen G,Morrisey EE,Vaughan AE
Tue Sep 29 00:00:00 UTC 2020
Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.
Cell discovery
Cai Y,Zhu G,Liu S,Pan Z,Quintero M,Poole CJ,Lu C,Zhu H,Islam B,Riggelen JV,Browning D,Liu K,Blumberg R,Singh N,Li H
Thu Oct 01 00:00:00 UTC 2020
Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine.
Communications biology
Kawaguchi M,Yamamoto K,Takeda N,Fukushima T,Yamashita F,Sato K,Kitamura K,Hippo Y,Janetka JW,Kataoka H
Tue May 05 00:00:00 UTC 2020
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours.
Nature communications
Fu R,Han CF,Ni T,Di L,Liu LJ,Lv WC,Bi YR,Jiang N,He Y,Li HM,Wang S,Xie H,Chen BA,Wang XS,Weiss SJ,Lu T,Guo QL,Wu ZQ
Fri Jul 19 00:00:00 UTC 2019
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours.
Nature communications
Fu R,Han CF,Ni T,Di L,Liu LJ,Lv WC,Bi YR,Jiang N,He Y,Li HM,Wang S,Xie H,Chen BA,Wang XS,Weiss SJ,Lu T,Guo QL,Wu ZQ
Fri Jul 19 00:00:00 UTC 2019
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nature communications
Fenderico N,van Scherpenzeel RC,Goldflam M,Proverbio D,Jordens I,Kralj T,Stryeck S,Bass TZ,Hermans G,Ullman C,Aastrup T,Gros P,Maurice MM
Mon Jan 21 00:00:00 UTC 2019
c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration.
Cell death & disease
Aquila I,Cianflone E,Scalise M,Marino F,Mancuso T,Filardo A,Smith AJ,Cappetta D,De Angelis A,Urbanek K,Isidori AM,Torella M,Agosti V,Viglietto G,Nadal-Ginard B,Ellison-Hughes GM,Torella D
Tue Jun 04 00:00:00 UTC 2019
SIRT3 elicited an anti-Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.
Cancer medicine
Xu L,Li Y,Zhou L,Dorfman RG,Liu L,Cai R,Jiang C,Tang D,Wang Y,Zou X,Wang L,Zhang M
Wed May 01 00:00:00 UTC 2019
Functional Oocytes Derived from Granulosa Cells.
Cell reports
Tian C,Liu L,Ye X,Fu H,Sheng X,Wang L,Wang H,Heng D,Liu L
315-09 was used in Cell Culture to demonstrate that funtional oocytes posessing high genomic stability can be produced in vitro from somatic gPSCs through cellular reprogramming, facilitated by protonic sodium or acid - overall a safe and effective chemical induction technique.
Tue Dec 24 00:00:00 UTC 2019
Mediator complex interaction partners organize the transcriptional network that defines neural stem cells.
Nature communications
Quevedo M,Meert L,Dekker MR,Dekkers DHW,Brandsma JH,van den Berg DLC,Ozgür Z,van IJcken WFJ,Demmers J,Fornerod M,Poot RA
Mon Jun 17 00:00:00 UTC 2019
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis.
Nature communications
Slowicka K,Serramito-Gómez I,Boada-Romero E,Martens A,Sze M,Petta I,Vikkula HK,De Rycke R,Parthoens E,Lippens S,Savvides SN,Wullaert A,Vereecke L,Pimentel-Muiños FX,van Loo G
Tue Apr 23 00:00:00 UTC 2019
Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development.
Cell reports
Komabayashi-Suzuki M,Yamanishi E,Watanabe C,Okamura M,Tabata H,Iwai R,Ajioka I,Matsushita J,Kidoya H,Takakura N,Okamoto T,Kinoshita K,Ichihashi M,Nagata KI,Ema M,Mizutani KI
315-09 was used in Cell Culture to investigate blood vessel development in the brain, and this relationship with neuronal progenitors and other different cell types.
Tue Oct 29 00:00:00 UTC 2019
Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
Cell
Cho SW,Xu J,Sun R,Mumbach MR,Carter AC,Chen YG,Yost KE,Kim J,He J,Nevins SA,Chin SF,Caldas C,Liu SJ,Horlbeck MA,Lim DA,Weissman JS,Curtis C,Chang HY
Thu May 31 00:00:00 UTC 2018
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Cell
Biton M,Haber AL,Rogel N,Burgin G,Beyaz S,Schnell A,Ashenberg O,Su CW,Smillie C,Shekhar K,Chen Z,Wu C,Ordovas-Montanes J,Alvarez D,Herbst RH,Zhang M,Tirosh I,Dionne D,Nguyen LT,Xifaras ME,Shalek AK,von Andrian UH,Graham DB,Rozenblatt-Rosen O,Shi HN,Kuchroo V,Yilmaz OH,Regev A,Xavier RJ
Thu Nov 15 00:00:00 UTC 2018
Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function.
Cell
Shah PT,Stratton JA,Stykel MG,Abbasi S,Sharma S,Mayr KA,Koblinger K,Whelan PJ,Biernaskie J
Thu May 03 00:00:00 UTC 2018
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
Immunity
Nadjsombati MS,McGinty JW,Lyons-Cohen MR,Jaffe JB,DiPeso L,Schneider C,Miller CN,Pollack JL,Nagana Gowda GA,Fontana MF,Erle DJ,Anderson MS,Locksley RM,Raftery D,von Moltke J
Tue Jul 17 00:00:00 UTC 2018
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors.
Cancer cell
Andricovich J,Perkail S,Kai Y,Casasanta N,Peng W,Tzatsos A
Mon Mar 12 00:00:00 UTC 2018
PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.
Cancer cell
Morita M,Sato T,Nomura M,Sakamoto Y,Inoue Y,Tanaka R,Ito S,Kurosawa K,Yamaguchi K,Sugiura Y,Takizaki H,Yamashita Y,Katakura R,Sato I,Kawai M,Okada Y,Watanabe H,Kondoh G,Matsumoto S,Kishimoto A,Obata M,Matsumoto M,Fukuhara T,Motohashi H,Suematsu M,Komatsu M,Nakayama KI,Watanabe T,Soga T,Shima H,Maemondo M,Tanuma N
Mon Mar 12 00:00:00 UTC 2018
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.
Cell stem cell
Mihaylova MM,Cheng CW,Cao AQ,Tripathi S,Mana MD,Bauer-Rowe KE,Abu-Remaileh M,Clavain L,Erdemir A,Lewis CA,Freinkman E,Dickey AS,La Spada AR,Huang Y,Bell GW,Deshpande V,Carmeliet P,Katajisto P,Sabatini DM,Yilmaz ÖH
315-09 was used in Cell Culture to study the role of adult stem and progenitor cells in responding to short-term fasting and investigate whether such responses improve regeneration.
Thu May 03 00:00:00 UTC 2018
Tuberous sclerosis complex-associated CNS abnormalities depend on hyperactivation of mTORC1 and Akt.
The Journal of clinical investigation
Zordan P,Cominelli M,Cascino F,Tratta E,Poliani PL,Galli R
Mon Apr 02 00:00:00 UTC 2018
Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.
Science translational medicine
Strnadel J,Carromeu C,Bardy C,Navarro M,Platoshyn O,Glud AN,Marsala S,Kafka J,Miyanohara A,Kato T,Tadokoro T,Hefferan MP,Kamizato K,Yoshizumi T,Juhas S,Juhasova J,Ho CS,Kheradmand T,Chen P,Bohaciakova D,Hruska-Plochan M,Todd AJ,Driscoll SP,Glenn TD,Pfaff SL,Klima J,Ciacci J,Curtis E,Gage FH,Bui J,Yamada K,Muotri AR,Marsala M
Wed May 09 00:00:00 UTC 2018
Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.
The Journal of experimental medicine
Kanaya T,Sakakibara S,Jinnohara T,Hachisuka M,Tachibana N,Hidano S,Kobayashi T,Kimura S,Iwanaga T,Nakagawa T,Katsuno T,Kato N,Akiyama T,Sato T,Williams IR,Ohno H
Mon Feb 05 00:00:00 UTC 2018
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
The Journal of experimental medicine
Buczacki SJA,Popova S,Biggs E,Koukorava C,Buzzelli J,Vermeulen L,Hazelwood L,Francies H,Garnett MJ,Winton DJ
Mon Jul 02 00:00:00 UTC 2018
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
The Journal of experimental medicine
Aden K,Tran F,Ito G,Sheibani-Tezerji R,Lipinski S,Kuiper JW,Tschurtschenthaler M,Saveljeva S,Bhattacharyya J,Häsler R,Bartsch K,Luzius A,Jentzsch M,Falk-Paulsen M,Stengel ST,Welz L,Schwarzer R,Rabe B,Barchet W,Krautwald S,Hartmann G,Pasparakis M,Blumberg RS,Schreiber S,Kaser A,Rosenstiel P
Mon Nov 05 00:00:00 UTC 2018
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
The Journal of experimental medicine
Schmidt S,Schumacher N,Schwarz J,Tangermann S,Kenner L,Schlederer M,Sibilia M,Linder M,Altendorf-Hofmann A,Knösel T,Gruber ES,Oberhuber G,Bolik J,Rehman A,Sinha A,Lokau J,Arnold P,Cabron AS,Zunke F,Becker-Pauly C,Preaudet A,Nguyen P,Huynh J,Afshar-Sterle S,Chand AL,Westermann J,Dempsey PJ,Garbers C,Schmidt-Arras D,Rosenstiel P,Putoczki T,Ernst M,Rose-John S
Mon Apr 02 00:00:00 UTC 2018
EGFR is required for FOS-dependent bone tumor development via RSK2/CREB signaling.
EMBO molecular medicine
Linder M,Glitzner E,Srivatsa S,Bakiri L,Matsuoka K,Shahrouzi P,Dumanic M,Novoszel P,Mohr T,Langer O,Wanek T,Mitterhauser M,Wagner EF,Sibilia M
Thu Nov 01 00:00:00 UTC 2018
PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis.
Developmental cell
Kim MJ,Xia B,Suh HN,Lee SH,Jun S,Lien EM,Zhang J,Chen K,Park JI
315-09 was used in Cell Culture to unveil that the PAF-Myc signaling axis is indispensable for intestinal regeneration and tumorigenesis by positively regulating self-renewing cells.
Mon Mar 12 00:00:00 UTC 2018
Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling.
Science signaling
Bian G,Yu C,Liu L,Fang C,Chen K,Ren P,Zhang Q,Liu F,Zhang K,Xue Q,Xiang J,Guo H,Song J,Zhao Y,Wu W,Chung SK,Sun R,Ju G,Wang J
Tue Oct 23 00:00:00 UTC 2018
Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer.
Cellular and molecular gastroenterology and hepatology
Wang Y,Kim R,Gunasekara DB,Reed MI,DiSalvo M,Nguyen DL,Bultman SJ,Sims CE,Magness ST,Allbritton NL
315-09 was used in Cell Culture to show the in vitro human colon crypt array accurately mimicked the architecture, luminal accessibility, tissue polarity, cell migration, and cellular responses of in vivo intestinal crypts.
Mon Mar 18 00:00:00 UTC 2024
Sonic hedgehog signalling regulates the self-renewal and proliferation of skin-derived precursor cells in mice.
Cell proliferation
Park S,Kim H,Kim K,Roh S
Sat Dec 01 00:00:00 UTC 2018
P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis.
Stem cells (Dayton, Ohio)
Leeson HC,Kasherman MA,Chan-Ling T,Lovelace MD,Brownlie JC,Toppinen KM,Gu BJ,Weible MW
Thu Nov 01 00:00:00 UTC 2018
Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways.
Cell biology international
Taketomi T,Onimura T,Yoshiga D,Muratsu D,Sanui T,Fukuda T,Kusukawa J,Nakamura S
Sat Sep 01 00:00:00 UTC 2018
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Nature communications
Fellows R,Denizot J,Stellato C,Cuomo A,Jain P,Stoyanova E,Balázsi S,Hajnády Z,Liebert A,Kazakevych J,Blackburn H,Corrêa RO,Fachi JL,Sato FT,Ribeiro WR,Ferreira CM,Perée H,Spagnuolo M,Mattiuz R,Matolcsi C,Guedes J,Clark J,Veldhoen M,Bonaldi T,Vinolo MAR,Varga-Weisz P
Tue Jan 09 00:00:00 UTC 2018
Polyaniline cryogels: Biocompatibility of novel conducting macroporous material.
Scientific reports
Humpolíček P,Radaszkiewicz KA,Capáková Z,Pacherník J,Bober P,Kašpárková V,Rejmontová P,Lehocký M,Ponížil P,Stejskal J
Tue Jan 09 00:00:00 UTC 2018
Enhanced Biological Response of AVS-Functionalized Ti-6Al-4V Alloy through Covalent Immobilization of Collagen.
Scientific reports
Rezvanian P,Daza R,López PA,Ramos M,González-Nieto D,Elices M,Guinea GV,Pérez-Rigueiro J
Tue Feb 20 00:00:00 UTC 2018
ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Nature communications
Koren E,Yosefzon Y,Ankawa R,Soteriou D,Jacob A,Nevelsky A,Ben-Yosef R,Bar-Sela G,Fuchs Y
Fri Nov 02 00:00:00 UTC 2018
ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration.
Cell death & disease
Zhang H,Shi JH,Jiang H,Wang K,Lu JY,Jiang X,Ma X,Chen YX,Ren AJ,Zheng J,Xie Z,Guo S,Xu X,Zhang WJ
Tue May 01 00:00:00 UTC 2018
Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation and Epithelial Monolayer Function.
Scientific reports
Puzan M,Hosic S,Ghio C,Koppes A
Fri Apr 20 00:00:00 UTC 2018
Mature enteroendocrine cells contribute to basal and pathological stem cell dynamics in the small intestine.
American journal of physiology. Gastrointestinal and liver physiology
Sei Y,Feng J,Samsel L,White A,Zhao X,Yun S,Citrin D,McCoy JP,Sundaresan S,Hayes MM,Merchant JL,Leiter A,Wank SA
315-09 was used in Tissue/organ culture to study a mechanism in which a specified cell can dedifferentiate and contribute to normal tissue plasticity as well as the development of EEC-derived intestinal tumors under pathologic conditions.
Mon Oct 01 00:00:00 UTC 2018
Pharmacological activation of epidermal growth factor receptor signaling inhibits colitis-associated cancer in mice.
Scientific reports
Dubé PE,Liu CY,Girish N,Washington MK,Polk DB
Thu Jun 14 00:00:00 UTC 2018
Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound-Healing Applications.
Scientific reports
Liao AH,Hung CR,Chen HK,Chiang CP
Tue May 29 00:00:00 UTC 2018
Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound-Healing Applications.
Scientific reports
Liao AH,Hung CR,Chen HK,Chiang CP
Tue May 29 00:00:00 UTC 2018
Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound-Healing Applications.
Scientific reports
Liao AH,Hung CR,Chen HK,Chiang CP
Tue May 29 00:00:00 UTC 2018
Subcellular localisation modulates ubiquitylation and degradation of Ascl1.
Scientific reports
Gillotin S,Davies JD,Philpott A
Thu Mar 15 00:00:00 UTC 2018
Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation.
Cell death & disease
Bigas J,Sevilla LM,Carceller E,Boix J,Pérez P
Tue May 22 00:00:00 UTC 2018
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.
Nature communications
Grevys A,Nilsen J,Sand KMK,Daba MB,Øynebråten I,Bern M,McAdam MB,Foss S,Schlothauer T,Michaelsen TE,Christianson GJ,Roopenian DC,Blumberg RS,Sandlie I,Andersen JT
Mon Feb 12 00:00:00 UTC 2018
Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.
Nature communications
Muta Y,Fujita Y,Sumiyama K,Sakurai A,Taketo MM,Chiba T,Seno H,Aoki K,Matsuda M,Imajo M
Tue Jun 05 00:00:00 UTC 2018
A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture.
Scientific reports
Eenjes E,Mertens TCJ,Buscop-van Kempen MJ,van Wijck Y,Taube C,Rottier RJ,Hiemstra PS
Wed May 09 00:00:00 UTC 2018
Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor cortex.
Cell death & disease
Geribaldi-Doldán N,Carrasco M,Murillo-Carretero M,Domínguez-García S,García-Cózar FJ,Muñoz-Miranda JP,Del Río-García V,Verástegui C,Castro C
Tue Aug 28 00:00:00 UTC 2018
Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs.
Nature communications
Ikeda T,Hikichi T,Miura H,Shibata H,Mitsunaga K,Yamada Y,Woltjen K,Miyamoto K,Hiratani I,Yamada Y,Hotta A,Yamamoto T,Okita K,Masui S
Wed Apr 11 00:00:00 UTC 2018
A single-cell survey of the small intestinal epithelium.
Nature
Haber AL,Biton M,Rogel N,Herbst RH,Shekhar K,Smillie C,Burgin G,Delorey TM,Howitt MR,Katz Y,Tirosh I,Beyaz S,Dionne D,Zhang M,Raychowdhury R,Garrett WS,Rozenblatt-Rosen O,Shi HN,Yilmaz O,Xavier RJ,Regev A
Thu Nov 16 00:00:00 UTC 2017
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
Nature biotechnology
Roper J,Tammela T,Cetinbas NM,Akkad A,Roghanian A,Rickelt S,Almeqdadi M,Wu K,Oberli MA,Sánchez-Rivera FJ,Park YK,Liang X,Eng G,Taylor MS,Azimi R,Kedrin D,Neupane R,Beyaz S,Sicinska ET,Suarez Y,Yoo J,Chen L,Zukerberg L,Katajisto P,Deshpande V,Bass AJ,Tsichlis PN,Lees J,Langer R,Hynes RO,Chen J,Bhutkar A,Jacks T,Yilmaz ÖH
315-09 was used in Cell Culture to investigate cancer tumorigenesis modelling in mice.
Thu Jun 01 00:00:00 UTC 2017
Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.
Cell
Qin EY,Cooper DD,Abbott KL,Lennon J,Nagaraja S,Mackay A,Jones C,Vogel H,Jackson PK,Monje M
Thu Aug 24 00:00:00 UTC 2017
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
Cell
Bellono NW,Bayrer JR,Leitch DB,Castro J,Zhang C,O'Donnell TA,Brierley SM,Ingraham HA,Julius D
Thu Jun 29 00:00:00 UTC 2017
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.
Cell host & microbe
Tsai PY,Zhang B,He WQ,Zha JM,Odenwald MA,Singh G,Tamura A,Shen L,Sailer A,Yeruva S,Kuo WT,Fu YX,Tsukita S,Turner JR
315-09 was used in Cell Culture to investigate the pathogenic effects of diarrhea.
Wed Jun 14 00:00:00 UTC 2017
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
315-09 was used in Cell Culture to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 UTC 2017
Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis.
Neuron
Beckervordersandforth R,Ebert B,Schäffner I,Moss J,Fiebig C,Shin J,Moore DL,Ghosh L,Trinchero MF,Stockburger C,Friedland K,Steib K,von Wittgenstein J,Keiner S,Redecker C,Hölter SM,Xiang W,Wurst W,Jagasia R,Schinder AF,Ming GL,Toni N,Jessberger S,Song H,Lie DC
Wed Feb 08 00:00:00 UTC 2017
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
The Journal of experimental medicine
Matsuzawa-Ishimoto Y,Shono Y,Gomez LE,Hubbard-Lucey VM,Cammer M,Neil J,Dewan MZ,Lieberman SR,Lazrak A,Marinis JM,Beal A,Harris PA,Bertin J,Liu C,Ding Y,van den Brink MRM,Cadwell K
Mon Dec 04 00:00:00 UTC 2017
IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.
The Journal of experimental medicine
Jinnohara T,Kanaya T,Hase K,Sakakibara S,Kato T,Tachibana N,Sasaki T,Hashimoto Y,Sato T,Watarai H,Kunisawa J,Shibata N,Williams IR,Kiyono H,Ohno H
Mon Jun 05 00:00:00 UTC 2017
Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18.
Hepatology (Baltimore, Md.)
Ravà M,D'Andrea A,Doni M,Kress TR,Ostuni R,Bianchi V,Morelli MJ,Collino A,Ghisletti S,Nicoli P,Recordati C,Iascone M,Sonzogni A,D'Antiga L,Shukla R,Faulkner GJ,Natoli G,Campaner S,Amati B
Mon May 01 00:00:00 UTC 2017
ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis.
The EMBO journal
Horiguchi H,Endo M,Kawane K,Kadomatsu T,Terada K,Morinaga J,Araki K,Miyata K,Oike Y
Wed Feb 15 00:00:00 UTC 2017
Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.
Proceedings of the National Academy of Sciences of the United States of America
Schutgens F,Rookmaaker MB,Blokzijl F,van Boxtel R,Vries R,Cuppen E,Verhaar MC,Clevers H
Tue Dec 26 00:00:00 UTC 2017
TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.
Cell death and differentiation
Cammareri P,Vincent DF,Hodder MC,Ridgway RA,Murgia C,Nobis M,Campbell AD,Varga J,Huels DJ,Subramani C,Prescott KLH,Nixon C,Hedley A,Barry ST,Greten FR,Inman GJ,Sansom OJ
Sun Oct 01 00:00:00 UTC 2017
Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells.
Cancer science
Usui T,Sakurai M,Nishikawa S,Umata K,Nemoto Y,Haraguchi T,Itamoto K,Mizuno T,Noguchi S,Mori T,Iwai S,Nakagawa T,Yamawaki H,Ohama T,Sato K
Fri Dec 01 00:00:00 UTC 2017
Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro.
Nanomedicine (London, England)
Ingallina C,Costa PM,Ghirga F,Klippstein R,Wang JT,Berardozzi S,Hodgins N,Infante P,Pollard SM,Botta B,Al-Jamal KT
315-09 was used in Cell Culture to show that NC-GlaB has the potential to be utilised in a preclinical setting and justifies the need to perform therapeutic experiments on mice.
Sat Apr 01 00:00:00 UTC 2017
Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro.
Nanomedicine (London, England)
Ingallina C,Costa PM,Ghirga F,Klippstein R,Wang JT,Berardozzi S,Hodgins N,Infante P,Pollard SM,Botta B,Al-Jamal KT
315-09 was used in Cell Culture to show that NC-GlaB has the potential to be utilised in a preclinical setting and justifies the need to perform therapeutic experiments on mice.
Sat Apr 01 00:00:00 UTC 2017
Bone Morphogenetic Protein Promotes Lewis X Stage-Specific Embryonic Antigen 1 Expression Thereby Interfering with Neural Precursor and Stem Cell Proliferation.
Stem cells (Dayton, Ohio)
Luque-Molina I,Khatri P,Schmidt-Edelkraut U,Simeonova IK,Hölzl-Wenig G,Mandl C,Ciccolini F
Fri Dec 01 00:00:00 UTC 2017
IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery V,Goldson AJ,Dainty JR,Chieppa M,Sobolewski A
Sat Jul 01 00:00:00 UTC 2017
IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
Journal of immunology (Baltimore, Md. : 1950)
Zepp JA,Zhao J,Liu C,Bulek K,Wu L,Chen X,Hao Y,Wang Z,Wang X,Ouyang W,Kalady MF,Carman J,Yang WP,Zhu J,Blackburn C,Huang YH,Hamilton TA,Su B,Li X
Fri Dec 01 00:00:00 UTC 2017
M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway.
Oncotarget
Yuan J,Ge H,Liu W,Zhu H,Chen Y,Zhang X,Yang Y,Yin Y,Chen W,Wu W,Yang Y,Lin J
315-09 was used in Cell Culture to confirm that M2 microglia supernatant can activate the PPARγ signaling pathway and promote neurogenesis and oligodendrogenesis from NSPCs differentiation.
Tue Mar 21 00:00:00 UTC 2017
Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis.
Physiological reports
Usui T,Sakurai M,Kawasaki H,Ohama T,Yamawaki H,Sato K
Thu Jun 01 00:00:00 UTC 2017
Primary aldosteronism patients show skin alterations and abnormal activation of glucocorticoid receptor in keratinocytes.
Scientific reports
Boix J,Bigas J,Sevilla LM,Iacobone M,Citton M,Torresan F,Caroccia B,Rossi GP,Pérez P
Fri Nov 17 00:00:00 UTC 2017
Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction.
JCI insight
De Pauw A,Andre E,Sekkali B,Bouzin C,Esfahani H,Barbier N,Loriot A,De Smet C,Vanhoutte L,Moniotte S,Gerber B,di Mauro V,Catalucci D,Feron O,Hilfiker-Kleiner D,Balligand JL
315-09 was used in Cell Culture to conclude that miR-29a and Dnmt3a epigenetically regulate CPC differentiation through Wnt inhibition.
Thu Jun 15 00:00:00 UTC 2017
Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice.
The Journal of biological chemistry
Liu J,Shang D,Xiao Y,Zhong P,Cheng H,Zhou R
Fri Sep 29 00:00:00 UTC 2017
Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.
Nature communications
Vallecillo-García P,Orgeur M,Vom Hofe-Schneider S,Stumm J,Kappert V,Ibrahim DM,Börno ST,Hayashi S,Relaix F,Hildebrandt K,Sengle G,Koch M,Timmermann B,Marazzi G,Sassoon DA,Duprez D,Stricker S
Tue Oct 31 00:00:00 UTC 2017
MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors.
Scientific reports
Ji HP,Xiong Y,Song WT,Zhang ED,Gao ZL,Yao F,Su T,Zhou RR,Xia XB
Tue Sep 12 00:00:00 UTC 2017
Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.
Stem cell reports
Li B,Dorrell C,Canaday PS,Pelz C,Haft A,Finegold M,Grompe M
Tue Aug 08 00:00:00 UTC 2017
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.
Nature communications
Kitagawa M,Liao PJ,Lee KH,Wong J,Shang SC,Minami N,Sampetrean O,Saya H,Lingyun D,Prabhu N,Diam GK,Sobota R,Larsson A,Nordlund P,McCormick F,Ghosh S,Epstein DM,Dymock BW,Lee SH
Tue Dec 19 00:00:00 UTC 2017
Liquid Marble as Bioreactor for Engineering Three-Dimensional Toroid Tissues.
Scientific reports
Vadivelu RK,Kamble H,Munaz A,Nguyen NT
Thu Sep 28 00:00:00 UTC 2017
Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy.
Scientific reports
Yang M,Arai A,Udagawa N,Hiraga T,Lijuan Z,Ito S,Komori T,Moriishi T,Matsuo K,Shimoda K,Zahalka AH,Kobayashi Y,Takahashi N,Mizoguchi T
Mon Jul 10 00:00:00 UTC 2017
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.
Scientific reports
Bryant DT,Landles C,Papadopoulou AS,Benjamin AC,Duckworth JK,Rosahl T,Benn CL,Bates GP
Tue Sep 19 00:00:00 UTC 2017
Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1 +/- granule cell precursors after radiation injury.
Scientific reports
Tanno B,Leonardi S,Babini G,Giardullo P,De Stefano I,Pasquali E,Saran A,Mancuso M
Fri Oct 27 00:00:00 UTC 2017
Ex vivo Culture of Fetal Mouse Gastric Epithelial Progenitors.
Bio-protocol
Vallone VF,Leprovots M,Vassart G,Garcia MI
315-09 was used in Cell Culture to report an adapted protocol for isolation and ex vivo culture and maintenance of fetal epithelial progenitors from distal pre-glandular stomach growing as gastric spheroids.
Thu Jan 05 00:00:00 UTC 2017
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Nature communications
Lüningschrör P,Binotti B,Dombert B,Heimann P,Perez-Lara A,Slotta C,Thau-Habermann N,R von Collenberg C,Karl F,Damme M,Horowitz A,Maystadt I,Füchtbauer A,Füchtbauer EM,Jablonka S,Blum R,Üçeyler N,Petri S,Kaltschmidt B,Jahn R,Kaltschmidt C,Sendtner M
Mon Oct 30 00:00:00 UTC 2017
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 UTC 2016
PI3-kinase mutation linked to insulin and growth factor resistance in vivo.
The Journal of clinical investigation
Winnay JN,Solheim MH,Dirice E,Sakaguchi M,Noh HL,Kang HJ,Takahashi H,Chudasama KK,Kim JK,Molven A,Kahn CR,Njølstad PR
Fri Apr 01 00:00:00 UTC 2016
PI3-kinase mutation linked to insulin and growth factor resistance in vivo.
The Journal of clinical investigation
Winnay JN,Solheim MH,Dirice E,Sakaguchi M,Noh HL,Kang HJ,Takahashi H,Chudasama KK,Kim JK,Molven A,Kahn CR,Njølstad PR
Fri Apr 01 00:00:00 UTC 2016
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Genes & development
Kwan J,Sczaniecka A,Heidary Arash E,Nguyen L,Chen CC,Ratkovic S,Klezovitch O,Attisano L,McNeill H,Emili A,Vasioukhin V
315-09 was used in Cell Culture to report here that DLG5 functions as an evolutionarily conserved scaffold and negative regulator of Hippo signaling, which controls organ size through the modulation of cell proliferation and differentiation.
Thu Dec 15 00:00:00 UTC 2016
Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.
Proceedings of the National Academy of Sciences of the United States of America
Yeh SC,Wang PY,Lou YW,Khoo KH,Hsiao M,Hsu TL,Wong CH
Tue May 17 00:00:00 UTC 2016
Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells.
Stem cells (Dayton, Ohio)
Sullivan JM,Havrda MC,Kettenbach AN,Paolella BR,Zhang Z,Gerber SA,Israel MA
Sun May 01 00:00:00 UTC 2016
PDGFR-β Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke.
Stem cells (Dayton, Ohio)
Sato H,Ishii Y,Yamamoto S,Azuma E,Takahashi Y,Hamashima T,Umezawa A,Mori H,Kuroda S,Endo S,Sasahara M
Tue Mar 01 00:00:00 UTC 2016
Chemical Screening Identifies EUrd as a Novel Inhibitor Against Temozolomide-Resistant Glioblastoma-Initiating Cells.
Stem cells (Dayton, Ohio)
Tsukamoto Y,Ohtsu N,Echizenya S,Otsuguro S,Ogura R,Natsumeda M,Isogawa M,Aoki H,Ichikawa S,Sakaitani M,Matsuda A,Maenaka K,Fujii Y,Kondo T
Mon Aug 01 00:00:00 UTC 2016
Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential.
Stem cells (Dayton, Ohio)
Kwon OJ,Zhang L,Xin L
Fri Jan 01 00:00:00 UTC 2016
MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2-Lin28/let-7 Signaling Pathway.
Stem cells (Dayton, Ohio)
Morgado AL,Rodrigues CM,Solá S
Sun May 01 00:00:00 UTC 2016
Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene.
Biology open
Fuchs C,Gawlas S,Heher P,Nikouli S,Paar H,Ivankovic M,Schultheis M,Klammer J,Gottschamel T,Capetanaki Y,Weitzer G
315-09 was used in Cell Culture to show that desmin activates transcription of nkx2.5 reporter genes, rescues nkx2.5 haploinsufficiency in cardiac progenitor cells, and is responsible for the proper expression of Nkx2.5 in adult cardiac side population stem cells, introducing desmin as a newly discovered and unexpected player in the regulatory network guiding cardiomyogenesis in cardiac stem cells.
Tue Jan 19 00:00:00 UTC 2016
Hiding inside? Intracellular expression of non-glycosylated c-kit protein in cardiac progenitor cells.
Stem cell research
Shi H,Drummond CA,Fan X,Haller ST,Liu J,Malhotra D,Tian J
315-09 was used in Cell Culture to demonstrate that cardiac progenitor cell c-kit is expressed in cardiosphere-derived cells and directly participates in their differentiation into an endothelial lineage.
Sun May 01 00:00:00 UTC 2016
ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing.
Nature methods
Chen X,Shen Y,Draper W,Buenrostro JD,Litzenburger U,Cho SW,Satpathy AT,Carter AC,Ghosh RP,East-Seletsky A,Doudna JA,Greenleaf WJ,Liphardt JT,Chang HY
315-09 was used in Cell Culture to demonstrate the assay of transposase-accessible chromatin with visualization (ATAC-see), a transposase-mediated imaging technology that employs direct imaging of the accessible genome in situ, cell sorting, and deep sequencing to reveal the identity of the imaged elements.
Thu Dec 01 00:00:00 UTC 2016
Poly-L-ornithine enhances migration of neural stem/progenitor cells via promoting α-Actinin 4 binding to actin filaments.
Scientific reports
Ge H,Yu A,Chen J,Yuan J,Yin Y,Duanmu W,Tan L,Yang Y,Lan C,Chen W,Feng H,Hu R
Tue Nov 22 00:00:00 UTC 2016
Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream.
Scientific reports
Langenfurth A,Gu S,Bautze V,Zhang C,Neumann JE,Schüller U,Stock K,Wolf SA,Maier AM,Mastrella G,Pak A,Cheng H,Kälin RE,Holmbeck K,Strotmann J,Kettenmann H,Glass R
Tue Aug 30 00:00:00 UTC 2016
A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death.
Cell death discovery
Furness S,Hare DL,Kourakis A,Turnley AM,Wookey PJ
Wed Sep 30 00:00:00 UTC 2020
Cell-permeable p38 MAP kinase promotes migration of adult neural stem/progenitor cells.
Scientific reports
Hamanoue M,Morioka K,Ohsawa I,Ohsawa K,Kobayashi M,Tsuburaya K,Akasaka Y,Mikami T,Ogata T,Takamatsu K
Tue Apr 12 00:00:00 UTC 2016
SCF/c-kit transactivates CXCR4-serine 339 phosphorylation through G protein-coupled receptor kinase 6 and regulates cardiac stem cell migration.
Scientific reports
Zuo K,Kuang D,Wang Y,Xia Y,Tong W,Wang X,Chen Y,Duan Y,Wang G
Wed Jun 01 00:00:00 UTC 2016
ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C γ1 and protein kinase C pathways.
Scientific reports
Wolf C,Qian Y,Brooke MA,Kelsell DP,Franzke CW
Thu Dec 22 00:00:00 UTC 2016
Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts.
The Journal of biological chemistry
Kim SM,Kim JW,Kwak TH,Park SW,Kim KP,Park H,Lim KT,Kang K,Kim J,Yang JH,Han H,Lee I,Hyun JK,Bae YM,Schöler HR,Lee HT,Han DW
Fri Jul 01 00:00:00 UTC 2016
Antiangiogenic therapy using endostatin increases the number of ALDH+ lung cancer stem cells by generating intratumor hypoxia.
Scientific reports
Yu Y,Wang YY,Wang YQ,Wang X,Liu YY,Wang JT,Du C,Wang L,Li M,Luo F,Jiang M
Wed Oct 05 00:00:00 UTC 2016
MiR218 Modulates Wnt Signaling in Mouse Cardiac Stem Cells by Promoting Proliferation and Inhibiting Differentiation through a Positive Feedback Loop.
Scientific reports
Wang Y,Liu J,Cui J,Sun M,Du W,Chen T,Ming X,Zhang L,Tian J,Li J,Yin L,Liu F,Pu Z,Lv B,Hou J,Yu B
Wed Feb 10 00:00:00 UTC 2016
Hypoxic Preconditioning Inhibits Hypoxia-induced Apoptosis of Cardiac Progenitor Cells via the PI3K/Akt-DNMT1-p53 Pathway.
Scientific reports
Xu R,Sun Y,Chen Z,Yao Y,Ma G
Thu Aug 04 00:00:00 UTC 2016
Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.
Scientific reports
Wang G,Zhang L,Chen X,Xue X,Guo Q,Liu M,Zhao J
Fri May 13 00:00:00 UTC 2016
Lentivirus-Based Stable Gene Delivery into Intestinal Organoids.
Methods in molecular biology (Clifton, N.J.)
Maru Y,Orihashi K,Hippo Y
315-09 was used in Cell Culture to demonstrate that this method allows for highly efficient infection of intestinal organoids after overnight incubation of Matrigel-attached cells with lentiviral particles.
Wed Dec 13 00:00:00 UTC 2017
Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier.
Nature communications
Campos Y,Qiu X,Gomero E,Wakefield R,Horner L,Brutkowski W,Han YG,Solecki D,Frase S,Bongiovanni A,d'Azzo A
Thu Jun 23 00:00:00 UTC 2016
Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.
Stem cell reports
Zhang P,Xing C,Rhodes SD,He Y,Deng K,Li Z,He F,Zhu C,Nguyen L,Zhou Y,Chen S,Mohammad KS,Guise TA,Abdel-Wahab O,Xu M,Wang QF,Yang FC
Tue Jun 14 00:00:00 UTC 2016
Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity.
Scientific reports
Chng SH,Kundu P,Dominguez-Brauer C,Teo WL,Kawajiri K,Fujii-Kuriyama Y,Mak TW,Pettersson S
Tue Apr 12 00:00:00 UTC 2016
Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice.
The Journal of clinical investigation
Mozafari S,Laterza C,Roussel D,Bachelin C,Marteyn A,Deboux C,Martino G,Baron-Van Evercooren A
Tue Sep 01 00:00:00 UTC 2015
The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing.
The Journal of experimental medicine
Lee SH,Kim MY,Kim HY,Lee YM,Kim H,Nam KA,Roh MR,Min do S,Chung KY,Choi KY
Mon Jun 29 00:00:00 UTC 2015
Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.
The EMBO journal
Tao S,Tang D,Morita Y,Sperka T,Omrani O,Lechel A,Sakk V,Kraus J,Kestler HA,Kühl M,Rudolph KL
Wed Mar 04 00:00:00 UTC 2015
E-cadherin can limit the transforming properties of activating β-catenin mutations.
The EMBO journal
Huels DJ,Ridgway RA,Radulescu S,Leushacke M,Campbell AD,Biswas S,Leedham S,Serra S,Chetty R,Moreaux G,Parry L,Matthews J,Song F,Hedley A,Kalna G,Ceteci F,Reed KR,Meniel VS,Maguire A,Doyle B,Söderberg O,Barker N,Watson A,Larue L,Clarke AR,Sansom OJ
Mon Sep 14 00:00:00 UTC 2015
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Bartesaghi S,Graziano V,Galavotti S,Henriquez NV,Betts J,Saxena J,Minieri V,A D,Karlsson A,Martins LM,Capasso M,Nicotera P,Brandner S,De Laurenzi V,Salomoni P
Tue Jan 27 00:00:00 UTC 2015
An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.
Proceedings of the National Academy of Sciences of the United States of America
Schneeberger K,Vogel GF,Teunissen H,van Ommen DD,Begthel H,El Bouazzaoui L,van Vugt AH,Beekman JM,Klumperman J,Müller T,Janecke A,Gerner P,Huber LA,Hess MW,Clevers H,van Es JH,Nieuwenhuis EE,Middendorp S
Tue Oct 06 00:00:00 UTC 2015
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.
Proceedings of the National Academy of Sciences of the United States of America
Suhara T,Hishiki T,Kasahara M,Hayakawa N,Oyaizu T,Nakanishi T,Kubo A,Morisaki H,Kaelin WG,Suematsu M,Minamishima YA
Tue Sep 15 00:00:00 UTC 2015
Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation.
Cancer science
Nakaguro M,Kiyonari S,Kishida S,Cao D,Murakami-Tonami Y,Ichikawa H,Takeuchi I,Nakamura S,Kadomatsu K
Sun Mar 01 00:00:00 UTC 2015
NeuroD1 promotes neuroblastoma cell growth by inducing the expression of ALK.
Cancer science
Lu F,Kishida S,Mu P,Huang P,Cao D,Tsubota S,Kadomatsu K
Wed Apr 01 00:00:00 UTC 2015
Age-Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis.
Stem cells (Dayton, Ohio)
Yousef H,Morgenthaler A,Schlesinger C,Bugaj L,Conboy IM,Schaffer DV
Fri May 01 00:00:00 UTC 2015
Adult DRG Stem/Progenitor Cells Generate Pericytes in the Presence of Central Nervous System (CNS) Developmental Cues, and Schwann Cells in Response to CNS Demyelination.
Stem cells (Dayton, Ohio)
Vidal M,Maniglier M,Deboux C,Bachelin C,Zujovic V,Baron-Van Evercooren A
Mon Jun 01 00:00:00 UTC 2015
Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity.
Stem cells (Dayton, Ohio)
Stoll EA,Makin R,Sweet IR,Trevelyan AJ,Miwa S,Horner PJ,Turnbull DM
Wed Jul 01 00:00:00 UTC 2015
Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment.
The Journal of biological chemistry
Huang Y,Hamana T,Liu J,Wang C,An L,You P,Chang JYF,Xu J,McKeehan WL,Wang F
Fri Jul 17 00:00:00 UTC 2015
Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1.
Nature communications
Garcez PP,Diaz-Alonso J,Crespo-Enriquez I,Castro D,Bell D,Guillemot F
Tue Mar 10 00:00:00 UTC 2015
Poly-L-ornithine promotes preferred differentiation of neural stem/progenitor cells via ERK signalling pathway.
Scientific reports
Ge H,Tan L,Wu P,Yin Y,Liu X,Meng H,Cui G,Wu N,Lin J,Hu R,Feng H
Tue Oct 27 00:00:00 UTC 2015
Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors.
Nature biotechnology
Maza I,Caspi I,Zviran A,Chomsky E,Rais Y,Viukov S,Geula S,Buenrostro JD,Weinberger L,Krupalnik V,Hanna S,Zerbib M,Dutton JR,Greenleaf WJ,Massarwa R,Novershtern N,Hanna JH
315-09 was used in Cell Culture to show that the vast majority of reprogrammed cardiomyocytes or neural stem cells obtained from mouse fibroblasts by OSKM-induced 'transdifferentiation' pass through a transient pluripotent state, and that their derivation is molecularly coupled to iPSC formation mechanisms.
Wed Jul 01 00:00:00 UTC 2015
Analysis of Wnt signalling dynamics during colon crypt development in 3D culture.
Scientific reports
Tan CW,Hirokawa Y,Burgess AW
Thu Jun 18 00:00:00 UTC 2015
Generation of three-dimensional multiple spheroid model of olfactory ensheathing cells using floating liquid marbles.
Scientific reports
Vadivelu RK,Ooi CH,Yao RQ,Tello Velasquez J,Pastrana E,Diaz-Nido J,Lim F,Ekberg JA,Nguyen NT,St John JA
Wed Oct 14 00:00:00 UTC 2015
p53- and p73-independent activation of TIGAR expression in vivo.
Cell death & disease
Lee P,Hock AK,Vousden KH,Cheung EC
Thu Aug 06 00:00:00 UTC 2015
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
Scientific reports
Thakur R,Trivedi R,Rastogi N,Singh M,Mishra DP
Thu May 14 00:00:00 UTC 2015
γ-Aminobutyric A receptor (GABA(A)R) regulates aquaporin 4 expression in the subependymal zone: relevance to neural precursors and water exchange.
The Journal of biological chemistry
Li Y,Schmidt-Edelkraut U,Poetz F,Oliva I,Mandl C,Hölzl-Wenig G,Schönig K,Bartsch D,Ciccolini F
Fri Feb 13 00:00:00 UTC 2015
Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.
Nature communications
Liu X,Hall SRR,Wang Z,Huang H,Ghanta S,Di Sante M,Leri A,Anversa P,Perrella MA
Mon Nov 23 00:00:00 UTC 2015
STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Nature communications
Pencik J,Schlederer M,Gruber W,Unger C,Walker SM,Chalaris A,Marié IJ,Hassler MR,Javaheri T,Aksoy O,Blayney JK,Prutsch N,Skucha A,Herac M,Krämer OH,Mazal P,Grebien F,Egger G,Poli V,Mikulits W,Eferl R,Esterbauer H,Kennedy R,Fend F,Scharpf M,Braun M,Perner S,Levy DE,Malcolm T,Turner SD,Haitel A,Susani M,Moazzami A,Rose-John S,Aberger F,Merkel O,Moriggl R,Culig Z,Dolznig H,Kenner L
Wed Jul 22 00:00:00 UTC 2015
Citrullination regulates pluripotency and histone H1 binding to chromatin.
Nature
Christophorou MA,Castelo-Branco G,Halley-Stott RP,Oliveira CS,Loos R,Radzisheuskaya A,Mowen KA,Bertone P,Silva JC,Zernicka-Goetz M,Nielsen ML,Gurdon JB,Kouzarides T
Thu Mar 06 00:00:00 UTC 2014
Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
The Journal of clinical investigation
de Jong PR,Takahashi N,Harris AR,Lee J,Bertin S,Jeffries J,Jung M,Duong J,Triano AI,Lee J,Niv Y,Herdman DS,Taniguchi K,Kim CW,Dong H,Eckmann L,Stanford SM,Bottini N,Corr M,Raz E
Mon Sep 01 00:00:00 UTC 2014
Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
The Journal of clinical investigation
de Jong PR,Takahashi N,Harris AR,Lee J,Bertin S,Jeffries J,Jung M,Duong J,Triano AI,Lee J,Niv Y,Herdman DS,Taniguchi K,Kim CW,Dong H,Eckmann L,Stanford SM,Bottini N,Corr M,Raz E
Mon Sep 01 00:00:00 UTC 2014
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
EMBO molecular medicine
Peter S,Bultinck J,Myant K,Jaenicke LA,Walz S,Müller J,Gmachl M,Treu M,Boehmelt G,Ade CP,Schmitz W,Wiegering A,Otto C,Popov N,Sansom O,Kraut N,Eilers M
Mon Dec 01 00:00:00 UTC 2014
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
The EMBO journal
Charlaftis N,Suddason T,Wu X,Anwar S,Karin M,Gallagher E
Mon Nov 03 00:00:00 UTC 2014
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele.
The EMBO journal
Basak O,van de Born M,Korving J,Beumer J,van der Elst S,van Es JH,Clevers H
Wed Sep 17 00:00:00 UTC 2014
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.
Proceedings of the National Academy of Sciences of the United States of America
Wiener Z,Band AM,Kallio P,Högström J,Hyvönen V,Kaijalainen S,Ritvos O,Haglund C,Kruuna O,Robine S,Louvard D,Ben-Neriah Y,Alitalo K
Tue May 27 00:00:00 UTC 2014
Role of BRCA1 in brain development.
Proceedings of the National Academy of Sciences of the United States of America
Pao GM,Zhu Q,Perez-Garcia CG,Chou SJ,Suh H,Gage FH,O'Leary DD,Verma IM
Tue Apr 01 00:00:00 UTC 2014
NogoR1 and PirB signaling stimulates neural stem cell survival and proliferation.
Stem cells (Dayton, Ohio)
Ramasamy S,Yu F,Hong Yu Y,Srivats H,Dawe GS,Ahmed S
Sun Jun 01 00:00:00 UTC 2014
CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironment.
Stem cells (Dayton, Ohio)
Kinugasa Y,Matsui T,Takakura N
Wed Jan 01 00:00:00 UTC 2014
EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Z,Xiao C,Gibson AM,Bass SA,Khurana Hershey GK
Sat Feb 01 00:00:00 UTC 2014
Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium.
Journal of immunology (Baltimore, Md. : 1950)
Skoczek DA,Walczysko P,Horn N,Parris A,Clare S,Williams MR,Sobolewski A
Tue Jul 01 00:00:00 UTC 2014
Lentiviral labeling of mouse and human enteric nervous system stem cells for regenerative medicine studies.
Neurogastroenterology and motility
Natarajan D,Cooper J,Choudhury S,Delalande JM,McCann C,Howe SJ,Thapar N,Burns AJ
Wed Oct 01 00:00:00 UTC 2014
Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.
Cell death & disease
Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T
Thu May 15 00:00:00 UTC 2014
Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.
Scientific reports
Khatri P,Obernier K,Simeonova IK,Hellwig A,Hölzl-Wenig G,Mandl C,Scholl C,Wölfl S,Winkler J,Gaspar JA,Sachinidis A,Ciccolini F
Wed Jan 22 00:00:00 UTC 2014
Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.
Nature communications
Chanrion M,Kuperstein I,Barrière C,El Marjou F,Cohen D,Vignjevic D,Stimmer L,Paul-Gilloteaux P,Bièche I,Tavares Sdos R,Boccia GF,Cacheux W,Meseure D,Fre S,Martignetti L,Legoix-Né P,Girard E,Fetler L,Barillot E,Louvard D,Zinovyev A,Robine S
Wed Oct 08 00:00:00 UTC 2014
Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.
Nature communications
Chanrion M,Kuperstein I,Barrière C,El Marjou F,Cohen D,Vignjevic D,Stimmer L,Paul-Gilloteaux P,Bièche I,Tavares Sdos R,Boccia GF,Cacheux W,Meseure D,Fre S,Martignetti L,Legoix-Né P,Girard E,Fetler L,Barillot E,Louvard D,Zinovyev A,Robine S
Wed Oct 08 00:00:00 UTC 2014
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
Fri Oct 24 00:00:00 UTC 2014
Deletion of Fgfr1 in osteoblasts enhances mobilization of EPCs into peripheral blood in a mouse endotoxemia model.
International journal of biological sciences
Zhang Y,Su N,Luo F,Wen X,Tang Y,Yang J,Chen S,Jiang W,Du X,Chen L
Fri May 15 00:00:00 UTC 2015
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
Cell
Fritsch R,de Krijger I,Fritsch K,George R,Reason B,Kumar MS,Diefenbacher M,Stamp G,Downward J
Thu May 23 00:00:00 UTC 2013
Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair.
Cell
Ellison GM,Vicinanza C,Smith AJ,Aquila I,Leone A,Waring CD,Henning BJ,Stirparo GG,Papait R,Scarfò M,Agosti V,Viglietto G,Condorelli G,Indolfi C,Ottolenghi S,Torella D,Nadal-Ginard B
Thu Aug 15 00:00:00 UTC 2013
1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit.
Cancer cell
Zhao W,Wang L,Han H,Jin K,Lin N,Guo T,Chen Y,Cheng H,Lu F,Fang W,Wang Y,Xing B,Zhang Z
Mon Apr 15 00:00:00 UTC 2013
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Blood
Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM
Thu Jun 13 00:00:00 UTC 2013
Lithium rescues synaptic plasticity and memory in Down syndrome mice.
The Journal of clinical investigation
Contestabile A,Greco B,Ghezzi D,Tucci V,Benfenati F,Gasparini L
Tue Jan 01 00:00:00 UTC 2013
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.
Proceedings of the National Academy of Sciences of the United States of America
Leonova KI,Brodsky L,Lipchick B,Pal M,Novototskaya L,Chenchik AA,Sen GC,Komarova EA,Gudkov AV
Wed Jan 02 00:00:00 UTC 2013
Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.
Proceedings of the National Academy of Sciences of the United States of America
Hikichi T,Matoba R,Ikeda T,Watanabe A,Yamamoto T,Yoshitake S,Tamura-Nakano M,Kimura T,Kamon M,Shimura M,Kawakami K,Okuda A,Okochi H,Inoue T,Suzuki A,Masui S
Tue Apr 16 00:00:00 UTC 2013
Genetic reconstitution of tumorigenesis in primary intestinal cells.
Proceedings of the National Academy of Sciences of the United States of America
Onuma K,Ochiai M,Orihashi K,Takahashi M,Imai T,Nakagama H,Hippo Y
Tue Jul 02 00:00:00 UTC 2013
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells.
Oncogene
Galavotti S,Bartesaghi S,Faccenda D,Shaked-Rabi M,Sanzone S,McEvoy A,Dinsdale D,Condorelli F,Brandner S,Campanella M,Grose R,Jones C,Salomoni P
315-09 was used in Cell Culture to investigate glioblastoma multiforme prognosis with GBM stem cells.
Thu Feb 07 00:00:00 UTC 2013
Surface tethered epidermal growth factor protects proliferating and differentiating multipotential stromal cells from FasL-induced apoptosis.
Stem cells (Dayton, Ohio)
Rodrigues M,Blair H,Stockdale L,Griffith L,Wells A
Tue Jan 01 00:00:00 UTC 2013
Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation.
The Journal of biological chemistry
Yoon S,Baik JH
Fri Oct 04 00:00:00 UTC 2013
In vitro expansion of fetal neural progenitors as adherent cell lines.
Methods in molecular biology (Clifton, N.J.)
Pollard SM
315-09 was used in In vitro experiments to describe protocols and troubleshooting advice for establishing adherent NS cell lines from the mouse fetal forebrain.
Tue Feb 25 00:00:00 UTC 2014
An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation.
PloS one
Liu C,Teng ZQ,McQuate AL,Jobe EM,Christ CC,von Hoyningen-Huene SJ,Reyes MD,Polich ED,Xing Y,Li Y,Guo W,Zhao X
Tue Jul 09 00:00:00 UTC 2013
Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells.
Scientific reports
Hisha H,Tanaka T,Kanno S,Tokuyama Y,Komai Y,Ohe S,Yanai H,Omachi T,Ueno H
Fri Nov 15 00:00:00 UTC 2013
Functional vascular smooth muscle-like cells derived from adult mouse uterine mesothelial cells.
PloS one
Lachaud CC,Pezzolla D,Domínguez-Rodríguez A,Smani T,Soria B,Hmadcha A
Mon Dec 02 00:00:00 UTC 2013
In vivo tracking of murine adipose tissue-derived multipotent adult stem cells and ex vivo cross-validation.
International journal of molecular imaging
Garrovo C,Bergamin N,Bates D,Cesselli D,Beltrami AP,Lorenzon A,Ferrari R,Alberto Beltrami C,Lorusso V,Biffi S
Wed Feb 13 00:00:00 UTC 2013
Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved.
Cell death & disease
Fusar Poli E,Zalfa C,D'Avanzo F,Tomanin R,Carlessi L,Bossi M,Nodari LR,Binda E,Marmiroli P,Scarpa M,Delia D,Vescovi AL,De Filippis L
Thu Nov 07 00:00:00 UTC 2013
Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis.
The Journal of biological chemistry
Caballero-Franco C,Choo MK,Sano Y,Ritprajak P,Sakurai H,Otsu K,Mizoguchi A,Park JM
Fri Aug 16 00:00:00 UTC 2013
Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy.
The Journal of biological chemistry
Tanik SA,Schultheiss CE,Volpicelli-Daley LA,Brunden KR,Lee VM
Fri May 24 00:00:00 UTC 2013
Boosting bioluminescence neuroimaging: an optimized protocol for brain studies.
PloS one
Aswendt M,Adamczak J,Couillard-Despres S,Hoehn M
Tue Aug 20 00:00:00 UTC 2013
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Nature
Koo BK,Spit M,Jordens I,Low TY,Stange DE,van de Wetering M,van Es JH,Mohammed S,Heck AJ,Maurice MM,Clevers H
Thu Aug 30 00:00:00 UTC 2012
Androgenetic haploid embryonic stem cells produce live transgenic mice.
Nature
Li W,Shuai L,Wan H,Dong M,Wang M,Sang L,Feng C,Luo GZ,Li T,Li X,Wang L,Zheng QY,Sheng C,Wu HJ,Liu Z,Liu L,Wang L,Wang XJ,Zhao XY,Zhou Q
Thu Oct 18 00:00:00 UTC 2012
Epidermal growth factor receptor inhibits colitis-associated cancer in mice.
The Journal of clinical investigation
Dubé PE,Yan F,Punit S,Girish N,McElroy SJ,Washington MK,Polk DB
Wed Aug 01 00:00:00 UTC 2012
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
The Journal of clinical investigation
Jamieson T,Clarke M,Steele CW,Samuel MS,Neumann J,Jung A,Huels D,Olson MF,Das S,Nibbs RJ,Sansom OJ
Sat Sep 01 00:00:00 UTC 2012
Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.
Brain : a journal of neurology
Sakata H,Narasimhan P,Niizuma K,Maier CM,Wakai T,Chan PH
315-09 was used in Cell Culture to investigate whether cellular reprogramming of neural stem cells with IL-6 facilitates the effectiveness of cell transplantation therapy in ischaemic stroke.
Thu Nov 01 00:00:00 UTC 2012
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.
The EMBO journal
Wilson CH,Crombie C,van der Weyden L,Poulogiannis G,Rust AG,Pardo M,Gracia T,Yu L,Choudhary J,Poulin GB,McIntyre RE,Winton DJ,March HN,Arends MJ,Fraser AG,Adams DJ
Wed May 30 00:00:00 UTC 2012
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus.
Proceedings of the National Academy of Sciences of the United States of America
Jeanneteau FD,Lambert WM,Ismaili N,Bath KG,Lee FS,Garabedian MJ,Chao MV
Tue Jan 24 00:00:00 UTC 2012
Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells.
Proceedings of the National Academy of Sciences of the United States of America
Koso H,Takeda H,Yew CC,Ward JM,Nariai N,Ueno K,Nagasaki M,Watanabe S,Rust AG,Adams DJ,Copeland NG,Jenkins NA
Tue Oct 30 00:00:00 UTC 2012
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).
Proceedings of the National Academy of Sciences of the United States of America
Durand A,Donahue B,Peignon G,Letourneur F,Cagnard N,Slomianny C,Perret C,Shroyer NF,Romagnolo B
Tue Jun 05 00:00:00 UTC 2012
Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America
Omori E,Inagaki M,Mishina Y,Matsumoto K,Ninomiya-Tsuji J
Tue Feb 28 00:00:00 UTC 2012
Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke.
Cell death and differentiation
Takata M,Nakagomi T,Kashiwamura S,Nakano-Doi A,Saino O,Nakagomi N,Okamura H,Mimura O,Taguchi A,Matsuyama T
Tue May 01 00:00:00 UTC 2012
Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Stem cells (Dayton, Ohio)
Turco MY,Furia L,Dietze A,Fernandez Diaz L,Ronzoni S,Sciullo A,Simeone A,Constam D,Faretta M,Lanfrancone L
Thu Nov 01 00:00:00 UTC 2012
Neural stem cells directly differentiated from partially reprogrammed fibroblasts rapidly acquire gliogenic competency.
Stem cells (Dayton, Ohio)
Matsui T,Takano M,Yoshida K,Ono S,Fujisaki C,Matsuzaki Y,Toyama Y,Nakamura M,Okano H,Akamatsu W
Fri Jun 01 00:00:00 UTC 2012
Ras activation induces expression of Raet1 family NK receptor ligands.
Journal of immunology (Baltimore, Md. : 1950)
Liu XV,Ho SS,Tan JJ,Kamran N,Gasser S
Wed Aug 15 00:00:00 UTC 2012
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Swanson CD,Akama-Garren EH,Stein EA,Petralia JD,Ruiz PJ,Edalati A,Lindstrom TM,Robinson WH
Sun Apr 01 00:00:00 UTC 2012
In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes.
PloS one
Czekaj M,Haas J,Gebhardt M,Müller-Reichert T,Humphries P,Farrar J,Bartsch U,Ader M
Tue Apr 09 00:00:00 UTC 2013
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
PloS one
Bastea LI,Döppler H,Balogun B,Storz P
Mon Jun 04 00:00:00 UTC 2012
A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate.
PloS one
Doan LT,Javier AL,Furr NM,Nguyen KL,Cho KW,Monuki ES
Tue Mar 12 00:00:00 UTC 2013
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
PloS one
Santos DM,Xavier JM,Morgado AL,Solá S,Rodrigues CM
Fri Jul 13 00:00:00 UTC 2012
Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the Notch signaling pathway.
The Journal of biological chemistry
Yagi H,Saito T,Yanagisawa M,Yu RK,Kato K
Fri Jul 13 00:00:00 UTC 2012
Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo.
PloS one
Ioannidou K,Anderson KI,Strachan D,Edgar JM,Barnett SC
Mon Jun 11 00:00:00 UTC 2012
Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling.
BMC cell biology
Moriyama M,Moriyama H,Ueda A,Nishibata Y,Okura H,Ichinose A,Matsuyama A,Hayakawa T
Tue Aug 07 00:00:00 UTC 2012
Sorting live stem cells based on Sox2 mRNA expression.
PloS one
Larsson HM,Lee ST,Roccio M,Velluto D,Lutolf MP,Frey P,Hubbell JA
Tue Jun 11 00:00:00 UTC 2013
PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes.
PloS one
Kanakasabai S,Pestereva E,Chearwae W,Gupta SK,Ansari S,Bright JJ
Mon May 13 00:00:00 UTC 2013
Transactivation of EGFR by LPS induces COX-2 expression in enterocytes.
PloS one
McElroy SJ,Hobbs S,Kallen M,Tejera N,Rosen MJ,Grishin A,Matta P,Schneider C,Upperman J,Ford H,Polk DB,Weitkamp JH
Mon Sep 17 00:00:00 UTC 2012
Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.
The Journal of biological chemistry
Bernard JK,McCann SP,Bhardwaj V,Washington MK,Frey MR
Fri Nov 16 00:00:00 UTC 2012
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
PloS one
Muto J,Imai T,Ogawa D,Nishimoto Y,Okada Y,Mabuchi Y,Kawase T,Iwanami A,Mischel PS,Saya H,Yoshida K,Matsuzaki Y,Okano H
Mon Aug 20 00:00:00 UTC 2012
Flavin mononucleotide-based fluorescent proteins function in mammalian cells without oxygen requirement.
PloS one
Walter J,Hausmann S,Drepper T,Puls M,Eggert T,Dihné M
Tue Mar 12 00:00:00 UTC 2013
Hypoxic preconditioning improves survival of cardiac progenitor cells: role of stromal cell derived factor-1α-CXCR4 axis.
PloS one
Yan F,Yao Y,Chen L,Li Y,Sheng Z,Ma G
Tue Mar 26 00:00:00 UTC 2013
ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.
PloS one
Schumacher T,Krohn M,Hofrichter J,Lange C,Stenzel J,Steffen J,Dunkelmann T,Paarmann K,Fröhlich C,Uecker A,Plath AS,Sommer A,Brüning T,Heinze HJ,Pahnke J
Mon Aug 27 00:00:00 UTC 2012
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.
PloS one
Justilien V,Regala RP,Tseng IC,Walsh MP,Batra J,Radisky ES,Murray NR,Fields AP
Mon Aug 27 00:00:00 UTC 2012
The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.
PloS one
Méndez-Gómez HR,Vicario-Abejón C
Tue May 08 00:00:00 UTC 2012
Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.
PloS one
Sountoulidis A,Stavropoulos A,Giaglis S,Apostolou E,Monteiro R,Chuva de Sousa Lopes SM,Chen H,Stripp BR,Mummery C,Andreakos E,Sideras P
Wed May 15 00:00:00 UTC 2013
Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations.
Frontiers in cellular neuroscience
Muñetón-Gómez VC,Doncel-Pérez E,Fernandez AP,Serrano J,Pozo-Rodrigálvarez A,Vellosillo-Huerta L,Taylor JS,Cardona-Gómez GP,Nieto-Sampedro M,Martínez-Murillo R
Tue Oct 02 00:00:00 UTC 2012
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.
PloS one
Ruffner H,Sprunger J,Charlat O,Leighton-Davies J,Grosshans B,Salathe A,Zietzling S,Beck V,Therier M,Isken A,Xie Y,Zhang Y,Hao H,Shi X,Liu D,Song Q,Clay I,Hintzen G,Tchorz J,Bouchez LC,Michaud G,Finan P,Myer VE,Bouwmeester T,Porter J,Hild M,Bassilana F,Parker CN,Cong F
Wed Jan 16 00:00:00 UTC 2013
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Nature
Sato T,van Es JH,Snippert HJ,Stange DE,Vries RG,van den Born M,Barker N,Shroyer NF,van de Wetering M,Clevers H
Thu Jan 20 00:00:00 UTC 2011
Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning.
Cell
Kondrashov N,Pusic A,Stumpf CR,Shimizu K,Hsieh AC,Ishijima J,Shiroishi T,Barna M
Fri Apr 29 00:00:00 UTC 2011
A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.
Nature methods
Horie K,Kokubu C,Yoshida J,Akagi K,Isotani A,Oshitani A,Yusa K,Ikeda R,Huang Y,Bradley A,Takeda J
Sun Oct 23 00:00:00 UTC 2011
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.
Nature cell biology
Sperka T,Song Z,Morita Y,Nalapareddy K,Guachalla LM,Lechel A,Begus-Nahrmann Y,Burkhalter MD,Mach M,Schlaudraff F,Liss B,Ju Z,Speicher MR,Rudolph KL
Sun Dec 04 00:00:00 UTC 2011
Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells.
Autophagy
Tanabe F,Yone K,Kawabata N,Sakakima H,Matsuda F,Ishidou Y,Maeda S,Abematsu M,Komiya S,Setoguchi T
315-09 was used in Cell Culture to suggest that pharmacological inducers of autophagy may be useful for treating cervical spondylotic myelopathy patients.
Thu Dec 01 00:00:00 UTC 2011
Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells.
Autophagy
Tanabe F,Yone K,Kawabata N,Sakakima H,Matsuda F,Ishidou Y,Maeda S,Abematsu M,Komiya S,Setoguchi T
315-09 was used in Cell Culture to suggest that pharmacological inducers of autophagy may be useful for treating cervical spondylotic myelopathy patients.
Thu Dec 01 00:00:00 UTC 2011
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.
Genes & development
Calvo CF,Fontaine RH,Soueid J,Tammela T,Makinen T,Alfaro-Cervello C,Bonnaud F,Miguez A,Benhaim L,Xu Y,Barallobre MJ,Moutkine I,Lyytikkä J,Tatlisumak T,Pytowski B,Zalc B,Richardson W,Kessaris N,Garcia-Verdugo JM,Alitalo K,Eichmann A,Thomas JL
Fri Apr 15 00:00:00 UTC 2011
Core promoter recognition complex changes accompany liver development.
Proceedings of the National Academy of Sciences of the United States of America
D'Alessio JA,Ng R,Willenbring H,Tjian R
Tue Mar 08 00:00:00 UTC 2011
Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone.
Stem cells (Dayton, Ohio)
Stoll EA,Habibi BA,Mikheev AM,Lasiene J,Massey SC,Swanson KR,Rostomily RC,Horner PJ
Thu Dec 01 00:00:00 UTC 2011
Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells.
Stem cells (Dayton, Ohio)
Hide T,Takezaki T,Nakatani Y,Nakamura H,Kuratsu J,Kondo T
Fri Apr 01 00:00:00 UTC 2011
Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells.
Journal of cell science
Sun Y,Hu J,Zhou L,Pollard SM,Smith A
Wed Jun 01 00:00:00 UTC 2011
Long-term cultured human neural stem cells undergo spontaneous transformation to tumor-initiating cells.
International journal of biological sciences
Wu W,He Q,Li X,Zhang X,Lu A,Ge R,Zhen H,Chang AE,Li Q,Shen L
Mon Dec 12 00:00:00 UTC 2011
Helicobacter pylori infection of gastrointestinal epithelial cells in vitro induces mesenchymal stem cell migration through an NF-κB-dependent pathway.
PloS one
Ferrand J,Lehours P,Schmid-Alliana A,Mégraud F,Varon C
Mon May 21 00:00:00 UTC 2012
Role of C/EBPβ transcription factor in adult hippocampal neurogenesis.
PloS one
Cortes-Canteli M,Aguilar-Morante D,Sanz-Sancristobal M,Megias D,Santos A,Perez-Castillo A
Thu Feb 02 00:00:00 UTC 2012
Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism.
The Journal of biological chemistry
Stoll EA,Cheung W,Mikheev AM,Sweet IR,Bielas JH,Zhang J,Rostomily RC,Horner PJ
Fri Nov 04 00:00:00 UTC 2011
Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation.
PloS one
Turbic A,Leong SY,Turnley AM
Fri Feb 10 00:00:00 UTC 2012
Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro.
PloS one
Saito H,Takeuchi M,Chida K,Miyajima A
Thu May 03 00:00:00 UTC 2012
Isolation of radial glia-like neural stem cells from fetal and adult mouse forebrain via selective adhesion to a novel adhesive peptide-conjugate.
PloS one
Markó K,Kohidi T,Hádinger N,Jelitai M,Mezo G,Madarász E
Fri Jul 20 00:00:00 UTC 2012
c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8).
The Journal of biological chemistry
Mitra S,Lee JS,Cantrell M,Van den Berg CL
Fri Apr 29 00:00:00 UTC 2011
Silencing of the rotavirus NSP4 protein decreases the incidence of biliary atresia in murine model.
PloS one
Feng J,Yang J,Zheng S,Qiu Y,Chai C
Fri Dec 30 00:00:00 UTC 2011
Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-β.
PloS one
Kawelke N,Vasel M,Sens C,Au Av,Dooley S,Nakchbandi IA
Mon Apr 09 00:00:00 UTC 2012
3D culture of adult mouse neural stem cells within functionalized self-assembling peptide scaffolds.
International journal of nanomedicine
Cunha C,Panseri S,Villa O,Silva D,Gelain F
Fri Nov 04 00:00:00 UTC 2011
CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway.
PloS one
Jijiwa M,Demir H,Gupta S,Leung C,Joshi K,Orozco N,Huang T,Yildiz VO,Shibahara I,de Jesus JA,Yong WH,Mischel PS,Fernandez S,Kornblum HI,Nakano I
Tue Feb 14 00:00:00 UTC 2012
Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin.
Stem cell research & therapy
Demars MP,Bartholomew A,Strakova Z,Lazarov O
Tue Aug 30 00:00:00 UTC 2011
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.
Nature
Méndez-Ferrer S,Michurina TV,Ferraro F,Mazloom AR,Macarthur BD,Lira SA,Scadden DT,Ma'ayan A,Enikolopov GN,Frenette PS
Thu Aug 12 00:00:00 UTC 2010
Distinct factors control histone variant H3.3 localization at specific genomic regions.
Cell
Goldberg AD,Banaszynski LA,Noh KM,Lewis PW,Elsaesser SJ,Stadler S,Dewell S,Law M,Guo X,Li X,Wen D,Chapgier A,DeKelver RC,Miller JC,Lee YL,Boydston EA,Holmes MC,Gregory PD,Greally JM,Rafii S,Yang C,Scambler PJ,Garrick D,Gibbons RJ,Higgs DR,Cristea IM,Urnov FD,Zheng D,Allis CD
Fri Mar 05 00:00:00 UTC 2010
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
Cancer cell
Kim J,Tang JY,Gong R,Kim J,Lee JJ,Clemons KV,Chong CR,Chang KS,Fereshteh M,Gardner D,Reya T,Liu JO,Epstein EH,Stevens DA,Beachy PA
Tue Apr 13 00:00:00 UTC 2010
Cross talk between microRNA and epigenetic regulation in adult neurogenesis.
The Journal of cell biology
Szulwach KE,Li X,Smrt RD,Li Y,Luo Y,Lin L,Santistevan NJ,Li W,Zhao X,Jin P
Mon Apr 05 00:00:00 UTC 2010
Nogo-a regulates neural precursor migration in the embryonic mouse cortex.
Cerebral cortex (New York, N.Y. : 1991)
Mathis C,Schröter A,Thallmair M,Schwab ME
Fri Oct 01 00:00:00 UTC 2010
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
Cellular microbiology
Khaminets A,Hunn JP,Könen-Waisman S,Zhao YO,Preukschat D,Coers J,Boyle JP,Ong YC,Boothroyd JC,Reichmann G,Howard JC
Thu Jul 01 00:00:00 UTC 2010
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
Cellular microbiology
Khaminets A,Hunn JP,Könen-Waisman S,Zhao YO,Preukschat D,Coers J,Boyle JP,Ong YC,Boothroyd JC,Reichmann G,Howard JC
Thu Jul 01 00:00:00 UTC 2010
Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells.
Tissue engineering. Part A
Zhao L,Jiang S,Hantash BM
Mon Feb 01 00:00:00 UTC 2010
HNK-1 epitope-carrying tenascin-C spliced variant regulates the proliferation of mouse embryonic neural stem cells.
The Journal of biological chemistry
Yagi H,Yanagisawa M,Suzuki Y,Nakatani Y,Ariga T,Kato K,Yu RK
Fri Nov 26 00:00:00 UTC 2010
Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells.
ASN neuro
Yanagisawa M,Ariga T,Yu RK
Mon Mar 15 00:00:00 UTC 2010
Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.
PloS one
Aguilar-Morante D,Morales-Garcia JA,Sanz-SanCristobal M,Garcia-Cabezas MA,Santos A,Perez-Castillo A
Mon Nov 08 00:00:00 UTC 2010
Glycine-spacers influence functional motifs exposure and self-assembling propensity of functionalized substrates tailored for neural stem cell cultures.
Frontiers in neuroengineering
Taraballi F,Natalello A,Campione M,Villa O,Doglia SM,Paleari A,Gelain F
Thu Jul 14 00:00:00 UTC 2011
Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.
PloS one
Chen P,O'Neal JF,Ebelt ND,Cantrell MA,Mitra S,Nasrazadani A,Vandenbroek TL,Heasley LE,Van Den Berg CL
Mon May 03 00:00:00 UTC 2010
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
BMC neuroscience
Garavaglia A,Moiana A,Camnasio S,Bolognini D,Papait R,Rigamonti D,Cattaneo E
Tue Jan 19 00:00:00 UTC 2010
The NKG2D ligands RAE-1δ and RAE-1ε differ with respect to their receptor affinity, expression profiles and transcriptional regulation.
PloS one
Cédile O,Popa N,Pollet-Villard F,Garmy N,Ibrahim EC,Boucraut J
Tue Oct 19 00:00:00 UTC 2010
Mutations in SCG10 are not involved in Hirschsprung disease.
PloS one
Alves MM,Osinga J,Verheij JB,Metzger M,Eggen BJ,Hofstra RM
Mon Dec 20 00:00:00 UTC 2010
Involvement of beta1-integrin up-regulation in basic fibroblast growth factor- and epidermal growth factor-induced proliferation of mouse neuroepithelial cells.
The Journal of biological chemistry
Suzuki Y,Yanagisawa M,Yagi H,Nakatani Y,Yu RK
Fri Jun 11 00:00:00 UTC 2010
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature
Sato T,Vries RG,Snippert HJ,van de Wetering M,Barker N,Stange DE,van Es JH,Abo A,Kujala P,Peters PJ,Clevers H
Thu May 14 00:00:00 UTC 2009
Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors.
Cancer cell
Li M,Lee KF,Lu Y,Clarke I,Shih D,Eberhart C,Collins VP,Van Meter T,Picard D,Zhou L,Boutros PC,Modena P,Liang ML,Scherer SW,Bouffet E,Rutka JT,Pomeroy SL,Lau CC,Taylor MD,Gajjar A,Dirks PB,Hawkins CE,Huang A
Tue Dec 08 00:00:00 UTC 2009
De novo induction of genetically engineered brain tumors in mice using plasmid DNA.
Cancer research
Wiesner SM,Decker SA,Larson JD,Ericson K,Forster C,Gallardo JL,Long C,Demorest ZL,Zamora EA,Low WC,SantaCruz K,Largaespada DA,Ohlfest JR
Thu Jan 15 00:00:00 UTC 2009
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment.
Proceedings of the National Academy of Sciences of the United States of America
Bertolini G,Roz L,Perego P,Tortoreto M,Fontanella E,Gatti L,Pratesi G,Fabbri A,Andriani F,Tinelli S,Roz E,Caserini R,Lo Vullo S,Camerini T,Mariani L,Delia D,Calabrò E,Pastorino U,Sozzi G
Tue Sep 22 00:00:00 UTC 2009
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development.
Proceedings of the National Academy of Sciences of the United States of America
Montgomery RL,Hsieh J,Barbosa AC,Richardson JA,Olson EN
Tue May 12 00:00:00 UTC 2009
Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America
Morris ZS,McClatchey AI
Tue Jun 16 00:00:00 UTC 2009
Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling.
Stem cells (Dayton, Ohio)
Müller S,Chakrapani BP,Schwegler H,Hofmann HD,Kirsch M
Sun Feb 01 00:00:00 UTC 2009
Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction.
Stem cells (Dayton, Ohio)
Nakagomi N,Nakagomi T,Kubo S,Nakano-Doi A,Saino O,Takata M,Yoshikawa H,Stern DM,Matsuyama T,Taguchi A
Tue Sep 01 00:00:00 UTC 2009
Maintenance of undifferentiated state and self-renewal of embryonic neural stem cells by Polycomb protein Ring1B.
Stem cells (Dayton, Ohio)
Román-Trufero M,Méndez-Gómez HR,Pérez C,Hijikata A,Fujimura Y,Endo T,Koseki H,Vicario-Abejón C,Vidal M
Wed Jul 01 00:00:00 UTC 2009
Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Whang MI,Guerra N,Raulet DH
Wed Apr 15 00:00:00 UTC 2009
Gene expression and differentiation characteristics in mice E13.5 and E17.5 neural retinal progenitors.
Molecular vision
Sun X,Jiang R,Zhang Y,Chen M,Xiang P,Qi Y,Gao Q,Huang B,Ge J
Wed Dec 02 00:00:00 UTC 2009
Glioblastoma formation from cell population depleted of Prominin1-expressing cells.
PloS one
Nishide K,Nakatani Y,Kiyonari H,Kondo T
Mon Aug 31 00:00:00 UTC 2009
High-density microwell chip for culture and analysis of stem cells.
PloS one
Lindström S,Eriksson M,Vazin T,Sandberg J,Lundeberg J,Frisén J,Andersson-Svahn H
Mon Sep 14 00:00:00 UTC 2009
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1.
The Journal of cell biology
Blagoveshchenskaya A,Cheong FY,Rohde HM,Glover G,Knödler A,Nicolson T,Boehmelt G,Mayinger P
Mon Feb 25 00:00:00 UTC 2008
Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance.
Stem cells (Dayton, Ohio)
Akita K,von Holst A,Furukawa Y,Mikami T,Sugahara K,Faissner A
Sat Mar 01 00:00:00 UTC 2008
Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells.
Stem cells (Dayton, Ohio)
Okada Y,Matsumoto A,Shimazaki T,Enoki R,Koizumi A,Ishii S,Itoyama Y,Sobue G,Okano H
Mon Dec 01 00:00:00 UTC 2008
