Product References
Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells.
Cell reports. Medicine
Sprooten J,Vanmeerbeek I,Datsi A,Govaerts J,Naulaerts S,Laureano RS,Borràs DM,Calvet A,Malviya V,Kuballa M,Felsberg J,Sabel MC,Rapp M,Knobbe-Thomsen C,Liu P,Zhao L,Kepp O,Boon L,Tejpar S,Borst J,Kroemer G,Schlenner S,De Vleeschouwer S,Sorg RV,Garg AD
216-16 was used in In vitro experiments to propose that a multimodal immunotherapy and vaccination regimen is mandatory to overcome T cell-depleted tumors.
Tue Jan 16 00:00:00 UTC 2024
Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes.
Autophagy
Wang YT,Sansone A,Smirnov A,Stallings CL,Orvedahl A
216-16 was used in In vitro experiments to identify autophagy gene sets and specific cell types that protect against fatal inflammation due to CSS, highlighting important differences in two commonly used murine models of the disorder.
Sat Apr 01 00:00:00 UTC 2023
Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis.
Nature communications
Yang WL,Qiu W,Zhang T,Xu K,Gu ZJ,Zhou Y,Xu HJ,Yang ZZ,Shen B,Zhao YL,Zhou Q,Yang Y,Li W,Yang PY,Yang YG
216-16 was used in Cell Culture to demonstrate a RNA 5-methylcytosine mediated cell intrinsic function in Th17 cells and suggests Nsun2 as a potential therapeutic target for autoimmune disease.
Thu Feb 16 00:00:00 UTC 2023
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
Immunity
Kiss MG,Mindur JE,Yates AG,Lee D,Fullard JF,Anzai A,Poller WC,Christie KA,Iwamoto Y,Roudko V,Downey J,Chan CT,Huynh P,Janssen H,Ntranos A,Hoffmann JD,Jacob W,Goswami S,Singh S,Leppert D,Kuhle J,Kim-Schulze S,Nahrendorf M,Kleinstiver BP,Probert F,Roussos P,Swirski FK,McAlpine CS
216-16 was used in Cell Culture to establish IL-3:IL-3RA as a glial-peripheral immune network that prompts immune cell recruitment to the CNS and worsens MS.
Tue Jul 11 00:00:00 UTC 2023
Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms.
Clinical cancer research : an official journal of the American Association for Cancer Research
Gurska LM,Okabe R,Schurer A,Tong MM,Soto M,Choi D,Ames K,Glushakow-Smith S,Montoya A,Tein E,Miles LA,Cheng H,Hankey-Giblin P,Levine RL,Goel S,Halmos B,Gritsman K
216-16 was used in Cell Culture to demonstrate that crizotinib has preclinical efficacy in MPN patient cells, JAK2-mutated cell lines, and a JAK2-mutated mouse model, and that the combination of crizotinib with JAK inhibitors suppresses JAK inhibitor persistence.
Wed Mar 01 00:00:00 UTC 2023
Multidimensional Analysis of Lung Lymph Nodes in a Mouse Model of Allergic Lung Inflammation following and Indeno[1,2,3-cd]pyrene Exposure.
Environmental health perspectives
Liu KY,Gao Y,Xiao W,Fu J,Huang S,Han X,Hsu SH,Xiao X,Huang SK,Zhou Y
216-16 was used in Cell Culture to explore the impact of environmental PM2.5 and indeno[1,2,3-cd]pyrene (IP), a prominent polycyclic aromatic hydrocarbon, as a model, on Tfh cells and the subsequent pulmonary allergic responses.
Wed Mar 01 00:00:00 UTC 2023
Human lncRNA SUGCT-AS1 Regulates the Proinflammatory Response of Macrophage.
International journal of molecular sciences
Lim YH,Yoon G,Ryu Y,Jeong D,Song J,Kim YS,Ahn Y,Kook H,Kim YK
216-16 was used in Cell Culture to suggest that long non-coding RNAs can be used for future studies on macrophage regulation.
Mon Aug 28 00:00:00 UTC 2023
Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen specificity.
iScience
Agrafiotis A,Neumeier D,Hong KL,Chowdhury T,Ehling R,Kuhn R,Sandu I,Kreiner V,Cotet TS,Shlesinger D,Laslo D,Anzböck S,Starkie D,Lightwood DJ,Oxenius A,Reddy ST,Yermanos A
216-16 was used in In vitro experiments to determine the relationship between antibody repertoires, gene expression signatures, and antigen specificity across 100,000 B cells.
Fri Mar 17 00:00:00 UTC 2023
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
International journal of biological sciences
Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z
216-16 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.
Tue Nov 07 00:00:00 UTC 2023
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Cancer discovery
Liu Y,Li Q,Alikarami F,Barrett DR,Mahdavi L,Li H,Tang S,Khan TA,Michino M,Hill C,Song L,Yang L,Li Y,Pokharel SP,Stamford AW,Liverton N,Renzetti LM,Taylor S,Watt GF,Ladduwahetty T,Kargman S,Meinke PT,Foley MA,Shi J,Li H,Carroll M,Chen CW,Gardini A,Maillard I,Huggins DJ,Bernt KM,Wan L
216-16 was used in In vitro experiments to study the therapeutic potential of chromatin reader eleven-nineteen leukemia (ENL) dependency in acute myeloid leukemia (AML).
Wed Nov 02 00:00:00 UTC 2022
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
Cell stem cell
Gadomski S,Fielding C,García-García A,Korn C,Kapeni C,Ashraf S,Villadiego J,Toro RD,Domingues O,Skepper JN,Michel T,Zimmer J,Sendtner R,Dillon S,Poole KES,Holdsworth G,Sendtner M,Toledo-Aral JJ,De Bari C,McCaskie AW,Robey PG,Méndez-Ferrer S
216-16 was used in Cell Culture to uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.
Thu Apr 07 00:00:00 UTC 2022
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
The Journal of experimental medicine
Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T
Mon Jan 03 00:00:00 UTC 2022
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.
Development (Cambridge, England)
Vrij EJ,Scholte Op Reimer YS,Roa Fuentes L,Misteli Guerreiro I,Holzmann V,Frias Aldeguer J,Sestini G,Koo BK,Kind J,van Blitterswijk CA,Rivron NC
216-16 was used in In vitro experiments to create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn) to suggest that self-organization can arise from lineage bifurcation followed by a pendulum of induction that propagates over time.
Sat Oct 15 00:00:00 UTC 2022
Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis.
European journal of immunology
Neumeier D,Pedrioli A,Genovese A,Sandu I,Ehling R,Hong KL,Papadopoulou C,Agrafiotis A,Kuhn R,Shlesinger D,Robbiani D,Han J,Hauri L,Csepregi L,Greiff V,Merkler D,Reddy ST,Oxenius A,Yermanos A
216-16 was used in Sample Preparation (FC/FACS) to investigate plasma cell antibody production.
Tue Feb 01 00:00:00 UTC 2022
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Cell metabolism
Hochrein SM,Wu H,Eckstein M,Arrigoni L,Herman JS,Schumacher F,Gerecke C,Rosenfeldt M,Grün D,Kleuser B,Gasteiger G,Kastenmüller W,Ghesquière B,Van den Bossche J,Abel ED,Vaeth M
216-16 was used in In vitro experiments to show that GLUT3-dependent glucose uptake controls a metabolic-transcriptional circuit that regulates the pathogenicity of Th17 cells.
Tue Apr 05 00:00:00 UTC 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
216-16 was used in Sample Preparation (Western Blotting) to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 UTC 2022
Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection.
PLoS pathogens
Lee AJ,Feng E,Chew MV,Balint E,Poznanski SM,Giles E,Zhang A,Marzok A,Revill SD,Vahedi F,Dubey A,Ayaub E,Jimenez-Saiz R,McGrath JJC,Ritchie TM,Jordana M,Jonigk DD,Ackermann M,Ask K,Miller M,Richards CD,Ashkar AA
216-16 was used in In vivo experiments to demonstrate that IFNs inhibit macrophage-mediated MMP production to prevent virus-induced immunopathology and uncover MMPs as a therapeutic target towards viral infections.
Sun May 01 00:00:00 UTC 2022
Evaluation of Glutaminolysis in T Cells.
Current protocols
Tajima M,Strober W
216-16 was used in Cell Culture to provide one element of such tracking by describing protocols for the assessment of the contribution of glutaminolysis to overall ATP production within different T cell subsets.
Thu Sep 01 00:00:00 UTC 2022
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
Thu Jan 07 00:00:00 UTC 2021
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Cell
Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL
216-16 was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.
Thu Aug 05 00:00:00 UTC 2021
Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.
Immunity
Roberto MP,Varano G,Vinas-Castells R,Holmes AB,Kumar R,Pasqualucci L,Farinha P,Scott DW,Dominguez-Sola D
Tue Aug 10 00:00:00 UTC 2021
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance.
Immunity
Dikiy S,Li J,Bai L,Jiang M,Janke L,Zong X,Hao X,Hoyos B,Wang ZM,Xu B,Fan Y,Rudensky AY,Feng Y
Tue May 11 00:00:00 UTC 2021
Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.
Immunity
Flommersfeld S,Böttcher JP,Ersching J,Flossdorf M,Meiser P,Pachmayr LO,Leube J,Hensel I,Jarosch S,Zhang Q,Chaudhry MZ,Andrae I,Schiemann M,Busch DH,Cicin-Sain L,Sun JC,Gasteiger G,Victora GD,Höfer T,Buchholz VR,Grassmann S
Tue Oct 12 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons.
Immunity
Klawonn AM,Fritz M,Castany S,Pignatelli M,Canal C,Similä F,Tejeda HA,Levinsson J,Jaarola M,Jakobsson J,Hidalgo J,Heilig M,Bonci A,Engblom D
Tue Feb 09 00:00:00 UTC 2021
Cold exposure protects from neuroinflammation through immunologic reprogramming.
Cell metabolism
Spiljar M,Steinbach K,Rigo D,Suárez-Zamorano N,Wagner I,Hadadi N,Vincenti I,Page N,Klimek B,Rochat MA,Kreutzfeldt M,Chevalier C,Stojanović O,Bejuy O,Colin D,Mack M,Cansever D,Greter M,Merkler D,Trajkovski M
Tue Nov 02 00:00:00 UTC 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
216-16 was used in In vitro experiments to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 UTC 2021
Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.
International journal of oral science
Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y
Thu Sep 30 00:00:00 UTC 2021
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
Cellular & molecular immunology
Permanyer M,Bošnjak B,Glage S,Friedrichsen M,Floess S,Huehn J,Patzer GE,Odak I,Eckert N,Zargari R,Ospina-Quintero L,Georgiev H,Förster R
Mon Feb 01 00:00:00 UTC 2021
Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.
The Journal of clinical investigation
Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T
Mon Feb 15 00:00:00 UTC 2021
Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.
The Journal of clinical investigation
Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T
Mon Feb 15 00:00:00 UTC 2021
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Molecular cell
Orellana EA,Liu Q,Yankova E,Pirouz M,De Braekeleer E,Zhang W,Lim J,Aspris D,Sendinc E,Garyfallos DA,Gu M,Ali R,Gutierrez A,Mikutis S,Bernardes GJL,Fischer ES,Bradley A,Vassiliou GS,Slack FJ,Tzelepis K,Gregory RI
216-16 was used in Cell Culture to conclude that METTL1-mediated tRNA modification drives oncogenic transformation through a remodeling of the mRNA translatome" to increase expression of growth-promoting proteins and represents a promising anti-cancer target."
Thu Aug 19 00:00:00 UTC 2021
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
216-16 was used in Cell Culture to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.
Thu Jul 01 00:00:00 UTC 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 UTC 2021
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.
The Journal of experimental medicine
Xiao Y,Qureischi M,Dietz L,Vaeth M,Vallabhapurapu SD,Klein-Hessling S,Klein M,Liang C,König A,Serfling E,Mottok A,Bopp T,Rosenwald A,Buttmann M,Berberich I,Beilhack A,Berberich-Siebelt F
Mon Jan 04 00:00:00 UTC 2021
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
The Journal of experimental medicine
Kiuchi M,Onodera A,Kokubo K,Ichikawa T,Morimoto Y,Kawakami E,Takayama N,Eto K,Koseki H,Hirahara K,Nakayama T
Mon Apr 05 00:00:00 UTC 2021
STING agonist promotes CAR T cell trafficking and persistence in breast cancer.
The Journal of experimental medicine
Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS
Mon Feb 01 00:00:00 UTC 2021
Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function.
Autophagy
Yang G,Song W,Postoak JL,Chen J,Martinez J,Zhang J,Wu L,Van Kaer L
216-16 was used in Cell Culture to study the contribution of PIK3C3 to T cell metabolism and function to show that Pik3c3-deficient T cells exhibit impaired cellular metabolism, and that Pik3c3-deficient CD4+ T cells fail to differentiate into T helper 1 cells, changes which are associated with reduced levels of active mitochondria upon T cell activation.
Sat May 01 00:00:00 UTC 2021
Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.
Leukemia
Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM
Mon Nov 01 00:00:00 UTC 2021
Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway.
Proceedings of the National Academy of Sciences of the United States of America
Zheng W,Song H,Luo Z,Wu H,Chen L,Wang Y,Cui H,Zhang Y,Wang B,Li W,Liu Y,Zhang J,Chu Y,Luo F,Liu J
Tue Mar 16 00:00:00 UTC 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
216-16 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.
Wed Apr 03 00:00:00 UTC 2024
Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus.
Journal of immunology (Baltimore, Md. : 1950)
Sonoda S,Murata S,Kato H,Zakaria F,Kyumoto-Nakamura Y,Uehara N,Yamaza H,Kukita T,Yamaza T
Tue Jun 15 00:00:00 UTC 2021
Development of an Optimized Culture System for Generating Mouse Alveolar Macrophage-like Cells.
Journal of immunology (Baltimore, Md. : 1950)
Luo M,Lai W,He Z,Wu L
Wed Sep 15 00:00:00 UTC 2021
Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.
Journal of immunology (Baltimore, Md. : 1950)
Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH
Mon Nov 15 00:00:00 UTC 2021
Scaffold compound L971 exhibits anti-inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways.
Journal of cellular and molecular medicine
Li M,Yan Y,Zhang X,Zhang Y,Xu X,Zhang L,Lu L,Wang J,Zhang Y,Song Q,Zhao C
Thu Jul 01 00:00:00 UTC 2021
HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4+ T Cell Activation and Th17 Cell Differentiation.
Journal of immunology research
Yu S,Tripod M,Atasoy U,Chen J
Mon Jan 10 00:00:00 UTC 2022
Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis.
Scientific reports
Yamada H,Saegusa J,Sendo S,Ueda Y,Okano T,Shinohara M,Morinobu A
Fri Aug 27 00:00:00 UTC 2021
High-resolution characterization of gene function using single-cell CRISPR tiling screen.
Nature communications
Yang L,Chan AKN,Miyashita K,Delaney CD,Wang X,Li H,Pokharel SP,Li S,Li M,Xu X,Lu W,Liu Q,Mattson N,Chen KY,Wang J,Yuan YC,Horne D,Rosen ST,Soto-Feliciano Y,Feng Z,Hoshii T,Xiao G,Müschen M,Chen J,Armstrong SA,Chen CW
Thu Jul 01 00:00:00 UTC 2021
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Nature communications
Supper E,Rudat S,Iyer V,Droop A,Wong K,Spinella JF,Thomas P,Sauvageau G,Adams DJ,Wong CC
Fri Apr 30 00:00:00 UTC 2021
Protocol to produce high-titer retrovirus for transduction of mouse bone marrow cells.
STAR protocols
Qu J,Yang Z
216-16 was used in Cell Culture to demonstrate a modified protocol to overcome challenges associated with achieving high transduction efficiency in bone marrow cells in transplantation which enables reproducible and high-efficient retroviral transduction of hematopoietic stem and progenitor cells (HSPCs) for bone marrow transplantation (BMT).
Fri Jun 18 00:00:00 UTC 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
Mon Jan 11 00:00:00 UTC 2021
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Nature communications
He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J
Fri Jul 16 00:00:00 UTC 2021
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Nature communications
He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J
Fri Jul 16 00:00:00 UTC 2021
Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.
iScience
Nguyen GT,Xu S,Adams W,Leong JM,Bunnell SC,Mansour MK,Sykes DB,Mecsas J
Fri Aug 20 00:00:00 UTC 2021
MMP12 knockout prevents weight and muscle loss in tumor-bearing mice.
BMC cancer
Jiang L,Yang M,He S,Li Z,Li H,Niu T,Xie D,Mei Y,He X,Wei L,Huang P,Huang M,Zhang R,Wang L,Li J
216-16 was used in In vitro experiments to show that MMP12 is essential for controlling body weight of Apc Min/+ mice.
Sat Dec 04 00:00:00 UTC 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
Tue Jul 13 00:00:00 UTC 2021
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.
Nature communications
Khateb A,Deshpande A,Feng Y,Finlay D,Lee JS,Lazar I,Fabre B,Li Y,Fujita Y,Zhang T,Yin J,Pass I,Livneh I,Jeremias I,Burian C,Mason JR,Almog R,Horesh N,Ofran Y,Brown K,Vuori K,Jackson M,Ruppin E,Deshpande AJ,Ronai ZA
Mon Sep 13 00:00:00 UTC 2021
Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity.
Cancer cell international
Mei Y,Wang M,Lu G,Li J,Peng L,Lang Y,Yang M,Jiang L,Li C,Zheng L,Liu Z,Xie D,Guo L,Huang B,Zeng M,Shi Y,Qian C
216-16 was used in Cell Culture to suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.
Wed Feb 10 00:00:00 UTC 2021
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
iScience
AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB
Fri Jun 25 00:00:00 UTC 2021
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Cell reports
Karki R,Sundaram B,Sharma BR,Lee S,Malireddi RKS,Nguyen LN,Christgen S,Zheng M,Wang Y,Samir P,Neale G,Vogel P,Kanneganti TD
Tue Oct 19 00:00:00 UTC 2021
Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway.
Cell death & disease
Baba T,Yoshida T,Tanabe Y,Nishimura T,Morishita S,Gotoh N,Hirao A,Hanayama R,Mukaida N
Fri Mar 26 00:00:00 UTC 2021
Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro.
Redox biology
Pescador N,Francisco V,Vázquez P,Esquinas EM,González-Páramos C,Valdecantos MP,García-Martínez I,Urrutia AA,Ruiz L,Escalona-Garrido C,Foretz M,Viollet B,Fernández-Moreno MÁ,Calle-Pascual AL,Obregón MJ,Aragonés J,Valverde ÁM
216-16 was used in Cell Culture to find the impact of metformin on macrophages by suppressing a HIF1α-dependent proinflammatory program is likely responsible for a secondary beneficial effect on insulin-mediated glucose uptake and β-adrenergic responses in brown adipocytes.
Tue Oct 19 00:00:00 UTC 2021
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
The Journal of clinical investigation
Zheng J,Meyerholz D,Wong LR,Gelb M,Murakami M,Perlman S
Tue Jun 01 00:00:00 UTC 2021
Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells' maturation and function.
Open life sciences
Guo B,Peng Y,Gu Y,Zhong Y,Su C,Liu L,Chai D,Song T,Zhao N,Yan X,Xu T
216-16 was used in In vitro experiments to indicate that resveratrol (RES) participated in protecting against the pathological process of ALI by modulating the maturation and function of cDCs.
Fri Aug 16 00:00:00 UTC 2024
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Journal of experimental & clinical cancer research : CR
Wang F,Li Z,Zhou J,Wang G,Zhang W,Xu J,Liang A
216-16 was used in Cell Culture to investigate SIRT1 expression and function in T-cell acute lymphoblastic leukemia.
Wed Aug 18 00:00:00 UTC 2021
RORα is critical for mTORC1 activity in T cell-mediated colitis.
Cell reports
Chi X,Jin W,Bai X,Zhao X,Shao J,Li J,Sun Q,Su B,Wang X,Yang XO,Dong C
Tue Sep 14 00:00:00 UTC 2021
Slit2 Inhibits Breast Cancer Metastasis by Activating M1-Like Phagocytic and Antifibrotic Macrophages.
Cancer research
Ahirwar DK,Charan M,Mishra S,Verma AK,Shilo K,Ramaswamy B,Ganju RK
216-16 was used in Cell Culture to provide evidence that the antitumor effect of Slit2 in breast cancer occurs by activating the phagocytic activity of M1-like tumor-associated macrophages against tumor cells and diminishing fibrosis.
Fri Oct 15 00:00:00 UTC 2021
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.
eLife
Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ
216-16 was used in Cell Culture to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.
Tue Nov 02 00:00:00 UTC 2021
Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells.
Cell reports
Adlung L,Stapor P,Tönsing C,Schmiester L,Schwarzmüller LE,Postawa L,Wang D,Timmer J,Klingmüller U,Hasenauer J,Schilling M
Tue Aug 10 00:00:00 UTC 2021
Engineering of a bona fide light-operated calcium channel.
Nature communications
He L,Wang L,Zeng H,Tan P,Ma G,Zheng S,Li Y,Sun L,Dou F,Siwko S,Huang Y,Wang Y,Zhou Y
Mon Jan 11 00:00:00 UTC 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
216-16 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.
Thu Dec 02 00:00:00 UTC 2021
Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells.
Cells
Dey AK,Gonon A,Pécheur EI,Pezet M,Villiers C,Marche PN
216-16 was used in Cell Culture to investigate gold nanoparticle effect on the immune system.
Thu Jan 07 00:00:00 UTC 2021
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Nature communications
Debackere K,Marcelis L,Demeyer S,Vanden Bempt M,Mentens N,Gielen O,Jacobs K,Broux M,Verhoef G,Michaux L,Graux C,Wlodarska I,Gaulard P,de Leval L,Tousseyn T,Cools J,Dierickx D
Thu Jun 17 00:00:00 UTC 2021
Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3.
Cell reports
Sun Y,Zhou Y,Shi Y,Zhang Y,Liu K,Liang R,Sun P,Chang X,Tang W,Zhang Y,Li J,Wang S,Zhu Y,Han X
Tue Jan 05 00:00:00 UTC 2021
In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim GR,Kim WJ,Lim S,Lee HG,Koo JH,Nam KH,Kim SM,Park SD,Choi JM
Thu Jul 01 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.
Nature communications
Bian Z,Shi L,Kidder K,Zen K,Garnett-Benson C,Liu Y
Fri May 28 00:00:00 UTC 2021
Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Cell death & disease
Buffolo F,Petrosino V,Albini M,Moschetta M,Carlini F,Floss T,Kerlero de Rosbo N,Cesca F,Rocchi A,Uccelli A,Benfenati F
Mon Feb 15 00:00:00 UTC 2021
TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
Nature communications
Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y
Mon Jan 04 00:00:00 UTC 2021
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.
Nature medicine
Cerezo-Wallis D,Contreras-Alcalde M,Troulé K,Catena X,Mucientes C,Calvo TG,Cañón E,Tejedo C,Pennacchi PC,Hogan S,Kölblinger P,Tejero H,Chen AX,Ibarz N,Graña-Castro O,Martinez L,Muñoz J,Ortiz-Romero P,Rodriguez-Peralto JL,Gómez-López G,Al-Shahrour F,Rabadán R,Levesque MP,Olmeda D,Soengas MS
Tue Dec 01 00:00:00 UTC 2020
Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.
Immunity
Wong R,Belk JA,Govero J,Uhrlaub JL,Reinartz D,Zhao H,Errico JM,D'Souza L,Ripperger TJ,Nikolich-Zugich J,Shlomchik MJ,Satpathy AT,Fremont DH,Diamond MS,Bhattacharya D
Tue Nov 17 00:00:00 UTC 2020
The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.
Immunity
Chang D,Xing Q,Su Y,Zhao X,Xu W,Wang X,Dong C
Tue Sep 15 00:00:00 UTC 2020
Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.
Immunity
Kim D,Nguyen QT,Lee J,Lee SH,Janocha A,Kim S,Le HT,Dvorina N,Weiss K,Cameron MJ,Asosingh K,Erzurum SC,Baldwin WM,Lee JS,Min B
Tue Sep 15 00:00:00 UTC 2020
Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.
Immunity
Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C
Tue Feb 18 00:00:00 UTC 2020
Vitamin B6 Addiction in Acute Myeloid Leukemia.
Cancer cell
Chen CC,Li B,Millman SE,Chen C,Li X,Morris JP,Mayle A,Ho YJ,Loizou E,Liu H,Qin W,Shah H,Violante S,Cross JR,Lowe SW,Zhang L
Mon Jan 13 00:00:00 UTC 2020
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Cell metabolism
Roy DG,Chen J,Mamane V,Ma EH,Muhire BM,Sheldon RD,Shorstova T,Koning R,Johnson RM,Esaulova E,Williams KS,Hayes S,Steadman M,Samborska B,Swain A,Daigneault A,Chubukov V,Roddy TP,Foulkes W,Pospisilik JA,Bourgeois-Daigneault MC,Artyomov MN,Witcher M,Krawczyk CM,Larochelle C,Jones RG
216-16 was used in In vitro experiments to investigate the role of methionine on CD4+ T helper cells.
Tue Feb 04 00:00:00 UTC 2020
SIRT1 is downregulated by autophagy in senescence and ageing.
Nature cell biology
Xu C,Wang L,Fozouni P,Evjen G,Chandra V,Jiang J,Lu C,Nicastri M,Bretz C,Winkler JD,Amaravadi R,Garcia BA,Adams PD,Ott M,Tong W,Johansen T,Dou Z,Berger SL
216-16 was used in In vitro experiments to investigate SIRT1 homeostasis in mammalian senescence and aging.
Thu Oct 01 00:00:00 UTC 2020
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Blood
He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J
Thu Jul 09 00:00:00 UTC 2020
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.
Blood
Gleitz HFE,Dugourd AJF,Leimkühler NB,Snoeren IAM,Fuchs SNR,Menzel S,Ziegler S,Kröger N,Triviai I,Büsche G,Kreipe H,Banjanin B,Pritchard JE,Hoogenboezem R,Bindels EM,Schumacher N,Rose-John S,Elf S,Saez-Rodriguez J,Kramann R,Schneider RK
Thu Oct 29 00:00:00 UTC 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 UTC 2020
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Blood
Numata A,Kwok HS,Zhou QL,Li J,Tirado-Magallanes R,Angarica VE,Hannah R,Park J,Wang CQ,Krishnan V,Rajagopalan D,Zhang Y,Zhou S,Welner RS,Osato M,Jha S,Bohlander SK,Göttgens B,Yang H,Benoukraf T,Lough JW,Bararia D,Tenen DG
Thu Oct 08 00:00:00 UTC 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
Wed Jul 01 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
216-16 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
216-16 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 UTC 2020
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.
The Journal of clinical investigation
Matthias J,Heink S,Picard F,Zeiträg J,Kolz A,Chao YY,Soll D,de Almeida GP,Glasmacher E,Jacobsen ID,Riedel T,Peters A,Floess S,Huehn J,Baumjohann D,Huber M,Korn T,Zielinski CE
Tue Sep 01 00:00:00 UTC 2020
Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.
The Journal of experimental medicine
Gao Y,Deason K,Jain A,Irizarry-Caro RA,Dozmorov I,Coughlin LA,Rauch I,Evers BM,Koh AY,Wakeland EK,Pasare C
Mon Apr 06 00:00:00 UTC 2020
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
The Journal of experimental medicine
Kang L,Zhang X,Ji L,Kou T,Smith SM,Zhao B,Guo X,Pineda-Torra I,Wu L,Hu X
Mon Apr 06 00:00:00 UTC 2020
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
The Journal of experimental medicine
Kang L,Zhang X,Ji L,Kou T,Smith SM,Zhao B,Guo X,Pineda-Torra I,Wu L,Hu X
Mon Apr 06 00:00:00 UTC 2020
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
The Journal of experimental medicine
Yan D,Wang J,Sun H,Zamani A,Zhang H,Chen W,Tang A,Ruan Q,Yang X,Chen YH,Wan X
Mon Feb 03 00:00:00 UTC 2020
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.
The Journal of experimental medicine
Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z
Mon Feb 03 00:00:00 UTC 2020
STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.
EMBO molecular medicine
Kahlfuss S,Kaufmann U,Concepcion AR,Noyer L,Raphael D,Vaeth M,Yang J,Pancholi P,Maus M,Muller J,Kozhaya L,Khodadadi-Jamayran A,Sun Z,Shaw P,Unutmaz D,Stathopulos PB,Feist C,Cameron SB,Turvey SE,Feske S
Fri Aug 07 00:00:00 UTC 2020
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.
Proceedings of the National Academy of Sciences of the United States of America
Mikami N,Kawakami R,Chen KY,Sugimoto A,Ohkura N,Sakaguchi S
Tue Jun 02 00:00:00 UTC 2020
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways.
Proceedings of the National Academy of Sciences of the United States of America
Morianos I,Trochoutsou AI,Papadopoulou G,Semitekolou M,Banos A,Konstantopoulos D,Manousopoulou A,Kapasa M,Wei P,Lomenick B,Belaidi E,Kalamatas T,Karageorgiou K,Doskas T,Sallusto F,Pan F,Garbis SD,Quintana FJ,Xanthou G
Tue Jun 02 00:00:00 UTC 2020
Enzalutamide, an Androgen Receptor Antagonist, Enhances Myeloid Cell-Mediated Immune Suppression and Tumor Progression.
Cancer immunology research
Consiglio CR,Udartseva O,Ramsey KD,Bush C,Gollnick SO
216-16 was used in Cell Culture to investigate how AR antagonism affects myeloid cell function and metabolism in an AR-independent murine colon tumor model.
Tue Sep 01 00:00:00 UTC 2020
Differentiation of c-Kit+ CD24+ natural killer cells into myeloid cells in a GATA-2-dependent manner.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Song B,Lee JM,Park YJ,Kim IK,Kim BS,Shin KS,Jeon I,Koh CH,Bae EA,Seo H,Byun Y,Kang CY
Sun Mar 01 00:00:00 UTC 2020
IQGAP1 restrains T-cell cosignaling mediated by OX40.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T
Wed Jan 01 00:00:00 UTC 2020
Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hewitson JP,West KA,James KR,Rani GF,Dey N,Romano A,Brown N,Teichmann SA,Kaye PM,Lagos D
Mon Jun 01 00:00:00 UTC 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 UTC 2020
Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.
Journal of immunology (Baltimore, Md. : 1950)
Yan J,Hedl M,Abraham C
Sat Aug 15 00:00:00 UTC 2020
Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.
Journal of immunology (Baltimore, Md. : 1950)
Kidder K,Bian Z,Shi L,Liu Y
Sun Nov 15 00:00:00 UTC 2020
Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Francisco D,Wang Y,Conway M,Hurbon AN,Dy ABC,Addison KJ,Chu HW,Voelker DR,Ledford JG,Kraft M
Fri May 15 00:00:00 UTC 2020
Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1.
Journal of immunology (Baltimore, Md. : 1950)
Vyas SP,Hansda AK,Kaplan MH,Goswami R
Sun Mar 01 00:00:00 UTC 2020
RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chen J,Martindale JL,Abdelmohsen K,Kumar G,Fortina PM,Gorospe M,Rostami A,Yu S
Wed Apr 15 00:00:00 UTC 2020
Suppression of Mll1-Complex by Stat3/Cebpβ-Induced miR-21a/21b/181b Maintains the Accumulation, Homeostasis, and Immunosuppressive Function of Polymorphonuclear Myeloid-Derived Suppressor Cells.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Z,Huang X,Wang E,Huang Y,Yang R
Mon Jun 15 00:00:00 UTC 2020
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG
Wed Jan 01 00:00:00 UTC 2020
Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity.
Journal of immunology (Baltimore, Md. : 1950)
Schick J,Schäfer J,Alexander C,Dichtl S,Murray PJ,Christensen D,Sorg U,Pfeffer K,Schleicher U,Lang R
Wed Jul 15 00:00:00 UTC 2020
P2Y6 Deficiency Enhances Dendritic Cell-Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,He C,Zhang J,Zhang H,Wei H,Wu S,Jiang W
Wed Jul 15 00:00:00 UTC 2020
A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.
Journal of cellular and molecular medicine
Bachmann M,Lamprecht L,Gonther S,Pfeilschifter J,Mühl H
Tue Sep 01 00:00:00 UTC 2020
Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism.
American journal of physiology. Cell physiology
Liu F,Wang X,Geng H,Bu HF,Wang P,De Plaen IG,Yang H,Qian J,Tan XD
Wed Apr 01 00:00:00 UTC 2020
Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis.
Nature communications
Azizov V,Dietel K,Steffen F,Dürholz K,Meidenbauer J,Lucas S,Frech M,Omata Y,Tajik N,Knipfer L,Kolenbrander A,Seubert S,Lapuente D,Sokolova MV,Hofmann J,Tenbusch M,Ramming A,Steffen U,Nimmerjahn F,Linker R,Wirtz S,Herrmann M,Temchura V,Sarter K,Schett G,Zaiss MM
Fri Apr 24 00:00:00 UTC 2020
Foxo3 Promotes the Differentiation and Function of Follicular Helper T Cells.
Cell reports
Qi H,Tian D,Li M,Zhang C,Jin H,Liu L,Zhao X,Ma L,Zhao W,Ge Q,Duan T,Zhang D
216-16 was used in Cell Culture to unveil a critical role of Foxo3 in the regulation of Tfh differentiation and IL-21 production.
Tue May 12 00:00:00 UTC 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
Tue Jan 14 00:00:00 UTC 2020
CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response.
Cell reports
Bromley SK,Akbaba H,Mani V,Mora-Buch R,Chasse AY,Sama A,Luster AD
216-16 was used in In vitro experiments to study the requirement for CD49a in the formation, localization, persistence, and function of cutaneous CD8+ tissue-resident memory T cells.
Tue Sep 01 00:00:00 UTC 2020
Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells.
Cell reports
Browning LM,Miller C,Kuczma M,Pietrzak M,Jing Y,Rempala G,Muranski P,Ignatowicz L,Kraj P
216-16 was used in In vitro experiments to establish that BMPs, a large cytokine family, are an essential link between stromal tissues and the adaptive immune system involved in sustaining tissue homeostasis by promoting immunological tolerance.
Tue Oct 06 00:00:00 UTC 2020
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.
Science advances
Kong H,Reczek CR,McElroy GS,Steinert EM,Wang T,Sabatini DM,Chandel NS
216-16 was used in Cell Culture to demonstrate that mitochondrial complex I is a dominant metabolic determinant of mROS-dependent cellular fitness, using mitochondria-targeted antioxidants (MVE or MitoTEMPO) to pharmcologically inhibit mitochondrial complex I.
Sun Nov 01 00:00:00 UTC 2020
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.
Nature communications
Basilico S,Wang X,Kennedy A,Tzelepis K,Giotopoulos G,Kinston SJ,Quiros PM,Wong K,Adams DJ,Carnevalli LS,Huntly BJP,Vassiliou GS,Calero-Nieto FJ,Göttgens B
Mon Mar 16 00:00:00 UTC 2020
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Nature communications
Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C
Wed Jan 29 00:00:00 UTC 2020
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Nature communications
Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE
Tue Apr 14 00:00:00 UTC 2020
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Nature communications
Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE
Tue Apr 14 00:00:00 UTC 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
216-16 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 UTC 2020
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nature communications
Zhang Y,Guo Y,Gough SM,Zhang J,Vann KR,Li K,Cai L,Shi X,Aplan PD,Wang GG,Kutateladze TG
Fri Jul 03 00:00:00 UTC 2020
Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation.
Cell death & disease
Tan J,Liu H,Huang M,Li N,Tang S,Meng J,Tang S,Zhou H,Kijlstra A,Yang P,Hou S
Sat Aug 22 00:00:00 UTC 2020
Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature.
Journal of the American Heart Association
Tyrrell DJ,Blin MG,Song J,Wood SC,Goldstein DR
216-16 was used in Cell Culture to study the mechanism of how aging impairs the integrity of the blood-brain barrier to show that aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels.
Tue Dec 01 00:00:00 UTC 2020
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
Thu Oct 31 00:00:00 UTC 2019
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Cell
Rojas OL,Pröbstel AK,Porfilio EA,Wang AA,Charabati M,Sun T,Lee DSW,Galicia G,Ramaglia V,Ward LA,Leung LYT,Najafi G,Khaleghi K,Garcillán B,Li A,Besla R,Naouar I,Cao EY,Chiaranunt P,Burrows K,Robinson HG,Allanach JR,Yam J,Luck H,Campbell DJ,Allman D,Brooks DG,Tomura M,Baumann R,Zamvil SS,Bar-Or A,Horwitz MS,Winer DA,Mortha A,Mackay F,Prat A,Osborne LC,Robbins C,Baranzini SE,Gommerman JL
Thu Jan 24 00:00:00 UTC 2019
The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.
Immunity
Xu W,Zhao X,Wang X,Feng H,Gou M,Jin W,Wang X,Liu X,Dong C
Tue Nov 19 00:00:00 UTC 2019
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
216-16 was used in In vitro experiments to investigate pathogenic lymphocyte in chronic inflammatory disease.
Tue May 21 00:00:00 UTC 2019
Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.
Immunity
Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR
Tue Jun 18 00:00:00 UTC 2019
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.
Immunity
Tyrkalska SD,Pérez-Oliva AB,Rodríguez-Ruiz L,Martínez-Morcillo FJ,Alcaraz-Pérez F,Martínez-Navarro FJ,Lachaud C,Ahmed N,Schroeder T,Pardo-Sánchez I,Candel S,López-Muñoz A,Choudhuri A,Rossmann MP,Zon LI,Cayuela ML,García-Moreno D,Mulero V
Tue Jul 16 00:00:00 UTC 2019
GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.
Cancer cell
Mondragón L,Mhaidly R,De Donatis GM,Tosolini M,Dao P,Martin AR,Pons C,Chiche J,Jacquin M,Imbert V,Proïcs E,Boyer L,Doye A,Luciano F,Neels JG,Coutant F,Fabien N,Sormani L,Rubio-Patiño C,Bossowski JP,Muller F,Marchetti S,Villa E,Peyron JF,Gaulard P,Lemonnier F,Asnafi V,Genestier L,Benhida R,Fournié JJ,Passeron T,Ricci JE,Verhoeyen E
Mon Sep 16 00:00:00 UTC 2019
Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.
Blood
Mack EA,Stein SJ,Rome KS,Xu L,Wertheim GB,Melo RCN,Pear WS
Thu May 30 00:00:00 UTC 2019
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.
Blood
Abdul-Aziz AM,Sun Y,Hellmich C,Marlein CR,Mistry J,Forde E,Piddock RE,Shafat MS,Morfakis A,Mehta T,Di Palma F,Macaulay I,Ingham CJ,Haestier A,Collins A,Campisi J,Bowles KM,Rushworth SA
Thu Jan 31 00:00:00 UTC 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 UTC 2019
Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.
The Journal of clinical investigation
Kaushik DK,Bhattacharya A,Mirzaei R,Rawji KS,Ahn Y,Rho JM,Yong VW
Tue May 21 00:00:00 UTC 2019
Type I interferon induces CXCL13 to support ectopic germinal center formation.
The Journal of experimental medicine
Denton AE,Innocentin S,Carr EJ,Bradford BM,Lafouresse F,Mabbott NA,Mörbe U,Ludewig B,Groom JR,Good-Jacobson KL,Linterman MA
Mon Mar 04 00:00:00 UTC 2019
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
The Journal of experimental medicine
Sun X,Cui Y,Feng H,Liu H,Liu X
Mon Dec 02 00:00:00 UTC 2019
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
The Journal of experimental medicine
Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B
Mon Feb 04 00:00:00 UTC 2019
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
The Journal of experimental medicine
Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B
Mon Feb 04 00:00:00 UTC 2019
Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.
The Journal of experimental medicine
Tanaka H,Arima Y,Kamimura D,Tanaka Y,Takahashi N,Uehata T,Maeda K,Satoh T,Murakami M,Akira S
Mon Jun 03 00:00:00 UTC 2019
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
The Journal of experimental medicine
Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP
Mon Apr 01 00:00:00 UTC 2019
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
The Journal of experimental medicine
Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP
Mon Apr 01 00:00:00 UTC 2019
TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone.
The Journal of experimental medicine
Albright AR,Kabat J,Li M,Raso F,Reboldi A,Muppidi JR
Mon Nov 04 00:00:00 UTC 2019
Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
The Journal of experimental medicine
Chen Z,Amro EM,Becker F,Hölzer M,Rasa SMM,Njeru SN,Han B,Di Sanzo S,Chen Y,Tang D,Tao S,Haenold R,Groth M,Romanov VS,Kirkpatrick JM,Kraus JM,Kestler HA,Marz M,Ori A,Neri F,Morita Y,Rudolph KL
Mon Jan 07 00:00:00 UTC 2019
A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity.
Journal of the American Society of Nephrology : JASN
Hagenstein J,Melderis S,Nosko A,Warkotsch MT,Richter JV,Ramcke T,Herrnstadt GR,Scheller J,Yan I,Mittrücker HW,Kluger MA,Steinmetz OM
216-16 was used in In vitro experiments to study the complex role of CD4+ T cell intrinsic IL-6 receptor (IL-6R) signaling.
Thu Aug 01 00:00:00 UTC 2019
Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.
Developmental cell
Li H,Natarajan A,Ezike J,Barrasa MI,Le Y,Feder ZA,Yang H,Ma C,Markoulaki S,Lodish HF
216-16 was used in In vitro experiments to demonstrate a continuum of transcriptomic states in committed transit-amplifying erythropoietic progenitors, which correlates with a continuum of proliferative potentials in these cells.
Mon Apr 08 00:00:00 UTC 2019
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Genes & development
Labi V,Peng S,Klironomos F,Munschauer M,Kastelic N,Chakraborty T,Schoeler K,Derudder E,Martella M,Mastrobuoni G,Hernandez-Miranda LR,Lahmann I,Kocks C,Birchmeier C,Kempa S,Quintanilla-Martinez de Fend L,Landthaler M,Rajewsky N,Rajewsky K
216-16 was used in Cell Culture to conclude that the interaction of miR-17∼92 with a single target is essential for life, and BIM regulation by miRNAs serves as a rheostat controlling cell survival in specific physiological contexts.
Sun Dec 01 00:00:00 UTC 2019
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
Cell systems
Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV
216-16 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.
Wed Oct 23 00:00:00 UTC 2019
Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.
Aging cell
Yue S,Zheng X,Zheng Y
Thu Aug 01 00:00:00 UTC 2019
VISTA expressed in tumour cells regulates T cell function.
British journal of cancer
Mulati K,Hamanishi J,Matsumura N,Chamoto K,Mise N,Abiko K,Baba T,Yamaguchi K,Horikawa N,Murakami R,Taki M,Budiman K,Zeng X,Hosoe Y,Azuma M,Konishi I,Mandai M
Tue Jan 01 00:00:00 UTC 2019
Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.
EMBO reports
Schuler F,Afreen S,Manzl C,Häcker G,Erlacher M,Villunger A
Thu Aug 01 00:00:00 UTC 2019
BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.
Mucosal immunology
Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J
Sun Sep 01 00:00:00 UTC 2019
High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.
Journal of lipid research
Townsend LK,Medak KD,Peppler WT,Meers GM,Rector RS,LeBlanc PJ,Wright DC
Mon Jul 01 00:00:00 UTC 2019
Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.
Cancer science
Chu Y,Chen Y,Li M,Shi D,Wang B,Lian Y,Cheng X,Wang X,Xu M,Cheng T,Shi J,Yuan W
Mon Jul 01 00:00:00 UTC 2019
Chromosome Transplantation: Correction of the Chronic Granulomatous Disease Defect in Mouse Induced Pluripotent Stem Cells.
Stem cells (Dayton, Ohio)
Castelli A,Susani L,Menale C,Muggeo S,Caldana E,Strina D,Cassani B,Recordati C,Scanziani E,Ficara F,Villa A,Vezzoni P,Paulis M
Mon Jul 01 00:00:00 UTC 2019
Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells.
Cell death & disease
Yang J,Yang X,Yang J,Li M
Wed Feb 13 00:00:00 UTC 2019
Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.
Scientific reports
Minshawi F,White MRH,Muller W,Humphreys N,Jackson D,Campbell BJ,Adamson A,Papoutsopoulou S
Thu Jan 17 00:00:00 UTC 2019
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation.
Nature communications
Zhou J,Huang S,Wang Z,Huang J,Xu L,Tang X,Wan YY,Li QJ,Symonds ALJ,Long H,Zhu B
Mon Jun 03 00:00:00 UTC 2019
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Nature communications
Lückel C,Picard F,Raifer H,Campos Carrascosa L,Guralnik A,Zhang Y,Klein M,Bittner S,Steffen F,Moos S,Marini F,Gloury R,Kurschus FC,Chao YY,Bertrams W,Sexl V,Schmeck B,Bonetti L,Grusdat M,Lohoff M,Zielinski CE,Zipp F,Kallies A,Brenner D,Berger M,Bopp T,Tackenberg B,Huber M
Mon Dec 16 00:00:00 UTC 2019
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.
Cell reports
Luo H,Mu WC,Karki R,Chiang HH,Mohrin M,Shin JJ,Ohkubo R,Ito K,Kanneganti TD,Chen D
216-16 was used in Cell Culture to assess whether the NLRP3 inflammasome is aberrantly activated in haematopoietic stem cells during physiological ageing.
Tue Jan 22 00:00:00 UTC 2019
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.
Nature communications
Luu M,Pautz S,Kohl V,Singh R,Romero R,Lucas S,Hofmann J,Raifer H,Vachharajani N,Carrascosa LC,Lamp B,Nist A,Stiewe T,Shaul Y,Adhikary T,Zaiss MM,Lauth M,Steinhoff U,Visekruna A
Fri Feb 15 00:00:00 UTC 2019
MSC Transplantation Improves Lacrimal Gland Regeneration after Surgically Induced Dry Eye Disease in Mice.
Scientific reports
Dietrich J,Ott L,Roth M,Witt J,Geerling G,Mertsch S,Schrader S
Wed Dec 04 00:00:00 UTC 2019
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.
Nature communications
Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T
Fri Dec 06 00:00:00 UTC 2019
Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.
Cell reports
Myers DR,Norlin E,Vercoulen Y,Roose JP
216-16 was used in Cell Culture to investigate the role of Rasgrp1 in selective and robust tonic mTORC1 signals in CD4+ T cells.
Tue May 07 00:00:00 UTC 2019
Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.
The Journal of biological chemistry
Yin W,Song Y,Chang X
Fri Jan 04 00:00:00 UTC 2019
A reporter mouse for non-invasive detection of toll-like receptor ligands induced acute phase responses.
Scientific reports
Huang CF,Chiu SY,Huang HW,Cheng BH,Pan HM,Huang WL,Chang HH,Liao CC,Jiang ST,Su YC
Fri Dec 13 00:00:00 UTC 2019
Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis.
Scientific reports
Zhang Y,Hu N,Dong F
Thu Jan 24 00:00:00 UTC 2019
IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival.
Scientific reports
Wang Y,Richter L,Becker M,Amador C,Hyde RK
Mon Feb 11 00:00:00 UTC 2019
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
The Journal of biological chemistry
Frossi B,Antoniali G,Yu K,Akhtar N,Kaplan MH,Kelley MR,Tell G,Pucillo CEM
Fri Mar 29 00:00:00 UTC 2019
Interleukin-22 promotes tumor angiogenesis.
Angiogenesis
Protopsaltis NJ,Liang W,Nudleman E,Ferrara N
216-16 was used in Cell Culture to demonstrate that interleukin-22, a key effector cytokine expressed by TH17 cells, directly acts on endothelial cells to promote tumour angiogenesis and is therefore a potential therapeutic target for blocking tumour angiogenesis.
Wed May 01 00:00:00 UTC 2019
Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.
Stem cell research & therapy
I T,Sumita Y,Yoshida T,Honma R,Iwatake M,Raudales JLM,Shizuno T,Kuroshima S,Masuda H,Seki M,Tran SD,Asahara T,Asahina I
216-16 was used in Cell Culture to investigate methods conditioning peripheral blood mononuclear cells to regenerate salivary gland following head and neck cancer treatment.
Thu Oct 17 00:00:00 UTC 2019
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration.
Nature communications
Sala D,Cunningham TJ,Stec MJ,Etxaniz U,Nicoletti C,Dall'Agnese A,Puri PL,Duester G,Latella L,Sacco A
Wed Apr 17 00:00:00 UTC 2019
Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.
Scientific reports
Lin CH,Wang Z,Duque-Afonso J,Wong SH,Demeter J,Loktev AV,Somervaille TCP,Jackson PK,Cleary ML
Wed Mar 20 00:00:00 UTC 2019
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
Thu Mar 01 00:00:00 UTC 2018
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
Nature biotechnology
Kosicki M,Tomberg K,Bradley A
Sat Sep 01 00:00:00 UTC 2018
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.
Cell
Grohmann M,Wiede F,Dodd GT,Gurzov EN,Ooi GJ,Butt T,Rasmiena AA,Kaur S,Gulati T,Goh PK,Treloar AE,Archer S,Brown WA,Muller M,Watt MJ,Ohara O,McLean CA,Tiganis T
Thu Nov 15 00:00:00 UTC 2018
CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.
Cell
Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH
216-16 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.
Thu Jun 28 00:00:00 UTC 2018
The Energetics and Physiological Impact of Cohesin Extrusion.
Cell
Vian L,Pękowska A,Rao SSP,Kieffer-Kwon KR,Jung S,Baranello L,Huang SC,El Khattabi L,Dose M,Pruett N,Sanborn AL,Canela A,Maman Y,Oksanen A,Resch W,Li X,Lee B,Kovalchuk AL,Tang Z,Nelson S,Di Pierro M,Cheng RR,Machol I,St Hilaire BG,Durand NC,Shamim MS,Stamenova EK,Onuchic JN,Ruan Y,Nussenzweig A,Levens D,Aiden EL,Casellas R
Thu May 17 00:00:00 UTC 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y
Thu Sep 20 00:00:00 UTC 2018
An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis.
Immunity
Fatkhullina AR,Peshkova IO,Dzutsev A,Aghayev T,McCulloch JA,Thovarai V,Badger JH,Vats R,Sundd P,Tang HY,Kossenkov AV,Hazen SL,Trinchieri G,Grivennikov SI,Koltsova EK
Tue Nov 20 00:00:00 UTC 2018
The Majority of CD45- Ter119- CD31- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.
Immunity
Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS
Tue Oct 16 00:00:00 UTC 2018
The Majority of CD45- Ter119- CD31- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.
Immunity
Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS
Tue Oct 16 00:00:00 UTC 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 UTC 2018
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.
Cancer cell
Kleppe M,Koche R,Zou L,van Galen P,Hill CE,Dong L,De Groote S,Papalexi E,Hanasoge Somasundara AV,Cordner K,Keller M,Farnoud N,Medina J,McGovern E,Reyes J,Roberts J,Witkin M,Rapaport F,Teruya-Feldstein J,Qi J,Rampal R,Bernstein BE,Bradner JE,Levine RL
Mon Jan 08 00:00:00 UTC 2018
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Cancer cell
Booth CAG,Barkas N,Neo WH,Boukarabila H,Soilleux EJ,Giotopoulos G,Farnoud N,Giustacchini A,Ashley N,Carrelha J,Jamieson L,Atkinson D,Bouriez-Jones T,Prinjha RK,Milne TA,Teachey DT,Papaemmanuil E,Huntly BJP,Jacobsen SEW,Mead AJ
Mon Feb 12 00:00:00 UTC 2018
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.
Cancer cell
Cortes JR,Ambesi-Impiombato A,Couronné L,Quinn SA,Kim CS,da Silva Almeida AC,West Z,Belver L,Martin MS,Scourzic L,Bhagat G,Bernard OA,Ferrando AA,Palomero T
Mon Feb 12 00:00:00 UTC 2018
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Vanden Bempt M,Demeyer S,Broux M,De Bie J,Bornschein S,Mentens N,Vandepoel R,Geerdens E,Radaelli E,Bornhauser BC,Kulozik AE,Meijerink JP,Bourquin JP,de Bock CE,Cools J
Mon Aug 13 00:00:00 UTC 2018
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Vanden Bempt M,Demeyer S,Broux M,De Bie J,Bornschein S,Mentens N,Vandepoel R,Geerdens E,Radaelli E,Bornhauser BC,Kulozik AE,Meijerink JP,Bourquin JP,de Bock CE,Cools J
Mon Aug 13 00:00:00 UTC 2018
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Cancer cell
Maes T,Mascaró C,Tirapu I,Estiarte A,Ciceri F,Lunardi S,Guibourt N,Perdones A,Lufino MMP,Somervaille TCP,Wiseman DH,Duy C,Melnick A,Willekens C,Ortega A,Martinell M,Valls N,Kurz G,Fyfe M,Castro-Palomino JC,Buesa C
Mon Mar 12 00:00:00 UTC 2018
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Blood
Gallipoli P,Giotopoulos G,Tzelepis K,Costa ASH,Vohra S,Medina-Perez P,Basheer F,Marando L,Di Lisio L,Dias JML,Yun H,Sasca D,Horton SJ,Vassiliou G,Frezza C,Huntly BJP
Thu Apr 12 00:00:00 UTC 2018
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.
Blood
El Ashkar S,Schwaller J,Pieters T,Goossens S,Demeulemeester J,Christ F,Van Belle S,Juge S,Boeckx N,Engelman A,Van Vlierberghe P,Debyser Z,De Rijck J
Thu Jan 04 00:00:00 UTC 2018
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.
The Journal of clinical investigation
Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J
Tue May 01 00:00:00 UTC 2018
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
The Journal of experimental medicine
Chen S,Yun F,Yao Y,Cao M,Zhang Y,Wang J,Song X,Qian Y
Mon Nov 05 00:00:00 UTC 2018
BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
The Journal of experimental medicine
Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C
Mon Sep 03 00:00:00 UTC 2018
Trim33 mediates the proinflammatory function of Th17 cells.
The Journal of experimental medicine
Tanaka S,Jiang Y,Martinez GJ,Tanaka K,Yan X,Kurosaki T,Kaartinen V,Feng XH,Tian Q,Wang X,Dong C
216-16 was used in In vitro experiments to study the mechanism by which transforming growth factor-β regulates reciprocal regulatory T cell and T helper 17 differentiation.
Mon Jul 02 00:00:00 UTC 2018
Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.
The Journal of experimental medicine
Barbieri D,Elvira-Matelot E,Pelinski Y,Genève L,de Laval B,Yogarajah G,Pecquet C,Constantinescu SN,Porteu F
Mon May 07 00:00:00 UTC 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.
The Journal of experimental medicine
Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J
Mon Jul 02 00:00:00 UTC 2018
Kinetics of adult hematopoietic stem cell differentiation in vivo.
The Journal of experimental medicine
Upadhaya S,Sawai CM,Papalexi E,Rashidfarrokhi A,Jang G,Chattopadhyay P,Satija R,Reizis B
Mon Nov 05 00:00:00 UTC 2018
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America
Sharma S,Čermáková K,De Rijck J,Demeulemeester J,Fábry M,El Ashkar S,Van Belle S,Lepšík M,Tesina P,Duchoslav V,Novák P,Hubálek M,Srb P,Christ F,Řezáčová P,Hodges HC,Debyser Z,Veverka V
Tue Jul 24 00:00:00 UTC 2018
SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America
Sen S,Wang F,Zhang J,He Z,Ma J,Gwack Y,Xu J,Sun Z
Tue Jan 16 00:00:00 UTC 2018
Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.
Proceedings of the National Academy of Sciences of the United States of America
Das P,Veazey KJ,Van HT,Kaushik S,Lin K,Lu Y,Ishii M,Kikuta J,Ge K,Nussenzweig A,Santos MA
Tue Oct 23 00:00:00 UTC 2018
Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality.
Journal of immunology (Baltimore, Md. : 1950)
Lim TJF,Su IH
Sat Dec 15 00:00:00 UTC 2018
Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.
Journal of immunology (Baltimore, Md. : 1950)
Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA
Thu Feb 01 00:00:00 UTC 2018
CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.
Journal of immunology (Baltimore, Md. : 1950)
Woo JS,Srikanth S,Kim KD,Elsaesser H,Lu J,Pellegrini M,Brooks DG,Sun Z,Gwack Y
Wed Aug 15 00:00:00 UTC 2018
miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A.
Journal of immunology (Baltimore, Md. : 1950)
Bian J,Liu R,Fan T,Liao L,Wang S,Geng W,Wang T,Shi W,Ruan Q
Sat Sep 01 00:00:00 UTC 2018
A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Zehrer A,Pick R,Salvermoser M,Boda A,Miller M,Stark K,Weckbach LT,Walzog B,Begandt D
Sat Sep 15 00:00:00 UTC 2018
Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Fuseini H,Yung JA,Cephus JY,Zhang J,Goleniewska K,Polosukhin VV,Peebles RS,Newcomb DC
Mon Oct 01 00:00:00 UTC 2018
Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program.
Journal of immunology (Baltimore, Md. : 1950)
Do NN,Willenborg S,Eckes B,Jüngst C,Sengle G,Zaucke F,Eming SA
Sun Jul 15 00:00:00 UTC 2018
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Journal of immunology (Baltimore, Md. : 1950)
Hashiguchi Y,Yabe R,Chung SH,Murayama MA,Yoshida K,Matsuo K,Kubo S,Saijo S,Nakamura Y,Matsue H,Iwakura Y
Sun Jul 01 00:00:00 UTC 2018
Lnc-chop Promotes Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor and Inflammatory Environments.
Journal of immunology (Baltimore, Md. : 1950)
Gao Y,Wang T,Li Y,Zhang Y,Yang R
Sun Apr 15 00:00:00 UTC 2018
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.
Nature communications
Calcinotto A,Brevi A,Chesi M,Ferrarese R,Garcia Perez L,Grioni M,Kumar S,Garbitt VM,Sharik ME,Henderson KJ,Tonon G,Tomura M,Miwa Y,Esplugues E,Flavell RA,Huber S,Canducci F,Rajkumar VS,Bergsagel PL,Bellone M
Mon Dec 03 00:00:00 UTC 2018
Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.
Cell death & disease
Lv Q,Shi C,Qiao S,Cao N,Guan C,Dai Y,Wei Z
Thu Aug 30 00:00:00 UTC 2018
Single cell analysis of kynurenine and System L amino acid transport in T cells.
Nature communications
Sinclair LV,Neyens D,Ramsay G,Taylor PM,Cantrell DA
Thu May 17 00:00:00 UTC 2018
PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway.
Cell death & disease
Lei Z,Duan H,Zhao T,Zhang Y,Li G,Meng J,Zhang S,Yan W
Wed Mar 07 00:00:00 UTC 2018
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.
Nature communications
Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C
Thu Apr 12 00:00:00 UTC 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
Wed Sep 26 00:00:00 UTC 2018
Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats.
Scientific reports
Tong WW,Zhang C,Hong T,Liu DH,Wang C,Li J,He XK,Xu WD
Mon Feb 19 00:00:00 UTC 2018
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.
Nature communications
Numata A,Kwok HS,Kawasaki A,Li J,Zhou QL,Kerry J,Benoukraf T,Bararia D,Li F,Ballabio E,Tapia M,Deshpande AJ,Welner RS,Delwel R,Yang H,Milne TA,Taneja R,Tenen DG
Tue Apr 24 00:00:00 UTC 2018
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.
Nature communications
Meng X,Grötsch B,Luo Y,Knaup KX,Wiesener MS,Chen XX,Jantsch J,Fillatreau S,Schett G,Bozec A
Wed Jan 17 00:00:00 UTC 2018
A conserved enhancer regulates Il9 expression in multiple lineages.
Nature communications
Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH
Thu Nov 15 00:00:00 UTC 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Tue Dec 11 00:00:00 UTC 2018
Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation.
Nature communications
Izumi T,Imai J,Yamamoto J,Kawana Y,Endo A,Sugawara H,Kohata M,Asai Y,Takahashi K,Kodama S,Kaneko K,Gao J,Uno K,Sawada S,Kalinichenko VV,Ishigaki Y,Yamada T,Katagiri H
Thu Dec 13 00:00:00 UTC 2018
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.
Nature communications
Su H,Hu J,Huang L,Yang Y,Thenoz M,Kuchmiy A,Hu Y,Li P,Feng H,Zhou Y,Taghon T,Van Vlierberghe P,Qing G,Chen Z,Liu H
Mon Oct 15 00:00:00 UTC 2018
In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation.
Stem cell reports
Kauts ML,Rodriguez-Seoane C,Kaimakis P,Mendes SC,Cortés-Lavaud X,Hill U,Dzierzak E
Tue Jan 09 00:00:00 UTC 2018
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.
Cell discovery
Rothberg JLM,Maganti HB,Jrade H,Porter CJ,Palidwor GA,Cafariello C,Battaion HL,Khan ST,Perkins TJ,Paulson RF,Ito CY,Stanford WL
Thu Aug 17 00:00:00 UTC 2023
TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.
Nature communications
Zhang HX,Xu ZS,Lin H,Li M,Xia T,Cui K,Wang SY,Li Y,Shu HB,Wang YY
Fri Aug 24 00:00:00 UTC 2018
ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.
Nature communications
Massara M,Bonavita O,Savino B,Caronni N,Mollica Poeta V,Sironi M,Setten E,Recordati C,Crisafulli L,Ficara F,Mantovani A,Locati M,Bonecchi R
Wed Feb 14 00:00:00 UTC 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 UTC 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
216-16 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 UTC 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
216-16 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 UTC 2018
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.
eLife
Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R
216-16 was used in Cell Culture to examine the role of glutamine catabolism in fuelling the de novo synthesis of glutathionine, and directing the lineage choice of T cells.
Mon Sep 10 00:00:00 UTC 2018
SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.
Nature communications
Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K
Tue Oct 30 00:00:00 UTC 2018
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Nature communications
Tzelepis K,De Braekeleer E,Aspris D,Barbieri I,Vijayabaskar MS,Liu WH,Gozdecka M,Metzakopian E,Toop HD,Dudek M,Robson SC,Hermida-Prado F,Yang YH,Babaei-Jadidi R,Garyfallos DA,Ponstingl H,Dias JML,Gallipoli P,Seiler M,Buonamici S,Vick B,Bannister AJ,Rad R,Prinjha RK,Marioni JC,Huntly B,Batson J,Morris JC,Pina C,Bradley A,Jeremias I,Bates DO,Yusa K,Kouzarides T,Vassiliou GS
Wed Dec 19 00:00:00 UTC 2018
Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues.
Oncotarget
Muccioli M,Nandigam H,Loftus T,Singh M,Venkatesh A,Wright J,Pate M,McCall K,Benencia F
216-16 was used in Enzyme-linked immunosorbent assay to investigate the potential of mouse and human ovarian cancer cells to produce inflammatory factors in response to pathogen recognition receptor signalling.
Fri Nov 30 00:00:00 UTC 2018
Exercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice.
Scientific reports
Castellani LN,Peppler WT,Miotto PM,Bush N,Wright DC
Mon Jan 15 00:00:00 UTC 2018
Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.
Nature communications
Xu Y,Sun Y,Shen H,Dai Y,Liu H,Li R,Zhang H,Wu L,Zhu X,Liu X
Mon Sep 24 00:00:00 UTC 2018
Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells.
Scientific reports
Rodrigues CFD,Serrano E,Patrício MI,Val MM,Albuquerque P,Fonseca J,Gomes CMF,Abrunhosa AJ,Paiva A,Carvalho L,Botelho MF,Almeida L,Carreira IM,Alpoim MC
Wed Aug 01 00:00:00 UTC 2018
MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.
Cell death & disease
Hartmann JU,Bräuer-Hartmann D,Kardosova M,Wurm AA,Wilke F,Schödel C,Gerloff D,Katzerke C,Krakowsky R,Namasu CY,Bill M,Schwind S,Müller-Tidow C,Niederwieser D,Alberich-Jorda M,Behre G
Thu Jul 26 00:00:00 UTC 2018
Honokiol is a FOXM1 antagonist.
Cell death & disease
Halasi M,Hitchinson B,Shah BN,Váraljai R,Khan I,Benevolenskaya EV,Gaponenko V,Arbiser JL,Gartel AL
Wed Jan 24 00:00:00 UTC 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
Tue Jan 02 00:00:00 UTC 2018
PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes.
Scientific reports
Yano H,Sakai M,Matsukawa T,Yagi T,Naganuma T,Mitsushima M,Iida S,Inaba Y,Inoue H,Unoki-Kubota H,Kaburagi Y,Asahara SI,Kido Y,Minami S,Kasuga M,Matsumoto M
Mon Sep 24 00:00:00 UTC 2018
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.
Stem cell research & therapy
Philipp D,Suhr L,Wahlers T,Choi YH,Paunel-Görgülü A
Thu Oct 25 00:00:00 UTC 2018
Host defense against oral microbiota by bone-damaging T cells.
Nature communications
Tsukasaki M,Komatsu N,Nagashima K,Nitta T,Pluemsakunthai W,Shukunami C,Iwakura Y,Nakashima T,Okamoto K,Takayanagi H
Fri Feb 16 00:00:00 UTC 2018
Discovery of stimulation-responsive immune enhancers with CRISPR activation.
Nature
Simeonov DR,Gowen BG,Boontanrart M,Roth TL,Gagnon JD,Mumbach MR,Satpathy AT,Lee Y,Bray NL,Chan AY,Lituiev DS,Nguyen ML,Gate RE,Subramaniam M,Li Z,Woo JM,Mitros T,Ray GJ,Curie GL,Naddaf N,Chu JS,Ma H,Boyer E,Van Gool F,Huang H,Liu R,Tobin VR,Schumann K,Daly MJ,Farh KK,Ansel KM,Ye CJ,Greenleaf WJ,Anderson MS,Bluestone JA,Chang HY,Corn JE,Marson A
Thu Sep 07 00:00:00 UTC 2017
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.
Nature
Barbieri I,Tzelepis K,Pandolfini L,Shi J,Millán-Zambrano G,Robson SC,Aspris D,Migliori V,Bannister AJ,Han N,De Braekeleer E,Ponstingl H,Hendrick A,Vakoc CR,Vassiliou GS,Kouzarides T
Thu Dec 07 00:00:00 UTC 2017
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cell
Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I
216-16 was used in In vitro experiments to determine the role of TET2 deficiency in leukaemia stem cell maintenance.
Thu Sep 07 00:00:00 UTC 2017
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.
Cell
Moretti J,Roy S,Bozec D,Martinez J,Chapman JR,Ueberheide B,Lamming DW,Chen ZJ,Horng T,Yeretssian G,Green DR,Blander JM
Thu Nov 02 00:00:00 UTC 2017
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Immunity
Essig K,Hu D,Guimaraes JC,Alterauge D,Edelmann S,Raj T,Kranich J,Behrens G,Heiseke A,Floess S,Klein J,Maiser A,Marschall S,Hrabĕ de Angelis M,Leonhardt H,Calkhoven CF,Noessner E,Brocker T,Huehn J,Krug AB,Zavolan M,Baumjohann D,Heissmeyer V
Tue Dec 19 00:00:00 UTC 2017
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
216-16 was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.
Tue Dec 19 00:00:00 UTC 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
Tue Dec 19 00:00:00 UTC 2017
Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Cancer cell
Poh AR,Love CG,Masson F,Preaudet A,Tsui C,Whitehead L,Monard S,Khakham Y,Burstroem L,Lessene G,Sieber O,Lowell C,Putoczki TL,O'Donoghue RJJ,Ernst M
Mon Apr 10 00:00:00 UTC 2017
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.
Cancer cell
Gu Y,Zhang J,Ma X,Kim BW,Wang H,Li J,Pan Y,Xu Y,Ding L,Yang L,Guo C,Wu X,Wu J,Wu K,Gan X,Li G,Li L,Forman SJ,Chan WC,Xu R,Huang W
Mon Jul 10 00:00:00 UTC 2017
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer cell
Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P
Mon Jun 12 00:00:00 UTC 2017
Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation.
Cell metabolism
Tarasenko TN,Pacheco SE,Koenig MK,Gomez-Rodriguez J,Kapnick SM,Diaz F,Zerfas PM,Barca E,Sudderth J,DeBerardinis RJ,Covian R,Balaban RS,DiMauro S,McGuire PJ
216-16 was used in Cell Culture to emphasize the role of COX particularly in T cells as a metabolic checkpoint for cell fate decisions following T cell activation, with heterogeneous effects in T cell subsets while also highlighting the utility of translational models that recapitulate human mitochondrial disease for understanding immunometabolism.
Tue Jun 06 00:00:00 UTC 2017
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.
Cell host & microbe
Tsai PY,Zhang B,He WQ,Zha JM,Odenwald MA,Singh G,Tamura A,Shen L,Sailer A,Yeruva S,Kuo WT,Fu YX,Tsukita S,Turner JR
216-16 was used in Cell Culture to investigate the pathogenic effects of diarrhea.
Wed Jun 14 00:00:00 UTC 2017
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.
Blood
Man N,Tan Y,Sun XJ,Liu F,Cheng G,Greenblatt SM,Martinez C,Karl DL,Ando K,Sun M,Hou D,Chen B,Xu M,Yang FC,Chen Z,Chen S,Nimer SD,Wang L
Thu May 18 00:00:00 UTC 2017
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Blood
Dovey OM,Cooper JL,Mupo A,Grove CS,Lynn C,Conte N,Andrews RM,Pacharne S,Tzelepis K,Vijayabaskar MS,Green P,Rad R,Arends M,Wright P,Yusa K,Bradley A,Varela I,Vassiliou GS
Thu Oct 26 00:00:00 UTC 2017
CSF-1-induced Src signaling can instruct monocytic lineage choice.
Blood
Endele M,Loeffler D,Kokkaliaris KD,Hilsenbeck O,Skylaki S,Hoppe PS,Schambach A,Stanley ER,Schroeder T
Thu Mar 23 00:00:00 UTC 2017
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.
The Journal of clinical investigation
Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L
Mon Oct 02 00:00:00 UTC 2017
LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.
Nucleic acids research
Stanulovic VS,Cauchy P,Assi SA,Hoogenkamp M
216-16 was used in In vitro experiments to show that Lmo2-/- mouse embryonic stem cells differentiated to Flk-1+ haemangioblasts, but less efficiently to haemogenic endothelium.
Fri Sep 29 00:00:00 UTC 2017
PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
The Journal of experimental medicine
Wiede F,Dudakov JA,Lu KH,Dodd GT,Butt T,Godfrey DI,Strasser A,Boyd RL,Tiganis T
Mon Sep 04 00:00:00 UTC 2017
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
The Journal of experimental medicine
Öhlund D,Handly-Santana A,Biffi G,Elyada E,Almeida AS,Ponz-Sarvise M,Corbo V,Oni TE,Hearn SA,Lee EJ,Chio II,Hwang CI,Tiriac H,Baker LA,Engle DD,Feig C,Kultti A,Egeblad M,Fearon DT,Crawford JM,Clevers H,Park Y,Tuveson DA
Mon Mar 06 00:00:00 UTC 2017
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
Mon May 01 00:00:00 UTC 2017
PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
EMBO molecular medicine
Azad A,Yin Lim S,D'Costa Z,Jones K,Diana A,Sansom OJ,Kruger P,Liu S,McKenna WG,Dushek O,Muschel RJ,Fokas E
Wed Feb 01 00:00:00 UTC 2017
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Gao X,Lee HY,Li W,Platt RJ,Barrasa MI,Ma Q,Elmes RR,Rosenfeld MG,Lodish HF
Tue Sep 19 00:00:00 UTC 2017
Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence.
Cancer immunology research
Kottke T,Evgin L,Shim KG,Rommelfanger D,Boisgerault N,Zaidi S,Diaz RM,Thompson J,Ilett E,Coffey M,Selby P,Pandha H,Harrington K,Melcher A,Vile R
216-16 was used in Cell Culture to investigate TNFα and immune activation in minimal residual disease recurrence.
Wed Nov 01 00:00:00 UTC 2017
Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity.
Journal of lipid research
Sun S,Wang R,Song J,Guan M,Li N,Zhang X,Zhao Z,Zhang J
Wed Nov 01 00:00:00 UTC 2017
On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Ukah TK,Cattin-Roy AN,Chen W,Miller MM,Barik S,Zaghouani H
Tue Aug 01 00:00:00 UTC 2017
A Schistosoma japonicum Infection Promotes the Expansion of Myeloid-Derived Suppressor Cells by Activating the JAK/STAT3 Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Qiu H,Xie H,Qi Y,Cha H,Qu J,Wang M,Feng Y,Ye X,Mu J,Huang J
Thu Jun 15 00:00:00 UTC 2017
IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery V,Goldson AJ,Dainty JR,Chieppa M,Sobolewski A
Sat Jul 01 00:00:00 UTC 2017
A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury.
Journal of immunology (Baltimore, Md. : 1950)
Kleinschmidt D,Giannou AD,McGee HM,Kempski J,Steglich B,Huber FJ,Ernst TM,Shiri AM,Wegscheid C,Tasika E,Hübener P,Huber P,Bedke T,Steffens N,Agalioti T,Fuchs T,Noll J,Lotter H,Tiegs G,Lohse AW,Axelrod JH,Galun E,Flavell RA,Gagliani N,Huber S
Fri Dec 15 00:00:00 UTC 2017
A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Montoya MM,Maul J,Singh PB,Pua HH,Dahlström F,Wu N,Huang X,Ansel KM,Baumjohann D
Sat Jul 15 00:00:00 UTC 2017
TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy.
Journal of immunology (Baltimore, Md. : 1950)
Ye J,Wang Y,Liu X,Li L,Opejin A,Hsueh EC,Luo H,Wang T,Hawiger D,Peng G
Tue Aug 01 00:00:00 UTC 2017
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Ulrich BJ,Hummel SA,Khan I,Meuris B,Cherukuri Y,Dent AL,Janga SC,Kaplan MH
Thu Jun 01 00:00:00 UTC 2017
The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.
Molecular and cellular biology
Peraki I,Palis J,Mavrothalassitis G
216-16 was used in In vitro experiments to study how Erf is required in all three waves of embryonic hematopoiesis to show that Erf is required for both primitive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis as well as for the normal function of HSCs.
Sun Oct 01 00:00:00 UTC 2017
Murine Retrovirally-Transduced Bone Marrow Engraftment Models of MLL-Fusion-Driven Acute Myelogenous Leukemias (AML).
Current protocols in pharmacology
Stubbs MC,Krivtsov AV
216-16 was used in In vitro experiments to define protocols which focus on bone marrow-derived models only, using one particular MLL fusion, MLL-AF9.
Mon Sep 11 00:00:00 UTC 2017
Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.
Scientific reports
Ayaub EA,Dubey A,Imani J,Botelho F,Kolb MRJ,Richards CD,Ask K
Mon Oct 16 00:00:00 UTC 2017
The AP-1 transcription factor JunB is required for Th17 cell differentiation.
Scientific reports
Yamazaki S,Tanaka Y,Araki H,Kohda A,Sanematsu F,Arasaki T,Duan X,Miura F,Katagiri T,Shindo R,Nakano H,Ito T,Fukui Y,Endo S,Sumimoto H
Tue Dec 12 00:00:00 UTC 2017
p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
Nature communications
Okuma A,Hanyu A,Watanabe S,Hara E
Tue Dec 12 00:00:00 UTC 2017
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Nature communications
Romagnani A,Vettore V,Rezzonico-Jost T,Hampe S,Rottoli E,Nadolni W,Perotti M,Meier MA,Hermanns C,Geiger S,Wennemuth G,Recordati C,Matsushita M,Muehlich S,Proietti M,Chubanov V,Gudermann T,Grassi F,Zierler S
Mon Dec 04 00:00:00 UTC 2017
Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
Scientific reports
Lee YS,Lee MH,Kim HJ,Won HR,Kim CH
Tue Nov 14 00:00:00 UTC 2017
Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.
Molecular therapy. Methods & clinical development
Lee S,Kivimäe S,Szoka FC
216-16 was used in In vitro experiments to generate Hoxb8-dependent myeloid progenitors (HDPs) by transducing lineage-negative bone marrow cells with a constitutively expressed Hoxb8 flanked by loxP. HDPs proliferate indefinitely and differentiate into MΦ when Hoxb8 is removed by a tamoxifen-inducible Cre.
Fri Dec 15 00:00:00 UTC 2017
An unexpected protein interaction promotes drug resistance in leukemia.
Nature communications
Pitre A,Ge Y,Lin W,Wang Y,Fukuda Y,Temirov J,Phillips AH,Peters JL,Fan Y,Ma J,Nourse A,Sinha C,Lin H,Kriwacki R,Downing JR,Gruber TA,Centonze VE,Naren AP,Chen T,Schuetz JD
Thu Nov 16 00:00:00 UTC 2017
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.
The Journal of biological chemistry
Chen J,Martindale JL,Cramer C,Gorospe M,Atasoy U,Drew PD,Yu S
Fri Sep 01 00:00:00 UTC 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
Fri Feb 03 00:00:00 UTC 2017
CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development.
Cell reports
Hawila E,Razon H,Wildbaum G,Blattner C,Sapir Y,Shaked Y,Umansky V,Karin N
216-16 was used in Cell Culture to show that, beyond chemoattraction, the interaction between CCR5 and its ligands promotes the proliferation of CCR5+ PMN-MDSCs at the BM and, later, potentiates their immune-suppressive activities at the tumor site in part by inducing arginase-1.
Tue Nov 21 00:00:00 UTC 2017
TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.
Scientific reports
Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML
Mon Oct 16 00:00:00 UTC 2017
Hematopoietic pannexin 1 function is critical for neuropathic pain.
Scientific reports
Weaver JL,Arandjelovic S,Brown G,K Mendu S,S Schappe M,Buckley MW,Chiu YH,Shu S,Kim JK,Chung J,Krupa J,Jevtovic-Todorovic V,Desai BN,Ravichandran KS,Bayliss DA
Tue Feb 14 00:00:00 UTC 2017
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
Nature communications
Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S
Wed Mar 15 00:00:00 UTC 2017
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
NPJ Parkinson's disease
Sarkar S,Malovic E,Harishchandra DS,Ghaisas S,Panicker N,Charli A,Palanisamy BN,Rokad D,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG
Wed Sep 30 00:00:00 UTC 2020
The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression.
The Journal of biological chemistry
Foreman HC,Armstrong J,Santana AL,Krug LT,Reich NC
Fri Sep 29 00:00:00 UTC 2017
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Nature communications
Ranjan S,Goihl A,Kohli S,Gadi I,Pierau M,Shahzad K,Gupta D,Bock F,Wang H,Shaikh H,Kähne T,Reinhold D,Bank U,Zenclussen AC,Niemz J,Schnöder TM,Brunner-Weinzierl M,Fischer T,Kalinski T,Schraven B,Luft T,Huehn J,Naumann M,Heidel FH,Isermann B
Mon Aug 21 00:00:00 UTC 2017
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Cell
Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL
Thu Apr 07 00:00:00 UTC 2016
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Cell
Sykes DB,Kfoury YS,Mercier FE,Wawer MJ,Law JM,Haynes MK,Lewis TA,Schajnovitz A,Jain E,Lee D,Meyer H,Pierce KA,Tolliday NJ,Waller A,Ferrara SJ,Eheim AL,Stoeckigt D,Maxcy KL,Cobert JM,Bachand J,Szekely BA,Mukherjee S,Sklar LA,Kotz JD,Clish CB,Sadreyev RI,Clemons PA,Janzer A,Schreiber SL,Scadden DT
Thu Sep 22 00:00:00 UTC 2016
Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis.
Immunity
Matthews SP,McMillan SJ,Colbert JD,Lawrence RA,Watts C
Tue Apr 19 00:00:00 UTC 2016
CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.
Immunity
Zhang C,Xin H,Zhang W,Yazaki PJ,Zhang Z,Le K,Li W,Lee H,Kwak L,Forman S,Jove R,Yu H
Tue Apr 19 00:00:00 UTC 2016
MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor.
Immunity
Yang HY,Barbi J,Wu CY,Zheng Y,Vignali PD,Wu X,Tao JH,Park BV,Bandara S,Novack L,Ni X,Yang X,Chang KY,Wu RC,Zhang J,Yang CW,Pardoll DM,Li H,Pan F
Tue Jul 19 00:00:00 UTC 2016
Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.
Immunity
Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J
Tue Aug 16 00:00:00 UTC 2016
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.
Immunity
Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C
Tue Jun 21 00:00:00 UTC 2016
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 UTC 2016
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.
Blood
Baba T,Tanabe Y,Yoshikawa S,Yamanishi Y,Morishita S,Komatsu N,Karasuyama H,Hirao A,Mukaida N
Thu May 26 00:00:00 UTC 2016
Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Blood
Schulze I,Rohde C,Scheller-Wendorff M,Bäumer N,Krause A,Herbst F,Riemke P,Hebestreit K,Tschanter P,Lin Q,Linhart H,Godley LA,Glimm H,Dugas M,Wagner W,Berdel WE,Rosenbauer F,Müller-Tidow C
Thu Mar 24 00:00:00 UTC 2016
High-dose dexamethasone corrects impaired myeloid-derived suppressor cell function via Ets1 in immune thrombocytopenia.
Blood
Hou Y,Feng Q,Xu M,Li GS,Liu XN,Sheng Z,Zhou H,Ma J,Wei Y,Sun YX,Yu YY,Qiu JH,Shao LL,Liu XG,Hou M,Peng J
Thu Mar 24 00:00:00 UTC 2016
Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.
Blood
Mascarenhas MI,Bacon WA,Kapeni C,Fitch SR,Kimber G,Cheng SW,Li J,Green AR,Ottersbach K
Thu May 12 00:00:00 UTC 2016
MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.
Blood
Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH
Thu Oct 27 00:00:00 UTC 2016
FGF23 signaling impairs neutrophil recruitment and host defense during CKD.
The Journal of clinical investigation
Rossaint J,Oehmichen J,Van Aken H,Reuter S,Pavenstädt HJ,Meersch M,Unruh M,Zarbock A
Tue Mar 01 00:00:00 UTC 2016
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.
The Journal of clinical investigation
Janowski AM,Colegio OR,Hornick EE,McNiff JM,Martin MD,Badovinac VP,Norian LA,Zhang W,Cassel SL,Sutterwala FS
Mon Oct 03 00:00:00 UTC 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Thu Dec 01 00:00:00 UTC 2016
miR-23∼27∼24 clusters control effector T cell differentiation and function.
The Journal of experimental medicine
Cho S,Wu CJ,Yasuda T,Cruz LO,Khan AA,Lin LL,Nguyen DT,Miller M,Lee HM,Kuo ML,Broide DH,Rajewsky K,Rudensky AY,Lu LF
Mon Feb 08 00:00:00 UTC 2016
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.
The Journal of experimental medicine
Young K,Borikar S,Bell R,Kuffler L,Philip V,Trowbridge JJ
Mon Oct 17 00:00:00 UTC 2016
A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.
The Journal of experimental medicine
Liu WH,Kang SG,Huang Z,Wu CJ,Jin HY,Maine CJ,Liu Y,Shepherd J,Sabouri-Ghomi M,Gonzalez-Martin A,Xu S,Hoffmann A,Zheng Y,Lu LF,Xiao N,Fu G,Xiao C
Mon Aug 22 00:00:00 UTC 2016
Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.
The Journal of experimental medicine
Hatlen MA,Arora K,Vacic V,Grabowska EA,Liao W,Riley-Gillis B,Oschwald DM,Wang L,Joergens JE,Shih AH,Rapaport F,Gu S,Voza F,Asai T,Neel BG,Kharas MG,Gonen M,Levine RL,Nimer SD
Mon Jan 11 00:00:00 UTC 2016
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.
The Journal of experimental medicine
Bannard O,McGowan SJ,Ersching J,Ishido S,Victora GD,Shin JS,Cyster JG
Mon May 30 00:00:00 UTC 2016
Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
The Journal of experimental medicine
Tang D,Tao S,Chen Z,Koliesnik IO,Calmes PG,Hoerr V,Han B,Gebert N,Zörnig M,Löffler B,Morita Y,Rudolph KL
Mon Apr 04 00:00:00 UTC 2016
Targeting MTHFD2 in acute myeloid leukemia.
The Journal of experimental medicine
Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K
Mon Jun 27 00:00:00 UTC 2016
Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Woo JS,Srikanth S,Nishi M,Ping P,Takeshima H,Gwack Y
Tue Mar 08 00:00:00 UTC 2016
Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation.
Proceedings of the National Academy of Sciences of the United States of America
Kang JA,Park SH,Jeong SP,Han MH,Lee CR,Lee KM,Kim N,Song MR,Choi M,Ye M,Jung G,Lee WW,Eom SH,Park CS,Park SG
Tue Aug 02 00:00:00 UTC 2016
Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque.
Stem cells (Dayton, Ohio)
Leszczynska A,O'Doherty A,Farrell E,Pindjakova J,O'Brien FJ,O'Brien T,Barry F,Murphy M
Fri Apr 01 00:00:00 UTC 2016
AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.
Stem cells (Dayton, Ohio)
Singh S,Moirangthem RD,Vaidya A,Jalnapurkar S,Limaye L,Kale V
Thu Sep 01 00:00:00 UTC 2016
STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Verdan FF,Hufford MM,Dent AL,Kaplan MH
Fri Apr 15 00:00:00 UTC 2016
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Journal of immunology (Baltimore, Md. : 1950)
Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y
Sat Oct 15 00:00:00 UTC 2016
IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Goplen NP,Saxena V,Knudson KM,Schrum AG,Gil D,Daniels MA,Zamoyska R,Teixeiro E
Thu Sep 15 00:00:00 UTC 2016
Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.
Journal of immunology (Baltimore, Md. : 1950)
Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K
Sun May 01 00:00:00 UTC 2016
Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Speth JM,Bourdonnay E,Penke LR,Mancuso P,Moore BB,Weinberg JB,Peters-Golden M
Wed Jun 15 00:00:00 UTC 2016
Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Su P,Chen S,Zheng YH,Zhou HY,Yan CH,Yu F,Zhang YG,He L,Zhang Y,Wang Y,Wu L,Wu X,Yu B,Ma LY,Yang Z,Wang J,Zhao G,Zhu J,Wu ZY,Sun B
Mon Aug 15 00:00:00 UTC 2016
Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Matsumura K,Iwai H,Kato-Miyazawa M,Kirikae F,Zhao J,Yanagawa T,Ishii T,Miyoshi-Akiyama T,Funatogawa K,Kirikae T
Sat Oct 15 00:00:00 UTC 2016
The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH
Thu Sep 15 00:00:00 UTC 2016
TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.
Journal of immunology (Baltimore, Md. : 1950)
Kourepini E,Paschalidis N,Simoes DC,Aggelakopoulou M,Grogan JL,Panoutsakopoulou V
Sun May 01 00:00:00 UTC 2016
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Kaufmann U,Shaw PJ,Kozhaya L,Subramanian R,Gaida K,Unutmaz D,McBride HJ,Feske S
Fri Jan 15 00:00:00 UTC 2016
Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Radtke D,Lacher SM,Szumilas N,Sandrock L,Ackermann J,Nitschke L,Zinser E
Fri Apr 01 00:00:00 UTC 2016
Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jones LL,Alli R,Li B,Geiger TL
Fri Apr 01 00:00:00 UTC 2016
ERβ in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Panoutsakopoulou V
Wed Jun 15 00:00:00 UTC 2016
Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
Brucklacher-Waldert V,Ferreira C,Innocentin S,Kamdar S,Withers DR,Kullberg MC,Veldhoen M
Wed Jun 15 00:00:00 UTC 2016
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
Nature communications
White Y,Bagchi A,Van Ziffle J,Inguva A,Bollag G,Zhang C,Carias H,Dickens D,Loh M,Shannon K,Firestone AJ
Mon Feb 08 00:00:00 UTC 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
216-16 was used in In vitro experiments to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Thu Mar 03 00:00:00 UTC 2016
USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.
Stem cell reports
Higuchi M,Kawamura H,Matsuki H,Hara T,Takahashi M,Saito S,Saito K,Jiang S,Naito M,Kiyonari H,Fujii M
Tue Dec 13 00:00:00 UTC 2016
Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.
Nature communications
George J,Uyar A,Young K,Kuffler L,Waldron-Francis K,Marquez E,Ucar D,Trowbridge JJ
Mon Jul 11 00:00:00 UTC 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 UTC 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 UTC 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
216-16 was used in Cell Culture to identify EphrinB2 as an essential regulator of adult haematopoiesis but not generation of endothelial cells.
Thu Jun 02 00:00:00 UTC 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
216-16 was used in Cell Culture to identify EphrinB2 as an essential regulator of adult haematopoiesis but not generation of endothelial cells.
Thu Jun 02 00:00:00 UTC 2016
TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.
Scientific reports
Chen X,Nie Y,Xiao H,Bian Z,Scarzello AJ,Song NY,Trivett AL,Yang D,Oppenheim JJ
Wed Sep 07 00:00:00 UTC 2016
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Nature communications
Ding X,Ray Chaudhuri A,Callen E,Pang Y,Biswas K,Klarmann KD,Martin BK,Burkett S,Cleveland L,Stauffer S,Sullivan T,Dewan A,Marks H,Tubbs AT,Wong N,Buehler E,Akagi K,Martin SE,Keller JR,Nussenzweig A,Sharan SK
Mon Aug 08 00:00:00 UTC 2016
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood cancer journal
Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M
Fri Jan 08 00:00:00 UTC 2016
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
Nature communications
Gu Z,Churchman M,Roberts K,Li Y,Liu Y,Harvey RC,McCastlain K,Reshmi SC,Payne-Turner D,Iacobucci I,Shao Y,Chen IM,Valentine M,Pei D,Mungall KL,Mungall AJ,Ma Y,Moore R,Marra M,Stonerock E,Gastier-Foster JM,Devidas M,Dai Y,Wood B,Borowitz M,Larsen EE,Maloney K,Mattano LA,Angiolillo A,Salzer WL,Burke MJ,Gianni F,Spinelli O,Radich JP,Minden MD,Moorman AV,Patel B,Fielding AK,Rowe JM,Luger SM,Bhatia R,Aldoss I,Forman SJ,Kohlschmidt J,Mrózek K,Marcucci G,Bloomfield CD,Stock W,Kornblau S,Kantarjian HM,Konopleva M,Paietta E,Willman CL,Loh ML,Hunger SP,Mullighan CG
Tue Nov 08 00:00:00 UTC 2016
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Nature communications
Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C
Tue Aug 02 00:00:00 UTC 2016
Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research.
Methods in molecular biology (Clifton, N.J.)
Peng C,Li S
216-16 was used in Cell Culture to describe how we utilize this triple gene system to prove the function of Pten as a tumor suppressor in leukemogenesis.
Mon Dec 18 00:00:00 UTC 2017
Induction of Chronic Myeloid Leukemia in Mice.
Methods in molecular biology (Clifton, N.J.)
Zhang H,Li S
216-16 was used in In vitro experiments to describe methods for induction of CML in mice with BCR-ABL.
Fri Jan 26 00:00:00 UTC 2018
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Scientific reports
Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ
Mon May 23 00:00:00 UTC 2016
Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.
Scientific reports
Liu J,Copland DA,Theodoropoulou S,Chiu HA,Barba MD,Mak KW,Mack M,Nicholson LB,Dick AD
Fri Feb 05 00:00:00 UTC 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
Tue May 17 00:00:00 UTC 2016
Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock.
The Journal of biological chemistry
Luo MC,Zhou SY,Feng DY,Xiao J,Li WY,Xu CD,Wang HY,Zhou T
Fri Oct 14 00:00:00 UTC 2016
Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.
The Journal of biological chemistry
Pasi S,Kant R,Surolia A
Fri Jun 03 00:00:00 UTC 2016
Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model.
Cell death & disease
Liu Q,Chen L,Atkinson JM,Claxton DF,Wang HG
Thu Sep 08 00:00:00 UTC 2016
Bone-protective Functions of Netrin 1 Protein.
The Journal of biological chemistry
Maruyama K,Kawasaki T,Hamaguchi M,Hashimoto M,Furu M,Ito H,Fujii T,Takemura N,Karuppuchamy T,Kondo T,Kawasaki T,Fukasaka M,Misawa T,Saitoh T,Suzuki Y,Martino MM,Kumagai Y,Akira S
Fri Nov 11 00:00:00 UTC 2016
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Nature
Chen Z,Shojaee S,Buchner M,Geng H,Lee JW,Klemm L,Titz B,Graeber TG,Park E,Tan YX,Satterthwaite A,Paietta E,Hunger SP,Willman CL,Melnick A,Loh ML,Jung JU,Coligan JE,Bolland S,Mak TW,Limnander A,Jumaa H,Reth M,Weiss A,Lowell CA,Müschen M
Thu May 21 00:00:00 UTC 2015
Acute inflammation stimulates a regenerative response in the neonatal mouse heart.
Cell research
Han C,Nie Y,Lian H,Liu R,He F,Huang H,Hu S
Thu Oct 01 00:00:00 UTC 2015
Acute inflammation stimulates a regenerative response in the neonatal mouse heart.
Cell research
Han C,Nie Y,Lian H,Liu R,He F,Huang H,Hu S
Thu Oct 01 00:00:00 UTC 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
Tue Dec 15 00:00:00 UTC 2015
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
Immunity
Ichiyama K,Chen T,Wang X,Yan X,Kim BS,Tanaka S,Ndiaye-Lobry D,Deng Y,Zou Y,Zheng P,Tian Q,Aifantis I,Wei L,Dong C
Tue Apr 21 00:00:00 UTC 2015
T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.
Immunity
Cook KD,Shpargel KB,Starmer J,Whitfield-Larry F,Conley B,Allard DE,Rager JE,Fry RC,Davenport ML,Magnuson T,Whitmire JK,Su MA
Tue Oct 20 00:00:00 UTC 2015
IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Blood
Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS
Thu Feb 26 00:00:00 UTC 2015
MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.
Blood
Roychoudhury J,Clark JP,Gracia-Maldonado G,Unnisa Z,Wunderlich M,Link KA,Dasgupta N,Aronow B,Huang G,Mulloy JC,Kumar AR
Thu Apr 16 00:00:00 UTC 2015
Morgana acts as an oncosuppressor in chronic myeloid leukemia.
Blood
Di Savino A,Panuzzo C,Rocca S,Familiari U,Piazza R,Crivellaro S,Carrà G,Ferretti R,Fusella F,Giugliano E,Camporeale A,Franco I,Miniscalco B,Cutrin JC,Turco E,Silengo L,Hirsch E,Rege-Cambrin G,Gambacorti-Passerini C,Pandolfi PP,Papotti M,Saglio G,Tarone G,Morotti A,Brancaccio M
Thu Apr 02 00:00:00 UTC 2015
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Blood
Xiao N,Laha S,Das SP,Morlock K,Jesneck JL,Raffel GD
Thu Feb 05 00:00:00 UTC 2015
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN.
Blood
Grisouard J,Shimizu T,Duek A,Kubovcakova L,Hao-Shen H,Dirnhofer S,Skoda RC
Thu Mar 26 00:00:00 UTC 2015
Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.
Blood
Kosoff RE,Aslan JE,Kostyak JC,Dulaimi E,Chow HY,Prudnikova TY,Radu M,Kunapuli SP,McCarty OJ,Chernoff J
Thu May 07 00:00:00 UTC 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
Fri May 01 00:00:00 UTC 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 UTC 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 UTC 2015
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
The Journal of clinical investigation
Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML
Tue Sep 01 00:00:00 UTC 2015
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
The Journal of experimental medicine
Lim HW,Kang SG,Ryu JK,Schilling B,Fei M,Lee IS,Kehasse A,Shirakawa K,Yokoyama M,Schnölzer M,Kasler HG,Kwon HS,Gibson BW,Sato H,Akassoglou K,Xiao C,Littman DR,Ott M,Verdin E
Mon May 04 00:00:00 UTC 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
Mon Oct 19 00:00:00 UTC 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
Mon Oct 19 00:00:00 UTC 2015
The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
The Journal of experimental medicine
Barnes MJ,Li CM,Xu Y,An J,Huang Y,Cyster JG
Mon Jun 29 00:00:00 UTC 2015
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.
The Journal of experimental medicine
Bourdonnay E,Zasłona Z,Penke LR,Speth JM,Schneider DJ,Przybranowski S,Swanson JA,Mancuso P,Freeman CM,Curtis JL,Peters-Golden M
Mon May 04 00:00:00 UTC 2015
The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression.
Proceedings of the National Academy of Sciences of the United States of America
Choi J,Jeon S,Choi S,Park K,Seong RH
Tue Feb 17 00:00:00 UTC 2015
T-cell receptor α enhancer is inactivated in αβ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
del Blanco B,Angulo Ú,Krangel MS,Hernández-Munain C
Tue Apr 07 00:00:00 UTC 2015
Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America
Smith DJ,Liu S,Ji S,Li B,McLaughlin J,Cheng D,Witte ON,Yang L
Tue Feb 03 00:00:00 UTC 2015
NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.
European journal of immunology
Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S
Fri May 01 00:00:00 UTC 2015
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
European journal of immunology
Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC
Wed Apr 01 00:00:00 UTC 2015
MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells.
Oncogenesis
Wenge DV,Felipe-Fumero E,Angenendt L,Schliemann C,Schmidt E,Schmidt LH,Thiede C,Ehninger G,Berdel WE,Arteaga MF,Mikesch JH
Mon Dec 21 00:00:00 UTC 2015
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Stem cells (Dayton, Ohio)
Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW
Fri May 01 00:00:00 UTC 2015
Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cimen Bozkus C,Elzey BD,Crist SA,Ellies LG,Ratliff TL
Tue Dec 01 00:00:00 UTC 2015
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.
Journal of immunology (Baltimore, Md. : 1950)
Xiao Y,Qiao G,Tang J,Tang R,Guo H,Warwar S,Langdon WY,Tao L,Zhang J
Sun Nov 01 00:00:00 UTC 2015
IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals.
Journal of immunology (Baltimore, Md. : 1950)
Stoycheva D,Deiser K,Stärck L,Nishanth G,Schlüter D,Uckert W,Schüler T
Thu Jan 15 00:00:00 UTC 2015
The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.
Journal of immunology (Baltimore, Md. : 1950)
Viret C,Mahiddine K,Baker RL,Haskins K,Guerder S
Tue Sep 01 00:00:00 UTC 2015
IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Arbelaez CA,Glatigny S,Duhen R,Eberl G,Oukka M,Bettelli E
Tue Sep 01 00:00:00 UTC 2015
Foxo1 Is a T Cell-Intrinsic Inhibitor of the RORγt-Th17 Program.
Journal of immunology (Baltimore, Md. : 1950)
Lainé A,Martin B,Luka M,Mir L,Auffray C,Lucas B,Bismuth G,Charvet C
Sat Aug 15 00:00:00 UTC 2015
IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Heiseke AF,Jeuk BH,Markota A,Straub T,Lehr HA,Reindl W,Krug AB
Tue Dec 15 00:00:00 UTC 2015
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.
Journal of immunology (Baltimore, Md. : 1950)
Boland BS,Widjaja CE,Banno A,Zhang B,Kim SH,Stoven S,Peterson MR,Jones MC,Su HI,Crowe SE,Bui JD,Ho SB,Okugawa Y,Goel A,Marietta EV,Khosroheidari M,Jepsen K,Aramburu J,López-Rodríguez C,Sandborn WJ,Murray JA,Harismendy O,Chang JT
Sun Mar 15 00:00:00 UTC 2015
Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Reynolds AE,Kuraoka M,Kelsoe G
Thu Jan 01 00:00:00 UTC 2015
Transmembrane TNF-TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression.
Journal of immunology (Baltimore, Md. : 1950)
Miller PG,Bonn MB,McKarns SC
Tue Sep 15 00:00:00 UTC 2015
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.
Journal of immunology (Baltimore, Md. : 1950)
Ebel ME,Awe O,Kaplan MH,Kansas GS
Mon Jun 15 00:00:00 UTC 2015
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Bornancin F,Renner F,Touil R,Sic H,Kolb Y,Touil-Allaoui I,Rush JS,Smith PA,Bigaud M,Junker-Walker U,Burkhart C,Dawson J,Niwa S,Katopodis A,Nuesslein-Hildesheim B,Weckbecker G,Zenke G,Kinzel B,Traggiai E,Brenner D,Brüstle A,St Paul M,Zamurovic N,McCoy KD,Rolink A,Régnier CH,Mak TW,Ohashi PS,Patel DD,Calzascia T
Wed Apr 15 00:00:00 UTC 2015
IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses.
Journal of immunology (Baltimore, Md. : 1950)
Gorbacheva V,Fan R,Wang X,Baldwin WM,Fairchild RL,Valujskikh A
Sun Feb 01 00:00:00 UTC 2015
Activated pancreatic stellate cells can impair pancreatic islet function in mice.
Upsala journal of medical sciences
Zang G,Sandberg M,Carlsson PO,Welsh N,Jansson L,Barbu A
216-16 was used in Cell Culture to investigate the morphology and relationships of pancreatic stellate cells and islets in mice.
Tue May 03 00:00:00 UTC 2016
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.
Nature communications
Buchner M,Park E,Geng H,Klemm L,Flach J,Passegué E,Schjerven H,Melnick A,Paietta E,Kopanja D,Raychaudhuri P,Müschen M
Tue Mar 10 00:00:00 UTC 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 UTC 2015
The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development.
Scientific reports
Zheng H,Tan Z,Zhou T,Zhu F,Ding Y,Liu T,Wu Y,Xu W
Tue Dec 15 00:00:00 UTC 2015
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.
Nature communications
Haetscher N,Feuermann Y,Wingert S,Rehage M,Thalheimer FB,Weiser C,Bohnenberger H,Jung K,Schroeder T,Serve H,Oellerich T,Hennighausen L,Rieger MA
Wed Nov 25 00:00:00 UTC 2015
Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.
Nature communications
Balasubramani A,Larjo A,Bassein JA,Chang X,Hastie RB,Togher SM,Lähdesmäki H,Rao A
Mon Jun 22 00:00:00 UTC 2015
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.
Nature communications
Tsukamoto H,Senju S,Matsumura K,Swain SL,Nishimura Y
Tue Apr 07 00:00:00 UTC 2015
Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury.
Scientific reports
Lin W,Yuan N,Wang Z,Cao Y,Fang Y,Li X,Xu F,Song L,Wang J,Zhang H,Yan L,Xu L,Zhang X,Zhang S,Wang J
Tue Jul 21 00:00:00 UTC 2015
Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.
Nature communications
Regha K,Assi SA,Tsoulaki O,Gilmour J,Lacaud G,Bonifer C
Thu May 28 00:00:00 UTC 2015
Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.
Nature communications
Regha K,Assi SA,Tsoulaki O,Gilmour J,Lacaud G,Bonifer C
Thu May 28 00:00:00 UTC 2015
Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.
Molecular therapy. Methods & clinical development
Ungari S,Montepeloso A,Morena F,Cocchiarella F,Recchia A,Martino S,Gentner B,Naldini L,Biffi A
Wed Oct 28 00:00:00 UTC 2015
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
Scientific reports
Thakur R,Trivedi R,Rastogi N,Singh M,Mishra DP
Thu May 14 00:00:00 UTC 2015
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Nature communications
Cook PC,Owen H,Deaton AM,Borger JG,Brown SL,Clouaire T,Jones GR,Jones LH,Lundie RJ,Marley AK,Morrison VL,Phythian-Adams AT,Wachter E,Webb LM,Sutherland TE,Thomas GD,Grainger JR,Selfridge J,McKenzie AN,Allen JE,Fagerholm SC,Maizels RM,Ivens AC,Bird A,MacDonald AS
Fri Apr 24 00:00:00 UTC 2015
Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.
Nature communications
Yoon JH,Sudo K,Kuroda M,Kato M,Lee IK,Han JS,Nakae S,Imamura T,Kim J,Ju JH,Kim DK,Matsuzaki K,Weinstein M,Matsumoto I,Sumida T,Mamura M
Tue Jul 21 00:00:00 UTC 2015
Defective repair of uracil causes telomere defects in mouse hematopoietic cells.
The Journal of biological chemistry
Vallabhaneni H,Zhou F,Maul RW,Sarkar J,Yin J,Lei M,Harrington L,Gearhart PJ,Liu Y
Fri Feb 27 00:00:00 UTC 2015
Function of a Foxp3 cis-element in protecting regulatory T cell identity.
Cell
Li X,Liang Y,LeBlanc M,Benner C,Zheng Y
Thu Aug 14 00:00:00 UTC 2014
Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
Cell
Cunningham JT,Moreno MV,Lodi A,Ronen SM,Ruggero D
Thu May 22 00:00:00 UTC 2014
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
Thu Oct 16 00:00:00 UTC 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
216-16 was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.
Thu May 01 00:00:00 UTC 2014
Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.
Blood
Komeno Y,Yan M,Matsuura S,Lam K,Lo MC,Huang YJ,Tenen DG,Downing JR,Zhang DE
Thu Jun 12 00:00:00 UTC 2014
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
Blood
Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J
Thu Nov 13 00:00:00 UTC 2014
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Blood
Lu EP,McLellan M,Ding L,Fulton R,Mardis ER,Wilson RK,Miller CA,Westervelt P,DiPersio JF,Link DC,Walter MJ,Ley TJ,Graubert TA
Thu Dec 18 00:00:00 UTC 2014
Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.
Blood
Pawlikowska P,Fouchet P,Vainchenker W,Rosselli F,Naim V
Thu Dec 04 00:00:00 UTC 2014
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
Blood
de Laval B,Pawlikowska P,Barbieri D,Besnard-Guerin C,Cico A,Kumar R,Gaudry M,Baud V,Porteu F
Thu Jan 23 00:00:00 UTC 2014
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.
The Journal of clinical investigation
Herrmann A,Priceman SJ,Swiderski P,Kujawski M,Xin H,Cherryholmes GA,Zhang W,Zhang C,Lahtz C,Kowolik C,Forman SJ,Kortylewski M,Yu H
Tue Jul 01 00:00:00 UTC 2014
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
The Journal of clinical investigation
Choi SH,Kim BG,Robinson J,Fink S,Yan M,Sporn MB,Markowitz SD,Letterio JJ
Sun Jun 01 00:00:00 UTC 2014
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.
The Journal of clinical investigation
Jones M,Osawa G,Regal JA,Weinberg DN,Taggart J,Kocak H,Friedman A,Ferguson DO,Keegan CE,Maillard I
Wed Jan 01 00:00:00 UTC 2014
Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.
The Journal of clinical investigation
Wegiel B,Larsen R,Gallo D,Chin BY,Harris C,Mannam P,Kaczmarek E,Lee PJ,Zuckerbraun BS,Flavell R,Soares MP,Otterbein LE
Sat Nov 01 00:00:00 UTC 2014
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
The Journal of clinical investigation
Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP
Tue Apr 01 00:00:00 UTC 2014
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
The Journal of experimental medicine
Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E
Mon Aug 25 00:00:00 UTC 2014
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.
The Journal of experimental medicine
Shin JY,Hu W,Naramura M,Park CY
Mon Feb 10 00:00:00 UTC 2014
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
The Journal of experimental medicine
Tanaka S,Suto A,Iwamoto T,Kashiwakuma D,Kagami S,Suzuki K,Takatori H,Tamachi T,Hirose K,Onodera A,Suzuki J,Ohara O,Yamashita M,Nakayama T,Nakajima H
Mon Aug 25 00:00:00 UTC 2014
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.
The Journal of experimental medicine
Gomez-Rodriguez J,Wohlfert EA,Handon R,Meylan F,Wu JZ,Anderson SM,Kirby MR,Belkaid Y,Schwartzberg PL
Mon Mar 10 00:00:00 UTC 2014
CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.
The Journal of experimental medicine
Cortez VS,Cervantes-Barragan L,Song C,Gilfillan S,McDonald KG,Tussiwand R,Edelson BT,Murakami Y,Murphy KM,Newberry RD,Sibley LD,Colonna M
Mon Apr 07 00:00:00 UTC 2014
Initiation of MLL-rearranged AML is dependent on C/EBPα.
The Journal of experimental medicine
Ohlsson E,Hasemann MS,Willer A,Lauridsen FK,Rapin N,Jendholm J,Porse BT
Mon Jan 13 00:00:00 UTC 2014
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
The Journal of experimental medicine
Beck TC,Gomes AC,Cyster JG,Pereira JP
Mon Dec 15 00:00:00 UTC 2014
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
EMBO molecular medicine
Bilbao D,Luciani L,Johannesson B,Piszczek A,Rosenthal N
Sat Nov 01 00:00:00 UTC 2014
Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.
Proceedings of the National Academy of Sciences of the United States of America
Watanabe Y,Onodera A,Kanai U,Ichikawa T,Obata-Ninomiya K,Wada T,Kiuchi M,Iwamura C,Tumes DJ,Shinoda K,Yagi R,Motohashi S,Hirahara K,Nakayama T
Tue Sep 02 00:00:00 UTC 2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M
Tue Dec 30 00:00:00 UTC 2014
Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.
Proceedings of the National Academy of Sciences of the United States of America
Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS
Tue Jul 29 00:00:00 UTC 2014
Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.
Proceedings of the National Academy of Sciences of the United States of America
Shi J,Kundrat L,Pishesha N,Bilate A,Theile C,Maruyama T,Dougan SK,Ploegh HL,Lodish HF
Tue Jul 15 00:00:00 UTC 2014
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
Proceedings of the National Academy of Sciences of the United States of America
Kaiser WJ,Daley-Bauer LP,Thapa RJ,Mandal P,Berger SB,Huang C,Sundararajan A,Guo H,Roback L,Speck SH,Bertin J,Gough PJ,Balachandran S,Mocarski ES
Tue May 27 00:00:00 UTC 2014
Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.
Blood cancer journal
Sprissler C,Belenki D,Maurer H,Aumann K,Pfeifer D,Klein C,Müller TA,Kissel S,Hülsdünker J,Alexandrovski J,Brummer T,Jumaa H,Duyster J,Dierks C
Fri Aug 22 00:00:00 UTC 2014
Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.
Blood cancer journal
Nakaya Y,Shide K,Naito H,Niwa T,Horio T,Miyake J,Shimoda K
Fri Jan 10 00:00:00 UTC 2014
Autocrine interleukin-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels.
Stem cells (Dayton, Ohio)
Ke F,Zhang L,Liu Z,Liu J,Yan S,Xu Z,Bai J,Zhu H,Lou F,Wang H,Shi Y,Jiang Y,Su B,Wang H
Wed Oct 01 00:00:00 UTC 2014
Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.
Stem cells (Dayton, Ohio)
Glenn JD,Smith MD,Calabresi PA,Whartenby KA
Wed Oct 01 00:00:00 UTC 2014
Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development.
Stem cells (Dayton, Ohio)
Dong CY,Liu XY,Wang N,Wang LN,Yang BX,Ren Q,Liang HY,Ma XT
Mon Dec 01 00:00:00 UTC 2014
Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ikeda S,Saijo S,Murayama MA,Shimizu K,Akitsu A,Iwakura Y
Sat Feb 15 00:00:00 UTC 2014
Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kim KD,Srikanth S,Tan YV,Yee MK,Jew M,Damoiseaux R,Jung ME,Shimizu S,An DS,Ribalet B,Waschek JA,Gwack Y
Wed Jan 01 00:00:00 UTC 2014
Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance.
Journal of immunology (Baltimore, Md. : 1950)
Fisher Y,Strominger I,Biton S,Nemirovsky A,Baron R,Monsonego A
Wed Jan 01 00:00:00 UTC 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
Tue Apr 01 00:00:00 UTC 2014
CCAAT/enhancer-binding protein α negatively regulates IFN-γ expression in T cells.
Journal of immunology (Baltimore, Md. : 1950)
Tanaka S,Tanaka K,Magnusson F,Chung Y,Martinez GJ,Wang YH,Nurieva RI,Kurosaki T,Dong C
Mon Dec 15 00:00:00 UTC 2014
The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Hou Y,Lin H,Zhu L,Liu Z,Hu F,Shi J,Yang T,Shi X,Guo H,Tan X,Zhang L,Wang Q,Li Z,Zhao Y
Tue Jul 01 00:00:00 UTC 2014
Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.
Journal of immunology (Baltimore, Md. : 1950)
Stärck L,Popp K,Pircher H,Uckert W
Wed Jan 01 00:00:00 UTC 2014
MicroRNA-155 and MicroRNA-21 promote the expansion of functional myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Li L,Zhang J,Diao W,Wang D,Wei Y,Zhang CY,Zen K
Sat Feb 01 00:00:00 UTC 2014
Th17 cells demonstrate stable cytokine production in a proallergic environment.
Journal of immunology (Baltimore, Md. : 1950)
Glosson-Byers NL,Sehra S,Stritesky GL,Yu Q,Awe O,Pham D,Bruns HA,Kaplan MH
Mon Sep 15 00:00:00 UTC 2014
Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Pawaria S,Ramani K,Maers K,Liu Y,Kane LP,Levesque MC,Biswas PS
Wed Oct 01 00:00:00 UTC 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
Wed Jan 01 00:00:00 UTC 2014
SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions.
Journal of immunology (Baltimore, Md. : 1950)
Chu C,Wang Y,Zhang X,Ni X,Cao J,Xu W,Dong Z,Yuan P,Wei W,Ma Y,Zhang L,Wu L,Qi H
Wed Oct 15 00:00:00 UTC 2014
Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.
Human molecular genetics
Accornero F,Kanisicak O,Tjondrokoesoemo A,Attia AC,McNally EM,Molkentin JD
216-16 was used in Cell Culture to segregate the cell types in diseased muscle that underlie transforming growth factor (TGFβ)-dependent pathology, as the central effector of muscular dystrophy (MD) and fibrotic disease.
Sat Dec 20 00:00:00 UTC 2014
Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation.
The Journal of biological chemistry
Roy A,Ganesh G,Sippola H,Bolin S,Sawesi O,Dagälv A,Schlenner SM,Feyerabend T,Rodewald HR,Kjellén L,Hellman L,Åbrink M
Fri Jan 03 00:00:00 UTC 2014
Meprin metalloproteases inactivate interleukin 6.
The Journal of biological chemistry
Keiffer TR,Bond JS
Fri Mar 14 00:00:00 UTC 2014
Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
The Journal of biological chemistry
Lopez M,Meier D,Müller A,Franken P,Fujita J,Fontana A
Fri Jan 31 00:00:00 UTC 2014
Reporter gene technologies for imaging cell fates in hematopoiesis.
Methods in molecular biology (Clifton, N.J.)
Kusy S,Contag CH
216-16 was used in Cell Culture to provide adequate background information to allow the design and implementation of an experimental system for in vivo imaging in mice.
Thu Sep 11 00:00:00 UTC 2014
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
Nature communications
Piunti A,Rossi A,Cerutti A,Albert M,Jammula S,Scelfo A,Cedrone L,Fragola G,Olsson L,Koseki H,Testa G,Casola S,Helin K,d'Adda di Fagagna F,Pasini D
Mon Apr 14 00:00:00 UTC 2014
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.
Cell death & disease
Lu H,Fang EF,Sykora P,Kulikowicz T,Zhang Y,Becker KG,Croteau DL,Bohr VA
Thu May 15 00:00:00 UTC 2014
miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.
Immunity
Sonda N,Simonato F,Peranzoni E,Calì B,Bortoluzzi S,Bisognin A,Wang E,Marincola FM,Naldini L,Gentner B,Trautwein C,Sackett SD,Zanovello P,Molon B,Bronte V
Thu Jun 27 00:00:00 UTC 2013
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
Cancer cell
Arteaga MF,Mikesch JH,Qiu J,Christensen J,Helin K,Kogan SC,Dong S,So CW
Mon Mar 18 00:00:00 UTC 2013
DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding.
Blood
Schoofs T,Rohde C,Hebestreit K,Klein HU,Göllner S,Schulze I,Lerdrup M,Dietrich N,Agrawal-Singh S,Witten A,Stoll M,Lengfelder E,Hofmann WK,Schlenke P,Büchner T,Hansen K,Berdel WE,Rosenbauer F,Dugas M,Müller-Tidow C
Thu Jan 03 00:00:00 UTC 2013
A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
Blood
Conway AE,Scotland PB,Lavau CP,Wechsler DS
Thu Jun 06 00:00:00 UTC 2013
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Blood
Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM
Thu Jun 13 00:00:00 UTC 2013
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Blood
May RM,Okumura M,Hsu CJ,Bassiri H,Yang E,Rak G,Mace EM,Philip NH,Zhang W,Baumgart T,Orange JS,Nichols KE,Kambayashi T
Thu Apr 18 00:00:00 UTC 2013
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
Blood
Santoro F,Botrugno OA,Dal Zuffo R,Pallavicini I,Matthews GM,Cluse L,Barozzi I,Senese S,Fornasari L,Moretti S,Altucci L,Pelicci PG,Chiocca S,Johnstone RW,Minucci S
Thu Apr 25 00:00:00 UTC 2013
Interferon-γ impairs proliferation of hematopoietic stem cells in mice.
Blood
de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA
Thu May 02 00:00:00 UTC 2013
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
The Journal of clinical investigation
Huber M,Heink S,Pagenstecher A,Reinhard K,Ritter J,Visekruna A,Guralnik A,Bollig N,Jeltsch K,Heinemann C,Wittmann E,Buch T,Prazeres da Costa O,Brüstle A,Brenner D,Mak TW,Mittrücker HW,Tackenberg B,Kamradt T,Lohoff M
Tue Jan 01 00:00:00 UTC 2013
GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.
The Journal of clinical investigation
Ye P,Chen W,Wu J,Huang X,Li J,Wang S,Liu Z,Wang G,Yang X,Zhang P,Lv Q,Xia J
Wed May 01 00:00:00 UTC 2013
Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
The Journal of clinical investigation
Martin H,Mali RS,Ma P,Chatterjee A,Ramdas B,Sims E,Munugalavadla V,Ghosh J,Mattingly RR,Visconte V,Tiu RV,Vlaar CP,Dharmawardhane S,Kapur R
Tue Oct 01 00:00:00 UTC 2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
The Journal of experimental medicine
Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I
Mon Feb 11 00:00:00 UTC 2013
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.
The Journal of experimental medicine
Liu X,Li H,Zhong B,Blonska M,Gorjestani S,Yan M,Tian Q,Zhang DE,Lin X,Dong C
Mon Jul 29 00:00:00 UTC 2013
TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.
The Journal of experimental medicine
Yi Z,Stunz LL,Bishop GA
Mon Jun 03 00:00:00 UTC 2013
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling.
Proceedings of the National Academy of Sciences of the United States of America
Jin HS,Liao L,Park Y,Liu YC
Tue Jan 08 00:00:00 UTC 2013
CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Arndt K,Grinenko T,Mende N,Reichert D,Portz M,Ripich T,Carmeliet P,Corbeil D,Waskow C
Tue Apr 02 00:00:00 UTC 2013
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH
Tue Feb 05 00:00:00 UTC 2013
Lymphocyte-derived ACh regulates local innate but not adaptive immunity.
Proceedings of the National Academy of Sciences of the United States of America
Reardon C,Duncan GS,Brüstle A,Brenner D,Tusche MW,Olofsson PS,Rosas-Ballina M,Tracey KJ,Mak TW
Tue Jan 22 00:00:00 UTC 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
Wed Mar 06 00:00:00 UTC 2013
Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.
Oncogenesis
Ng KP,Hu Z,Ebrahem Q,Negrotto S,Lausen J,Saunthararajah Y
Mon Nov 04 00:00:00 UTC 2013
Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.
Stem cells (Dayton, Ohio)
Porter RL,Georger MA,Bromberg O,McGrath KE,Frisch BJ,Becker MW,Calvi LM
Fri Feb 01 00:00:00 UTC 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
Mon Apr 15 00:00:00 UTC 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 UTC 2013
Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Edwards JP,Fujii H,Zhou AX,Creemers J,Unutmaz D,Shevach EM
Sat Jun 01 00:00:00 UTC 2013
IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation.
Journal of immunology (Baltimore, Md. : 1950)
Yan B,Wei JJ,Yuan Y,Sun R,Li D,Luo J,Liao SJ,Zhou YH,Shu Y,Wang Q,Zhang GM,Feng ZH
Sat Jun 01 00:00:00 UTC 2013
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH
Mon Jul 15 00:00:00 UTC 2013
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
Journal of immunology (Baltimore, Md. : 1950)
Beurel E,Kaidanovich-Beilin O,Yeh WI,Song L,Palomo V,Michalek SM,Woodgett JR,Harrington LE,Eldar-Finkelman H,Martinez A,Jope RS
Wed May 15 00:00:00 UTC 2013
TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice.
Journal of immunology (Baltimore, Md. : 1950)
Heidegger S,Kirchner SK,Stephan N,Bohn B,Suhartha N,Hotz C,Anz D,Sandholzer N,Stecher B,Rüssmann H,Endres S,Bourquin C
Wed May 15 00:00:00 UTC 2013
Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Bassity E,Flies A,Strutt TM,Garcia-Hernandez Mde L,McKinstry KK,Zou T,Swain SL,Dutton RW
Tue Jan 01 00:00:00 UTC 2013
Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.
Journal of immunology (Baltimore, Md. : 1950)
Rolla S,Ingoglia G,Bardina V,Silengo L,Altruda F,Novelli F,Tolosano E
Sun Dec 01 00:00:00 UTC 2013
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Journal of immunology (Baltimore, Md. : 1950)
Wu SY,Yu JS,Liu FT,Miaw SC,Wu-Hsieh BA
Mon Apr 01 00:00:00 UTC 2013
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ
Fri Feb 01 00:00:00 UTC 2013
Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T
Mon Jul 15 00:00:00 UTC 2013
Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet.
Journal of immunology (Baltimore, Md. : 1950)
Duhen R,Glatigny S,Arbelaez CA,Blair TC,Oukka M,Bettelli E
Wed May 01 00:00:00 UTC 2013
Tumor-derived vascular pericytes anergize Th cells.
Journal of immunology (Baltimore, Md. : 1950)
Bose A,Barik S,Banerjee S,Ghosh T,Mallick A,Bhattacharyya Majumdar S,Goswami KK,Bhuniya A,Banerjee S,Baral R,Storkus WJ,Dasgupta PS,Majumdar S
Mon Jul 15 00:00:00 UTC 2013
CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Luo Y,Tremblay A,Zhang X,Dharma S,Mishra A,Liu Y
Tue Jan 01 00:00:00 UTC 2013
Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.
Journal of immunology (Baltimore, Md. : 1950)
Takeuchi H,Yokota-Nakatsuma A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M
Tue Oct 01 00:00:00 UTC 2013
Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kawashima H,Takatori H,Suzuki K,Iwata A,Yokota M,Suto A,Minamino T,Hirose K,Nakajima H
Tue Oct 01 00:00:00 UTC 2013
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Paster W,Brockmeyer C,Fu G,Simister PC,de Wet B,Martinez-Riaño A,Hoerter JA,Feller SM,Wülfing C,Gascoigne NR,Acuto O
Mon Apr 01 00:00:00 UTC 2013
Adhesion to substrates induces dendritic cell endothelization and decreases immunological response.
Immunobiology
Osterbur J,Sprague L,Muccioli M,Pate M,Mansfield K,McGinty J,Li Y,Li Y,Shirure V,Courreges MC,Benencia F
216-16 was used in Sample Preparation (ELISA) to investigate the effects of different soluble factors, substrates and culture surfaces on the phenotype and function of dendritic cells.
Tue Jan 01 00:00:00 UTC 2013
Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling.
PloS one
Raveney BJ,Oki S,Yamamura T
Tue Sep 10 00:00:00 UTC 2013
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.
The Journal of biological chemistry
Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH
Fri Sep 20 00:00:00 UTC 2013
IL-6 and epinephrine have divergent fiber type effects on intramuscular lipolysis.
Journal of applied physiology (Bethesda, Md. : 1985)
Macdonald TL,Wan Z,Frendo-Cumbo S,Dyck DJ,Wright DC
216-16 was used in In vitro experiments to determine whether IL-6 stimulates skeletal muscle lipolysis in a fibre type dependent manner and is required for epinephrine-stimulated lipolysis in murine skeletal muscle.
Fri Nov 01 00:00:00 UTC 2013
Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration.
The Journal of biological chemistry
Zhang C,Li Y,Wu Y,Wang L,Wang X,Du J
Fri Jan 18 00:00:00 UTC 2013
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Cell
Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA
Fri Jun 08 00:00:00 UTC 2012
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
Immunity
Gulen MF,Bulek K,Xiao H,Yu M,Gao J,Sun L,Beurel E,Kaidanovich-Beilin O,Fox PL,DiCorleto PE,Wang JA,Qin J,Wald DN,Woodgett JR,Jope RS,Carman J,Dongre A,Li X
Fri Nov 16 00:00:00 UTC 2012
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Cancer cell
Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,Ma J,Radtke I,Ding L,Cazzaniga G,Biondi A,Kornblau SM,Ravandi F,Kantarjian H,Nimer SD,Döhner K,Döhner H,Ley TJ,Ballerini P,Shurtleff S,Tomizawa D,Adachi S,Hayashi Y,Tawa A,Shih LY,Liang DC,Rubnitz JE,Pui CH,Mardis ER,Wilson RK,Downing JR
Tue Nov 13 00:00:00 UTC 2012
TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.
Blood
Spranger S,Jeremias I,Wilde S,Leisegang M,Stärck L,Mosetter B,Uckert W,Heemskerk MH,Schendel DJ,Frankenberger B
Thu Apr 12 00:00:00 UTC 2012
Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.
Blood
Cai M,Langer EM,Gill JG,Satpathy AT,Albring JC,KC W,Murphy TL,Murphy KM
Thu Jul 12 00:00:00 UTC 2012
Critical role of P1-Runx1 in mouse basophil development.
Blood
Mukai K,BenBarak MJ,Tachibana M,Nishida K,Karasuyama H,Taniuchi I,Galli SJ
Thu Jul 05 00:00:00 UTC 2012
Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.
Blood
Asai T,Liu Y,Di Giandomenico S,Bae N,Ndiaye-Lobry D,Deblasio A,Menendez S,Antipin Y,Reva B,Wevrick R,Nimer SD
Thu Aug 23 00:00:00 UTC 2012
Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood
Ottina E,Grespi F,Tischner D,Soratroi C,Geley S,Ploner A,Reichardt HM,Villunger A,Herold MJ
Thu Jun 21 00:00:00 UTC 2012
Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.
Blood
Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D
Thu Nov 01 00:00:00 UTC 2012
Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.
Blood
Guo H,Ma O,Speck NA,Friedman AD
Thu May 10 00:00:00 UTC 2012
KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.
Blood
Zhao L,Melenhorst JJ,Alemu L,Kirby M,Anderson S,Kench M,Hoogstraten-Miller S,Brinster L,Kamikubo Y,Gilliland DG,Liu PP
Thu Feb 09 00:00:00 UTC 2012
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.
Blood
Lin DC,Yin T,Koren-Michowitz M,Ding LW,Gueller S,Gery S,Tabayashi T,Bergholz U,Kazi JU,Rönnstrand L,Stocking C,Koeffler HP
Thu Oct 18 00:00:00 UTC 2012
Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity.
Blood
Lu H,Zhu S,Qian L,Xiang D,Zhang W,Nie A,Gao J,Wu M,Gao J,Lu B,Yu Y,Han W,Moldenhauer A
Thu May 24 00:00:00 UTC 2012
The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.
Blood
Fares J,Koller R,Humeniuk R,Wolff L,Bies J
Thu May 24 00:00:00 UTC 2012
SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.
Blood
Reddy PN,Sargin B,Choudhary C,Stein S,Grez M,Müller-Tidow C,Berdel WE,Serve H,Brandts CH
Thu Aug 23 00:00:00 UTC 2012
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis.
Blood
Yuan H,Wang Z,Li L,Zhang H,Modi H,Horne D,Bhatia R,Chen W
Thu Feb 23 00:00:00 UTC 2012
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.
Blood
Greenblatt S,Li L,Slape C,Nguyen B,Novak R,Duffield A,Huso D,Desiderio S,Borowitz MJ,Aplan P,Small D
Thu Mar 22 00:00:00 UTC 2012
EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.
Blood
Peslak SA,Wenger J,Bemis JC,Kingsley PD,Koniski AD,McGrath KE,Palis J
Thu Sep 20 00:00:00 UTC 2012
SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.
Cellular & molecular immunology
Zhang X,Han S,Kang Y,Guo M,Hong S,Liu F,Fu S,Wang L,Wang QX
Sat Sep 01 00:00:00 UTC 2012
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.
The Journal of clinical investigation
Jiang J,Balcerek J,Rozenova K,Cheng Y,Bersenev A,Wu C,Song Y,Tong W
Fri Jun 01 00:00:00 UTC 2012
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.
The Journal of clinical investigation
Schoppy DW,Ragland RL,Gilad O,Shastri N,Peters AA,Murga M,Fernandez-Capetillo O,Diehl JA,Brown EJ
Sun Jan 01 00:00:00 UTC 2012
Oxidative stress fuels Trypanosoma cruzi infection in mice.
The Journal of clinical investigation
Paiva CN,Feijó DF,Dutra FF,Carneiro VC,Freitas GB,Alves LS,Mesquita J,Fortes GB,Figueiredo RT,Souza HS,Fantappié MR,Lannes-Vieira J,Bozza MT
Sun Jul 01 00:00:00 UTC 2012
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
The Journal of clinical investigation
Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL
Sun Jan 01 00:00:00 UTC 2012
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
The Journal of clinical investigation
Brüstle A,Brenner D,Knobbe CB,Lang PA,Virtanen C,Hershenfield BM,Reardon C,Lacher SM,Ruland J,Ohashi PS,Mak TW
Sat Dec 01 00:00:00 UTC 2012
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
The Journal of experimental medicine
Block H,Herter JM,Rossaint J,Stadtmann A,Kliche S,Lowell CA,Zarbock A
Mon Feb 13 00:00:00 UTC 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
Mon Jan 16 00:00:00 UTC 2012
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
The Journal of experimental medicine
Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ
Mon Oct 22 00:00:00 UTC 2012
p85β phosphoinositide 3-kinase subunit regulates tumor progression.
Proceedings of the National Academy of Sciences of the United States of America
Cortés I,Sánchez-Ruíz J,Zuluaga S,Calvanese V,Marqués M,Hernández C,Rivera T,Kremer L,González-García A,Carrera AC
Tue Jul 10 00:00:00 UTC 2012
Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response.
Proceedings of the National Academy of Sciences of the United States of America
Perona-Wright G,Kohlmeier JE,Bassity E,Freitas TC,Mohrs K,Cookenham T,Situ H,Pearce EJ,Woodland DL,Mohrs M
Tue Nov 06 00:00:00 UTC 2012
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
Proceedings of the National Academy of Sciences of the United States of America
Cunningham L,Finckbeiner S,Hyde RK,Southall N,Marugan J,Yedavalli VR,Dehdashti SJ,Reinhold WC,Alemu L,Zhao L,Yeh JR,Sood R,Pommier Y,Austin CP,Jeang KT,Zheng W,Liu P
Tue Sep 04 00:00:00 UTC 2012
2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.
Proceedings of the National Academy of Sciences of the United States of America
Duncan GS,Brenner D,Tusche MW,Brüstle A,Knobbe CB,Elia AJ,Mock T,Bray MR,Krammer PH,Mak TW
Tue Dec 18 00:00:00 UTC 2012
MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination.
Proceedings of the National Academy of Sciences of the United States of America
Mycko MP,Cichalewska M,Machlanska A,Cwiklinska H,Mariasiewicz M,Selmaj KW
Tue May 15 00:00:00 UTC 2012
CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Poppensieker K,Otte DM,Schürmann B,Limmer A,Dresing P,Drews E,Schumak B,Klotz L,Raasch J,Mildner A,Waisman A,Scheu S,Knolle P,Förster I,Prinz M,Maier W,Zimmer A,Alferink J
Tue Mar 06 00:00:00 UTC 2012
Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model.
Arthritis research & therapy
Hashizume M,Yoshida H,Tanaka K,Suzuki M,Matsumoto I,Sumida T,Mihara M
Mon Apr 30 00:00:00 UTC 2012
Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Ha B,Zen K,Liu Y
Sun Jan 15 00:00:00 UTC 2012
Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Poovassery JS,Bishop GA
Wed Aug 15 00:00:00 UTC 2012
Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
Journal of immunology (Baltimore, Md. : 1950)
Cedeno-Laurent F,Opperman M,Barthel SR,Kuchroo VK,Dimitroff CJ
Sun Apr 01 00:00:00 UTC 2012
Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Singh NJ,Matzinger P
Fri Jun 15 00:00:00 UTC 2012
The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Ramon HE,Beal AM,Liu Y,Worthen GS,Oliver PM
Sun Apr 15 00:00:00 UTC 2012
Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.
Journal of immunology (Baltimore, Md. : 1950)
Kwon MJ,Ma J,Ding Y,Wang R,Sun Z
Fri Jun 15 00:00:00 UTC 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 UTC 2012
Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950)
Zhi L,Ustyugova IV,Chen X,Zhang Q,Wu MX
Wed Aug 15 00:00:00 UTC 2012
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Vincentz JW,Firulli AB,Kaplan MH
Sun Jul 15 00:00:00 UTC 2012
IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Newcomb DC,Boswell MG,Huckabee MM,Goleniewska K,Dulek DE,Reiss S,Lukacs NW,Kolls JK,Peebles RS
Wed Feb 01 00:00:00 UTC 2012
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
Shen S,Manser T
Sun Jan 01 00:00:00 UTC 2012
Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.
Journal of immunology (Baltimore, Md. : 1950)
Panzer M,Sitte S,Wirth S,Drexler I,Sparwasser T,Voehringer D
Sun Jan 15 00:00:00 UTC 2012
Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ueda A,Zhou L,Stein PL
Fri Jun 01 00:00:00 UTC 2012
Mouse CD11b+Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Yi H,Guo C,Yu X,Zuo D,Wang XY
Thu Nov 01 00:00:00 UTC 2012
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Eberle ME,Dalpke AH
Fri Jun 01 00:00:00 UTC 2012
NLRP3 inflammasome activity is negatively controlled by miR-223.
Journal of immunology (Baltimore, Md. : 1950)
Bauernfeind F,Rieger A,Schildberg FA,Knolle PA,Schmid-Burgk JL,Hornung V
Mon Oct 15 00:00:00 UTC 2012
Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.
Journal of immunology (Baltimore, Md. : 1950)
Perry DJ,Yin Y,Telarico T,Baker HV,Dozmorov I,Perl A,Morel L
Sun Jul 15 00:00:00 UTC 2012
IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Sun K,Hsiao HH,Li M,Ames E,Bouchlaka M,Welniak LA,Hagino T,Jagdeo J,Pai CC,Chen M,Blazar BR,Abedi M,Murphy WJ
Wed Aug 15 00:00:00 UTC 2012
Induction of histiocytic sarcoma in mouse skeletal muscle.
PloS one
Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ
Thu Feb 07 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Severe Developmental B Lymphopoietic Defects in Foxp3-Deficient Mice are Refractory to Adoptive Regulatory T Cell Therapy.
Frontiers in immunology
Riewaldt J,Düber S,Boernert M,Krey M,Dembinski M,Weiss S,Garbe AI,Kretschmer K
Thu Aug 23 00:00:00 UTC 2012
Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart.
The Journal of biological chemistry
Mir SA,Chatterjee A,Mitra A,Pathak K,Mahata SK,Sarkar S
Fri Jan 20 00:00:00 UTC 2012
MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.
PloS one
Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH
Thu Mar 28 00:00:00 UTC 2013
p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.
The Journal of biological chemistry
Hu P,Nebreda AR,Liu Y,Carlesso N,Kaplan M,Kapur R
Fri Sep 28 00:00:00 UTC 2012
Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.
PloS one
Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL
Thu Sep 27 00:00:00 UTC 2012
Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.
PloS one
Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL
Thu Sep 27 00:00:00 UTC 2012
The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.
PloS one
Yamada T,Park CS,Burns A,Nakada D,Lacorazza HD
Mon Oct 22 00:00:00 UTC 2012
Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells.
The Journal of biological chemistry
Hubackova S,Krejcikova K,Bartek J,Hodny Z
Fri Aug 03 00:00:00 UTC 2012
Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1.
PloS one
Arcipowski KM,Bishop GA
Mon Jan 14 00:00:00 UTC 2013
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity.
Nature
Sander LE,Davis MJ,Boekschoten MV,Amsen D,Dascher CC,Ryffel B,Swanson JA,Müller M,Blander JM
Sun May 22 00:00:00 UTC 2011
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Cell
Dang EV,Barbi J,Yang HY,Jinasena D,Yu H,Zheng Y,Bordman Z,Fu J,Kim Y,Yen HR,Luo W,Zeller K,Shimoda L,Topalian SL,Semenza GL,Dang CV,Pardoll DM,Pan F
Fri Sep 02 00:00:00 UTC 2011
The transcription factor STAT3 is required for T helper 2 cell development.
Immunity
Stritesky GL,Muthukrishnan R,Sehra S,Goswami R,Pham D,Travers J,Nguyen ET,Levy DE,Kaplan MH
Fri Jan 28 00:00:00 UTC 2011
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.
Immunity
Lu KT,Kanno Y,Cannons JL,Handon R,Bible P,Elkahloun AG,Anderson SM,Wei L,Sun H,O'Shea JJ,Schwartzberg PL
Fri Oct 28 00:00:00 UTC 2011
Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.
Immunity
Chang SH,Reynolds JM,Pappu BP,Chen G,Martinez GJ,Dong C
Fri Oct 28 00:00:00 UTC 2011
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Cancer cell
Bard-Chapeau EA,Li S,Ding J,Zhang SS,Zhu HH,Princen F,Fang DD,Han T,Bailly-Maitre B,Poli V,Varki NM,Wang H,Feng GS
Tue May 17 00:00:00 UTC 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 UTC 2011
IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development.
Cancer cell
Reynaud D,Pietras E,Barry-Holson K,Mir A,Binnewies M,Jeanne M,Sala-Torra O,Radich JP,Passegué E
Tue Nov 15 00:00:00 UTC 2011
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.
Blood
Nguyen AT,Taranova O,He J,Zhang Y
Thu Jun 23 00:00:00 UTC 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 UTC 2011
Macrophage development from HSCs requires PU.1-coordinated microRNA expression.
Blood
Ghani S,Riemke P,Schönheit J,Lenze D,Stumm J,Hoogenkamp M,Lagendijk A,Heinz S,Bonifer C,Bakkers J,Abdelilah-Seyfried S,Hummel M,Rosenbauer F
Thu Aug 25 00:00:00 UTC 2011
Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.
Blood
Chi AW,Chavez A,Xu L,Weber BN,Shestova O,Schaffer A,Wertheim G,Pear WS,Izon D,Bhandoola A
Thu Sep 08 00:00:00 UTC 2011
HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.
Blood
Flygare J,Rayon Estrada V,Shin C,Gupta S,Lodish HF
Thu Mar 24 00:00:00 UTC 2011
Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.
Blood
Li N,Matte-Martone C,Zheng H,Cui W,Venkatesan S,Tan HS,McNiff J,Demetris AJ,Roopenian D,Kaech S,Shlomchik WD
Thu Nov 24 00:00:00 UTC 2011
Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.
Blood
Negre O,Fusil F,Colomb C,Roth S,Gillet-Legrand B,Henri A,Beuzard Y,Bushman F,Leboulch P,Payen E
Thu May 19 00:00:00 UTC 2011
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
Blood
Aue G,Du Y,Cleveland SM,Smith SB,Davé UP,Liu D,Weniger MA,Metais JY,Jenkins NA,Copeland NG,Dunbar CE
Thu Oct 27 00:00:00 UTC 2011
SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.
Blood
Giroux M,Delisle JS,Gauthier SD,Heinonen KM,Hinsinger J,Houde B,Gaboury L,Brochu S,Wu J,Hébert MJ,Perreault C
Thu Feb 03 00:00:00 UTC 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
Thu Feb 24 00:00:00 UTC 2011
In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2.
Blood
Kitajima K,Minehata K,Sakimura K,Nakano T,Hara T
Thu Apr 07 00:00:00 UTC 2011
AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.
Blood
Steffen B,Knop M,Bergholz U,Vakhrusheva O,Rode M,Köhler G,Henrichs MP,Bulk E,Hehn S,Stehling M,Dugas M,Bäumer N,Tschanter P,Brandts C,Koschmieder S,Berdel WE,Serve H,Stocking C,Müller-Tidow C
Thu Apr 21 00:00:00 UTC 2011
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.
The Journal of clinical investigation
Hahn JN,Falck VG,Jirik FR
Sat Oct 01 00:00:00 UTC 2011
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
The Journal of clinical investigation
Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE
Sat Jan 01 00:00:00 UTC 2011
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
The Journal of experimental medicine
Knosp CA,Carroll HP,Elliott J,Saunders SP,Nel HJ,Amu S,Pratt JC,Spence S,Doran E,Cooke N,Jackson R,Swift J,Fitzgerald DC,Heaney LG,Fallon PG,Kissenpfennig A,Johnston JA
Mon Jul 04 00:00:00 UTC 2011
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
The Journal of experimental medicine
Hurtz C,Hatzi K,Cerchietti L,Braig M,Park E,Kim YM,Herzog S,Ramezani-Rad P,Jumaa H,Müller MC,Hofmann WK,Hochhaus A,Ye BH,Agarwal A,Druker BJ,Shah NP,Melnick AM,Müschen M
Mon Oct 24 00:00:00 UTC 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 UTC 2011
Tolerogenic function of Blimp-1 in dendritic cells.
The Journal of experimental medicine
Kim SJ,Zou YR,Goldstein J,Reizis B,Diamond B
Mon Oct 24 00:00:00 UTC 2011
Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants.
The Journal of experimental medicine
Purtha WE,Tedder TF,Johnson S,Bhattacharya D,Diamond MS
Mon Dec 19 00:00:00 UTC 2011
Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Baschant U,Frappart L,Rauchhaus U,Bruns L,Reichardt HM,Kamradt T,Bräuer R,Tuckermann JP
Tue Nov 29 00:00:00 UTC 2011
Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic beta-cells: potential involvement of the PLC-IP3-dependent pathway.
Diabetes
Suzuki T,Imai J,Yamada T,Ishigaki Y,Kaneko K,Uno K,Hasegawa Y,Ishihara H,Oka Y,Katagiri H
Tue Feb 01 00:00:00 UTC 2011
Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NFκB activation and antiviral cytokine production.
PLoS pathogens
Dong X,Feng P
Tue Nov 01 00:00:00 UTC 2011
Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NFκB activation and antiviral cytokine production.
PLoS pathogens
Dong X,Feng P
Tue Nov 01 00:00:00 UTC 2011
Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Li X,Koh AJ,Wang Z,Soki FN,Park SI,Pienta KJ,McCauley LK
Sat Jan 01 00:00:00 UTC 2011
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Ishizaki M,Akimoto T,Muromoto R,Yokoyama M,Ohshiro Y,Sekine Y,Maeda H,Shimoda K,Oritani K,Matsuda T
Fri Jul 01 00:00:00 UTC 2011
Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Beurel E,Yeh WI,Michalek SM,Harrington LE,Jope RS
Tue Feb 01 00:00:00 UTC 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
Thu Dec 15 00:00:00 UTC 2011
Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa R,Yoshida H,Asakawa M,Tamiya T,Inoue N,Morita R,Inoue H,Nakao A,Yoshimura A
Tue Nov 01 00:00:00 UTC 2011
Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant.
Journal of immunology (Baltimore, Md. : 1950)
Matte-Martone C,Venkatesan S,Tan HS,Athanasiadis I,Chang J,Pavisic J,Shlomchik WD
Mon Aug 15 00:00:00 UTC 2011
Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.
Journal of immunology (Baltimore, Md. : 1950)
Van Belle TL,Esplugues E,Liao J,Juntti T,Flavell RA,von Herrath MG
Thu Sep 15 00:00:00 UTC 2011
Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice.
Journal of immunology (Baltimore, Md. : 1950)
Ye F,Han L,Lu Q,Dong W,Chen Z,Shao H,Kaplan HJ,Li Q,Lu Q
Sat Oct 15 00:00:00 UTC 2011
High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Molinero LL,Miller ML,Evaristo C,Alegre ML
Fri Apr 15 00:00:00 UTC 2011
Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.
Journal of immunology (Baltimore, Md. : 1950)
Peng DJ,Zeng M,Muromoto R,Matsuda T,Shimoda K,Subramaniam M,Spelsberg TC,Wei WZ,Venuprasad K
Sun May 15 00:00:00 UTC 2011
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Soulard V,Bécourt C,Amniai L,Henrot P,Havenar-Daughton C,Blanchet C,Zitvogel L,Ryffel B,Cavaillon JM,Marie JC,Couillin I,Benlagha K
Sat Jan 15 00:00:00 UTC 2011
Sensitivity and resistance to regulation by IL-4 during Th17 maturation.
Journal of immunology (Baltimore, Md. : 1950)
Cooney LA,Towery K,Endres J,Fox DA
Tue Nov 01 00:00:00 UTC 2011
Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Cantor J,Slepak M,Ege N,Chang JT,Ginsberg MH
Fri Jul 15 00:00:00 UTC 2011
Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Newland S,Krejcí A,Phillips JM,Bray S,Cooke A
Tue Mar 15 00:00:00 UTC 2011
DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability.
Journal of immunology (Baltimore, Md. : 1950)
Sumpter TL,Packiam V,Turnquist HR,Castellaneta A,Yoshida O,Thomson AW
Tue Feb 15 00:00:00 UTC 2011
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sehra S,Yao W,Nguyen ET,Ahyi AN,Tuana FM,Ahlfeld SK,Snider P,Tepper RS,Petrache I,Conway SJ,Kaplan MH
Fri Apr 15 00:00:00 UTC 2011
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950)
Grenningloh R,Tai TS,Frahm N,Hongo TC,Chicoine AT,Brander C,Kaufmann DE,Ho IC
Sat Jan 15 00:00:00 UTC 2011
Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.
Clinical & experimental metastasis
Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M
Sat Jan 01 00:00:00 UTC 2011
Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.
Clinical & experimental metastasis
Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M
Sat Jan 01 00:00:00 UTC 2011
Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.
The Journal of biological chemistry
Guo H,Friedman AD
Fri Jan 07 00:00:00 UTC 2011
The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.
BMC immunology
Sprague L,Muccioli M,Pate M,Meles E,McGinty J,Nandigam H,Venkatesh AK,Gu MY,Mansfield K,Rutowski A,Omosebi O,Courreges MC,Benencia F
Mon Jun 06 00:00:00 UTC 2011
The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.
BMC immunology
Sprague L,Muccioli M,Pate M,Meles E,McGinty J,Nandigam H,Venkatesh AK,Gu MY,Mansfield K,Rutowski A,Omosebi O,Courreges MC,Benencia F
Mon Jun 06 00:00:00 UTC 2011
Critical role of TCF-1 in repression of the IL-17 gene.
PloS one
Ma J,Wang R,Fang X,Ding Y,Sun Z
Tue Feb 28 00:00:00 UTC 2012
In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide.
International journal of nanomedicine
Mou Y,Hou Y,Chen B,Hua Z,Zhang Y,Xie H,Xia G,Wang Z,Huang X,Han W,Ni Y,Hu Q
Tue Mar 27 00:00:00 UTC 2012
Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat.
ASN neuro
Ghiani CA,Mattan NS,Nobuta H,Malvar JS,Boles J,Ross MG,Waschek JA,Carpenter EM,Fisher RS,de Vellis J
Thu Nov 17 00:00:00 UTC 2011
Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation.
The Journal of biological chemistry
Thaler R,Agsten M,Spitzer S,Paschalis EP,Karlic H,Klaushofer K,Varga F
Fri Feb 18 00:00:00 UTC 2011
Co-administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG.
PloS one
Singh V,Jain S,Gowthaman U,Parihar P,Gupta P,Gupta UD,Agrewala JN
Wed Jan 19 00:00:00 UTC 2011
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.
PloS one
Takeuchi H,Yokota A,Ohoka Y,Iwata M
Fri Jan 07 00:00:00 UTC 2011
Influence of synthetic superparamagnetic iron oxide on dendritic cells.
International journal of nanomedicine
Mou Y,Chen B,Zhang Y,Hou Y,Xie H,Xia G,Tang M,Huang X,Ni Y,Hu Q
Wed Feb 08 00:00:00 UTC 2012
Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.
PloS one
Persson J,Beyer I,Yumul R,Li Z,Kiem HP,Roffler S,Lieber A
Tue Nov 15 00:00:00 UTC 2011
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
The Journal of biological chemistry
Liu Z,Yang A,Wang Z,Bunting KD,Davuluri G,Green MR,Devireddy LR
Fri Jun 10 00:00:00 UTC 2011
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.
The Journal of biological chemistry
Dagälv A,Holmborn K,Kjellén L,Abrink M
Fri Dec 30 00:00:00 UTC 2011
MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts.
PloS one
Chen Z,Phillips LK,Gould E,Campisi J,Lee SW,Ormerod BK,Zwierzchoniewska M,Martinez OM,Palmer TD
Wed Mar 30 00:00:00 UTC 2011
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
PloS one
Eto D,Lao C,DiToro D,Barnett B,Escobar TC,Kageyama R,Yusuf I,Crotty S
Mon Mar 14 00:00:00 UTC 2011
Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation.
PloS one
Yang J,Yang X,Chu Y,Li M
Wed Feb 16 00:00:00 UTC 2011
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
PloS one
Iguchi-Hashimoto M,Usui T,Yoshifuji H,Shimizu M,Kobayashi S,Ito Y,Murakami K,Shiomi A,Yukawa N,Kawabata D,Nojima T,Ohmura K,Fujii T,Mimori T
Mon Mar 26 00:00:00 UTC 2012
Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.
The Journal of biological chemistry
Ehlting C,Ronkina N,Böhmer O,Albrecht U,Bode KA,Lang KS,Kotlyarov A,Radzioch D,Gaestel M,Häussinger D,Bode JG
Fri Jul 08 00:00:00 UTC 2011
Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.
PloS one
Heinonen KM,Vanegas JR,Lew D,Krosl J,Perreault C
Tue Apr 26 00:00:00 UTC 2011
Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage.
The Journal of biological chemistry
Zhu Y,Gumlaw N,Karman J,Zhao H,Zhang J,Jiang JL,Maniatis P,Edling A,Chuang WL,Siegel C,Shayman JA,Kaplan J,Jiang C,Cheng SH
Fri Apr 29 00:00:00 UTC 2011
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature
Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP
Thu Sep 16 00:00:00 UTC 2010
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.
Nature
Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H
Thu Apr 29 00:00:00 UTC 2010
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.
Nature
Nakada D,Saunders TL,Morrison SJ
Thu Dec 02 00:00:00 UTC 2010
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
Immunity
Gulen MF,Kang Z,Bulek K,Youzhong W,Kim TW,Chen Y,Altuntas CZ,Sass Bak-Jensen K,McGeachy MJ,Do JS,Xiao H,Delgoffe GM,Min B,Powell JD,Tuohy VK,Cua DJ,Li X
Fri Jan 29 00:00:00 UTC 2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
Cancer cell
Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW
Tue Dec 14 00:00:00 UTC 2010
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.
Blood
Li G,Miskimen KL,Wang Z,Xie XY,Brenzovich J,Ryan JJ,Tse W,Moriggl R,Bunting KD
Thu Feb 18 00:00:00 UTC 2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood
Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R
Thu Nov 18 00:00:00 UTC 2010
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Blood
Urbieta M,Barao I,Jones M,Jurecic R,Panoskaltsis-Mortari A,Blazar BR,Murphy WJ,Levy RB
Thu Jun 10 00:00:00 UTC 2010
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Blood
Juntilla MM,Patil VD,Calamito M,Joshi RP,Birnbaum MJ,Koretzky GA
Thu May 20 00:00:00 UTC 2010
FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment.
Blood
Gregory GD,Miccio A,Bersenev A,Wang Y,Hong W,Zhang Z,Poncz M,Tong W,Blobel GA
Thu Mar 18 00:00:00 UTC 2010
Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
Blood
Qiu JJ,Lu X,Zeisig BB,Ma Z,Cai X,Chen S,Gronemeyer H,Tweardy DJ,So CW,Dong S
Thu Jan 21 00:00:00 UTC 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 UTC 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 UTC 2010
Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.
Blood
Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H
Thu Jun 03 00:00:00 UTC 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 UTC 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 UTC 2010
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.
Blood
Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS
Thu Aug 26 00:00:00 UTC 2010
Leukemogenic transformation by HOXA cluster genes.
Blood
Bach C,Buhl S,Mueller D,García-Cuéllar MP,Maethner E,Slany RK
Thu Apr 08 00:00:00 UTC 2010
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Blood
Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y
Thu Jun 10 00:00:00 UTC 2010
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
The Journal of clinical investigation
Biswas PS,Gupta S,Chang E,Song L,Stirzaker RA,Liao JK,Bhagat G,Pernis AB
Wed Sep 01 00:00:00 UTC 2010
Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice.
The Journal of clinical investigation
Kovacic JC,Gupta R,Lee AC,Ma M,Fang F,Tolbert CN,Walts AD,Beltran LE,San H,Chen G,St Hilaire C,Boehm M
Fri Jan 01 00:00:00 UTC 2010
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.
The Journal of clinical investigation
Melton AC,Bailey-Bucktrout SL,Travis MA,Fife BT,Bluestone JA,Sheppard D
Wed Dec 01 00:00:00 UTC 2010
Lnk constrains myeloproliferative diseases in mice.
The Journal of clinical investigation
Bersenev A,Wu C,Balcerek J,Jing J,Kundu M,Blobel GA,Chikwava KR,Tong W
Tue Jun 01 00:00:00 UTC 2010
A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
The Journal of experimental medicine
Henderson RB,Grys K,Vehlow A,de Bettignies C,Zachacz A,Henley T,Turner M,Batista F,Tybulewicz VL
Mon Apr 12 00:00:00 UTC 2010
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice.
The Journal of experimental medicine
Schallenberg S,Tsai PY,Riewaldt J,Kretschmer K
Mon Jul 05 00:00:00 UTC 2010
A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma.
The Journal of experimental medicine
Wang YH,Voo KS,Liu B,Chen CY,Uygungil B,Spoede W,Bernstein JA,Huston DP,Liu YJ
Mon Oct 25 00:00:00 UTC 2010
Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Chou S,Lodish HF
Tue Apr 27 00:00:00 UTC 2010
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis.
PLoS pathogens
Garrison SP,Thornton JA,Häcker H,Webby R,Rehg JE,Parganas E,Zambetti GP,Tuomanen EI
Thu Dec 23 00:00:00 UTC 2010
Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway.
Stem cells (Dayton, Ohio)
Xynos A,Corbella P,Belmonte N,Zini R,Manfredini R,Ferrari G
Sat May 01 00:00:00 UTC 2010
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY
Wed Mar 31 00:00:00 UTC 2010
B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Kashiwakuma D,Suto A,Hiramatsu Y,Ikeda K,Takatori H,Suzuki K,Kagami S,Hirose K,Watanabe N,Iwamoto I,Nakajima H
Wed Sep 01 00:00:00 UTC 2010
Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Ying H,Yang L,Qiao G,Li Z,Zhang L,Yin F,Xie D,Zhang J
Sun Aug 01 00:00:00 UTC 2010
Cbl-b(-/-) T cells demonstrate in vivo resistance to regulatory T cells but a context-dependent resistance to TGF-beta.
Journal of immunology (Baltimore, Md. : 1950)
Adams CO,Housley WJ,Bhowmick S,Cone RE,Rajan TV,Forouhar F,Clark RB
Sun Aug 15 00:00:00 UTC 2010
FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Tartar DM,VanMorlan AM,Wan X,Guloglu FB,Jain R,Haymaker CL,Ellis JS,Hoeman CM,Cascio JA,Dhakal M,Oukka M,Zaghouani H
Thu Apr 01 00:00:00 UTC 2010
Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.
Journal of immunology (Baltimore, Md. : 1950)
Wang C,Kang SG,HogenEsch H,Love PE,Kim CH
Sat May 15 00:00:00 UTC 2010
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kastner L,Dwyer D,Qin FX
Mon Nov 15 00:00:00 UTC 2010
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y
Sun Aug 15 00:00:00 UTC 2010
CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura K,Farber JM,Kelsall BL
Wed Sep 15 00:00:00 UTC 2010
NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant.
Journal of immunology (Baltimore, Md. : 1950)
Hall LJ,Clare S,Dougan G
Thu Apr 15 00:00:00 UTC 2010
CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Iwakura Y,Yoshikai Y
Wed Dec 15 00:00:00 UTC 2010
Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction.
Journal of immunology (Baltimore, Md. : 1950)
Rolf J,Bell SE,Kovesdi D,Janas ML,Soond DR,Webb LM,Santinelli S,Saunders T,Hebeis B,Killeen N,Okkenhaug K,Turner M
Fri Oct 01 00:00:00 UTC 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 UTC 2010
IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.
Journal of immunology (Baltimore, Md. : 1950)
Yen JH,Kong W,Ganea D
Thu Apr 01 00:00:00 UTC 2010
Immune dysregulation by the rheumatoid arthritis shared epitope.
Journal of immunology (Baltimore, Md. : 1950)
De Almeida DE,Ling S,Pi X,Hartmann-Scruggs AM,Pumpens P,Holoshitz J
Sun Aug 01 00:00:00 UTC 2010
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Wrzesinski C,Paulos CM,Kaiser A,Muranski P,Palmer DC,Gattinoni L,Yu Z,Rosenberg SA,Restifo NP
Fri Jan 01 00:00:00 UTC 2010
Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.
PloS one
Domingues HS,Mues M,Lassmann H,Wekerle H,Krishnamoorthy G
Mon Nov 29 00:00:00 UTC 2010
SMAD2 is essential for TGF beta-mediated Th17 cell generation.
The Journal of biological chemistry
Malhotra N,Robertson E,Kang J
Fri Sep 17 00:00:00 UTC 2010
Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.
Self/nonself
Capurso NA,Look M,Jeanbart L,Nowyhed H,Abraham C,Craft J,Fahmy TM
216-16 was used in Cell Culture to develop a nanoparticulate drug delivery platform from poly(lactic-co-glycolic acid) capable of encapsulating and releasing retinoic acid.
Fri Oct 01 00:00:00 UTC 2010
Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.
Lipids in health and disease
Kong W,Yen JH,Vassiliou E,Adhikary S,Toscano MG,Ganea D
Mon Feb 01 00:00:00 UTC 2010
Characterization of oxidative guanine damage and repair in mammalian telomeres.
PLoS genetics
Wang Z,Rhee DB,Lu J,Bohr CT,Zhou F,Vallabhaneni H,de Souza-Pinto NC,Liu Y
Thu May 13 00:00:00 UTC 2010
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.
Nature
Yanai H,Ban T,Wang Z,Choi MK,Kawamura T,Negishi H,Nakasato M,Lu Y,Hangai S,Koshiba R,Savitsky D,Ronfani L,Akira S,Bianchi ME,Honda K,Tamura T,Kodama T,Taniguchi T
Thu Nov 05 00:00:00 UTC 2009
The AP-1 transcription factor Batf controls T(H)17 differentiation.
Nature
Schraml BU,Hildner K,Ise W,Lee WL,Smith WA,Solomon B,Sahota G,Sim J,Mukasa R,Cemerski S,Hatton RD,Stormo GD,Weaver CT,Russell JH,Murphy TL,Murphy KM
Thu Jul 16 00:00:00 UTC 2009
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Nature
Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG
Thu Jan 01 00:00:00 UTC 2009
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Immunity
Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL
Fri Oct 16 00:00:00 UTC 2009
Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis.
Immunity
Desvignes L,Ernst JD
Fri Dec 18 00:00:00 UTC 2009
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.
Immunity
Delgoffe GM,Kole TP,Zheng Y,Zarek PE,Matthews KL,Xiao B,Worley PF,Kozma SC,Powell JD
Fri Jun 19 00:00:00 UTC 2009
Negative regulation of activated alpha-2 integrins during thrombopoiesis.
Blood
Zou Z,Schmaier AA,Cheng L,Mericko P,Dickeson SK,Stricker TP,Santoro SA,Kahn ML
Thu Jun 18 00:00:00 UTC 2009
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood
Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK
Thu Apr 09 00:00:00 UTC 2009
Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.
Blood
Cochrane SW,Zhao Y,Welner RS,Sun XH
Thu Jan 29 00:00:00 UTC 2009
Genetic deletion of JAM-C reveals a role in myeloid progenitor generation.
Blood
Praetor A,McBride JM,Chiu H,Rangell L,Cabote L,Lee WP,Cupp J,Danilenko DM,Fong S
Thu Feb 26 00:00:00 UTC 2009
Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.
Blood
Kuo YH,Zaidi SK,Gornostaeva S,Komori T,Stein GS,Castilla LH
Thu Apr 02 00:00:00 UTC 2009
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
Blood
Allen JD,Jaffer ZM,Park SJ,Burgin S,Hofmann C,Sells MA,Chen S,Derr-Yellin E,Michels EG,McDaniel A,Bessler WK,Ingram DA,Atkinson SJ,Travers JB,Chernoff J,Clapp DW
Thu Mar 19 00:00:00 UTC 2009
Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.
Blood
Milsom MD,Schiedlmeier B,Bailey J,Kim MO,Li D,Jansen M,Ali AM,Kirby M,Baum C,Fairbairn LJ,Williams DA
Thu May 21 00:00:00 UTC 2009
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Blood
Xu H,Eleswarapu S,Geiger H,Szczur K,Daria D,Zheng Y,Settleman J,Srour EF,Williams DA,Filippi MD
Thu Oct 22 00:00:00 UTC 2009
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
Blood
Rice KL,Hormaeche I,Doulatov S,Flatow JM,Grimwade D,Mills KI,Leiva M,Ablain J,Ambardekar C,McConnell MJ,Dick JE,Licht JD
Thu Dec 24 00:00:00 UTC 2009
Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation.
Blood
Piconese S,Gri G,Tripodo C,Musio S,Gorzanelli A,Frossi B,Pedotti R,Pucillo CE,Colombo MP
Thu Sep 24 00:00:00 UTC 2009
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
Blood
Horman SR,Velu CS,Chaubey A,Bourdeau T,Zhu J,Paul WE,Gebelein B,Grimes HL
Thu May 28 00:00:00 UTC 2009
Critical role of class IA PI3K for c-Rel expression in B lymphocytes.
Blood
Matsuda S,Mikami Y,Ohtani M,Fujiwara M,Hirata Y,Minowa A,Terauchi Y,Kadowaki T,Koyasu S
Thu Jan 29 00:00:00 UTC 2009
Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation.
Blood
Yen JH,Ganea D
Thu Aug 13 00:00:00 UTC 2009
Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.
Blood
Horton SJ,Walf-Vorderwülbecke V,Chatters SJ,Sebire NJ,de Boer J,Williams O
Thu May 14 00:00:00 UTC 2009
Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model.
Blood
Hu X,Shen H,Tian C,Yu H,Zheng G,XuFeng R,Ju Z,Xu J,Wang J,Cheng T
Thu Oct 29 00:00:00 UTC 2009
Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.
Blood
Blue R,Kowalska MA,Hirsch J,Murcia M,Janczak CA,Harrington A,Jirouskova M,Li J,Fuentes R,Thornton MA,Filizola M,Poncz M,Coller BS
Thu Jul 02 00:00:00 UTC 2009
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.
Blood
Velu CS,Baktula AM,Grimes HL
Thu May 07 00:00:00 UTC 2009
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production.
Blood
Fang C,Zhang X,Miwa T,Song WC
Thu Jul 30 00:00:00 UTC 2009
In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations.
Blood
Carlson MJ,West ML,Coghill JM,Panoskaltsis-Mortari A,Blazar BR,Serody JS
Thu Feb 05 00:00:00 UTC 2009
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice.
The Journal of clinical investigation
Haak S,Croxford AL,Kreymborg K,Heppner FL,Pouly S,Becher B,Waisman A
Thu Jan 01 00:00:00 UTC 2009
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
The Journal of experimental medicine
Fukui R,Saitoh S,Matsumoto F,Kozuka-Hata H,Oyama M,Tabeta K,Beutler B,Miyake K
Mon Jun 08 00:00:00 UTC 2009
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE
Tue Apr 28 00:00:00 UTC 2009
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
Proceedings of the National Academy of Sciences of the United States of America
Schmaier AA,Zou Z,Kazlauskas A,Emert-Sedlak L,Fong KP,Neeves KB,Maloney SF,Diamond SL,Kunapuli SP,Ware J,Brass LF,Smithgall TE,Saksela K,Kahn ML
Tue Dec 15 00:00:00 UTC 2009
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.
Proceedings of the National Academy of Sciences of the United States of America
Komatsu N,Mariotti-Ferrandiz ME,Wang Y,Malissen B,Waldmann H,Hori S
Tue Feb 10 00:00:00 UTC 2009
Misguided transcriptional elongation causes mixed lineage leukemia.
PLoS biology
Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK
Sun Nov 01 00:00:00 UTC 2009
IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons.
Journal of immunology (Baltimore, Md. : 1950)
Curtis MM,Way SS,Wilson CB
Wed Jul 01 00:00:00 UTC 2009
Basophils can directly present or cross-present antigen to CD8 lymphocytes and alter CD8 T cell differentiation into IL-10-producing phenotypes.
Journal of immunology (Baltimore, Md. : 1950)
Kim S,Shen T,Min B
Tue Sep 01 00:00:00 UTC 2009
Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses.
Journal of immunology (Baltimore, Md. : 1950)
Tanaka S,Yoshimoto T,Naka T,Nakae S,Iwakura Y,Cua D,Kubo M
Tue Dec 01 00:00:00 UTC 2009
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
Sun Mar 15 00:00:00 UTC 2009
Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Li Z,Mao K,Zou J,Wang Y,Tao Z,Lin G,Tian L,Ji Y,Wu X,Zhu X,Sun S,Chen W,Xiang C,Sun B
Sun Nov 15 00:00:00 UTC 2009
Epicutaneous immunization with protein antigen in the presence of TLR4 ligand induces TCR alpha beta+CD4+ T contrasuppressor cells that reverse skin-induced suppression of Th1-mediated contact sensitivity.
Journal of immunology (Baltimore, Md. : 1950)
Ptak W,Majewska M,Bryniarski K,Ptak M,Lobo FM,Zajac K,Askenase PW,Szczepanik M
Thu Jan 15 00:00:00 UTC 2009
T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.
Journal of immunology (Baltimore, Md. : 1950)
Gondek DC,Roan NR,Starnbach MN
Wed Jul 15 00:00:00 UTC 2009
Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.
Journal of immunology (Baltimore, Md. : 1950)
Jeong M,Piao ZH,Kim MS,Lee SH,Yun S,Sun HN,Yoon SR,Chung JW,Kim TD,Jeon JH,Lee J,Kim HN,Choi JY,Choi I
Sat Aug 15 00:00:00 UTC 2009
Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.
Journal of immunology (Baltimore, Md. : 1950)
Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK
Sat Aug 15 00:00:00 UTC 2009
Antigen receptor signals rescue B cells from TLR tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Poovassery JS,Vanden Bush TJ,Bishop GA
Tue Sep 01 00:00:00 UTC 2009
SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Canonigo-Balancio AJ,Fos C,Prod'homme T,Bécart S,Altman A
Tue Dec 01 00:00:00 UTC 2009
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chang M,Lee AJ,Fitzpatrick L,Zhang M,Sun SC
Sun Mar 01 00:00:00 UTC 2009
Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Oyamada A,Ikebe H,Itsumi M,Saiwai H,Okada S,Shimoda K,Iwakura Y,Nakayama KI,Iwamoto Y,Yoshikai Y,Yamada H
Tue Dec 01 00:00:00 UTC 2009
A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Perona-Wright G,Jenkins SJ,O'Connor RA,Zienkiewicz D,McSorley HJ,Maizels RM,Anderton SM,MacDonald AS
Sun Mar 01 00:00:00 UTC 2009
The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling.
Journal of immunology (Baltimore, Md. : 1950)
Crabé S,Guay-Giroux A,Tormo AJ,Duluc D,Lissilaa R,Guilhot F,Mavoungou-Bigouagou U,Lefouili F,Cognet I,Ferlin W,Elson G,Jeannin P,Gauchat JF
Tue Dec 15 00:00:00 UTC 2009
Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Maue AC,Eaton SM,Lanthier PA,Sweet KB,Blumerman SL,Haynes L
Fri May 15 00:00:00 UTC 2009
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A
Sat Aug 01 00:00:00 UTC 2009
A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Newcomb DC,Zhou W,Moore ML,Goleniewska K,Hershey GK,Kolls JK,Peebles RS
Fri May 01 00:00:00 UTC 2009
Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Zheng H,Matte-Martone C,Jain D,McNiff J,Shlomchik WD
Fri May 15 00:00:00 UTC 2009
SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Leavenworth JW,Ma X,Mo YY,Pauza ME
Wed Jul 15 00:00:00 UTC 2009
IL-17A controls IL-17F production and maintains blood neutrophil counts in mice.
Journal of immunology (Baltimore, Md. : 1950)
von Vietinghoff S,Ley K
Wed Jul 15 00:00:00 UTC 2009
Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.
PloS one
Aguilar S,Scotton CJ,McNulty K,Nye E,Stamp G,Laurent G,Bonnet D,Janes SM
Tue Nov 24 00:00:00 UTC 2009
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.
The Journal of biological chemistry
Lin IJ,Zhou Z,Crusselle-Davis VJ,Moghimi B,Gandhi K,Anantharaman A,Pantic D,Huang S,Jayandharan G,Zhong L,Srivastava A,Bungert J
Fri Jul 24 00:00:00 UTC 2009
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation.
The Journal of biological chemistry
Martinez GJ,Zhang Z,Chung Y,Reynolds JM,Lin X,Jetten AM,Feng XH,Dong C
Fri Dec 18 00:00:00 UTC 2009
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
PloS one
Johnson KJ,Griswold IJ,O'Hare T,Corbin AS,Loriaux M,Deininger MW,Druker BJ
Tue Oct 13 00:00:00 UTC 2009
Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.
PloS one
Miletic AV,Graham DB,Sakata-Sogawa K,Hiroshima M,Hamann MJ,Cemerski S,Kloeppel T,Billadeau DD,Kanagawa O,Tokunaga M,Swat W
Wed Aug 12 00:00:00 UTC 2009
A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.
The Journal of biological chemistry
Zhao L,Dong H,Zhang CC,Kinch L,Osawa M,Iacovino M,Grishin NV,Kyba M,Huang LJ
Fri Sep 25 00:00:00 UTC 2009
IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor.
Immunity
Chen Q,Yang W,Gupta S,Biswas P,Smith P,Bhagat G,Pernis AB
Fri Dec 19 00:00:00 UTC 2008
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Immunity
Hill JA,Hall JA,Sun CM,Cai Q,Ghyselinck N,Chambon P,Belkaid Y,Mathis D,Benoist C
Fri Nov 14 00:00:00 UTC 2008
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Cancer cell
Krivtsov AV,Feng Z,Lemieux ME,Faber J,Vempati S,Sinha AU,Xia X,Jesneck J,Bracken AP,Silverman LB,Kutok JL,Kung AL,Armstrong SA
Tue Nov 04 00:00:00 UTC 2008
TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice.
Blood
Zhou Y,Du W,Koretsky T,Bagby GC,Pang Q
Mon Sep 15 00:00:00 UTC 2008
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Orabona C,Pallotta MT,Volpi C,Fallarino F,Vacca C,Bianchi R,Belladonna ML,Fioretti MC,Grohmann U,Puccetti P
Tue Dec 30 00:00:00 UTC 2008
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.
Proceedings of the National Academy of Sciences of the United States of America
Huber M,Brüstle A,Reinhard K,Guralnik A,Walter G,Mahiny A,von Löw E,Lohoff M
Tue Dec 30 00:00:00 UTC 2008
CCR6 regulates the migration of inflammatory and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Yamazaki T,Yang XO,Chung Y,Fukunaga A,Nurieva R,Pappu B,Martin-Orozco N,Kang HS,Ma L,Panopoulos AD,Craig S,Watowich SS,Jetten AM,Tian Q,Dong C
Mon Dec 15 00:00:00 UTC 2008
Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing.
Journal of immunology (Baltimore, Md. : 1950)
Sutherland RE,Olsen JS,McKinstry A,Villalta SA,Wolters PJ
Wed Oct 15 00:00:00 UTC 2008
Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.
Journal of immunology (Baltimore, Md. : 1950)
Kamimura D,Bevan MJ
Wed Oct 15 00:00:00 UTC 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
Sat Nov 01 00:00:00 UTC 2008
Bone marrow-derived dendritic cells generated in the presence of resolvin E1 induce apoptosis of activated CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Vassiliou EK,Kesler OM,Tadros JH,Ganea D
Wed Oct 01 00:00:00 UTC 2008
IL-23 promotes maintenance but not commitment to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Stritesky GL,Yeh N,Kaplan MH
Sat Nov 01 00:00:00 UTC 2008
Instant conditional transgenesis in the mouse hematopoietic compartment.
Journal of immunological methods
Csikós T,Reijmers RM,Uren AG,Spaargaren M,Pals ST
Wed Dec 31 00:00:00 UTC 2008
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
Tue Feb 10 00:00:00 UTC 2009
CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.
Journal of immune based therapies and vaccines
Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW
Tue Oct 28 00:00:00 UTC 2008
Murine retroviral bone marrow transplantation models for the study of human myeloproliferative disorders.
Current protocols in pharmacology
Gavrilescu LC,Van Etten RA
216-16 was used in In vitro experiments to describe protocols for the preparation of mouse bone marrow cells to express the relevant human oncogene before transplanting them into irradiated recipient mice.
Mon Dec 01 00:00:00 UTC 2008
PECAM-1: a multifaceted regulator of megakaryocytopoiesis.
Blood
Wu Y,Welte T,Michaud M,Madri JA
Wed Aug 01 00:00:00 UTC 2007
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
The Journal of clinical investigation
Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q
Thu Nov 01 00:00:00 UTC 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 UTC 2007
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.
Cell metabolism
Wang RH,Li C,Xu X,Zheng Y,Xiao C,Zerfas P,Cooperman S,Eckhaus M,Rouault T,Mishra L,Deng CX
216-16 was used in In vivo experiments to investigate hepcidin role in hereditary hemochromatosis.
Thu Dec 01 00:00:00 UTC 2005
B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yang M,Hase H,Legarda-Addison D,Varughese L,Seed B,Ting AT
Thu Sep 01 00:00:00 UTC 2005
Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain.
The Journal of biological chemistry
Yamauchi A,Marchal CC,Molitoris J,Pech N,Knaus U,Towe J,Atkinson SJ,Dinauer MC
Fri Jan 14 00:00:00 UTC 2005
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
Proceedings of the National Academy of Sciences of the United States of America
Ge Q,Palliser D,Eisen HN,Chen J
Tue Mar 05 00:00:00 UTC 2002
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 UTC 2003
Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.
Laboratory investigation; a journal of technical methods and pathology
Feraud O,Cao Y,Vittet D
Sat Dec 01 00:00:00 UTC 2001
Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.
Laboratory investigation; a journal of technical methods and pathology
Feraud O,Cao Y,Vittet D
Sat Dec 01 00:00:00 UTC 2001
Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells.
Blood
Vanderkerken K,Asosingh K,Braet F,Van Riet I,Van Camp B
Fri Jan 01 00:00:00 UTC 1999
Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells.
Blood
Vanderkerken K,Asosingh K,Braet F,Van Riet I,Van Camp B
Fri Jan 01 00:00:00 UTC 1999
