Product References
An Adaptable Protocol to Generate a Murine Enteroid-Macrophage Co-Culture System.
International journal of molecular sciences
Hentschel V,Govindarajan D,Seufferlein T,Armacki M
250-38 was used in Cell Culture to provide step-by-step instructions on how to set up a murine enteroid-macrophage co-culture by culturing cellular elements in proximity separated by a porous membrane.
Sat Jul 20 00:00:00 UTC 2024
Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cells.
Life science alliance
Nascakova Z,He J,Papa G,Francas B,Azizi F,Müller A
250-38 was used in Tissue/organ culture to indicate that H. pylori has stemness-inducing properties that depend on its ability to activate NF-κB signaling.
Fri Nov 01 00:00:00 UTC 2024
Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment.
Nature communications
Li N,Zhu Q,Tian Y,Ahn KJ,Wang X,Cramer Z,Jou J,Folkert IW,Yu P,Adams-Tzivelekidis S,Sehgal P,Mahmoud NN,Aarons CB,Roses RE,Thomas-Tikhonenko A,Furth EE,Stanger BZ,Rustgi A,Haldar M,Katona BW,Tan K,Lengner CJ
250-38 was used in Cell Culture to predict cancer-TME interactions from single cell transcriptomic maps of both human colorectal cancers and mouse models, ask how these interactions are altered in human tumour organoid (tumoroid) cultures, and functionally recapitulate human myeloid-carcinoma interactions in vitro.
Thu Nov 30 00:00:00 UTC 2023
Sucrose-induced hyperglycemia dysregulates intestinal zinc metabolism and integrity: risk factors for chronic diseases.
Frontiers in nutrition
Mitchell SB,Hung YH,Thorn TL,Zou J,Baser F,Gulec S,Cheung C,Aydemir TB
250-38 was used in Cell Culture to investigate how dietary sources of intestinal permeability, such as high sucrose consumption, impact transporter-mediated zinc homeostasis and subsequent zinc-dependent physiology contributing to disease development.
Mon Sep 23 00:00:00 UTC 2024
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
250-38 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
250-38 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
250-38 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model.
BMC genomics
Hung YH,Capeling M,Villanueva JW,Kanke M,Shanahan MT,Huang S,Cubitt R,Rinaldi VD,Schimenti JC,Spence JR,Sethupathy P
250-38 was used in In vitro experiments to highlight miRNA-mediated post-transcriptional regulation relevant to the event of SI lineage specification.
Thu Oct 26 00:00:00 UTC 2023
The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model.
Frontiers in immunology
Geyer M,Gaul LM,D Agosto SL,Corbo V,Queiroz K
250-38 was used in Tissue/organ culture to establish a 3D pancreatic ductal adenocarcinoma (PDAC) model cultured under flow, consisting of an endothelial tube, pancreatic stellate cells and PDAC organoids.
Mon May 22 00:00:00 UTC 2023
Simultaneous establishment of pancreatic cancer organoid and cancer-associated fibroblast using a single-pass endoscopic ultrasound-guided fine-needle biopsy specimen.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Kim S,Woo KJ,Yang CM,Park SH,Hwang JC,Yoo BM,Kim JH,Lee D,Yang MJ
250-38 was used in Cell Culture to demonstrate that the coestablishment of PDOs and CAFs is feasible even with a single-pass EUS-FNB sample, implying an expanding role of endoscopists in future precision medicine.
Wed Nov 01 00:00:00 UTC 2023
Epithelial colonization by gut dendritic cells promotes their functional diversification.
Immunity
Rivera CA,Randrian V,Richer W,Gerber-Ferder Y,Delgado MG,Chikina AS,Frede A,Sorini C,Maurin M,Kammoun-Chaari H,Parigi SM,Goudot C,Cabeza-Cabrerizo M,Baulande S,Lameiras S,Guermonprez P,Reis e Sousa C,Lecuit M,Moreau HD,Helft J,Vignjevic DM,Villablanca EJ,Lennon-Duménil AM
250-38 was used in Tissue/organ culture to investigate How tissue-specific cues orchestrate Dendritic cells diversification.
Tue Jan 11 00:00:00 UTC 2022
The preference for sugar over sweetener depends on a gut sensor cell.
Nature neuroscience
Buchanan KL,Rupprecht LE,Kaelberer MM,Sahasrabudhe A,Klein ME,Villalobos JA,Liu WW,Yang A,Gelman J,Park S,Anikeeva P,Bohórquez DV
Tue Feb 01 00:00:00 UTC 2022
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
The Journal of experimental medicine
Drurey C,Lindholm HT,Coakley G,Poveda MC,Löser S,Doolan R,Gerbe F,Jay P,Harris N,Oudhoff MJ,Maizels RM
Mon Jan 03 00:00:00 UTC 2022
Different responses to DNA damage determine ageing differences between organs.
Aging cell
Vougioukalaki M,Demmers J,Vermeij WP,Baar M,Bruens S,Magaraki A,Kuijk E,Jager M,Merzouk S,Brandt RMC,Kouwenberg J,van Boxtel R,Cuppen E,Pothof J,Hoeijmakers JHJ
Fri Apr 01 00:00:00 UTC 2022
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.
Development (Cambridge, England)
Vrij EJ,Scholte Op Reimer YS,Roa Fuentes L,Misteli Guerreiro I,Holzmann V,Frias Aldeguer J,Sestini G,Koo BK,Kind J,van Blitterswijk CA,Rivron NC
250-38 was used in In vitro experiments to create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn) to suggest that self-organization can arise from lineage bifurcation followed by a pendulum of induction that propagates over time.
Sat Oct 15 00:00:00 UTC 2022
Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.
Nature communications
Igarashi N,Miyata K,Loo TM,Chiba M,Hanyu A,Nishio M,Kawasaki H,Zheng H,Toyokuni S,Kon S,Moriyama K,Fujita Y,Takahashi A
250-38 was used in Cell Culture to provide evidence that cellular senescence inhibits cell competition-mediated elimination of oncogenic cells through HGF signaling, suggesting that it may lead to cancer incidence during aging.
Mon Jul 18 00:00:00 UTC 2022
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Nature communications
Belenguer G,Mastrogiovanni G,Pacini C,Hall Z,Dowbaj AM,Arnes-Benito R,Sljukic A,Prior N,Kakava S,Bradshaw CR,Davies S,Vacca M,Saeb-Parsy K,Koo BK,Huch M
Mon Jan 17 00:00:00 UTC 2022
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation.
The Journal of experimental medicine
Chaves-Pérez A,Santos-de-Frutos K,de la Rosa S,Herranz-Montoya I,Perna C,Djouder N
250-38 was used in In vitro experiments to demonstrate that transit-amplifying (TA) cells, marked by unconventional prefoldin RPB5 interactor (URI), control R-spondin production to guide ISC proliferation.
Mon Nov 07 00:00:00 UTC 2022
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Nature communications
Sebastian C,Ferrer C,Serra M,Choi JE,Ducano N,Mira A,Shah MS,Stopka SA,Perciaccante AJ,Isella C,Moya-Rull D,Vara-Messler M,Giordano S,Maldi E,Desai N,Capen DE,Medico E,Cetinbas M,Sadreyev RI,Brown D,Rivera MN,Sapino A,Breault DT,Agar NYR,Mostoslavsky R
250-38 was used in Tissue/organ culture to investigate the role and mechanisms of SIRT6 in tumor suppression in mice.
Mon Mar 21 00:00:00 UTC 2022
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme.
eLife
Jacquemin G,Wurmser A,Huyghe M,Sun W,Homayed Z,Merle C,Perkins M,Qasrawi F,Richon S,Dingli F,Arras G,Loew D,Vignjevic D,Pannequin J,Fre S
250-38 was used in Cell Culture to reveal the THBS1-YAP axis as the mechanistic link mediating paracrine interactions between epithelial cells in intestinal tumours.
Wed May 11 00:00:00 UTC 2022
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.
Immunity
Saxton RA,Henneberg LT,Calafiore M,Su L,Jude KM,Hanash AM,Garcia KC
Tue Apr 13 00:00:00 UTC 2021
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
Nature cell biology
Böttcher A,Büttner M,Tritschler S,Sterr M,Aliluev A,Oppenländer L,Burtscher I,Sass S,Irmler M,Beckers J,Ziegenhain C,Enard W,Schamberger AC,Verhamme FM,Eickelberg O,Theis FJ,Lickert H
250-38 was used in Cell Culture to investigate the role Wnt/PCP signalling on intestinal stem cells.
Fri Jan 01 00:00:00 UTC 2021
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Nature cell biology
Chumduri C,Gurumurthy RK,Berger H,Dietrich O,Kumar N,Koster S,Brinkmann V,Hoffmann K,Drabkina M,Arampatzi P,Son D,Klemm U,Mollenkopf HJ,Herbst H,Mangler M,Vogel J,Saliba AE,Meyer TF
Mon Feb 01 00:00:00 UTC 2021
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Cell stem cell
Breunig M,Merkle J,Wagner M,Melzer MK,Barth TFE,Engleitner T,Krumm J,Wiedenmann S,Cohrs CM,Perkhofer L,Jain G,Krüger J,Hermann PC,Schmid M,Madácsy T,Varga Á,Griger J,Azoitei N,Müller M,Wessely O,Robey PG,Heller S,Dantes Z,Reichert M,Günes C,Bolenz C,Kuhn F,Maléth J,Speier S,Liebau S,Sipos B,Kuster B,Seufferlein T,Rad R,Meier M,Hohwieler M,Kleger A
250-38 was used in Cell Culture to show that PDLOs enable in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background.
Thu Jun 03 00:00:00 UTC 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Mon Apr 05 00:00:00 UTC 2021
Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
EMBO molecular medicine
Heuberger J,Trimpert J,Vladimirova D,Goosmann C,Lin M,Schmuck R,Mollenkopf HJ,Brinkmann V,Tacke F,Osterrieder N,Sigal M
Fri Apr 09 00:00:00 UTC 2021
A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Murakami K,Terakado Y,Saito K,Jomen Y,Takeda H,Oshima M,Barker N
Tue Jan 26 00:00:00 UTC 2021
SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis.
Oncogene
Tong K,Kothari OA,Haro KS,Panda A,Bandari MM,Carrick JN,Hur JJ,Zhang L,Chan CS,Xing J,Gatza ML,Ganesan S,Verzi MP
Fri Oct 01 00:00:00 UTC 2021
Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity.
Glia
Vaes JEG,van Kammen CM,Trayford C,van der Toorn A,Ruhwedel T,Benders MJNL,Dijkhuizen RM,Möbius W,van Rijt SH,Nijboer CH
250-38 was used in Cell Culture to show that MSCs adapt their secretome after ex vivo exposure to dWMI milieu and identified several factors including IGF1, EGF, LIF, and IL11 that potently boost OL maturation.
Mon Mar 01 00:00:00 UTC 2021
Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition.
Oncogenesis
Maru Y,Tanaka N,Tatsumi Y,Nakamura Y,Itami M,Hippo Y
Fri Jun 25 00:00:00 UTC 2021
Intestinal extracellular vesicles are altered by vertical sleeve gastrectomy.
American journal of physiology. Gastrointestinal and liver physiology
Myronovych A,Peck BCE,An M,Zhu J,Warm A,Kupe A,Lubman DM,Seeley RJ
Fri Jan 01 00:00:00 UTC 2021
Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types.
American journal of physiology. Gastrointestinal and liver physiology
Shanahan MT,Kanke M,Oyesola OO,Hung YH,Koch-Laskowski K,Singh AP,Peck BCE,Biraud M,Sheahan B,Cortes JE,Gong H,Sahoo DK,Cubitt R,Kurpios NA,Mochel JP,Allenspach K,McElroy SJ,Ding S,von Moltke J,Dekaney CM,Tait-Wojno ED,Sethupathy P
Wed Dec 01 00:00:00 UTC 2021
Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut.
Molecular systems biology
Triana S,Metz-Zumaran C,Ramirez C,Kee C,Doldan P,Shahraz M,Schraivogel D,Gschwind AR,Sharma AK,Steinmetz LM,Herrmann C,Alexandrov T,Boulant S,Stanifer ML
Thu Apr 01 00:00:00 UTC 2021
Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea.
Cell reports
Kubota M,Scheibinger M,Jan TA,Heller S
Tue Jan 19 00:00:00 UTC 2021
Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation.
Nature communications
Kok SY,Oshima H,Takahashi K,Nakayama M,Murakami K,Ueda HR,Miyazono K,Oshima M
Mon Feb 08 00:00:00 UTC 2021
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response.
Nature communications
Yen YT,Chien M,Wu PY,Ho CC,Ho CT,Huang KC,Chiang SF,Chao KSC,Chen WT,Hung SC
Wed Dec 15 00:00:00 UTC 2021
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Cell reports
Schild T,McReynolds MR,Shea C,Low V,Schaffer BE,Asara JM,Piskounova E,Dephoure N,Rabinowitz JD,Gomes AP,Blenis J
Tue Jun 15 00:00:00 UTC 2021
CREPT is required for murine stem cell maintenance during intestinal regeneration.
Nature communications
Yang L,Yang H,Chu Y,Song Y,Ding L,Zhu B,Zhai W,Wang X,Kuang Y,Ren F,Jia B,Wu W,Ye X,Wang Y,Chang Z
Mon Jan 11 00:00:00 UTC 2021
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Nature communications
Leach JDG,Vlahov N,Tsantoulis P,Ridgway RA,Flanagan DJ,Gilroy K,Sphyris N,Vázquez EG,Vincent DF,Faller WJ,Hodder MC,Raven A,Fey S,Najumudeen AK,Strathdee D,Nixon C,Hughes M,Clark W,Shaw R,van Hooff SR,Huels DJ,Medema JP,Barry ST,Frame MC,Unciti-Broceta A,Leedham SJ,Inman GJ,Jackstadt R,Thompson BJ,Campbell AD,Tejpar S,Sansom OJ
Tue Jun 08 00:00:00 UTC 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
Fri Feb 05 00:00:00 UTC 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
Fri Feb 05 00:00:00 UTC 2021
Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency.
Nature communications
Shin S,Zhou H,He C,Wei Y,Wang Y,Shingu T,Zeng A,Wang S,Zhou X,Li H,Zhang Q,Mo Q,Long J,Lan F,Chen Y,Hu J
Fri May 21 00:00:00 UTC 2021
Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and Pancreas.
International journal of molecular sciences
Tarquis-Medina M,Scheibner K,González-García I,Bastidas-Ponce A,Sterr M,Jaki J,Schirge S,García-Cáceres C,Lickert H,Bakhti M
250-38 was used in Cell Culture to investigate the role and mechanisms of Synaptotagmin-13 in mice.
Sat Nov 20 00:00:00 UTC 2021
Long noncoding RNA Meg3 sponges miR-708 to inhibit intestinal tumorigenesis via SOCS3-repressed cancer stem cells growth.
Cell death & disease
Zhang S,Ji WW,Wei W,Zhan LX,Huang X
Tue Dec 21 00:00:00 UTC 2021
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Nature communications
Nielsen SR,Strøbech JE,Horton ER,Jackstadt R,Laitala A,Bravo MC,Maltese G,Jensen ARD,Reuten R,Rafaeva M,Karim SA,Hwang CI,Arnes L,Tuveson DA,Sansom OJ,Morton JP,Erler JT
Mon Jun 07 00:00:00 UTC 2021
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Nature communications
Nielsen SR,Strøbech JE,Horton ER,Jackstadt R,Laitala A,Bravo MC,Maltese G,Jensen ARD,Reuten R,Rafaeva M,Karim SA,Hwang CI,Arnes L,Tuveson DA,Sansom OJ,Morton JP,Erler JT
Mon Jun 07 00:00:00 UTC 2021
Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis.
Cell death & disease
Gudiño V,Cammareri P,Billard CV,Myant KB
Sat Sep 25 00:00:00 UTC 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
Thu Jul 22 00:00:00 UTC 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications
Karkampouna S,La Manna F,Benjak A,Kiener M,De Menna M,Zoni E,Grosjean J,Klima I,Garofoli A,Bolis M,Vallerga A,Theurillat JP,De Filippo MR,Genitsch V,Keller D,Booij TH,Stirnimann CU,Eng K,Sboner A,Ng CKY,Piscuoglio S,Gray PC,Spahn M,Rubin MA,Thalmann GN,Kruithof-de Julio M
Thu Feb 18 00:00:00 UTC 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
Thu Jan 14 00:00:00 UTC 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
Thu Jan 14 00:00:00 UTC 2021
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.
Nature communications
Nishina T,Deguchi Y,Ohshima D,Takeda W,Ohtsuka M,Shichino S,Ueha S,Yamazaki S,Kawauchi M,Nakamura E,Nishiyama C,Kojima Y,Adachi-Akahane S,Hasegawa M,Nakayama M,Oshima M,Yagita H,Shibuya K,Mikami T,Inohara N,Matsushima K,Tada N,Nakano H
Fri Apr 16 00:00:00 UTC 2021
mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.
Cell reports
Li K,Wu H,Wang A,Charron J,Mishina Y,Habib SL,Liu H,Li B
Tue May 04 00:00:00 UTC 2021
Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells.
Journal of visualized experiments : JoVE
Shechtman LA,Piarowski CM,Scott JK,Golden EJ,Gaillard D,Barlow LA
250-38 was used in In vitro experiments to adapt previously published protocols and a standardized method for generating taste organoids from taste progenitor cells isolated from the circumvallate papilla (CVP) of adult mice is presented.
Mon Apr 05 00:00:00 UTC 2021
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Nature communications
Iftekhar A,Berger H,Bouznad N,Heuberger J,Boccellato F,Dobrindt U,Hermeking H,Sigal M,Meyer TF
Fri Feb 12 00:00:00 UTC 2021
Multiplexed single-cell analysis of organoid signaling networks.
Nature protocols
Sufi J,Qin X,Rodriguez FC,Bu YJ,Vlckova P,Zapatero MR,Nitz M,Tape CJ
Fri Oct 01 00:00:00 UTC 2021
miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine.
Nature communications
Goga A,Yagabasan B,Herrmanns K,Godbersen S,Silva PN,Denzler R,Zünd M,Furter M,Schwank G,Sunagawa S,Hardt WD,Stoffel M
Mon Jun 07 00:00:00 UTC 2021
A RAC-GEF network critical for early intestinal tumourigenesis.
Nature communications
Pickering KA,Gilroy K,Cassidy JW,Fey SK,Najumudeen AK,Zeiger LB,Vincent DF,Gay DM,Johansson J,Fordham RP,Miller B,Clark W,Hedley A,Unal EB,Kiel C,McGhee E,Machesky LM,Nixon C,Johnsson AE,Bain M,Strathdee D,van Hoof SR,Medema JP,Anderson KI,Brachmann SM,Stucke VM,Malliri A,Drysdale M,Turner M,Serrano L,Myant K,Campbell AD,Sansom OJ
Mon Jan 04 00:00:00 UTC 2021
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.
Nature communications
Gudiño V,Pohl SÖ,Billard CV,Cammareri P,Bolado A,Aitken S,Stevenson D,Hall AE,Agostino M,Cassidy J,Nixon C,von Kriegsheim A,Freile P,Popplewell L,Dickson G,Murphy L,Wheeler A,Dunlop M,Din F,Strathdee D,Sansom OJ,Myant KB
Tue Apr 20 00:00:00 UTC 2021
Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration.
Cell reports. Medicine
Mihi B,Gong Q,Nolan LS,Gale SE,Goree M,Hu E,Lanik WE,Rimer JM,Liu V,Parks OB,Lewis AN,Agrawal P,Laury ML,Kumar P,Huang E,Bidani SS,Luke CJ,Kolls JK,Good M
Tue Jun 15 00:00:00 UTC 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
250-38 was used in Cell Culture to establish an efficient human alveolosphere culture method and sphere-based drug testing platform for SARS-CoV-2.
Tue Jun 08 00:00:00 UTC 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
250-38 was used in Cell Culture to establish an efficient human alveolosphere culture method and sphere-based drug testing platform for SARS-CoV-2.
Tue Jun 08 00:00:00 UTC 2021
Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling.
Scientific reports
Abdullah A,Herdenberg C,Hedman H
Wed Apr 21 00:00:00 UTC 2021
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.
Communications biology
Herdenberg C,Mutie PM,Billing O,Abdullah A,Strawbridge RJ,Dahlman I,Tuck S,Holmlund C,Arner P,Henriksson R,Franks PW,Hedman H
Tue Jan 19 00:00:00 UTC 2021
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity.
Cell reports
Mana MD,Hussey AM,Tzouanas CN,Imada S,Barrera Millan Y,Bahceci D,Saiz DR,Webb AT,Lewis CA,Carmeliet P,Mihaylova MM,Shalek AK,Yilmaz ÖH
Tue Jun 08 00:00:00 UTC 2021
Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice.
Communications biology
Song L,Chang R,Sun X,Lu L,Gao H,Lu H,Lin R,Xu X,Liu Z,Zhan L
Tue Feb 16 00:00:00 UTC 2021
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Cell
Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW
250-38 was used in Cell Culture to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.
Thu Apr 16 00:00:00 UTC 2020
An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.
Cell
Kawasaki K,Toshimitsu K,Matano M,Fujita M,Fujii M,Togasaki K,Ebisudani T,Shimokawa M,Takano A,Takahashi S,Ohta Y,Nanki K,Igarashi R,Ishimaru K,Ishida H,Sukawa Y,Sugimoto S,Saito Y,Maejima K,Sasagawa S,Lee H,Kim HG,Ha K,Hamamoto J,Fukunaga K,Maekawa A,Tanabe M,Ishihara S,Hamamoto Y,Yasuda H,Sekine S,Kudo A,Kitagawa Y,Kanai T,Nakagawa H,Sato T
Wed Nov 25 00:00:00 UTC 2020
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Cell
Lai NY,Musser MA,Pinho-Ribeiro FA,Baral P,Jacobson A,Ma P,Potts DE,Chen Z,Paik D,Soualhi S,Yan Y,Misra A,Goldstein K,Lagomarsino VN,Nordstrom A,Sivanathan KN,Wallrapp A,Kuchroo VK,Nowarski R,Starnbach MN,Shi H,Surana NK,An D,Wu C,Huh JR,Rao M,Chiu IM
Thu Jan 09 00:00:00 UTC 2020
Cell-type-specific signaling networks in heterocellular organoids.
Nature methods
Qin X,Sufi J,Vlckova P,Kyriakidou P,Acton SE,Li VSW,Nitz M,Tape CJ
Sun Mar 01 00:00:00 UTC 2020
Lineage Reversion Drives WNT Independence in Intestinal Cancer.
Cancer discovery
Han T,Goswami S,Hu Y,Tang F,Zafra MP,Murphy C,Cao Z,Poirier JT,Khurana E,Elemento O,Hechtman JF,Ganesh K,Yaeger R,Dow LE
250-38 was used in Tissue/organ culture to show that the accumulation of colorectal cancer-associated genetic alterations enables drug resistance and WNT-independent growth.
Thu Oct 01 00:00:00 UTC 2020
The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling.
Gastroenterology
Chen B,Dragomir MP,Fabris L,Bayraktar R,Knutsen E,Liu X,Tang C,Li Y,Shimura T,Ivkovic TC,De Los Santos MC,Anfossi S,Shimizu M,Shah MY,Ling H,Shen P,Multani AS,Pardini B,Burks JK,Katayama H,Reineke LC,Huo L,Syed M,Song S,Ferracin M,Oki E,Fromm B,Ivan C,Bhuvaneshwar K,Gusev Y,Mimori K,Menter D,Sen S,Matsuyama T,Uetake H,Vasilescu C,Kopetz S,Parker-Thornburg J,Taguchi A,Hanash SM,Girnita L,Slaby O,Goel A,Varani G,Gagea M,Li C,Ajani JA,Calin GA
250-38 was used in Cell Culture to study the relationship between the colon cancer-associated transcript 2 gene encoded long noncoding RNA and the development of chromosomal instability.
Tue Dec 01 00:00:00 UTC 2020
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Cell metabolism
Bensard CL,Wisidagama DR,Olson KA,Berg JA,Krah NM,Schell JC,Nowinski SM,Fogarty S,Bott AJ,Wei P,Dove KK,Tanner JM,Panic V,Cluntun A,Lettlova S,Earl CS,Namnath DF,Vázquez-Arreguín K,Villanueva CJ,Tantin D,Murtaugh LC,Evason KJ,Ducker GS,Thummel CS,Rutter J
250-38 was used in Cell Culture to study how the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (MPC), which couples glycolysis and glucose oxidation through mitochondrial pyruvate import, suggetsing that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation.
Tue Feb 04 00:00:00 UTC 2020
Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages.
Nature cell biology
Sato T,Ishikawa S,Asano J,Yamamoto H,Fujii M,Sato T,Yamamoto K,Kitagaki K,Akashi T,Okamoto R,Ohteki T
Sat Aug 01 00:00:00 UTC 2020
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.
Cell stem cell
Katsura H,Sontake V,Tata A,Kobayashi Y,Edwards CE,Heaton BE,Konkimalla A,Asakura T,Mikami Y,Fritch EJ,Lee PJ,Heaton NS,Boucher RC,Randell SH,Baric RS,Tata PR
250-38 was used in In vitro experiments to report a feeder-free, scalable, chemically defined, and modular alveolosphere culture system for the propagation and differentiation of human alveolar type 2 cells/pneumocytes derived from primary lung tissue.
Thu Dec 03 00:00:00 UTC 2020
Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Cell stem cell
Li Q,Sun Y,Jarugumilli GK,Liu S,Dang K,Cotton JL,Xiol J,Chan PY,DeRan M,Ma L,Li R,Zhu LJ,Li JH,Leiter AB,Ip YT,Camargo FD,Luo X,Johnson RL,Wu X,Mao J
250-38 was used in Tissue/organ culture to demonstrate if Lats1/2, the core Hippo kinases, are essential to maintain Wnt pathway activity and intestinal stem cells.
Thu May 07 00:00:00 UTC 2020
Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia.
The Journal of clinical investigation
Pinzon-Guzman C,Sangadala S,Riera KM,Popova EY,Manning E,Huh WJ,Alexander MS,Shelton JS,Boden SD,Goldenring JR
Mon Aug 03 00:00:00 UTC 2020
Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency.
The EMBO journal
Sun H,Yang X,Liang L,Zhang M,Li Y,Chen J,Wang F,Yang T,Meng F,Lai X,Li C,He J,He M,Xu Q,Li Q,Lin L,Pei D,Zheng H
Wed Apr 15 00:00:00 UTC 2020
LGR5 controls extracellular matrix production by stem cells in the developing intestine.
EMBO reports
Fernandez Vallone V,Leprovots M,Ribatallada-Soriano D,Gerbier R,Lefort A,Libert F,Vassart G,Garcia MI
Fri Jul 03 00:00:00 UTC 2020
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
Wed Feb 05 00:00:00 UTC 2020
3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis.
Frontiers in cell and developmental biology
Rabata A,Fedr R,Soucek K,Hampl A,Koledova Z
250-38 was used in Tissue/organ culture to present lung 3D cell culture models as useful tools to study the role and interplay of signaling pathways in postnatal lung development and homeostasis, and we reveal distinct roles for FGF ligands in regulation of mouse lung morphogenesis and differentiation ex vivo.
Wed Jul 31 00:00:00 UTC 2024
Regulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hou Q,Dong Y,Yu Q,Wang B,Le S,Guo Y,Zhang B
Sat Aug 01 00:00:00 UTC 2020
A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells.
Genesis (New York, N.Y. : 2000)
van de Moosdijk AAA,van de Grift YBC,de Man SMA,Zeeman AL,van Amerongen R
Tue Sep 01 00:00:00 UTC 2020
Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron.
Cell death & disease
Seiwert N,Wecklein S,Demuth P,Hasselwander S,Kemper TA,Schwerdtle T,Brunner T,Fahrer J
Wed Sep 23 00:00:00 UTC 2020
microRNA-181c-5p promotes the formation of insulin-producing cells from human induced pluripotent stem cells by targeting smad7 and TGIF2.
Cell death & disease
Li N,Jiang D,He Q,He F,Li Y,Deng C,Li F
Mon Jun 15 00:00:00 UTC 2020
TIGAR/AP-1 axis accelerates the division of Lgr5- reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation.
Cell death & disease
Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C
Mon Jul 06 00:00:00 UTC 2020
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Nature communications
Grinat J,Heuberger J,Vidal RO,Goveas N,Kosel F,Berenguer-Llergo A,Kranz A,Wulf-Goldenberg A,Behrens D,Melcher B,Sauer S,Vieth M,Batlle E,Stewart AF,Birchmeier W
Mon Dec 21 00:00:00 UTC 2020
Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells.
The Journal of biological chemistry
Lim KS,Yong ZWE,Wang H,Tan TZ,Huang RY,Yamamoto D,Inaki N,Hazawa M,Wong RW,Oshima H,Oshima M,Ito Y,Voon DC
Fri May 08 00:00:00 UTC 2020
A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses.
Redox biology
Okkelman IA,Neto N,Papkovsky DB,Monaghan MG,Dmitriev RI
250-38 was used in Tissue/organ culture to study the redox metabolism of Lgr5-GFP intestinal organoids by combined analysis of fluorescence-based FLIM for NAD(P)H and organoid oxygenation by phosphorescence-based PLIM,.
Sat Feb 01 00:00:00 UTC 2020
In vitro Self-organized Mouse Small Intestinal Epithelial Monolayer Protocol.
Bio-protocol
Altay G,Batlle E,Fernández-Majada V,Martinez E
250-38 was used in Cell Culture to investigate organoid geometry in models of intestinal epithelial monolayers.
Wed Feb 05 00:00:00 UTC 2020
MicroRNA-674-5p induced by HIF-1α targets XBP-1 in intestinal epithelial cell injury during endotoxemia.
Cell death discovery
Liu Z,Jiang J,Dai W,Wei H,Zhang X,Yang Z,Xiong Y
Tue Sep 26 00:00:00 UTC 2023
Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK Activation.
Cellular and molecular gastroenterology and hepatology
Sheng W,Malagola E,Nienhüser H,Zhang Z,Kim W,Zamechek L,Sepulveda A,Hata M,Hayakawa Y,Zhao CM,Chen D,Wang TC
250-38 was used in Cell Culture to study the genes involved in the mechanisms that lead to hypergastrinemia in enterochromaffin-like cells.
Fri Jul 09 00:00:00 UTC 2021
Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.
Nature communications
Claudinot S,Sakabe JI,Oshima H,Gonneau C,Mitsiadis T,Littman D,Bonfanti P,Martens G,Nicolas M,Rochat A,Barrandon Y
Fri Nov 06 00:00:00 UTC 2020
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Nature communications
Tsukiyama T,Zou J,Kim J,Ogamino S,Shino Y,Masuda T,Merenda A,Matsumoto M,Fujioka Y,Hirose T,Terai S,Takahashi H,Ishitani T,Nakayama KI,Ohba Y,Koo BK,Hatakeyama S
Tue Sep 15 00:00:00 UTC 2020
Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche.
Nature communications
Middelhoff M,Nienhüser H,Valenti G,Maurer HC,Hayakawa Y,Takahashi R,Kim W,Jiang Z,Malagola E,Cuti K,Tailor Y,Zamechek LB,Renz BW,Quante M,Yan KS,Wang TC
Wed Jan 08 00:00:00 UTC 2020
Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids.
Nature communications
Schuster B,Junkin M,Kashaf SS,Romero-Calvo I,Kirby K,Matthews J,Weber CR,Rzhetsky A,White KP,Tay S
Mon Oct 19 00:00:00 UTC 2020
TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis.
eLife
Chen M,Amado N,Tan J,Reis A,Ge M,Abreu JG,He X
250-38 was used in In vitro experiments to identify, via CRISPR/Cas9 genome-wide loss-of function screening, an orphan five-pass transmembrane protein TMEM79 (also called MATTRIN), as a specific antagonist of Wnt signaling.
Mon Sep 14 00:00:00 UTC 2020
Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties.
Nature communications
Nakayama M,Hong CP,Oshima H,Sakai E,Kim SJ,Oshima M
Mon May 11 00:00:00 UTC 2020
Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.
Cancers
Holokai L,Chakrabarti J,Lundy J,Croagh D,Adhikary P,Richards SS,Woodson C,Steele N,Kuester R,Scott A,Khreiss M,Frankel T,Merchant J,Jenkins BJ,Wang J,Shroff RT,Ahmad SA,Zavros Y
250-38 was used in Cell Culture to develop a clinically relevant in vitro organoid model to specifically target mechanisms that deplete myeloid-derived suppressor cells as a therapeutic strategy for pancreatic ductal adenocarcinoma.
Thu Dec 17 00:00:00 UTC 2020
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Cell reports
Stanifer ML,Kee C,Cortese M,Zumaran CM,Triana S,Mukenhirn M,Kraeusslich HG,Alexandrov T,Bartenschlager R,Boulant S
Tue Jul 07 00:00:00 UTC 2020
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Cell reports
Stanifer ML,Kee C,Cortese M,Zumaran CM,Triana S,Mukenhirn M,Kraeusslich HG,Alexandrov T,Bartenschlager R,Boulant S
Tue Jul 07 00:00:00 UTC 2020
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science advances
Zwiggelaar RT,Lindholm HT,Fosslie M,Terndrup Pedersen M,Ohta Y,Díez-Sánchez A,Martín-Alonso M,Ostrop J,Matano M,Parmar N,Kvaløy E,Spanjers RR,Nazmi K,Rye M,Drabløs F,Arrowsmith C,Arne Dahl J,Jensen KB,Sato T,Oudhoff MJ
250-38 was used in Tissue/organ culture to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures.
Tue Sep 01 00:00:00 UTC 2020
Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine.
Scientific reports
Sato T,Sase M,Ishikawa S,Kajita M,Asano J,Sato T,Mori Y,Ohteki T
Fri May 22 00:00:00 UTC 2020
Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.
Cell
Cheng CW,Biton M,Haber AL,Gunduz N,Eng G,Gaynor LT,Tripathi S,Calibasi-Kocal G,Rickelt S,Butty VL,Moreno-Serrano M,Iqbal AM,Bauer-Rowe KE,Imada S,Ulutas MS,Mylonas C,Whary MT,Levine SS,Basbinar Y,Hynes RO,Mino-Kenudson M,Deshpande V,Boyer LA,Fox JG,Terranova C,Rai K,Piwnica-Worms H,Mihaylova MM,Regev A,Yilmaz ÖH
Thu Aug 22 00:00:00 UTC 2019
A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.
Nature genetics
Chen L,Toke NH,Luo S,Vasoya RP,Fullem RL,Parthasarathy A,Perekatt AO,Verzi MP
250-38 was used in Cell Culture to investigate the function of SMAD4 and HNF4 on feed-forward regulatory module enterocyte identity.
Wed May 01 00:00:00 UTC 2019
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.
Cancer cell
Reina-Campos M,Linares JF,Duran A,Cordes T,L'Hermitte A,Badur MG,Bhangoo MS,Thorson PK,Richards A,Rooslid T,Garcia-Olmo DC,Nam-Cha SY,Salinas-Sanchez AS,Eng K,Beltran H,Scott DA,Metallo CM,Moscat J,Diaz-Meco MT
Mon Mar 18 00:00:00 UTC 2019
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Cancer cell
Jackstadt R,van Hooff SR,Leach JD,Cortes-Lavaud X,Lohuis JO,Ridgway RA,Wouters VM,Roper J,Kendall TJ,Roxburgh CS,Horgan PG,Nixon C,Nourse C,Gunzer M,Clark W,Hedley A,Yilmaz OH,Rashid M,Bailey P,Biankin AV,Campbell AD,Adams DJ,Barry ST,Steele CW,Medema JP,Sansom OJ
Mon Sep 16 00:00:00 UTC 2019
Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Cancer discovery
Schatoff EM,Goswami S,Zafra MP,Foronda M,Shusterman M,Leach BI,Katti A,Diaz BJ,Dow LE
250-38 was used in Cell Culture to use new animal models, human cell lines, and ex vivo organoid cultures, to show that tankyrase (TNKS) inhibition can control WNT hyperactivation and provide long-term tumor control in vivo, but that effective responses are critically dependent on how adenomatous polyposis coli (APC) is disrupted.
Tue Oct 01 00:00:00 UTC 2019
Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1.
Cell host & microbe
Liang S,Guo XK,Ou J,Huang R,Xue Q,Zhang B,Chung Y,Wu W,Dong C,Yang X,Hu X
250-38 was used in Cell Culture to uncover a regulatory circuit that couples host nutrient status to epithelial antimicrobial immunity.
Wed May 08 00:00:00 UTC 2019
Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.
The Journal of clinical investigation
Meir M,Burkard N,Ungewiß H,Diefenbacher M,Flemming S,Kannapin F,Germer CT,Schweinlin M,Metzger M,Waschke J,Schlegel N
Mon Jun 17 00:00:00 UTC 2019
NAD+ supplementation rejuvenates aged gut adult stem cells.
Aging cell
Igarashi M,Miura M,Williams E,Jaksch F,Kadowaki T,Yamauchi T,Guarente L
Sat Jun 01 00:00:00 UTC 2019
Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11.
American journal of physiology. Cell physiology
Katsumi T,Guicciardi ME,Azad A,Bronk SF,Krishnan A,Gores GJ
Tue Oct 01 00:00:00 UTC 2019
Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.
Cell death & disease
Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S
Thu Sep 26 00:00:00 UTC 2019
BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration.
Nature communications
Liu M,Sun T,Li N,Peng J,Fu D,Li W,Li L,Gao WQ
Thu Oct 10 00:00:00 UTC 2019
Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Nature communications
Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N
Tue Nov 26 00:00:00 UTC 2019
Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression.
Scientific reports
Kabakci Z,Käppeli S,Cantù C,Jensen LD,König C,Toggweiler J,Gentili C,Ribaudo G,Zagotto G,Basler K,Pinna LA,Cozza G,Ferrari S
Mon Feb 04 00:00:00 UTC 2019
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms.
Cell death & disease
Priem D,Devos M,Druwé S,Martens A,Slowicka K,Ting AT,Pasparakis M,Declercq W,Vandenabeele P,van Loo G,Bertrand MJM
Wed Sep 18 00:00:00 UTC 2019
Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation.
Scientific reports
Khare V,Krnjic A,Frick A,Gmainer C,Asboth M,Jimenez K,Lang M,Baumgartner M,Evstatiev R,Gasche C
Tue Feb 26 00:00:00 UTC 2019
Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.
Nature communications
Gay DM,Ridgway RA,Müller M,Hodder MC,Hedley A,Clark W,Leach JD,Jackstadt R,Nixon C,Huels DJ,Campbell AD,Bird TG,Sansom OJ
Wed Feb 13 00:00:00 UTC 2019
Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids.
Scientific reports
Yokoi Y,Nakamura K,Yoneda T,Kikuchi M,Sugimoto R,Shimizu Y,Ayabe T
Mon Feb 25 00:00:00 UTC 2019
Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
Cellular and molecular gastroenterology and hepatology
Jones JC,Brindley CD,Elder NH,Myers MG,Rajala MW,Dekaney CM,McNamee EN,Frey MR,Shroyer NF,Dempsey PJ
250-38 was used in In vitro experiments to show that Defa4Cre-expressing Paneth cells possess cellular plasticity, can dedifferentiate into multipotent stem cells upon Notch activation, and can contribute to intestinal regeneration in an acute injury model.
Tue Jun 04 00:00:00 UTC 2019
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
Nature communications
Soutto M,Chen Z,Bhat AA,Wang L,Zhu S,Gomaa A,Bates A,Bhat NS,Peng D,Belkhiri A,Piazuelo MB,Washington MK,Steven XC,Peek R,El-Rifai W
Wed Jul 10 00:00:00 UTC 2019
Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro.
Nature communications
Feldman A,Mukha D,Maor II,Sedov E,Koren E,Yosefzon Y,Shlomi T,Fuchs Y
Tue May 28 00:00:00 UTC 2019
Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.
Cell discovery
Cai Y,Zhu G,Liu S,Pan Z,Quintero M,Poole CJ,Lu C,Zhu H,Islam B,Riggelen JV,Browning D,Liu K,Blumberg R,Singh N,Li H
Thu Oct 01 00:00:00 UTC 2020
Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.
NPJ Regenerative medicine
Weiner AI,Jackson SR,Zhao G,Quansah KK,Farshchian JN,Neupauer KM,Littauer EQ,Paris AJ,Liberti DC,Scott Worthen G,Morrisey EE,Vaughan AE
Tue Sep 29 00:00:00 UTC 2020
Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine.
Communications biology
Kawaguchi M,Yamamoto K,Takeda N,Fukushima T,Yamashita F,Sato K,Kitamura K,Hippo Y,Janetka JW,Kataoka H
Tue May 05 00:00:00 UTC 2020
Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation.
Scientific reports
Fujiwara H,Tateishi K,Misumi K,Hayashi A,Igarashi K,Kato H,Nakatsuka T,Suzuki N,Yamamoto K,Kudo Y,Hayakawa Y,Nakagawa H,Tanaka Y,Ijichi H,Kogure H,Nakai Y,Isayama H,Hasegawa K,Fukayama M,Soga T,Koike K
Wed Dec 11 00:00:00 UTC 2019
A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Life science alliance
Heuberger J,Hill U,Förster S,Zimmermann K,Malchin V,Kühl AA,Stein U,Vieth M,Birchmeier W,Leutz A
250-38 was used in Cell Culture to suggest homeostatic and oncogenic suppressor functions of C/EBPα in the gut by restricting Wnt signaling.
Fri Feb 01 00:00:00 UTC 2019
Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function.
Scientific reports
Altay G,Larrañaga E,Tosi S,Barriga FM,Batlle E,Fernández-Majada V,Martínez E
Fri Jul 12 00:00:00 UTC 2019
Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease.
Scientific reports
Filippini D,Agosto S,Delfino P,Simbolo M,Piro G,Rusev B,Veghini L,Cantù C,Lupo F,Ugel S,De Sanctis F,Bronte V,Milella M,Tortora G,Scarpa A,Carbone C,Corbo V
Thu Aug 22 00:00:00 UTC 2019
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Cell
Biton M,Haber AL,Rogel N,Burgin G,Beyaz S,Schnell A,Ashenberg O,Su CW,Smillie C,Shekhar K,Chen Z,Wu C,Ordovas-Montanes J,Alvarez D,Herbst RH,Zhang M,Tirosh I,Dionne D,Nguyen LT,Xifaras ME,Shalek AK,von Andrian UH,Graham DB,Rozenblatt-Rosen O,Shi HN,Kuchroo V,Yilmaz OH,Regev A,Xavier RJ
Thu Nov 15 00:00:00 UTC 2018
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
Cell
Nanki K,Toshimitsu K,Takano A,Fujii M,Shimokawa M,Ohta Y,Matano M,Seino T,Nishikori S,Ishikawa K,Kawasaki K,Togasaki K,Takahashi S,Sukawa Y,Ishida H,Sugimoto S,Kawakubo H,Kim J,Kitagawa Y,Sekine S,Koo BK,Kanai T,Sato T
Thu Aug 09 00:00:00 UTC 2018
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.
Cell
Kinchen J,Chen HH,Parikh K,Antanaviciute A,Jagielowicz M,Fawkner-Corbett D,Ashley N,Cubitt L,Mellado-Gomez E,Attar M,Sharma E,Wills Q,Bowden R,Richter FC,Ahern D,Puri KD,Henault J,Gervais F,Koohy H,Simmons A
Thu Oct 04 00:00:00 UTC 2018
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.
Immunity
Nakanishi Y,Duran A,L'Hermitte A,Shelton PM,Nakanishi N,Reina-Campos M,Huang J,Soldevila F,Baaten BJG,Tauriello DVF,Castilla EA,Bhangoo MS,Bao F,Sigal D,Diaz-Meco MT,Moscat J
Tue Dec 18 00:00:00 UTC 2018
Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor.
Cancer cell
Huang J,Duran A,Reina-Campos M,Valencia T,Castilla EA,Müller TD,Tschöp MH,Moscat J,Diaz-Meco MT
Mon Apr 09 00:00:00 UTC 2018
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.
Cell stem cell
Mihaylova MM,Cheng CW,Cao AQ,Tripathi S,Mana MD,Bauer-Rowe KE,Abu-Remaileh M,Clavain L,Erdemir A,Lewis CA,Freinkman E,Dickey AS,La Spada AR,Huang Y,Bell GW,Deshpande V,Carmeliet P,Katajisto P,Sabatini DM,Yilmaz ÖH
250-38 was used in Cell Culture to study the role of adult stem and progenitor cells in responding to short-term fasting and investigate whether such responses improve regeneration.
Thu May 03 00:00:00 UTC 2018
Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis.
Cell stem cell
Wang B,Rong X,Palladino END,Wang J,Fogelman AM,Martín MG,Alrefai WA,Ford DA,Tontonoz P
250-38 was used in Cell Culture to study the association between membrane phospholipid remodeling and cholesterol biosynthesis, and demonstrate the role of cholesterol as a mitogen for intestinal stem cells (ISC), to investigate the specific regulatory relationships between membrane composition, ISC proliferation, and tumorigenesis.
Thu Feb 01 00:00:00 UTC 2018
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.
Cell stem cell
Yui S,Azzolin L,Maimets M,Pedersen MT,Fordham RP,Hansen SL,Larsen HL,Guiu J,Alves MRP,Rundsten CF,Johansen JV,Li Y,Madsen CD,Nakamura T,Watanabe M,Nielsen OH,Schweiger PJ,Piccolo S,Jensen KB
250-38 was used in Cell Culture to demonstrate that the epithelium is transiently reprogrammed into a primitive state during colonic regeneration.
Thu Jan 04 00:00:00 UTC 2018
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
The Journal of experimental medicine
Buczacki SJA,Popova S,Biggs E,Koukorava C,Buzzelli J,Vermeulen L,Hazelwood L,Francies H,Garnett MJ,Winton DJ
Mon Jul 02 00:00:00 UTC 2018
Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.
The Journal of experimental medicine
Kanaya T,Sakakibara S,Jinnohara T,Hachisuka M,Tachibana N,Hidano S,Kobayashi T,Kimura S,Iwanaga T,Nakagawa T,Katsuno T,Kato N,Akiyama T,Sato T,Williams IR,Ohno H
Mon Feb 05 00:00:00 UTC 2018
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
The Journal of experimental medicine
Schmidt S,Schumacher N,Schwarz J,Tangermann S,Kenner L,Schlederer M,Sibilia M,Linder M,Altendorf-Hofmann A,Knösel T,Gruber ES,Oberhuber G,Bolik J,Rehman A,Sinha A,Lokau J,Arnold P,Cabron AS,Zunke F,Becker-Pauly C,Preaudet A,Nguyen P,Huynh J,Afshar-Sterle S,Chand AL,Westermann J,Dempsey PJ,Garbers C,Schmidt-Arras D,Rosenstiel P,Putoczki T,Ernst M,Rose-John S
Mon Apr 02 00:00:00 UTC 2018
A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
The Journal of experimental medicine
Kattah MG,Shao L,Rosli YY,Shimizu H,Whang MI,Advincula R,Achacoso P,Shah S,Duong BH,Onizawa M,Tanbun P,Malynn BA,Ma A
Mon Jul 02 00:00:00 UTC 2018
Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche.
Developmental cell
Chee YC,Pahnke J,Bunte R,Adsool VA,Madan B,Virshup DM
250-38 was used in Cell Culture to investigate intestinal myofibroblast xenobiotic resistance.
Mon Sep 24 00:00:00 UTC 2018
PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis.
Developmental cell
Kim MJ,Xia B,Suh HN,Lee SH,Jun S,Lien EM,Zhang J,Chen K,Park JI
250-38 was used in Cell Culture to unveil that the PAF-Myc signaling axis is indispensable for intestinal regeneration and tumorigenesis by positively regulating self-renewing cells.
Mon Mar 12 00:00:00 UTC 2018
Notch Signaling Regulates Lgr5+ Olfactory Epithelium Progenitor/Stem Cell Turnover and Mediates Recovery of Lesioned Olfactory Epithelium in Mouse Model.
Stem cells (Dayton, Ohio)
Dai Q,Duan C,Ren W,Li F,Zheng Q,Wang L,Li W,Lu X,Ni W,Zhang Y,Chen Y,Wen T,Yu Y,Yu H
Wed Aug 01 00:00:00 UTC 2018
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell stem cell
Fujii M,Matano M,Toshimitsu K,Takano A,Mikami Y,Nishikori S,Sugimoto S,Sato T
250-38 was used in Tissue/organ culture to investigate maintenance of intestinal organoid culture with reflective cellular diversity.
Thu Dec 06 00:00:00 UTC 2018
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Nature communications
Fellows R,Denizot J,Stellato C,Cuomo A,Jain P,Stoyanova E,Balázsi S,Hajnády Z,Liebert A,Kazakevych J,Blackburn H,Corrêa RO,Fachi JL,Sato FT,Ribeiro WR,Ferreira CM,Perée H,Spagnuolo M,Mattiuz R,Matolcsi C,Guedes J,Clark J,Veldhoen M,Bonaldi T,Vinolo MAR,Varga-Weisz P
Tue Jan 09 00:00:00 UTC 2018
ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Nature communications
Koren E,Yosefzon Y,Ankawa R,Soteriou D,Jacob A,Nevelsky A,Ben-Yosef R,Bar-Sela G,Fuchs Y
Fri Nov 02 00:00:00 UTC 2018
Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers.
Scientific reports
Ohtsuka J,Oshima H,Ezawa I,Abe R,Oshima M,Ohki R
Fri Feb 02 00:00:00 UTC 2018
Mature enteroendocrine cells contribute to basal and pathological stem cell dynamics in the small intestine.
American journal of physiology. Gastrointestinal and liver physiology
Sei Y,Feng J,Samsel L,White A,Zhao X,Yun S,Citrin D,McCoy JP,Sundaresan S,Hayes MM,Merchant JL,Leiter A,Wank SA
250-38 was used in Tissue/organ culture to study a mechanism in which a specified cell can dedifferentiate and contribute to normal tissue plasticity as well as the development of EEC-derived intestinal tumors under pathologic conditions.
Mon Oct 01 00:00:00 UTC 2018
Reconstruction of the Human Colon Epithelium In Vivo.
Cell stem cell
Sugimoto S,Ohta Y,Fujii M,Matano M,Shimokawa M,Nanki K,Date S,Nishikori S,Nakazato Y,Nakamura T,Kanai T,Sato T
250-38 was used in Cell Culture to study the spatiotemporal dynamics of human colon stem cells (CoSCs) in vivo by establishing an orthotopic xenograft system for normal human colon organoids, enabling stable reconstruction of the human colon epithelium in vivo.
Thu Feb 01 00:00:00 UTC 2018
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
250-38 was used in Cell Culture to identify the mechanism by which activating transcription factor 3 mediates a cross-regulation in the barrier to maintain mucosal homeostasis and immunity.
Thu Sep 26 00:00:00 UTC 2019
TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.
eLife
Ramachandran A,Vizán P,Das D,Chakravarty P,Vogt J,Rogers KW,Müller P,Hinck AP,Sapkota GP,Hill CS
250-38 was used in Cell Culture to show that TGF-β-induced epithelial-to-mesenchymal transition requires signaling via both the SMAD3 and SMAD1/5 pathways, with SMAD1/5 signaling being essential to induce ID1.
Mon Jan 29 00:00:00 UTC 2018
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
Cell reports
Somerville TDD,Xu Y,Miyabayashi K,Tiriac H,Cleary CR,Maia-Silva D,Milazzo JP,Tuveson DA,Vakoc CR
250-38 was used in Cell Culture to investigate the effects of transcription factor TP63 expression and reprogramming on pancreatic ductal adenocarcinoma.
Tue Nov 13 00:00:00 UTC 2018
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.
Nature communications
López-Arribillaga E,Rodilla V,Colomer C,Vert A,Shelton A,Cheng JH,Yan B,Gonzalez-Perez A,Junttila MR,Iglesias M,Torres F,Albanell J,Villanueva A,Bigas A,Siebel CW,Espinosa L
Tue Jul 31 00:00:00 UTC 2018
Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.
Nature communications
Muta Y,Fujita Y,Sumiyama K,Sakurai A,Taketo MM,Chiba T,Seno H,Aoki K,Matsuda M,Imajo M
Tue Jun 05 00:00:00 UTC 2018
Knockdown of lncRNA H19 inhibits abnormal differentiation of small intestinal epithelial cells in diabetic mice.
Journal of cellular physiology
Shan TD,Lv SY,Tian ZB,Liu XS,Liu FG,Sun XG
250-38 was used in Cell Culture to provide the first evidence supporting the role of H19 in IECs of DM mice, and miR-141-3p targets not only protein-coding genes but also the lncRNA H19.
Mon Jan 01 00:00:00 UTC 2018
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
Cell
Bellono NW,Bayrer JR,Leitch DB,Castro J,Zhang C,O'Donnell TA,Brierley SM,Ingraham HA,Julius D
Thu Jun 29 00:00:00 UTC 2017
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Cell
Roe JS,Hwang CI,Somerville TDD,Milazzo JP,Lee EJ,Da Silva B,Maiorino L,Tiriac H,Young CM,Miyabayashi K,Filippini D,Creighton B,Burkhart RA,Buscaglia JM,Kim EJ,Grem JL,Lazenby AJ,Grunkemeyer JA,Hollingsworth MA,Grandgenett PM,Egeblad M,Park Y,Tuveson DA,Vakoc CR
250-38 was used in Cell Culture to use an organoid culture system to investigate how transcription and the enhancer landscape become altered during discrete stages of disease progression in a PDA mouse model.
Thu Aug 24 00:00:00 UTC 2017
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.
Cell host & microbe
Tsai PY,Zhang B,He WQ,Zha JM,Odenwald MA,Singh G,Tamura A,Shen L,Sailer A,Yeruva S,Kuo WT,Fu YX,Tsukita S,Turner JR
250-38 was used in Cell Culture to investigate the pathogenic effects of diarrhea.
Wed Jun 14 00:00:00 UTC 2017
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
The Journal of experimental medicine
Öhlund D,Handly-Santana A,Biffi G,Elyada E,Almeida AS,Ponz-Sarvise M,Corbo V,Oni TE,Hearn SA,Lee EJ,Chio II,Hwang CI,Tiriac H,Baker LA,Engle DD,Feig C,Kultti A,Egeblad M,Fearon DT,Crawford JM,Clevers H,Park Y,Tuveson DA
Mon Mar 06 00:00:00 UTC 2017
IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.
The Journal of experimental medicine
Jinnohara T,Kanaya T,Hase K,Sakakibara S,Kato T,Tachibana N,Sasaki T,Hashimoto Y,Sato T,Watarai H,Kunisawa J,Shibata N,Williams IR,Kiyono H,Ohno H
Mon Jun 05 00:00:00 UTC 2017
ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis.
The EMBO journal
Horiguchi H,Endo M,Kawane K,Kadomatsu T,Terada K,Morinaga J,Araki K,Miyata K,Oike Y
Wed Feb 15 00:00:00 UTC 2017
TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.
Cell death and differentiation
Cammareri P,Vincent DF,Hodder MC,Ridgway RA,Murgia C,Nobis M,Campbell AD,Varga J,Huels DJ,Subramani C,Prescott KLH,Nixon C,Hedley A,Barry ST,Greten FR,Inman GJ,Sansom OJ
Sun Oct 01 00:00:00 UTC 2017
IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery V,Goldson AJ,Dainty JR,Chieppa M,Sobolewski A
Sat Jul 01 00:00:00 UTC 2017
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Nature communications
Han T,Schatoff EM,Murphy C,Zafra MP,Wilkinson JE,Elemento O,Dow LE
250-38 was used in Tissue/organ culture to investigate a CRISPR-Cas9 model of colon cancer-associated chromosome rearrangements.
Tue Jul 11 00:00:00 UTC 2017
Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status.
The Journal of biological chemistry
Peck BC,Mah AT,Pitman WA,Ding S,Lund PK,Sethupathy P
Fri Feb 17 00:00:00 UTC 2017
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal.
Molecular systems biology
Chen KY,Srinivasan T,Tung KL,Belmonte JM,Wang L,Murthy PKL,Choi J,Rakhilin N,King S,Varanko AK,Witherspoon M,Nishimura N,Glazier JA,Lipkin SM,Bu P,Shen X
Fri Apr 28 00:00:00 UTC 2017
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.
The Journal of biological chemistry
Carmon KS,Gong X,Yi J,Wu L,Thomas A,Moore CM,Masuho I,Timson DJ,Martemyanov KA,Liu QJ
Fri Sep 08 00:00:00 UTC 2017
Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions.
Cell chemical biology
Dietrich L,Rathmer B,Ewan K,Bange T,Heinrichs S,Dale TC,Schade D,Grossmann TN
250-38 was used in Tissue/organ culture to develop a stapled peptide inhibitor that targets the interaction between β-catenin and T cell factor/lymphoid enhancer-binding factor transcription factors, which are crucially involved in Wnt signaling.
Thu Aug 17 00:00:00 UTC 2017
Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells.
Scientific reports
Sugimoto A,Miyazaki A,Kawarabayashi K,Shono M,Akazawa Y,Hasegawa T,Ueda-Yamaguchi K,Kitamura T,Yoshizaki K,Fukumoto S,Iwamoto T
Mon Dec 18 00:00:00 UTC 2017
Epithelial Chloride Transport by CFTR Requires TMEM16A.
Scientific reports
Benedetto R,Ousingsawat J,Wanitchakool P,Zhang Y,Holtzman MJ,Amaral M,Rock JR,Schreiber R,Kunzelmann K
Fri Sep 29 00:00:00 UTC 2017
Ex vivo Culture of Fetal Mouse Gastric Epithelial Progenitors.
Bio-protocol
Vallone VF,Leprovots M,Vassart G,Garcia MI
250-38 was used in Cell Culture to report an adapted protocol for isolation and ex vivo culture and maintenance of fetal epithelial progenitors from distal pre-glandular stomach growing as gastric spheroids.
Thu Jan 05 00:00:00 UTC 2017
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 UTC 2016
EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
The Journal of cell biology
Nakajo A,Yoshimura S,Togawa H,Kunii M,Iwano T,Izumi A,Noguchi Y,Watanabe A,Goto A,Sato T,Harada A
Mon Feb 01 00:00:00 UTC 2016
Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential.
Stem cells (Dayton, Ohio)
Kwon OJ,Zhang L,Xin L
Fri Jan 01 00:00:00 UTC 2016
Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.
Molecular therapy. Methods & clinical development
Lorenzi F,Babaei-Jadidi R,Sheard J,Spencer-Dene B,Nateri AS
Mon Apr 25 00:00:00 UTC 2016
ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.
Nature communications
de Jong PR,Taniguchi K,Harris AR,Bertin S,Takahashi N,Duong J,Campos AD,Powis G,Corr M,Karin M,Raz E
Tue May 17 00:00:00 UTC 2016
Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.
Nature communications
Jardé T,Lloyd-Lewis B,Thomas M,Kendrick H,Melchor L,Bougaret L,Watson PD,Ewan K,Smalley MJ,Dale TC
Wed Oct 26 00:00:00 UTC 2016
Lentivirus-Based Stable Gene Delivery into Intestinal Organoids.
Methods in molecular biology (Clifton, N.J.)
Maru Y,Orihashi K,Hippo Y
250-38 was used in Cell Culture to demonstrate that this method allows for highly efficient infection of intestinal organoids after overnight incubation of Matrigel-attached cells with lentiviral particles.
Wed Dec 13 00:00:00 UTC 2017
Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity.
Scientific reports
Chng SH,Kundu P,Dominguez-Brauer C,Teo WL,Kawajiri K,Fujii-Kuriyama Y,Mak TW,Pettersson S
Tue Apr 12 00:00:00 UTC 2016
Inducible in vivo genome editing with CRISPR-Cas9.
Nature biotechnology
Dow LE,Fisher J,O'Rourke KP,Muley A,Kastenhuber ER,Livshits G,Tschaharganeh DF,Socci ND,Lowe SW
250-38 was used in Cell Culture to describe a conditional transgenic approach that allows temporal control of CRISPR-Cas9 activity for inducible genome editing in adult mice.
Wed Apr 01 00:00:00 UTC 2015
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
The Journal of clinical investigation
Zhu X,Messer JS,Wang Y,Lin F,Cham CM,Chang J,Billiar TR,Lotze MT,Boone DL,Chang EB
Mon Mar 02 00:00:00 UTC 2015
Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.
The EMBO journal
Tao S,Tang D,Morita Y,Sperka T,Omrani O,Lechel A,Sakk V,Kraus J,Kestler HA,Kühl M,Rudolph KL
Wed Mar 04 00:00:00 UTC 2015
E-cadherin can limit the transforming properties of activating β-catenin mutations.
The EMBO journal
Huels DJ,Ridgway RA,Radulescu S,Leushacke M,Campbell AD,Biswas S,Leedham S,Serra S,Chetty R,Moreaux G,Parry L,Matthews J,Song F,Hedley A,Kalna G,Ceteci F,Reed KR,Meniel VS,Maguire A,Doyle B,Söderberg O,Barker N,Watson A,Larue L,Clarke AR,Sansom OJ
Mon Sep 14 00:00:00 UTC 2015
Scap is required for sterol synthesis and crypt growth in intestinal mucosa.
Journal of lipid research
McFarlane MR,Cantoria MJ,Linden AG,January BA,Liang G,Engelking LJ
Sat Aug 01 00:00:00 UTC 2015
A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness.
Stem cells (Dayton, Ohio)
Cambuli FM,Correa BR,Rezza A,Burns SC,Qiao M,Uren PJ,Kress E,Boussouar A,Galante PA,Penalva LO,Plateroti M
Tue Dec 01 00:00:00 UTC 2015
A 3-D enteroid-based model to study T-cell and epithelial cell interaction.
Journal of immunological methods
Rogoz A,Reis BS,Karssemeijer RA,Mucida D
250-38 was used in Cell Culture to describe a novel method for studying specific pathways in intestinal epithelial cell or immune cell compartments.
Mon Jun 01 00:00:00 UTC 2015
Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment.
The Journal of biological chemistry
Huang Y,Hamana T,Liu J,Wang C,An L,You P,Chang JYF,Xu J,McKeehan WL,Wang F
Fri Jul 17 00:00:00 UTC 2015
Efficient genetic engineering of human intestinal organoids using electroporation.
Nature protocols
Fujii M,Matano M,Nanki K,Sato T
250-38 was used in Cell Culture to describe how to stably integrate genes via the piggyBac transposon, as well as precise genome editing using the CRISPR-Cas9 system.
Thu Oct 01 00:00:00 UTC 2015
p53- and p73-independent activation of TIGAR expression in vivo.
Cell death & disease
Lee P,Hock AK,Vousden KH,Cheung EC
Thu Aug 06 00:00:00 UTC 2015
Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.
The Journal of biological chemistry
Moon C,Zhang W,Ren A,Arora K,Sinha C,Yarlagadda S,Woodrooffe K,Schuetz JD,Valasani KR,de Jonge HR,Shanmukhappa SK,Shata MT,Buddington RK,Parthasarathi K,Naren AP
Fri May 01 00:00:00 UTC 2015
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
Cell
Karthaus WR,Iaquinta PJ,Drost J,Gracanin A,van Boxtel R,Wongvipat J,Dowling CM,Gao D,Begthel H,Sachs N,Vries RGJ,Cuppen E,Chen Y,Sawyers CL,Clevers HC
Thu Sep 25 00:00:00 UTC 2014
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.
Nature methods
Yin X,Farin HF,van Es JH,Clevers H,Langer R,Karp JM
Wed Jan 01 00:00:00 UTC 2014
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
Immunity
Wang K,Kim MK,Di Caro G,Wong J,Shalapour S,Wan J,Zhang W,Zhong Z,Sanchez-Lopez E,Wu LW,Taniguchi K,Feng Y,Fearon E,Grivennikov SI,Karin M
Thu Dec 18 00:00:00 UTC 2014
Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
The Journal of clinical investigation
de Jong PR,Takahashi N,Harris AR,Lee J,Bertin S,Jeffries J,Jung M,Duong J,Triano AI,Lee J,Niv Y,Herdman DS,Taniguchi K,Kim CW,Dong H,Eckmann L,Stanford SM,Bottini N,Corr M,Raz E
Mon Sep 01 00:00:00 UTC 2014
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
EMBO molecular medicine
Peter S,Bultinck J,Myant K,Jaenicke LA,Walz S,Müller J,Gmachl M,Treu M,Boehmelt G,Ade CP,Schmitz W,Wiegering A,Otto C,Popov N,Sansom O,Kraut N,Eilers M
Mon Dec 01 00:00:00 UTC 2014
CDC42 inhibition suppresses progression of incipient intestinal tumors.
Cancer research
Sakamori R,Yu S,Zhang X,Hoffman A,Sun J,Das S,Vedula P,Li G,Fu J,Walker F,Yang CS,Yi Z,Hsu W,Yu DH,Shen L,Rodriguez AJ,Taketo MM,Bonder EM,Verzi MP,Gao N
250-38 was used in Cell Culture to use genetic and pharmacologic approaches in mouse colorectal cancer and human colorectal cancer xenograft models to demonstrate that incipient intestinal tumor cells activate CDC42, an APC-interacting small GTPase, as a crucial step in malignant progression.
Wed Oct 01 00:00:00 UTC 2014
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.
Proceedings of the National Academy of Sciences of the United States of America
Wiener Z,Band AM,Kallio P,Högström J,Hyvönen V,Kaijalainen S,Ritvos O,Haglund C,Kruuna O,Robine S,Louvard D,Ben-Neriah Y,Alitalo K
Tue May 27 00:00:00 UTC 2014
Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo.
Proceedings of the National Academy of Sciences of the United States of America
Ren W,Lewandowski BC,Watson J,Aihara E,Iwatsuki K,Bachmanov AA,Margolskee RF,Jiang P
Tue Nov 18 00:00:00 UTC 2014
Expansion of murine periosteal progenitor cells with fibroblast growth factor 2 reveals an intrinsic endochondral ossification program mediated by bone morphogenetic protein 2.
Stem cells (Dayton, Ohio)
van Gastel N,Stegen S,Stockmans I,Moermans K,Schrooten J,Graf D,Luyten FP,Carmeliet G
Mon Sep 01 00:00:00 UTC 2014
STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis.
Journal of immunology (Baltimore, Md. : 1950)
Backert I,Koralov SB,Wirtz S,Kitowski V,Billmeier U,Martini E,Hofmann K,Hildner K,Wittkopf N,Brecht K,Waldner M,Rajewsky K,Neurath MF,Becker C,Neufert C
Wed Oct 01 00:00:00 UTC 2014
Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium.
Journal of immunology (Baltimore, Md. : 1950)
Skoczek DA,Walczysko P,Horn N,Parris A,Clare S,Williams MR,Sobolewski A
Tue Jul 01 00:00:00 UTC 2014
Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.
Cell death & disease
Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T
Thu May 15 00:00:00 UTC 2014
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Cancer cell
Cooks T,Pateras IS,Tarcic O,Solomon H,Schetter AJ,Wilder S,Lozano G,Pikarsky E,Forshew T,Rosenfeld N,Harpaz N,Itzkowitz S,Harris CC,Rotter V,Gorgoulis VG,Oren M
Mon May 13 00:00:00 UTC 2013
Genetic reconstitution of tumorigenesis in primary intestinal cells.
Proceedings of the National Academy of Sciences of the United States of America
Onuma K,Ochiai M,Orihashi K,Takahashi M,Imai T,Nakagama H,Hippo Y
Tue Jul 02 00:00:00 UTC 2013
Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors.
BMC cancer
Ludwig K,Tse ES,Wang JY
250-38 was used in Cell Culture to examine the effects of Wnt signalling and other crypt growth factors on colon cancer cell growth in 3D culture.
Thu May 02 00:00:00 UTC 2013
Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells.
Scientific reports
Hisha H,Tanaka T,Kanno S,Tokuyama Y,Komai Y,Ohe S,Yanai H,Omachi T,Ueno H
Fri Nov 15 00:00:00 UTC 2013
Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control.
Scientific reports
Honda Y,Ding X,Mussano F,Wiberg A,Ho CM,Nishimura I
Thu Dec 05 00:00:00 UTC 2013
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
Nature
Yilmaz ÖH,Katajisto P,Lamming DW,Gültekin Y,Bauer-Rowe KE,Sengupta S,Birsoy K,Dursun A,Yilmaz VO,Selig M,Nielsen GP,Mino-Kenudson M,Zukerberg LR,Bhan AK,Deshpande V,Sabatini DM
Thu Jun 28 00:00:00 UTC 2012
AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning.
Cell research
Qiao Y,Zhu Y,Sheng N,Chen J,Tao R,Zhu Q,Zhang T,Qian C,Jing N
Thu Nov 01 00:00:00 UTC 2012
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
The Journal of clinical investigation
Jamieson T,Clarke M,Steele CW,Samuel MS,Neumann J,Jung A,Huels D,Olson MF,Das S,Nibbs RJ,Sansom OJ
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Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.
The EMBO journal
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Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).
Proceedings of the National Academy of Sciences of the United States of America
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Tue Jun 05 00:00:00 UTC 2012
Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.
The Journal of biological chemistry
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Fri Aug 24 00:00:00 UTC 2012
Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling.
BMC cell biology
Moriyama M,Moriyama H,Ueda A,Nishibata Y,Okura H,Ichinose A,Matsuyama A,Hayakawa T
Tue Aug 07 00:00:00 UTC 2012
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.
PloS one
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Wed Jan 16 00:00:00 UTC 2013
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Nature
Sato T,van Es JH,Snippert HJ,Stange DE,Vries RG,van den Born M,Barker N,Shroyer NF,van de Wetering M,Clevers H
Thu Jan 20 00:00:00 UTC 2011
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.
Nature cell biology
Sperka T,Song Z,Morita Y,Nalapareddy K,Guachalla LM,Lechel A,Begus-Nahrmann Y,Burkhalter MD,Mach M,Schlaudraff F,Liss B,Ju Z,Speicher MR,Rudolph KL
Sun Dec 04 00:00:00 UTC 2011
Myb controls intestinal stem cell genes and self-renewal.
Stem cells (Dayton, Ohio)
Cheasley D,Pereira L,Lightowler S,Vincan E,Malaterre J,Ramsay RG
Thu Dec 01 00:00:00 UTC 2011
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature
Sato T,Vries RG,Snippert HJ,van de Wetering M,Barker N,Stange DE,van Es JH,Abo A,Kujala P,Peters PJ,Clevers H
Thu May 14 00:00:00 UTC 2009
