Gibco

PeproGMP® Human IL-15 Recombinant Protein, PeproTech®

PeproGMP® Human IL-15 Protein in Functional Assay (Functional)

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PeproGMP® Human IL-15 Protein (GMP200-15-50UG) in Functional

Bioassay of PeproGMP® Human IL-15 Recombinant Protein, PeproTech (Product # GMP200-15-50UG) compared to Human IL-15, Animal-Free Recombinant Protein, PeproTech (Product # AF-200-15-1MG), demonstrating comparable bioactivity across product grades.

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Product Details

GMP200-15-50UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

Product Specifications

Species

Human

Expression System

E. coli

Amino acid sequence

MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Molecular weight

12.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<0.1 EU/µg

Activity

Determined by the proliferation of CTLL-2 cells. PeproGMP Recombinant Human IL-15 has been tested against the WHO standard NIBSC 95/554. Find the International Unit (IU) value here.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient

Product Specific Information

Additional product information and specifications are provided on the Certificate of Analysis.

All PeproGMP® products are manufactured using animal-derived component free materials.

Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.

Target Information

IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.

For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

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Bioinformatics

Protein Aliases: il 15; IL-15; ILN; Interleukin; Interleukin-15; Interleukin15; M-IL-15; MGC9721