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Invitrogen
Rat B7-H6 Fc Chimera Recombinant Protein
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Product Details
RP-88270
Product Specifications
Species
Rat
Expression System
HEK293 cells
Amino acid sequence
Rat B7-H6, amino acids Met1-Ser308 (Accession # XP_006223356.1) with a C-terminal human IgG1 Fc region
Tag
Fc-tag
Molecular weight
60.4 kDa
Class
Recombinant
Type
Protein
Purity
>95% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Activity
1.Measured by its binding ability in a functional ELISA. 2.Immobilized rat NCR3-His at 10 µg/mL (100 µL/well) can bind rat B7-H6-Fc, the EC50 of rat B7-H6 -Fc is 1-20 ng/mL.
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (200 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells. B7-H6 binds with NKp30 present on NK cells. Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis. B7-H6 is not constitutively expressed on normal tissue. Whether it can be expressed endogenously under certain conditions is under investigation. B7-H6 has been detected on circulating pro-inflammatory CD14(+)CD16(+) monocytes in some patients with sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686I21167; natural killer cell cytotoxicity receptor 3 ligand 1
Entrez Gene ID: (Rat) 691092
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