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          • Proteins & Peptides ›
          • SARS-CoV-2 Spike Protein S1/S2 Proteins

          Invitrogen

          SARS-CoV-2 Spike Protein (S1/S2) (aa16-1213), His-Flag Tag Recombinant Protein

          View all (35) SARS-CoV-2 Spike Protein S1/S2 proteins

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          Cite SARS-CoV-2 Spike Protein (S1/S2) (aa16-1213), His-Flag Tag Recombinant Protein

          • Testing Data (1)
          SARS-CoV-2 Spike Protein (S1/S2) (aa16-1213), His-Flag Tag Protein in Functional Assay (Functional)
          Group 53 Created with Sketch.
          SARS-CoV-2 Spike Protein (S1/S2) (aa16-1213), His-Flag Tag Protein in Functional Assay (Functional)
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          SARS-CoV-2 Spike Protein (S1/S2) (aa16-1213), His-Flag Tag Protein (RP-87671) in Functional

          S-ECD Binding test using SARS-CoV-2 Spike Protein (S-ECD) (aa16-1213), His-Flag Tag Recombinant Protein (Product # RP-87671). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SARS-CoV-2 Spike Protein (S1/S2) (aa16-1213), His-Flag Tag Protein in Functional Assay (Functional)

          Product Details

          RP-87671

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          ELISA (ELISA)

          Assay-dependent
          -

          Control (Ctrl)

          Assay-dependent
          -
          Product Specifications

          Species

          Virus

          Expression System

          Insect cells

          Amino acid sequence

          SARS-CoV-2 Spike Protein S1+S2, amino acids 16-1213 (s-ECD region) with a His-tag and a FLAG-tag

          Tag

          DYKDDDDK-tag, His-tag

          Molecular weight

          135 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          >90% by SDS-PAGE

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Purification

          purified

          Storage buffer

          PBS, pH 7.4

          Contains

          no preservative

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Wet ice

          Product Specific Information

          Source: The protein was purified from SF21 cells.

          Target: The S-ECD target covers S1 and S2.

          Purity is > 95% by SDS-PAGE.

          Target Information

          SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. SARS-CoV-2 S is 1273 amino acids long and consists of a signal peptide (amino acids 1-13) located at the N-terminus, the S1 subunit (14-685 residues), and the S2 subunit (686-1273 residues); the last two regions are responsible for receptor binding and membrane fusion, respectively. The S-ECD is the extracellular domain of the Spike protein.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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