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Invitrogen
SARS-CoV-2 Spike Protein (S1/S2) (aa16-1213), His-Flag Tag Recombinant Protein
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Product Details
RP-87671
Applications
Tested Dilution
Publications
Product Specifications
Species
Virus
Expression System
Insect cells
Amino acid sequence
SARS-CoV-2 Spike Protein S1+S2, amino acids 16-1213 (s-ECD region) with a His-tag and a FLAG-tag
Tag
DYKDDDDK-tag, His-tag
Molecular weight
135 kDa
Class
Recombinant
Type
Protein
Purity
>90% by SDS-PAGE
Conjugate
Form
Liquid
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Source: The protein was purified from SF21 cells.
Target: The S-ECD target covers S1 and S2.
Purity is > 95% by SDS-PAGE.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. SARS-CoV-2 S is 1273 amino acids long and consists of a signal peptide (amino acids 1-13) located at the N-terminus, the S1 subunit (14-685 residues), and the S2 subunit (686-1273 residues); the last two regions are responsible for receptor binding and membrane fusion, respectively. The S-ECD is the extracellular domain of the Spike protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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