CDK8 Proteins

Protein Information

CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.

Synonyms

CDK8; CDK8 protein kinase; Cell division protein kinase 8; cyclin dependent kinase 8; cyclin-dependent kinase 8; K35; Mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35; RGD1560888