FAT1 Proteins

Protein Information

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.

Synonyms

2310038E12Rik; AU023433; Cadherin family member 7; cadherin FAT1 isoform +12; cadherin ME5; cadherin-related family member 8; cadherin-related tumor suppressor homolog; CDHF7; CDHR8; Fat; fat 1 cadherin; FAT atypical cadherin 1; FAT tumor suppressor 1; FAT tumor suppressor homolog 1; FAT tumor suppressor homolog 1 (Drosophila); FAT1; Fath; hFat1; ME5; mFat1; Protein fat homolog; protocadherin Fat 1; Protocadherin Fat 1, nuclear form