IL17RB Proteins

Protein Information

Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.

Synonyms

CRL4; cytokine receptor CRL4; cytokine receptor-like 4; ecotropic viral integration site 27; Evi27; IL-17 receptor B; IL-17 receptor homolog 1; IL-17B; IL-17B receptor; IL17BR; IL-17ER; IL17RB; IL-17RB; IL17RH1; IL-17Rh1; IL-20; interleukin 17 receptor B; interleukin 17 receptor homolog 1; interleukin 17B receptor; Interleukin-17 receptor B; interleukin-17B receptor; MGC138900; MGC138901; MGC5245; UNQ2501/PRO19612; ZCYTO7