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          • Proteins & Peptides ›
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          Integrin beta 1 (CD29) Proteins

          Integrin beta 1 (CD29) Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed?... Integrin beta 1 (CD29) Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us... Integrin beta 1 (CD29) Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.... Integrin beta 1 (CD29) Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

          Protein Information

          CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly during leukocyte emigration and extravascular migration. It is involved in regulating tissue damage and disease symptoms related to inflammatory bowel disease. In the presence of anti-tumor drugs, decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. ITGB1-dependent mechanisms enhance cytokine secretion in human airway smooth muscle in response to IL-1beta, facilitated by fibronectin and type I collagen. More than eight beta subunits with numerous splice variant isoforms have been identified in mammals, including two major forms: beta1A and beta1D. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.

          Synonyms

          4633401G24Rik; AA409975; AA960159; beta OL; Beta oligodendroglia; CD29; CSAT antigen; ENSMUSG00000051907; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; Gm9863; GPIIA; integrin beta 1; integrin beta 1 (fibronectin receptor beta); Integrin beta1; Integrin beta-1; integrin beta-1 subunit; integrin subunit beta 1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; Itgb1; JG22 antigen; MDF2; MSK12; RGD-receptor; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLAB; VLA-BETA

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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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          Invitrogen
          Human ITGB1 (aa 625-712) Control Fragment Recombinant Protein
          Invitrogen
          Human ITGB1 (aa 625-712) Control Fragment Recombinant Protein
          Host
          Species
          Human
          Expression System
          E. coli
          Product Grade
          Research Use Only
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          Ctrl BLOCK
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          Special offer
          Online exclusive
          Online offer:
          Cat # RP-108243

          100 µL

          Invitrogen
          Human ITGB1 (aa 29-128) Control Fragment Recombinant Protein
          Invitrogen
          Human ITGB1 (aa 29-128) Control Fragment Recombinant Protein
          Host
          Species
          Human
          Expression System
          E. coli
          Product Grade
          Research Use Only
          Application
          Ctrl BLOCK
          Price
          Special offer
          Online exclusive
          Online offer:
          Cat # RP-108215

          100 µL

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