MRPL4 Proteins

Protein Information

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms.

Synonyms

1110017G11Rik; 39S ribosomal protein L4, mitochondrial; CDABP0091; CGI-28; L4mt; Mitochondrial large ribosomal subunit protein uL4m; mitochondrial ribosomal protein L4; MNCb-3848; Mrpl4; MRP-L4; rm04