NO66 Proteins

Protein Information

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt]

Synonyms

2410016O06Rik; 60S ribosomal protein L8 histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; C14orf169; chromosome 14 open reading frame 169; FLJ21802; histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; MAPJD; MNCb-7109; myc associated protein with JmjC domain; MYC-associated protein with JmjC domain; No66; Nucleolar protein 66; RGD1307704; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; RIKEN cDNA 2410016O06 gene; RIOX1; ROX; similar to RIKEN cDNA 2410016O06; up-regulated in lung cancer 2; URLC2