RBM6 Proteins

Protein Information

DEF-3 and LUCA15 belong to an evolutionarily conserved family of RNA binding proteins and share similar expression patterns. Both DEF-3 and LUCA15 are highly expressed in adult heart and thymus as well as fetal kidney. Conversely, fetal thymus and adult kidney express very little DEF-3 and LUCA15. In the haemopoietic system of mice, the expression of DEF-3 is downregulated upon differentiation of progenitor cells into granulocytes but persists during macrophage development. Both DEF-3 and LUCA15 contain two zinc finger motifs, a bipartite nuclear signal and two RNA binding motifs. DEF-3 and LUCA15 are capable of specifically binding poly(G) RNA.

Synonyms

3G2; 4930506F14Rik; DEF3; Def-3; ETK2; g16; HEK2; HLC-11; Lung cancer antigen NY-LU-12; lung cancer protooncogene 11; mKIAA4015; NY-LU-12; Protein G16; RBM6; RGD1560367; RNA binding motif protein 6; RNA-binding motif protein 6; RNA-binding protein 6; RNA-binding protein DEF-3; TYRO6