SCK Proteins

Protein Information

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.

Synonyms

6720466E06; neuronal Shc adaptor homolog; protein Sck; Protein Sli; Sck; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC adaptor protein 2; Shc2; ShcB; SHC-transforming protein 2; SHC-transforming protein B; Sli; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2