SPACA3 Proteins

Protein Information

SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

Synonyms

1700025M08Rik; acrosomal sperm protein; ALLP17; Cancer/testis antigen 54; CT54; LYC3; lysozyme C; Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17; lysozyme-like protein 3; lysozyme-like sperm-specific secretory protein ALLP17; LYZC; LYZL3; mSLLP1; SLLP1; Spaca3; sperm acrosome associated 3; sperm acrosome membrane-associated protein 3; Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form; sperm c-type lysozyme-like protein; sperm lysozyme like protein 1; sperm lysozyme-like protein 1; sperm lysozyme-like protein 1 precusor; sperm lyzozyme-like acrosomal protein 1; sperm protein reactive with antisperm antibodies; Sperm protein reactive with ASA; SPRASA; UNQ424/PRO862