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          • Proteins & Peptides ›
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          SREBP1 Proteins

          SREBP1 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed?... SREBP1 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us... SREBP1 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.... SREBP1 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

          Protein Information

          Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.

          Synonyms

          ADD1; ADD-1; Adipocyte determination- and differentiation-dependent factor 1; BHLHD1; Class D basic helix-loop-helix protein 1; D630008H06; I79_010155; nt-SREBP1; Processed sterol regulatory element-binding protein 1; SREBF1; SREBP1; SREBP-1; SREBP1a; SREBP-1a; SREBP1c; SREBP-1c; sterol regulatory element binding protein 1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; sterol regulatory element binding-protein 1; sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1

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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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          Invitrogen
          Human SREBP1 (aa 249-331) Control Fragment Recombinant Protein
          Invitrogen
          Human SREBP1 (aa 249-331) Control Fragment Recombinant Protein
          Host
          Species
          Human
          Expression System
          E. coli
          Product Grade
          Research Use Only
          Application
          Ctrl BLOCK
          Price
          Special offer
          Online exclusive
          Online offer:
          Cat # RP-102940

          100 µL

          Invitrogen
          Human SREBP1 (aa 784-863) Control Fragment Recombinant Protein
          Invitrogen
          Human SREBP1 (aa 784-863) Control Fragment Recombinant Protein
          Host
          Species
          Human
          Expression System
          E. coli
          Product Grade
          Research Use Only
          Application
          Ctrl BLOCK
          Price
          Special offer
          Online exclusive
          Online offer:
          Cat # RP-106053

          100 µL

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