WDR7 Proteins

Protein Information

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependent exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described.

Synonyms

AI462727; Kiaa0541; mKIAA0541; rabconnectin-3 beta; rabconnectin-3beta; TGF-beta resistance associated; TGF-beta resistance-associated protein TRAG; TRAG; WD repeat domain 7; WD repeat-containing protein 7; Wd7; Wdr7