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Thermo Fisher Scientific has innovative solutions at every stage of the bio/pharmaceutical pipeline: discovery, development, clinical, manufacturing, and quality control. Our deep understanding of the challenges faced by producers of medicines allows us to forge partnerships that more quickly deliver next-generation drugs to market.
Your molecules are complex
Biotherapeutics such as monoclonal antibodies, biosimilars, antibody-drug conjugates, and nucleotide-based therapies are increasingly important drug product classes. Most biotherapeutic drug products are fundamentally more complex than traditional chemically synthesized products, and are subject to modification events, throughout development, manufacturing and storage.
You need fit-for-purpose tools at each biotherapeutic development stage
Well-designed characterization technologies provide unique insights which advance the development of biotherapeutics. Comprehensive characterization, allowing for full product understanding can save significant time and development costs. Throughout process development and manufacturing, tools are required for reliable monitoring of product microheterogeneity to ensure drug safety and efficacy.
Technology innovations to help you on your drug development journey
Our technology innovations have been specifically designed with the rapid pace and complexity challenges of biotherapeutic development in mind. From early discovery through to delivery of a commercial product, we provide technologies to confidently answer your analytical questions, bringing life-changing biotherapeutics to market faster than ever before.
Analytical solutions for biopharmaceutical characterization and control.
Your partner on every step of your journey
Application Note: Biologic Drug Identification at Fill and Finish ›
Infographic: 5 Reasons to use Process Mass Spectrometry in Biotechnology ›
Brochure: Analytical solutions for biopharmaceutical characterization and control ›
White Paper: Gradient Elution of Ionic Compounds ›
Brochure: Safely Accelerating Drug Development for Brighter Outcomes ›
Brochure: Simplify Carbohydrate Analysis ›
Brochure: Biopharma Solutions ›
Application Note: Antibody subunit analysis workflow on a quadrupole-Orbitrap mass spectrometer ›
eBook: Tomorrow's Quantitation Compendium ›
Case study: Top 10 Pharmaceutical Company Improves Laboratory Productivity ›
Brochure: Pharma Solution for manufacturing QA/QC ›
Brochure: SampleManager LIMS, SDMS, LES and ELN Software ›
eBook - How to Gain Process Understanding and Control ›
Application Note: Real time metabolite monitoring using the Ramina Process Analyzer System ›
Application Note: Ramina Glucose Monitoring ›
Ebook: A Guide to Improving Biotech Processes with Mass Spectrometry Gas Analysis ›
Ebook: Pharmaceutical Standards Guide for UV/Vis Instrumentation ›
eBook: Nucleic Acid Resource Guide ›
eBook: Protein quantification and qualification application compendium ›
Application Note: Biologic Drug Identification at Fill and Finish ›
Expedited Cryo-EM Structure-Based Drug Design: From Gene to Novel Chemistry ›
GPCR Researchers Find Cryo-EM Ideal For Drug Discovery ›
The Contract Research Organization and Its Role in Cryo-EM Adoption ›
The Next Digital Revolution in the Pharmaceutical Industry ›
Rapid Delivery of Pharmaceutical QA/QC LIMS ›
Accelerating Drug Discovery in the Digital Age ›
How an Integrated LIMS Platform can Transform Drug Development and Manufacturing Workflows ›
SampleManager Supports Thermo Fisher Pharma Services’ Pharma 4.0 Vision ›
AppsLab Library of Analytical Methods ›
Biologics Workflow and Process Map for Pharmaceutical and Biotech Manufacturing ›
Biotherapeutic Manufacturing Workflow ›
Improved Pharmaceutical and Biotech Manufacturing Processes ›
Learning Modules for Pharma and Biopharma Using Portable Spectroscopy ›
Pharma & Biopharma Learning Center ›
Workflow Solutions for Biologics ›
Analytical and Life Science Webinar Library ›
Leaders in Biopharma Characterization & Control Webinar ›
Nitrosamine Analysis Webinar ›
Single Particle Analysis webinars ›
Lab Informatics Software Webinars ›
Material Characterization Learning Center Webinars ›
Pharmaceutical Analysis Webinars with Spectroscopy, Extrusion, and XRD ›
Application Note: Biologic Drug Identification at Fill and Finish ›
Infographic: 5 Reasons to use Process Mass Spectrometry in Biotechnology ›
Brochure: Analytical solutions for biopharmaceutical characterization and control ›
White Paper: Gradient Elution of Ionic Compounds ›
Brochure: Safely Accelerating Drug Development for Brighter Outcomes ›
Brochure: Simplify Carbohydrate Analysis ›
Brochure: Biopharma Solutions ›
Application Note: Antibody subunit analysis workflow on a quadrupole-Orbitrap mass spectrometer ›
eBook: Tomorrow's Quantitation Compendium ›
Case study: Top 10 Pharmaceutical Company Improves Laboratory Productivity ›
Brochure: Pharma Solution for manufacturing QA/QC ›
Brochure: SampleManager LIMS, SDMS, LES and ELN Software ›
eBook - How to Gain Process Understanding and Control ›
Application Note: Real time metabolite monitoring using the Ramina Process Analyzer System ›
Application Note: Ramina Glucose Monitoring ›
Ebook: A Guide to Improving Biotech Processes with Mass Spectrometry Gas Analysis ›
Ebook: Pharmaceutical Standards Guide for UV/Vis Instrumentation ›
eBook: Nucleic Acid Resource Guide ›
eBook: Protein quantification and qualification application compendium ›
Application Note: Biologic Drug Identification at Fill and Finish ›
Expedited Cryo-EM Structure-Based Drug Design: From Gene to Novel Chemistry ›
GPCR Researchers Find Cryo-EM Ideal For Drug Discovery ›
The Contract Research Organization and Its Role in Cryo-EM Adoption ›
The Next Digital Revolution in the Pharmaceutical Industry ›
Rapid Delivery of Pharmaceutical QA/QC LIMS ›
Accelerating Drug Discovery in the Digital Age ›
How an Integrated LIMS Platform can Transform Drug Development and Manufacturing Workflows ›
SampleManager Supports Thermo Fisher Pharma Services’ Pharma 4.0 Vision ›
AppsLab Library of Analytical Methods ›
Biologics Workflow and Process Map for Pharmaceutical and Biotech Manufacturing ›
Biotherapeutic Manufacturing Workflow ›
Improved Pharmaceutical and Biotech Manufacturing Processes ›
Learning Modules for Pharma and Biopharma Using Portable Spectroscopy ›
Pharma & Biopharma Learning Center ›
Workflow Solutions for Biologics ›
Analytical and Life Science Webinar Library ›
Leaders in Biopharma Characterization & Control Webinar ›
Nitrosamine Analysis Webinar ›
Single Particle Analysis webinars ›
Lab Informatics Software Webinars ›
Material Characterization Learning Center Webinars ›
Pharmaceutical Analysis Webinars with Spectroscopy, Extrusion, and XRD ›
Our drug discovery and development team provides support, expertise, collaboration and customization to meet your unique needs. With our Invitrogen and Gibco portfolios of protein kinases, ADME/Tox products, primary & stem cell products, target-based assays, and custom biology services we help you drive efficiency in assay development, high-throughput screening, and metabolic and safety assessment.
Our advanced instrumentation and analytical workflows can help simplify the challenge of biopharmaceutical analysis. Discover our state-of-the-art analytical technologies for the entire range of protein characterization from post-translational modifications, three-dimensional structures and protein aggregation.
Quality control (QC) testing of pharmaceuticals must be rigorous and involves multiple techniques including GC/MS, LC/MS, and elemental analysis techniques. Impurities can take many forms, from solids to volatiles and everything in between. We have solutions for pharmaceutical testing organizations conducting small molecule impurities; from heavy metals to extractables and leachables.
The characterization of drug metabolites is an integral part of the discovery and development of new pharmaceutical compounds. High resolution accurate mass based LC/MS technology has become the leading technology for metabolite profiling, identification and quantification by offering high specificity and accuracy.
The challenges of managing your data and other laboratory information can be significant, from ensuring that any data and information produced is secure, easy to find and share, as well as meeting regulatory compliance. Thankfully, we have advanced laboratory data management solutions that provide comprehensive coverage of all laboratory data management requirements, helping you to meet your compliance requirements while increasing your data connectivity and productivity.
Addressing challenges in pharmaceuticals where API solubility and processing stability, taste-masking, enterics, and specialized dosage forms are critical projects, Thermo Scientific extruders and related analytical instrumentation provide the shortest path from feasibility studies to production in drug formulation and manufacturing.
The key element of PAT framework includes improved process understanding by defining Critical Process Parameters (CPP) and monitoring these CPPs to stay within a defined limit, either in-line or on-line, to maintain the product’s Critical Quality Attributes (CQA). PAT aims to Processes can become improve process efficiency, more efficient, with reduced over-processing, minimized deviations, and greater product consistency.
Nucleic acid therapeutics are changing healthcare by delivering promising drugs that use new technologies and modes of action to treat disease. Several of these innovative medicines are being utilized to treat infectious diseases, protein and gene deficiencies, and many types of cancers. With more and more effort and resources being directed into this area, we may only be at the beginning stages of a revolution in medicine.
Conventional models of one-drug-one-disease are changing fast. Genetic technologies are at the forefront, fueling new discoveries that link diseases, therapies, and patient responses. Thermo Fisher genetic analysis solutions are helping to rapidly drive connections for multi-therapeutic approaches to treat complex human diseases. Wherever you are in your journey from discovery to manufacturing, gain access to a breadth of genetic technologies that enables to you to keep up with the development pace of therapeutics, interventions, and vaccines.
Bioproduction
Thermo Fisher Scientific is here to help guide the way forward in the new age of drug development. Because your success is our success, it’s our job to help accelerate your biomanufacturing process so you can deliver competitive results and commercialize innovative therapies that help improve health and quality of life.
Cancer Research
Fighting cancer is more than your research—it’s your passion to advance science in the pursuit of better outcomes.Every factor in the service of this struggle is precious: from samples, technology, data, and budgets, to those who depend on your success. Every day, cancer continues to devastate lives. There’s simply no room for waste or error.
Because the obstacles are great and challenges many, we must partner together to become more efficient, move faster, and evolve more quickly than this tenacious disease. We at Thermo Fisher Scientific propose a bold new path forward to empower your next discovery.
Clinical & Diagnostics
Genetic information is rapidly transforming the future of healthcare by enabling accurate and affordable diagnosis and prognosis, targeted treatments, and monitoring solutions. We are committed to providing reliable and easy-to-use solutions, services, and support to meet the demanding needs of your work.
From scalable translational research solutions to proven clinical laboratory services and diagnostics, we are a partner you can trust to help you efficiently develop and apply differentiated clinical applications today, and for many years into the future.
Clinical & Translational Research
From scalable translational research solutions to proven clinical laboratory services and diagnostics, we are a partner you can trust to help you accelerate your path toward developing and applying differentiated clinical applications today and in the future.
Drug Discovery Using Cryo-Electron Microscopy
Successful outcomes in structure-based drug design are not always a given. For instance, structures of membrane proteins or large macromolecular complexes often cannot be obtained quickly enough with crystallography or NMR to impact the drug design process. Despite the fact that membrane proteins account for over 60% of drug targets, they make up only 2% of existing crystal structures. This means that drug discovery is largely being performed without structure-based insights as part of a researcher’s toolbox.
With an ongoing pressure to reduce the time-to-market of new drugs, cryo-electron microscopy (cryo-EM) can help you take greater advantage of rational drug design and the observation of structure-activity relationships. This minimizes the number of compounds that must be synthesized and assayed, giving you highly efficient drug candidates in fewer iterations.
Gas Analysis for Biotechnology
What if you could achieve faster off-gas composition analysis without sacrificing precision and quality? With our Prima mass spectrometers, you can. As the standard in gas analysis, our robust instruments provide improved precision, accuracy, long intervals between calibration, and resistance to contamination, so you can optimize industrial processes across many applications – from biopharma to biofuels.
Lab Automation
Looking to improve processes and increase efficiency while generating accurate, reliable results? Life scientists can rely on the comprehensive Thermo Scientific portfolio of laboratory automation solutions including robotic systems, automated incubators, microplate instrumentation, configurable platforms, and workflow scheduling software.
Whether automating a single step or your entire workflow, these solutions will reduce your cost of ownership and deliver a faster return on your investment.
Discover our solutions and strategies to help you get started on an automation journey towards a digitally connected lab. Embrace the transformation to accelerate science, drive productivity, and manage risk.
Pharmaceutical Analysis Solutions - Spectroscopy & Material Characterization tools
Our comprehensive portfolio includes X-ray plasmon spectroscopy (XPS), energy-dispersive spectroscopy (EDS), Raman,Fourier-transform infrared (FTIR), near-infrared (NIR), X-ray diffraction (XRD), rheometers, and ultraviolet-visible (UV-Vis) spectroscopy. Using our state-of-the-art instruments ensures quality control across all steps and phases of your workflow and provides drug product consistency from initial formulations to large-scale production, employing fast, non destructive methods. Thermo Scientific Pharmaceutical Extruders allow drug formulation labs to produce consistent API dispersion from initial research through clinical trials and production, with three different sizes of twin-screw extruders that offer the hot melt extrusion (HME) and wet granulation (twin-screw granulation or TSG) capabilities. When you need additional help, our services and support teams can provide repair of critical instruments and after-sales service and support.
Pharma and Biotech Manufacturing
Improve manufacturing processes and ensure patient safety
From raw material identification through the pharmaceutical manufacturing process, to finished and packaged pharmaceutical product inspection, our solutions help pharmaceutical and biopharmaceutical manufacturers save time, improve processes, protect brand integrity, and ensure patient safety.
Pharmaceutical Microbiology
Thermo Scientific™ microbiology solutions are designed to address the unique needs of the pharmaceutical and biotechnology industries. We deliver a range of validated solutions for the pharmaceutical microbiology laboratory, supporting the production and quality assurance of sterile pharmaceuticals, vaccines, and biotechnology products.
We understand patient safety is paramount and ensuring regulatory compliance is non-negotiable. With our commitment to bringing more to pharmaceutical microbiology—from raw materials to finished product, and from environmental monitoring to microbial identification and media fills—you can confidently rely on our product quality and expertise every step of the way.
Portable Pharmaceutical Manufacturing Solutions
Achieve maximum quality coverage while minimizing time-consuming laboratory sampling tests. With Thermo Scientific handheld NIR analyzer and Raman spectrometers, pharmaceutical and biotechnology manufacturers can obtain fast, accurate pharmaceutical analysis results and raw material verification through plastic bags, glass containers, blister packs and clear gel caps in less than 30 seconds in the field to combat the spread of falsified medicines.
Stem Cell Research
For over a decade, we have provided the key tools and resources you need to address challenges in stem cell research. Now we’ve harnessed these powerful innovations into a complete system to support every step of your stem cell research workflow. Our complete portfolio of stem cell research products and services allows you to simplify your workflow and enables the continuity, efficiency, and precision that drive discovery.
Organoids, Spheroids, & 3D Cell Culture
Organoids, spheroids, and the study of 3D cell culture models show great potential in many applications including disease modeling and regenerative medicine. 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically relevant context where 2D models have not proven as successful. Gain confidence to culture and analyze organoids and spheroids through validated protocols and educational resources.
Bioproduction
Thermo Fisher Scientific is here to help guide the way forward in the new age of drug development. Because your success is our success, it’s our job to help accelerate your biomanufacturing process so you can deliver competitive results and commercialize innovative therapies that help improve health and quality of life.
Cancer Research
Fighting cancer is more than your research—it’s your passion to advance science in the pursuit of better outcomes.Every factor in the service of this struggle is precious: from samples, technology, data, and budgets, to those who depend on your success. Every day, cancer continues to devastate lives. There’s simply no room for waste or error.
Because the obstacles are great and challenges many, we must partner together to become more efficient, move faster, and evolve more quickly than this tenacious disease. We at Thermo Fisher Scientific propose a bold new path forward to empower your next discovery.
Clinical & Diagnostics
Genetic information is rapidly transforming the future of healthcare by enabling accurate and affordable diagnosis and prognosis, targeted treatments, and monitoring solutions. We are committed to providing reliable and easy-to-use solutions, services, and support to meet the demanding needs of your work.
From scalable translational research solutions to proven clinical laboratory services and diagnostics, we are a partner you can trust to help you efficiently develop and apply differentiated clinical applications today, and for many years into the future.
Clinical & Translational Research
From scalable translational research solutions to proven clinical laboratory services and diagnostics, we are a partner you can trust to help you accelerate your path toward developing and applying differentiated clinical applications today and in the future.
Drug Discovery Using Cryo-Electron Microscopy
Successful outcomes in structure-based drug design are not always a given. For instance, structures of membrane proteins or large macromolecular complexes often cannot be obtained quickly enough with crystallography or NMR to impact the drug design process. Despite the fact that membrane proteins account for over 60% of drug targets, they make up only 2% of existing crystal structures. This means that drug discovery is largely being performed without structure-based insights as part of a researcher’s toolbox.
With an ongoing pressure to reduce the time-to-market of new drugs, cryo-electron microscopy (cryo-EM) can help you take greater advantage of rational drug design and the observation of structure-activity relationships. This minimizes the number of compounds that must be synthesized and assayed, giving you highly efficient drug candidates in fewer iterations.
Gas Analysis for Biotechnology
What if you could achieve faster off-gas composition analysis without sacrificing precision and quality? With our Prima mass spectrometers, you can. As the standard in gas analysis, our robust instruments provide improved precision, accuracy, long intervals between calibration, and resistance to contamination, so you can optimize industrial processes across many applications – from biopharma to biofuels.
Lab Automation
Looking to improve processes and increase efficiency while generating accurate, reliable results? Life scientists can rely on the comprehensive Thermo Scientific portfolio of laboratory automation solutions including robotic systems, automated incubators, microplate instrumentation, configurable platforms, and workflow scheduling software.
Whether automating a single step or your entire workflow, these solutions will reduce your cost of ownership and deliver a faster return on your investment.
Discover our solutions and strategies to help you get started on an automation journey towards a digitally connected lab. Embrace the transformation to accelerate science, drive productivity, and manage risk.
Pharmaceutical Analysis Solutions - Spectroscopy & Material Characterization tools
Our comprehensive portfolio includes X-ray plasmon spectroscopy (XPS), energy-dispersive spectroscopy (EDS), Raman,Fourier-transform infrared (FTIR), near-infrared (NIR), X-ray diffraction (XRD), rheometers, and ultraviolet-visible (UV-Vis) spectroscopy. Using our state-of-the-art instruments ensures quality control across all steps and phases of your workflow and provides drug product consistency from initial formulations to large-scale production, employing fast, non destructive methods. Thermo Scientific Pharmaceutical Extruders allow drug formulation labs to produce consistent API dispersion from initial research through clinical trials and production, with three different sizes of twin-screw extruders that offer the hot melt extrusion (HME) and wet granulation (twin-screw granulation or TSG) capabilities. When you need additional help, our services and support teams can provide repair of critical instruments and after-sales service and support.
Pharma and Biotech Manufacturing
Improve manufacturing processes and ensure patient safety
From raw material identification through the pharmaceutical manufacturing process, to finished and packaged pharmaceutical product inspection, our solutions help pharmaceutical and biopharmaceutical manufacturers save time, improve processes, protect brand integrity, and ensure patient safety.
Pharmaceutical Microbiology
Thermo Scientific™ microbiology solutions are designed to address the unique needs of the pharmaceutical and biotechnology industries. We deliver a range of validated solutions for the pharmaceutical microbiology laboratory, supporting the production and quality assurance of sterile pharmaceuticals, vaccines, and biotechnology products.
We understand patient safety is paramount and ensuring regulatory compliance is non-negotiable. With our commitment to bringing more to pharmaceutical microbiology—from raw materials to finished product, and from environmental monitoring to microbial identification and media fills—you can confidently rely on our product quality and expertise every step of the way.
Portable Pharmaceutical Manufacturing Solutions
Achieve maximum quality coverage while minimizing time-consuming laboratory sampling tests. With Thermo Scientific handheld NIR analyzer and Raman spectrometers, pharmaceutical and biotechnology manufacturers can obtain fast, accurate pharmaceutical analysis results and raw material verification through plastic bags, glass containers, blister packs and clear gel caps in less than 30 seconds in the field to combat the spread of falsified medicines.
Stem Cell Research
For over a decade, we have provided the key tools and resources you need to address challenges in stem cell research. Now we’ve harnessed these powerful innovations into a complete system to support every step of your stem cell research workflow. Our complete portfolio of stem cell research products and services allows you to simplify your workflow and enables the continuity, efficiency, and precision that drive discovery.
Organoids, Spheroids, & 3D Cell Culture
Organoids, spheroids, and the study of 3D cell culture models show great potential in many applications including disease modeling and regenerative medicine. 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically relevant context where 2D models have not proven as successful. Gain confidence to culture and analyze organoids and spheroids through validated protocols and educational resources.
From the identification, synthesis, and optimization of targets to vaccine production, delivery, and testing, Thermo Fisher Scientific provides expertise and an unparalleled array of reliable and scalable tools, services, and support to help you accelerate your productivity and innovation.
Connect with our integrated solutions to support your cell therapy development at every stage. Through our high-quality materials and services, our goal is to support your research through every phase: from initial discovery through clinical trials to commercially viable cell therapies.
Forge an innovative path towards a cure by tapping into our decades of experience in delivering gene therapy solutions that can help you navigate obstacles and challenges. Our end-to-end solutions, high quality products and unrivaled services are here to support you at every step of the way, from gene therapy research to gene therapy commercialization.
We help our customers stay a step ahead on the path to precision medicine. When you partner with us, our scientific expertise and broad portfolio of innovative research tools are at your fingertips, meeting your every need from discovery to commercialization.
From CRISPR-Cas9 gene editing tools and transfection reagents to SelectScreen services and cell culture media, we provide expertise and an unparalleled array of scalable tools, services, and support designed to deliver high-quality results and accelerate your productivity and innovation.
From protein expression systems and immunoassays to bioreactors and plastics, we provide high performing reagents and full-process universal equipment and consumables to effectively minimize cross-contamination and maintain environmental stability.
As a professional raw material supplier, Thermo Fisher can also provide complete OEM solutions for in vitro transcription to better meet customers’ needs for free of animal-origin ingredients and antibiotics, and a wider range of quality inspections.
Next-generation solutions to accelerate scientific research and streamline manufacturing operations, our full suite of lab informatics capabilities delivers the right solution to fit your unique needs.
Our comprehensive portfolio includes X-ray plasmon spectroscopy (XPS), energy-dispersive spectroscopy (EDS), Raman,Fourier-transform infrared (FTIR), near-infrared (NIR), X-ray diffraction (XRD), rheometers, and ultraviolet-visible (UV-Vis) spectroscopy. Using our state-of-the-art instruments ensures quality control across all steps and phases of your workflow and provides drug product consistency from initial formulations to large-scale production, employing fast, non destructive methods.
We understand the challenges in pharmaceuticals - where API solubility and processing stability, taste-masking, enterics, and specialized dosage forms are critical. Our instruments (including extruders, rheometers, compounders, spectrometers and granulators) provide the shortest path from feasibility studies to production in drug formulation and manufacturing.
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