Transformative genome editing technologies, such as the CRISPR-Cas9 system, enable researchers to study, alter, create, and re-create highly complex pathways, DNA sequences, genes, and natural biological systems. Our latest genome editing tools allow you to build organ- and disease-specific models to drive understanding of how individual genes and mutations influence disease development and progression.
Advance your discoveries with fast, accurate results enabled by innovative products across the gene editing workflow.
Building efficient and precise gene editing experiments
Our early understanding of how bacteria use CRISPR to target bacteriophage came from the cheese and yogurt industry. Scientists studying different strains of the dairy-culturing bacterium Streptococcus thermophilus in the early 2000s demonstrated that bacteria use CRISPR and the related enzyme Cas9 to build adaptive immunity by cutting up segments of the invading viruses’ DNA and incorporating them into their own genomes. They went on to adapt CRISPR to easily distinguish and tag different strains of bacteria, kill particular strains within a mix of bacteria and inoculate bacteria against specific pathogens, all of which has had a tremendous impact on industry.
 | Design your gene editing experiments like an expertThe Invitrogen TrueDesign Genome Editor is a free online tool that enables scientists of all experience levels to easily design, select, and order reagents for precise gene editing experiments. |
 | Next-generation Cas9 proteins deliver maximum CRISPR editing efficiencyTrueCut Cas9 proteins are designed to deliver consistently high CRISPR editing efficiency across a range of gene targets and cell types. |
Delivering CRISPR-Cas9 components into cultured cells
 | Transfect with the best of what’s NxTThe Invitrogen Neon Nxt Electroporation System is designed to efficiently and effectively transfect challenging cell lines using a proprietary pipette tip technology—reducing sample loss, lowering contamination risk, and saving you steps. |
 | Find your yes in a sea of maybesBased on a short list of questions, the Invitrogen TransfectionSelect Tool recommends products, protocols and citations for high-efficiency transfection. |
Validating gene editing experiments
 | GeneArt Genome Cleavage Detection KitThis T7 endonuclease based method is a quick way to detect double stranded DNA breaks and validate exceptional gRNA for your genome editing experiment. |
Explore additional validation methods and available solutions at thermofisher.com/crisprvalidation
Building efficient and precise gene editing experiments
Our early understanding of how bacteria use CRISPR to target bacteriophage came from the cheese and yogurt industry. Scientists studying different strains of the dairy-culturing bacterium Streptococcus thermophilus in the early 2000s demonstrated that bacteria use CRISPR and the related enzyme Cas9 to build adaptive immunity by cutting up segments of the invading viruses’ DNA and incorporating them into their own genomes. They went on to adapt CRISPR to easily distinguish and tag different strains of bacteria, kill particular strains within a mix of bacteria and inoculate bacteria against specific pathogens, all of which has had a tremendous impact on industry.
| Design your gene editing experiments like an expertThe Invitrogen TrueDesign Genome Editor is a free online tool that enables scientists of all experience levels to easily design, select, and order reagents for precise gene editing experiments. |
| Next-generation Cas9 proteins deliver maximum CRISPR editing efficiencyTrueCut Cas9 proteins are designed to deliver consistently high CRISPR editing efficiency across a range of gene targets and cell types. |
Delivering CRISPR-Cas9 components into cultured cells
| Transfect with the best of what’s NxTThe Invitrogen Neon Nxt Electroporation System is designed to efficiently and effectively transfect challenging cell lines using a proprietary pipette tip technology—reducing sample loss, lowering contamination risk, and saving you steps. |
| Find your yes in a sea of maybesBased on a short list of questions, the Invitrogen TransfectionSelect Tool recommends products, protocols and citations for high-efficiency transfection. |
Validating gene editing experiments
| GeneArt Genome Cleavage Detection KitThis T7 endonuclease based method is a quick way to detect double stranded DNA breaks and validate exceptional gRNA for your genome editing experiment. |
Explore additional validation methods and available solutions at thermofisher.com/crisprvalidation
Featured resources
Gene editing resource guide
Step-by-step guide to help eliminate the trial-and-error of gene editing, enabling you to get answers faster and with less effort.
CRISPR Gene Editing Webinar Series
In this series of webinars, hear from innovators how the use of gene editing technology is enabling a variety of advanced applications.
Infographic: CRISPR Tips & Tricks
This infographic will serve as your guide with best practices, pro tips and troubleshooting advice for CRISPR-Cas9.
For Research Use Only. Not for use in diagnostic procedures.