Furin Antibodies

Antibodies that detect Furin can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Furin in Human, Mouse, Rat and Canine samples. Our Furin polyclonal, recombinant... Antibodies that detect Furin can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Furin in Human, Mouse, Rat and Canine samples. Our Furin polyclonal, recombinant monoclonal and monoclonal antibodies... Antibodies that detect Furin can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Furin in Human, Mouse, Rat and Canine samples. Our Furin polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit, Goat, Alpaca and Mouse. These antibodies have been verified by Relative expression, Cell treatment and Knockdown to confirm specificity to Furin. Find the Furin antibody that fits your needs. Choose from 1 of 13 Furin antibodies, which have been validated in experiments with 88 publications and 66 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP,... Antibodies that detect Furin can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Furin in Human, Mouse, Rat and Canine samples. Our Furin polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit, Goat, Alpaca and Mouse. These antibodies have been verified by Relative expression, Cell treatment and Knockdown to confirm specificity to Furin. Find the Furin antibody that fits your needs. Choose from 1 of 13 Furin antibodies, which have been validated in experiments with 88 publications and 66 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.

Synonyms

9130404I01Rik; dibasic processing enzyme; dibasic-processing enzyme; FES upstream region; FUR; FURIN; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; furin, paired basic amino acid cleaving enzyme; PACE; Paired basic amino acid cleaving enzyme (furin); paired basic amino acid residue cleaving enzyme; paired basic amino acid residue-cleaving enzyme; Pcsk3; Prohormone convertase 3; proprotein convertase subtilisin/kexin type 3; Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); proprotein convertase subtilisin/kexin type3; SPC1; subtilisin pro-protein processing enzyme

Furin Antibodies

Target Information

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