Product References
Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway.
Frontiers in cardiovascular medicine
Kishimoto H,Nakano T,Torisu K,Tokumoto M,Uchida Y,Yamada S,Taniguchi M,Kitazono T
Published figure using Furin polyclonal antibody (Product # PA1-062) in Western Blot
Sat Mar 11 00:00:00 UTC 2023
SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells.
Experimental dermatology
Ni L,Li P,Li M,Huang S,Dang N
PA1-062 was used in Western Blotting to characterize the function and interaction of ITGAX, SERPINB8 and furin in BRAF V600E mutant melanoma.
Sun Jan 01 00:00:00 UTC 2023
SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells.
Experimental dermatology
Ni L,Li P,Li M,Huang S,Dang N
PA1-062 was used in Western Blotting to characterize the function and interaction of ITGAX, SERPINB8 and furin in BRAF V600E mutant melanoma.
Sun Jan 01 00:00:00 UTC 2023
Generation of Mature DENVs via Genetic Modification and Directed Evolution.
mBio
Tse LV,Meganck RM,Dong S,Adams LE,White LJ,Mallory ML,Jadi R,de Silva AM,Baric RS
Published figure using Furin polyclonal antibody (Product # PA1-062) in Immunocytochemistry
Tue Jun 28 00:00:00 UTC 2022
TMED3 Complex Mediates ER Stress-Associated Secretion of CFTR, Pendrin, and SARS-CoV-2 Spike.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Park H,Seo SK,Sim JR,Hwang SJ,Kim YJ,Shin DH,Jang DG,Noh SH,Park PG,Ko SH,Shin MH,Choi JY,Ito Y,Kang CM,Lee JM,Lee MG
PA1-062 was used in Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to provide evidence for a common role of TMED3 and related TMEDs in the ER stress-associated, Golgi-independent secretion of transmembrane proteins.
Mon Aug 01 00:00:00 UTC 2022
Visualizing intra-Golgi localization and transport by side-averaging Golgi ministacks.
The Journal of cell biology
Tie HC,Mahajan D,Lu L
PA1-062 was used in Immunocytochemistry-immunofluorescence to support constitutive cargos exit at the trans-Golgi while the secretory targeting to the trans-Golgi network is signal dependent.
Mon Jun 06 00:00:00 UTC 2022
The proprotein convertase furin inhibits IL-13-induced inflammation in airway smooth muscle by regulating integrin-associated signaling complexes.
American journal of physiology. Lung cellular and molecular physiology
Wu Y,Huang Y,Zhang W,Gunst SJ
PA1-062 was used in Western Blotting to demonstrate that furin inhibits inflammation in airway smooth muscle induced by IL-13 and that the anti-inflammatory effects of furin are mediated by activating integrin proteins and integrin-associated signaling complexes that regulate Akt-mediated pathways to the nucleus.
Thu Jul 01 00:00:00 UTC 2021
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.
Nature communications
Vichas A,Riley AK,Nkinsi NT,Kamlapurkar S,Parrish PCR,Lo A,Duke F,Chen J,Fung I,Watson J,Rees M,Gabel AM,Thomas JD,Bradley RK,Lee JK,Hatch EM,Baine MK,Rekhtman N,Ladanyi M,Piccioni F,Berger AH
PA1-062 was used in Western Blot to provide a genome-wide atlas of oncogenic RIT1 functional interactions and identify components of the RAS pathway, spindle assembly checkpoint, and Hippo/YAP1 network as candidate therapeutic targets in RIT1-mutant lung cancer.
Mon Aug 09 00:00:00 UTC 2021
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.
Nature communications
Vichas A,Riley AK,Nkinsi NT,Kamlapurkar S,Parrish PCR,Lo A,Duke F,Chen J,Fung I,Watson J,Rees M,Gabel AM,Thomas JD,Bradley RK,Lee JK,Hatch EM,Baine MK,Rekhtman N,Ladanyi M,Piccioni F,Berger AH
PA1-062 was used in Western Blot to provide a genome-wide atlas of oncogenic RIT1 functional interactions and identify components of the RAS pathway, spindle assembly checkpoint, and Hippo/YAP1 network as candidate therapeutic targets in RIT1-mutant lung cancer.
Mon Aug 09 00:00:00 UTC 2021
TGF-β1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells.
Cells
Yin J,Chang HM,Yi Y,Yao Y,Leung PCK
Published figure using Furin polyclonal antibody (Product # PA1-062) in Western Blot
Fri Jan 10 00:00:00 UTC 2020
Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing.
Disease models & mechanisms
Klaver E,Zhao P,May M,Flanagan-Steet H,Freeze HH,Gilmore R,Wells L,Contessa J,Steet R
PA1-062 was used in Western Blot to study the functional impact of the inhibition of N-linked glycosylation on glycoproteins.
Wed Jun 05 00:00:00 UTC 2019
FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing.
BMC biotechnology
Lemaitre RP,Bogdanova A,Borgonovo B,Woodruff JB,Drechsel DN
PA1-062 was used in Western Blotting to demonstrate that FlexiBAC can be used to produce high levels of mature, active forms of TGF-Β family growth factors, such as Activin A, as well as other proteins that are typically difficult to reconstitute, such as proteins rich in coiled-coil, low complexity, and disordered domains.
Fri Mar 29 00:00:00 UTC 2019
Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5.
Nature communications
Shi M,Chen B,Mahajan D,Boh BK,Zhou Y,Dutta B,Tie HC,Sze SK,Wu G,Lu L
PA1-062 was used in Western Blotting to demonstrate that SLC38A9, v-ATPase and Ragulator, but not Rag GTPases and mTORC1, are essential for amino acid-stimulated trafficking.
Mon Nov 26 00:00:00 UTC 2018
Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5.
Nature communications
Shi M,Chen B,Mahajan D,Boh BK,Zhou Y,Dutta B,Tie HC,Sze SK,Wu G,Lu L
PA1-062 was used in Western Blotting to demonstrate that SLC38A9, v-ATPase and Ragulator, but not Rag GTPases and mTORC1, are essential for amino acid-stimulated trafficking.
Mon Nov 26 00:00:00 UTC 2018
Proprotein convertase furin regulates osteocalcin and bone endocrine function.
The Journal of clinical investigation
Al Rifai O,Chow J,Lacombe J,Julien C,Faubert D,Susan-Resiga D,Essalmani R,Creemers JW,Seidah NG,Ferron M
PA1-062 was used in Western Blotting to show that the proprotein convertase furin is responsible for pro-osteocalcin maturation in vitro and in vivo.
Wed Nov 01 00:00:00 UTC 2017
Proprotein convertase furin regulates osteocalcin and bone endocrine function.
The Journal of clinical investigation
Al Rifai O,Chow J,Lacombe J,Julien C,Faubert D,Susan-Resiga D,Essalmani R,Creemers JW,Seidah NG,Ferron M
PA1-062 was used in Western Blotting to show that the proprotein convertase furin is responsible for pro-osteocalcin maturation in vitro and in vivo.
Wed Nov 01 00:00:00 UTC 2017
The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain.
Glia
Kawahara K,Hirata H,Ohbuchi K,Nishi K,Maeda A,Kuniyasu A,Yamada D,Maeda T,Tsuji A,Sawada M,Nakayama H
PA1062 was used in western blot to use antibodies to differentiate subtypes of microglia
Tue Nov 01 00:00:00 UTC 2016
The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain.
Glia
Kawahara K,Hirata H,Ohbuchi K,Nishi K,Maeda A,Kuniyasu A,Yamada D,Maeda T,Tsuji A,Sawada M,Nakayama H
PA1062 was used in western blot to use antibodies to differentiate subtypes of microglia
Tue Nov 01 00:00:00 UTC 2016
Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins.
Journal of virology
Bronnimann MP,Calton CM,Chiquette SF,Li S,Lu M,Chapman JA,Bratton KN,Schlegel AM,Campos SK
Published figure using Furin polyclonal antibody (Product # PA1-062) in Western Blot
Fri Jul 15 00:00:00 UTC 2016
Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition.
Bone
Yamamoto H,Ramos-Molina B,Lick AN,Prideaux M,Albornoz V,Bonewald L,Lindberg I
PA1-062 was used in immunocytochemistry to examine the osteoblast to osteocyte transition in regards to posttranslational processing
Tue Mar 01 00:00:00 UTC 2016
Recombinant BMP4 and BMP7 increase activin A production by up-regulating inhibin βA subunit and furin expression in human granulosa-lutein cells.
The Journal of clinical endocrinology and metabolism
Chang HM,Cheng JC,Klausen C,Leung PC
PA1-062 was used in immunocytochemistry and western blot to study endogenous activin A in human granulosa cells
Sun Mar 01 00:00:00 UTC 2015
Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
American journal of physiology. Lung cellular and molecular physiology
Kato S,Zhang R,Roberts JD
Published figure using Furin polyclonal antibody (Product # PA1-062) in Western Blot
Mon Jul 15 00:00:00 UTC 2013
Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types.
PloS one
Voura EB,English JL,Yu HY,Ho AT,Subarsky P,Hill RP,Hojilla CV,Khokha R
PA1-062 was used in blocking or activating experiment to develop an in vitro model of tumor cell extravasation to study the role of proteolysis
Tue Feb 24 00:00:00 UTC 2015
Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane.
The Journal of cell biology
Gerl MJ,Sampaio JL,Urban S,Kalvodova L,Verbavatz JM,Binnington B,Lindemann D,Lingwood CA,Shevchenko A,Schroeder C,Simons K
PA1-062 was used in western blot to perform a quantitative mass spectrometric analysis of the lipidomes of MDCK cells, MDCK apical membranes and the influenza virus envelope
Mon Jan 23 00:00:00 UTC 2012
Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface.
Journal of cellular physiology
Arsenault D,Lucien F,Dubois CM
Published figure using Furin polyclonal antibody (Product # PA1-062) in Immunoprecipitation
Wed Feb 01 00:00:00 UTC 2012
Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity.
PloS one
Reales E,Sharma N,Low SH,Fölsch H,Weimbs T
PA1-062 was used in immunocytochemistry to investigate the polarized localization of syntaxin 4 and its role in the establishment of epithelial cell polarity
Mon Nov 07 00:00:00 UTC 2011
Human testicular orphan receptor 4 enhances thyroid hormone receptor signaling.
Journal of cellular physiology
Huang YH,Liao CH,Chen RN,Liao CJ,Lin KH
PA1-062 was used in western blot to investigate the effect of testicular orphan receptor 4 on thyroid hormone receptor signal regulation
Mon Feb 01 00:00:00 UTC 2010
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology
Koike MA,Green KN,Blurton-Jones M,Laferla FM
PA1-062 was used in western blot to investigate the effect of oligemic hypoperfusion on tau and amyloid-beta in 3xTg-Alzheimer disease mice
Thu Jul 01 00:00:00 UTC 2010
A novel transmembrane domain mediating retention of a highly motile herpesvirus glycoprotein in the endoplasmic reticulum.
The Journal of general virology
Däubner T,Fink A,Seitz A,Tenzer S,Müller J,Strand D,Seckert CK,Janssen C,Renzaho A,Grzimek NK,Simon CO,Ebert S,Reddehase MJ,Oehrlein-Karpi SA,Lemmermann NA
PA1-062 was used in western blot to identify the mechanism for the retention of a herpesvirus glycoprotein in the endoplasmic reticulum
Tue Jun 01 00:00:00 UTC 2010
OCRL1 function in renal epithelial membrane traffic.
American journal of physiology. Renal physiology
Cui S,Guerriero CJ,Szalinski CM,Kinlough CL,Hughey RP,Weisz OA
PA1-062 was used in immunocytochemistry to study the function of OCRL1 in renal epithelial membrane trafficking
Mon Feb 01 00:00:00 UTC 2010
HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.
The Journal of biological chemistry
Yi L,Rosales T,Rose JJ,Chowdhury B,Knutson JR,Venkatesan S
PA1-062 was used in immunocytochemistry to study the mechanisms of HLA-1 down regulation by HIV-1 Nef.
Fri Oct 01 00:00:00 UTC 2010
Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.
The Journal of cell biology
Nokes RL,Fields IC,Collins RN,Fölsch H
PA1-062 was used in immunocytochemistry to study the role of Rab13 in maintaining the polarity of epithelial cells.
Mon Sep 08 00:00:00 UTC 2008
Identification of a pH sensor in the furin propeptide that regulates enzyme activation.
The Journal of biological chemistry
Feliciangeli SF,Thomas L,Scott GK,Subbian E,Hung CH,Molloy SS,Jean F,Shinde U,Thomas G
Published figure using Furin polyclonal antibody (Product # PA1-062) in Western Blot
Fri Jun 09 00:00:00 UTC 2006
Identification of a pH sensor in the furin propeptide that regulates enzyme activation.
The Journal of biological chemistry
Feliciangeli SF,Thomas L,Scott GK,Subbian E,Hung CH,Molloy SS,Jean F,Shinde U,Thomas G
Published figure using Furin polyclonal antibody (Product # PA1-062) in Western Blot
Fri Jun 09 00:00:00 UTC 2006
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.
Molecular biology of the cell
Nakamura N,Fukuda H,Kato A,Hirose S
PA1-062 was used in western blot to identify membrane-associated RING-CH (MARCH) and its binding to syntaxin 6.
Fri Apr 01 00:00:00 UTC 2005
Increased production of functional recombinant human clotting factor IX by baby hamster kidney cells engineered to overexpress VKORC1, the vitamin K 2,3-epoxide-reducing enzyme of the vitamin K cycle.
The Journal of biological chemistry
Wajih N,Hutson SM,Owen J,Wallin R
PA1-062 was used in western blot to demonstrate a new approach to increase production of functional recombinant human clotting factor IX by baby hamster kidney cells.
Fri Sep 09 00:00:00 UTC 2005
Sorting of furin in polarized epithelial and endothelial cells: expression beyond the Golgi apparatus.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Mayer G,Boileau G,Bendayan M
PA1-062 was used in immunohistochemistry to investigate the sorting of furin in polarized epithelial and endothelial cells
Sat May 01 00:00:00 UTC 2004
Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network. Identification of DKV582 as a recycling signal.
The Journal of biological chemistry
Wang X,Ma D,Keski-Oja J,Pei D
PA1-062 was used in immunocytochemistry to demonstrate the coordinated proteolytic activities among membrane-type matrix metalloproteinases .
Fri Mar 05 00:00:00 UTC 2004
The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells.
The Journal of cell biology
Ang AL,Fölsch H,Koivisto UM,Pypaert M,Mellman I
PA1-062 was used in immunocytochemistry to study the effect of Rab8 GTPase on AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells.
Mon Oct 27 00:00:00 UTC 2003
The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains.
The Journal of cell biology
Fölsch H,Pypaert M,Maday S,Pelletier L,Mellman I
PA1-062 was used in immunocytochemistry to investigate the different roles of the AP-1A and AP-1B clathrin adaptor complexes.
Mon Oct 27 00:00:00 UTC 2003
Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.
Cancer research
Kang T,Nagase H,Pei D
PA1-062 was used in immunocytochemistry to investigate the regulatory role of furin on MT3-MMP zymogen in the trans-Golgi network.
Fri Feb 01 00:00:00 UTC 2002
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
The Journal of biological chemistry
Anderson ED,Molloy SS,Jean F,Fei H,Shimamura S,Thomas G
PA1-062 was used in immunocytochemistry to investigate the role of the furin propeptide during the folding of the enzyme and its activation in vivo.
Fri Apr 12 00:00:00 UTC 2002
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
The Journal of biological chemistry
Anderson ED,Molloy SS,Jean F,Fei H,Shimamura S,Thomas G
PA1-062 was used in immunocytochemistry to investigate the role of the furin propeptide during the folding of the enzyme and its activation in vivo.
Fri Apr 12 00:00:00 UTC 2002
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
The Journal of biological chemistry
Anderson ED,Molloy SS,Jean F,Fei H,Shimamura S,Thomas G
PA1-062 was used in immunocytochemistry to investigate the role of the furin propeptide during the folding of the enzyme and its activation in vivo.
Fri Apr 12 00:00:00 UTC 2002
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
The Journal of biological chemistry
Anderson ED,Molloy SS,Jean F,Fei H,Shimamura S,Thomas G
PA1-062 was used in immunocytochemistry to investigate the role of the furin propeptide during the folding of the enzyme and its activation in vivo.
Fri Apr 12 00:00:00 UTC 2002
Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases.
The Journal of biological chemistry
Unsöld C,Pappano WN,Imamura Y,Steiglitz BM,Greenspan DS
PA1-062 was used in blocking/activating experiment to investigate how pro-alpha 1(V)2pro-alpha 2(V) heterotrimers are processed by means of BMP-1 or furin in vivo
Fri Feb 15 00:00:00 UTC 2002
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
The Journal of biological chemistry
Gao G,Westling J,Thompson VP,Howell TD,Gottschall PE,Sandy JD
PA1-062 was used in blocking/activating experiment to investigate the mechanism for the activation of ADAMTS4 proteolytic activity
Fri Mar 29 00:00:00 UTC 2002
Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites.
The Journal of biological chemistry
Kang T,Zhao YG,Pei D,Sucic JF,Sang QX
PA1-062 was used in immunocytochemistry to investigate the effect of furin on adamalysin 19/disintegrin and metalloproteinase 19.
Fri Jul 12 00:00:00 UTC 2002
Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells.
The Journal of cell biology
Fölsch H,Pypaert M,Schu P,Mellman I
Published figure using Furin polyclonal antibody (Product # PA1-062) in Immunocytochemistry
Mon Feb 05 00:00:00 UTC 2001
Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells.
The Journal of cell biology
Yeaman C,Grindstaff KK,Wright JR,Nelson WJ
PA1-062 was used in immunocytochemistry to investigate the role of Sec6/8 complex in exocytic transport of vesicles between TGN and plasma membrane in mammalian cells.
Mon Nov 12 00:00:00 UTC 2001
A protein-based therapeutic for human cytomegalovirus infection.
Proceedings of the National Academy of Sciences of the United States of America
Jean F,Thomas L,Molloy SS,Liu G,Jarvis MA,Nelson JA,Thomas G
PA1-062 was used in western blot to investigate the role of furin during the proteolytic activation.
Tue Mar 14 00:00:00 UTC 2000
A protein-based therapeutic for human cytomegalovirus infection.
Proceedings of the National Academy of Sciences of the United States of America
Jean F,Thomas L,Molloy SS,Liu G,Jarvis MA,Nelson JA,Thomas G
PA1-062 was used in western blot to investigate the role of furin during the proteolytic activation.
Tue Mar 14 00:00:00 UTC 2000
The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments.
Molecular biology of the cell
Xiang Y,Molloy SS,Thomas L,Thomas G
PA1-062 was used in immunocytochemistry to investigate the roles of the PC6B cytoplasmic domain during protein sorting.
Sat Apr 01 00:00:00 UTC 2000
A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.
The Journal of biological chemistry
Bennett BD,Denis P,Haniu M,Teplow DB,Kahn S,Louis JC,Citron M,Vassar R
PA1-062 was used in immunocytochemistry to demonstrate the role of a furin-like proprotein convertase in BACE maturation.
Fri Dec 01 00:00:00 UTC 2000
Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.
The Journal of cell biology
Liu G,Thomas L,Warren RA,Enns CA,Cunningham CC,Hartwig JH,Thomas G
PA1-062 was used in immunoprecipitation to investigate the role of the cytoskeletal protein ABP-280 in intracellular furin trafficking and its effect on furin proprotein processing.
Mon Dec 29 00:00:00 UTC 1997
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.
The EMBO journal
Molloy SS,Thomas L,VanSlyke JK,Stenberg PE,Thomas G
PA1-062 was used in immunocytochemistry to investigate the dynamic distribution and functional properties of furin in cells
Sat Jan 01 00:00:00 UTC 1994
