RUNX3 Antibodies

Target Information

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; AML2; CBFA3; CBF-alpha 3; CBF-alpha-3; core binding factor alpha 3; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2A3; PEBP2aC; PEBP2-alpha C; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; Runt related transcription factor 3; runt-related transcription factor 3; RUNX3; SL3/AKV core-binding factor alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; transcription factor AML2; transcription factor AML2/CBFA3