Proteintech

IRF3 Polyclonal Antibody

IRF3 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 14

IRF3 Antibody (11312-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using IRF3 antibody 11312-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

IRF3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IRF3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11312-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 118 publications 118 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 26 publications 26 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 8 publications 8 publications

ChIP assay (ChIP)

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 3 publications 3 publications

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Pig, Rat, Sheep

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IRF3 Fusion Protein Ag1858 (1-452 aa encoded by BC009395)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGTPKPRIL PWLVSQLDLG QLEGVAWVNK SRTRFRIPWK HGLRQDAQQE DFGIFQAWAE ATGAYVPGRD KPDLPTWKRN FRSALNRKEG LRLAEDRSKD PHDPHKIYEF VNSGVGDFSQ PDTSPDTNGG GSTSDTQEDI LDELLGNMVL APLPDPGPPS LAVAPEPCPQ PLRSPSLDNP TPFPNLGPSE NPLKRLLVPG EEWEFEVTAF YRGRQVFQQT ISCPEGLRLV GSEVGDRTLP GWPVTLPDPG MSLTDRGVMS YVRHVLSCLG GGLALWRAGQ WLWAQRLGHC HTYWAVSEEL LPNSGHGPDG EVPKDKEGGV FDLGPFIVGS WAPRSDYLHG RKRTLTTLCP LVLCGGVMAP GPAVDQEARD GQGCAHVPQG LGRNGPGRGC LLPGEYCGPA HFQQPPTLPH LRPVQGLPAG LGGGHGFPGP WGDLSPRSSW CASNPPVPHH LNQ (1-452 aa encoded by BC009395)

Target Information

IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Thu Nov 04 00:00:00 UTC 2021

Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.

Pathogens (Basel, Switzerland)

Zhou Y,Zhao S,Gao X,Jiang S,Ma J,Wang R,Li Q,Qin L,Tong Z,Wu J,Zhao J

Thu Mar 04 00:00:00 UTC 2021

Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation.

Frontiers in microbiology

Xie J,Zhang X,Chen L,Bi Y,Idris A,Xu S,Li X,Zhang Y,Feng R

Wed Nov 10 00:00:00 UTC 2021

Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation.

Frontiers in microbiology

Xie J,Zhang X,Chen L,Bi Y,Idris A,Xu S,Li X,Zhang Y,Feng R

Wed Nov 10 00:00:00 UTC 2021

PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Zhang N,Gao Y,Zeng Z,Luo Y,Jiang X,Zhang J,Li J,Zhang J,Gong Y,Xie C

Wed Sep 01 00:00:00 UTC 2021

Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.

Journal of immunology (Baltimore, Md. : 1950)

Zuo Q,Cheng Z,Zhang G,Xia Y,Xu G,Cao W,Yang X,Fu Y,He R,Fang P,Guo Y,Nie L,Huang Y,Liu L,Zhan J,Liu S,Zhu Y

Thu Jul 15 00:00:00 UTC 2021

Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.

Cellular & molecular immunology

Xu G,Deng F,Zuo Q,Liu L,Dou K,Cheng Z,Cao W,Luo C,Yu C,Liu S,Zhu Y

Tue Jun 01 00:00:00 UTC 2021

Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl₄/2-AAF.

Pharmaceutical biology

Xu Y,Xu W,Liu W,Chen G,Jiang S,Chen J,Jian X,Zhang H,Liu P,Mu Y

Wed Dec 01 00:00:00 UTC 2021

Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.

Veterinary microbiology

Liao Y,Liu C,Wang J,Song Y,Sabir N,Hussain T,Yao J,Luo L,Wang H,Cui Y,Yang L,Zhao D,Zhou X

Thu Jul 01 00:00:00 UTC 2021

Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.

Veterinary microbiology

Liao Y,Liu C,Wang J,Song Y,Sabir N,Hussain T,Yao J,Luo L,Wang H,Cui Y,Yang L,Zhao D,Zhou X

Thu Jul 01 00:00:00 UTC 2021

Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.

Science advances

Ma D,Yang M,Wang Q,Sun C,Shi H,Jing W,Bi Y,Shen X,Ma X,Qin Z,Lin Y,Zhu L,Zhao Y,Cheng Y,Han L

Mon Mar 01 00:00:00 UTC 2021

Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.

Immunology

Chen X,Xu Y,Tu W,Huang F,Zuo Y,Zhang HG,Jin L,Feng Q,Ren T,He J,Miao Y,Yuan Y,Zhao Q,Liu J,Zhang R,Zhu L,Qian F,Zhu C,Zheng H,Wang J

Thu Jul 01 00:00:00 UTC 2021

African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.

Veterinary microbiology

Yang K,Huang Q,Wang R,Zeng Y,Cheng M,Xue Y,Shi C,Ye L,Yang W,Jiang Y,Wang J,Huang H,Cao X,Yang G,Wang C

Wed Dec 01 00:00:00 UTC 2021

SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5.

Virologica Sinica

Wang DP,Zhang HY,Liao BW,Tong Z,Xu ZS,Wang YY,Yang Y

Thu Apr 01 00:00:00 UTC 2021

A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.

Cell reports

Sun H,Huang Y,Mei S,Xu F,Liu X,Zhao F,Yin L,Zhang D,Wei L,Wu C,Ma S,Wang J,Cen S,Liang C,Hu S,Guo F

Tue Jan 05 00:00:00 UTC 2021

The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.

Molecular and cellular endocrinology

Hu HQ,Qiao JT,Liu FQ,Wang JB,Sha S,He Q,Cui C,Song J,Zang N,Wang LS,Sun Z,Chen L,Hou XG

Tue Dec 01 00:00:00 UTC 2020

Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells.

Virology

Zhang L,Qiu S,Lu M,Huang C,Lv Y

Tue Sep 01 00:00:00 UTC 2020

Silica particles disorganize the polarization of pulmonary macrophages in mice.

Ecotoxicology and environmental safety

Zhao Y,Hao C,Bao L,Wang D,Li Y,Qu Y,Ding M,Zhao A,Yao W

Wed Apr 15 00:00:00 UTC 2020

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.

Viruses

Chen K,Xiao F,Hu D,Ge W,Tian M,Wang W,Pan P,Wu K,Wu J

Wed Dec 30 00:00:00 UTC 2020

Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.

The Journal of clinical investigation

Jauhari A,Baranov SV,Suofu Y,Kim J,Singh T,Yablonska S,Li F,Wang X,Oberly P,Minnigh MB,Poloyac SM,Carlisle DL,Friedlander RM

Mon Jun 01 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.

Veterinary research

Bo Z,Miao Y,Xi R,Zhong Q,Bao C,Chen H,Sun L,Qian Y,Jung YS,Dai J

Tue Sep 15 00:00:00 UTC 2020

Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response.

Journal of virology

Zou HM,Huang ZF,Yang Y,Luo WW,Wang SY,Luo MH,Fu YZ,Wang YY

Mon Jun 01 00:00:00 UTC 2020

The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.

ACS infectious diseases

Min YQ,Shi C,Yao T,Feng K,Mo Q,Deng F,Wang H,Ning YJ

Fri May 08 00:00:00 UTC 2020

The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.

ACS infectious diseases

Min YQ,Shi C,Yao T,Feng K,Mo Q,Deng F,Wang H,Ning YJ

Fri May 08 00:00:00 UTC 2020

Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3.

Frontiers in immunology

Wang P,Deng Y,Guo Y,Xu Z,Li Y,Ou X,Xie L,Lu M,Zhong J,Li B,Hu L,Deng S,Peng T,Cai M,Li M

Thu Apr 29 00:00:00 UTC 2021

Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.

Cellular & molecular immunology

Lou Y,Han M,Liu H,Niu Y,Liang Y,Guo J,Zhang W,Wang H

Thu Oct 01 00:00:00 UTC 2020

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.

Cell

Zierhut C,Yamaguchi N,Paredes M,Luo JD,Carroll T,Funabiki H

Thu Jul 11 00:00:00 UTC 2019

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.

Cell death and differentiation

Su Z,Dziedzic SA,Hu D,Barrett VJ,Broekema N,Li W,Qian L,Jia N,Ofengeim D,Najafov A,Zhu H,Knipe DM,Yuan J

Sat Jun 01 00:00:00 UTC 2019

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.

Cell death and differentiation

Su Z,Dziedzic SA,Hu D,Barrett VJ,Broekema N,Li W,Qian L,Jia N,Ofengeim D,Najafov A,Zhu H,Knipe DM,Yuan J

Sat Jun 01 00:00:00 UTC 2019

Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.

Journal of molecular cell biology

Yang Q,Tang J,Pei R,Gao X,Guo J,Xu C,Wang Y,Wang Q,Wu C,Zhou Y,Hu X,Zhao H,Wang Y,Chen X,Chen J

Fri Feb 01 00:00:00 UTC 2019

Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.

Journal of molecular cell biology

Yang Q,Tang J,Pei R,Gao X,Guo J,Xu C,Wang Y,Wang Q,Wu C,Zhou Y,Hu X,Zhao H,Wang Y,Chen X,Chen J

Fri Feb 01 00:00:00 UTC 2019

Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.

Journal of molecular cell biology

Yang Q,Tang J,Pei R,Gao X,Guo J,Xu C,Wang Y,Wang Q,Wu C,Zhou Y,Hu X,Zhao H,Wang Y,Chen X,Chen J

Fri Feb 01 00:00:00 UTC 2019

Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.

Journal of molecular cell biology

Yang Q,Tang J,Pei R,Gao X,Guo J,Xu C,Wang Y,Wang Q,Wu C,Zhou Y,Hu X,Zhao H,Wang Y,Chen X,Chen J

Fri Feb 01 00:00:00 UTC 2019

Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.

Journal of immunology (Baltimore, Md. : 1950)

Sanjo H,Nakayama J,Yoshizawa T,Fehling HJ,Akira S,Taki S

Thu Aug 15 00:00:00 UTC 2019

Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.

Frontiers in immunology

Guan X,Zhang M,Fu M,Luo S,Hu Q

Mon Sep 14 00:00:00 UTC 2020

Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study.

Frontiers in physiology

Chavez-Valdez R,Mottahedin A,Stridh L,Yellowhair TR,Jantzie LL,Northington FJ,Mallard C

Wed Sep 30 00:00:00 UTC 2020

TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.

The EMBO journal

Zhu W,Li J,Zhang R,Cai Y,Wang C,Qi S,Chen S,Liang X,Qi N,Hou F

Mon Sep 16 00:00:00 UTC 2019

A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.

Molecules (Basel, Switzerland)

Wan W,Wang L,Chen X,Zhu S,Shang W,Xiao G,Zhang LK

Wed Nov 20 00:00:00 UTC 2019

Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.

PLoS pathogens

Xu G,Xia Z,Deng F,Liu L,Wang Q,Yu Y,Wang F,Zhu C,Liu W,Cheng Z,Zhu Y,Zhou L,Zhang Y,Lu M,Liu S

Thu Aug 01 00:00:00 UTC 2019

PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.

Science signaling

Hu S,Sun H,Yin L,Li J,Mei S,Xu F,Wu C,Liu X,Zhao F,Zhang D,Huang Y,Ren L,Cen S,Wang J,Liang C,Guo F

Tue Nov 26 00:00:00 UTC 2019

NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.

Journal of immunology (Baltimore, Md. : 1950)

Xia Z,Xu G,Nie L,Liu L,Peng N,He Q,Zuo Q,Zhou Y,Cao Z,Liu S,Zhu Y

Thu Aug 15 00:00:00 UTC 2019

Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.

Nutrition & metabolism

Xue M,Liang H,Ji X,Liu Y,Ge Y,Hou L,Sun T

Tue Apr 12 00:00:00 UTC 2022

Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.

Nutrition & metabolism

Xue M,Liang H,Ji X,Liu Y,Ge Y,Hou L,Sun T

Tue Apr 12 00:00:00 UTC 2022

Dampened STING-Dependent Interferon Activation in Bats.

Cell host & microbe

Xie J,Li Y,Shen X,Goh G,Zhu Y,Cui J,Wang LF,Shi ZL,Zhou P

Wed Mar 14 00:00:00 UTC 2018

Dampened STING-Dependent Interferon Activation in Bats.

Cell host & microbe

Xie J,Li Y,Shen X,Goh G,Zhu Y,Cui J,Wang LF,Shi ZL,Zhou P

Wed Mar 14 00:00:00 UTC 2018

PTEN-L promotes type I interferon responses and antiviral immunity.

Cellular & molecular immunology

Cao Y,Wang H,Yang L,Zhang Z,Li C,Yuan X,Bu L,Chen L,Chen Y,Li CM,Guo D

Mon Jan 01 00:00:00 UTC 2018

PTEN-L promotes type I interferon responses and antiviral immunity.

Cellular & molecular immunology

Cao Y,Wang H,Yang L,Zhang Z,Li C,Yuan X,Bu L,Chen L,Chen Y,Li CM,Guo D

Mon Jan 01 00:00:00 UTC 2018

PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.

Journal of innate immunity

Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

Tue Oct 08 00:00:00 UTC 2019

PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.

Journal of innate immunity

Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

Tue Oct 08 00:00:00 UTC 2019

USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Cai J,Chen HY,Peng SJ,Meng JL,Wang Y,Zhou Y,Qian XP,Sun XY,Pang XW,Zhang Y,Zhang J

Mon Oct 01 00:00:00 UTC 2018

USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Cai J,Chen HY,Peng SJ,Meng JL,Wang Y,Zhou Y,Qian XP,Sun XY,Pang XW,Zhang Y,Zhang J

Mon Oct 01 00:00:00 UTC 2018

Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.

Biochemical and biophysical research communications

Wang X,Wu J,Wu Y,Chen H,Zhang S,Li J,Xin T,Jia H,Hou S,Jiang Y,Zhu H,Guo X

Fri Nov 30 00:00:00 UTC 2018

Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.

Biochemical and biophysical research communications

Wang X,Wu J,Wu Y,Chen H,Zhang S,Li J,Xin T,Jia H,Hou S,Jiang Y,Zhu H,Guo X

Fri Nov 30 00:00:00 UTC 2018

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.

Nature communications

Zhou P,Ding X,Wan X,Liu L,Yuan X,Zhang W,Hui X,Meng G,Xiao H,Li B,Zhong J,Hou F,Deng L,Zhang Y

Wed Mar 28 00:00:00 UTC 2018

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.

Nature communications

Zhou P,Ding X,Wan X,Liu L,Yuan X,Zhang W,Hui X,Meng G,Xiao H,Li B,Zhong J,Hou F,Deng L,Zhang Y

Wed Mar 28 00:00:00 UTC 2018

STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.

Experimental cell research

Cao Q,Juan CX,Zhang DQ,He J,Cao YZ,Pasha AB,Wang JY,Qi HX,Li S,Jin R,Zhou GP

Sat Sep 15 00:00:00 UTC 2018

Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity.

Journal of immunology (Baltimore, Md. : 1950)

Zheng Z,Yang J,Jiang X,Liu Y,Zhang X,Li M,Zhang M,Fu M,Hu K,Wang H,Luo MH,Gong P,Hu Q

Sun Jul 01 00:00:00 UTC 2018

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.

The Journal of experimental medicine

Lang X,Tang T,Jin T,Ding C,Zhou R,Jiang W

Wed Feb 01 00:00:00 UTC 2017

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.

The Journal of experimental medicine

Lang X,Tang T,Jin T,Ding C,Zhou R,Jiang W

Wed Feb 01 00:00:00 UTC 2017

Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.

Frontiers in immunology

Yi C,Zhao Z,Wang S,Sun X,Zhang D,Sun X,Zhang A,Jin M

Wed Nov 20 00:00:00 UTC 2019

Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.

Frontiers in immunology

Yi C,Zhao Z,Wang S,Sun X,Zhang D,Sun X,Zhang A,Jin M

Wed Nov 20 00:00:00 UTC 2019

Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.

Frontiers in immunology

Yi C,Zhao Z,Wang S,Sun X,Zhang D,Sun X,Zhang A,Jin M

Wed Nov 20 00:00:00 UTC 2019

Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.

Frontiers in immunology

Yi C,Zhao Z,Wang S,Sun X,Zhang D,Sun X,Zhang A,Jin M

Wed Nov 20 00:00:00 UTC 2019

GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.

PLoS pathogens

Nie Y,Ran Y,Zhang HY,Huang ZF,Pan ZY,Wang SY,Wang YY

Sat Apr 01 00:00:00 UTC 2017

GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.

PLoS pathogens

Nie Y,Ran Y,Zhang HY,Huang ZF,Pan ZY,Wang SY,Wang YY

Sat Apr 01 00:00:00 UTC 2017

West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.

Journal of virology

Zhang HL,Ye HQ,Liu SQ,Deng CL,Li XD,Shi PY,Zhang B

Fri Sep 15 00:00:00 UTC 2017

West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.

Journal of virology

Zhang HL,Ye HQ,Liu SQ,Deng CL,Li XD,Shi PY,Zhang B

Fri Sep 15 00:00:00 UTC 2017

West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.

Journal of virology

Zhang HL,Ye HQ,Liu SQ,Deng CL,Li XD,Shi PY,Zhang B

Fri Sep 15 00:00:00 UTC 2017

West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.

Journal of virology

Zhang HL,Ye HQ,Liu SQ,Deng CL,Li XD,Shi PY,Zhang B

Fri Sep 15 00:00:00 UTC 2017

Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.

Mediators of inflammation

Jiang Z,Song F,Li Y,Xue D,Deng G,Li M,Liu X,Wang Y

Tue Mar 27 00:00:00 UTC 2018

Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.

Mediators of inflammation

Jiang Z,Song F,Li Y,Xue D,Deng G,Li M,Liu X,Wang Y

Tue Mar 27 00:00:00 UTC 2018

Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.

Microbial pathogenesis

Zhao M,Wan B,Li H,He J,Chen X,Wang L,Wang Y,Xie S,Qiao S,Zhang G

Sun Oct 01 00:00:00 UTC 2017

Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.

Microbial pathogenesis

Zhao M,Wan B,Li H,He J,Chen X,Wang L,Wang Y,Xie S,Qiao S,Zhang G

Sun Oct 01 00:00:00 UTC 2017

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.

The Biochemical journal

Bakshi S,Taylor J,Strickson S,McCartney T,Cohen P

Wed Mar 15 00:00:00 UTC 2017

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.

The Biochemical journal

Bakshi S,Taylor J,Strickson S,McCartney T,Cohen P

Wed Mar 15 00:00:00 UTC 2017

The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.

Frontiers in cellular and infection microbiology

Chunfa L,Xin S,Qiang L,Sreevatsan S,Yang L,Zhao D,Zhou X

Wed Dec 27 00:00:00 UTC 2017

The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.

Frontiers in cellular and infection microbiology

Chunfa L,Xin S,Qiang L,Sreevatsan S,Yang L,Zhao D,Zhou X

Wed Dec 27 00:00:00 UTC 2017

Decreased expression of STING predicts poor prognosis in patients with gastric cancer.

Scientific reports

Song S,Peng P,Tang Z,Zhao J,Wu W,Li H,Shao M,Li L,Yang C,Duan F,Zhang M,Zhang J,Wu H,Li C,Wang X,Wang H,Ruan Y,Gu J

Wed Feb 08 00:00:00 UTC 2017

Decreased expression of STING predicts poor prognosis in patients with gastric cancer.

Scientific reports

Song S,Peng P,Tang Z,Zhao J,Wu W,Li H,Shao M,Li L,Yang C,Duan F,Zhang M,Zhang J,Wu H,Li C,Wang X,Wang H,Ruan Y,Gu J

Wed Feb 08 00:00:00 UTC 2017

Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.

Oncotarget

Lian S,Guo J,Wang L,Li W,Wang J,Ji H,Kong F,Xu B,Li S,Yang H

Fri Dec 29 00:00:00 UTC 2017

Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.

Oncotarget

Lian S,Guo J,Wang L,Li W,Wang J,Ji H,Kong F,Xu B,Li S,Yang H

Fri Dec 29 00:00:00 UTC 2017

The tumor suppressor PTEN has a critical role in antiviral innate immunity.

Nature immunology

Li S,Zhu M,Pan R,Fang T,Cao YY,Chen S,Zhao X,Lei CQ,Guo L,Chen Y,Li CM,Jokitalo E,Yin Y,Shu HB,Guo D

Tue Mar 01 00:00:00 UTC 2016

The tumor suppressor PTEN has a critical role in antiviral innate immunity.

Nature immunology

Li S,Zhu M,Pan R,Fang T,Cao YY,Chen S,Zhao X,Lei CQ,Guo L,Chen Y,Li CM,Jokitalo E,Yin Y,Shu HB,Guo D

Tue Mar 01 00:00:00 UTC 2016

The tumor suppressor PTEN has a critical role in antiviral innate immunity.

Nature immunology

Li S,Zhu M,Pan R,Fang T,Cao YY,Chen S,Zhao X,Lei CQ,Guo L,Chen Y,Li CM,Jokitalo E,Yin Y,Shu HB,Guo D

Tue Mar 01 00:00:00 UTC 2016

The tumor suppressor PTEN has a critical role in antiviral innate immunity.

Nature immunology

Li S,Zhu M,Pan R,Fang T,Cao YY,Chen S,Zhao X,Lei CQ,Guo L,Chen Y,Li CM,Jokitalo E,Yin Y,Shu HB,Guo D

Tue Mar 01 00:00:00 UTC 2016

Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.

Journal of virology

Zeng LP,Gao YT,Ge XY,Zhang Q,Peng C,Yang XL,Tan B,Chen J,Chmura AA,Daszak P,Shi ZL

Fri Jul 15 00:00:00 UTC 2016

Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.

Journal of virology

Zeng LP,Gao YT,Ge XY,Zhang Q,Peng C,Yang XL,Tan B,Chen J,Chmura AA,Daszak P,Shi ZL

Fri Jul 15 00:00:00 UTC 2016

Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.

Journal of neurochemistry

Li L,Qin JJ,Guo S,Zhang P,Gong J,Zhang XJ,Zheng A,Xia H,Li H

Mon Feb 01 00:00:00 UTC 2016

Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.

Journal of neurochemistry

Li L,Qin JJ,Guo S,Zhang P,Gong J,Zhang XJ,Zheng A,Xia H,Li H

Mon Feb 01 00:00:00 UTC 2016

Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.

Journal of neurochemistry

Li L,Qin JJ,Guo S,Zhang P,Gong J,Zhang XJ,Zheng A,Xia H,Li H

Mon Feb 01 00:00:00 UTC 2016

Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.

Journal of neurochemistry

Li L,Qin JJ,Guo S,Zhang P,Gong J,Zhang XJ,Zheng A,Xia H,Li H

Mon Feb 01 00:00:00 UTC 2016

Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.

Journal of neuroinflammation

Zhang X,Zheng Z,Liu X,Shu B,Mao P,Bai B,Hu Q,Luo M,Ma X,Cui Z,Wang H

Tue Aug 30 00:00:00 UTC 2016

Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.

Journal of neuroinflammation

Zhang X,Zheng Z,Liu X,Shu B,Mao P,Bai B,Hu Q,Luo M,Ma X,Cui Z,Wang H

Tue Aug 30 00:00:00 UTC 2016

AIM2 inhibits autophagy and IFN-β production during M. bovis infection.

Oncotarget

Liu C,Yue R,Yang Y,Cui Y,Yang L,Zhao D,Zhou X

Tue Jul 26 00:00:00 UTC 2016

AIM2 inhibits autophagy and IFN-β production during M. bovis infection.

Oncotarget

Liu C,Yue R,Yang Y,Cui Y,Yang L,Zhao D,Zhou X

Tue Jul 26 00:00:00 UTC 2016

Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.

Journal of neurochemistry

Li M,Guo S,Zhang P,Gong J,Zheng A,Zhang Y,Li H

Wed Jul 01 00:00:00 UTC 2015

Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.

Journal of neurochemistry

Li M,Guo S,Zhang P,Gong J,Zheng A,Zhang Y,Li H

Wed Jul 01 00:00:00 UTC 2015

Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.

Journal of neurochemistry

Li M,Guo S,Zhang P,Gong J,Zheng A,Zhang Y,Li H

Wed Jul 01 00:00:00 UTC 2015

Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.

Journal of neurochemistry

Li M,Guo S,Zhang P,Gong J,Zheng A,Zhang Y,Li H

Wed Jul 01 00:00:00 UTC 2015

HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang M,Liu Y,Wang P,Guan X,He S,Luo S,Li C,Hu K,Jin W,Du T,Yan Y,Zhang Z,Zheng Z,Wang H,Hu Q

Wed Apr 01 00:00:00 UTC 2015

HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang M,Liu Y,Wang P,Guan X,He S,Luo S,Li C,Hu K,Jin W,Du T,Yan Y,Zhang Z,Zheng Z,Wang H,Hu Q

Wed Apr 01 00:00:00 UTC 2015

HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang M,Liu Y,Wang P,Guan X,He S,Luo S,Li C,Hu K,Jin W,Du T,Yan Y,Zhang Z,Zheng Z,Wang H,Hu Q

Wed Apr 01 00:00:00 UTC 2015

HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang M,Liu Y,Wang P,Guan X,He S,Luo S,Li C,Hu K,Jin W,Du T,Yan Y,Zhang Z,Zheng Z,Wang H,Hu Q

Wed Apr 01 00:00:00 UTC 2015

Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.

Journal of immunology (Baltimore, Md. : 1950)

Zhu M,Fang T,Li S,Meng K,Guo D

Wed Jul 01 00:00:00 UTC 2015

Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.

Journal of immunology (Baltimore, Md. : 1950)

Zhu M,Fang T,Li S,Meng K,Guo D

Wed Jul 01 00:00:00 UTC 2015

An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs.

Journal of immunology (Baltimore, Md. : 1950)

Chen H,Pei R,Zhu W,Zeng R,Wang Y,Wang Y,Lu M,Chen X

Sat Feb 01 00:00:00 UTC 2014

An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs.

Journal of immunology (Baltimore, Md. : 1950)

Chen H,Pei R,Zhu W,Zeng R,Wang Y,Wang Y,Lu M,Chen X

Sat Feb 01 00:00:00 UTC 2014

Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.

Cellular signalling

Gu M,Zhang T,lin W,Liu Z,Lai R,Xia D,Huang H,Wang X

Mon Dec 01 00:00:00 UTC 2014

Cellular signalling

Gu M,Zhang T,lin W,Liu Z,Lai R,Xia D,Huang H,Wang X

Mon Dec 01 00:00:00 UTC 2014

Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.

Journal of immunology (Baltimore, Md. : 1950)

Luo H,Zhang Z,Zheng Z,Ke X,Zhang X,Li Q,Liu Y,Bai B,Mao P,Hu Q,Wang H

Mon Jul 15 00:00:00 UTC 2013

Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.

Journal of immunology (Baltimore, Md. : 1950)

Luo H,Zhang Z,Zheng Z,Ke X,Zhang X,Li Q,Liu Y,Bai B,Mao P,Hu Q,Wang H

Mon Jul 15 00:00:00 UTC 2013

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang Z,Zheng Z,Luo H,Meng J,Li H,Li Q,Zhang X,Ke X,Bai B,Mao P,Hu Q,Wang H

Wed Aug 01 00:00:00 UTC 2012

Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang Z,Zheng Z,Luo H,Meng J,Li H,Li Q,Zhang X,Ke X,Bai B,Mao P,Hu Q,Wang H

Wed Aug 01 00:00:00 UTC 2012

Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang Z,Zheng Z,Luo H,Meng J,Li H,Li Q,Zhang X,Ke X,Bai B,Mao P,Hu Q,Wang H

Wed Aug 01 00:00:00 UTC 2012

Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.

Journal of immunology (Baltimore, Md. : 1950)

Zhang Z,Zheng Z,Luo H,Meng J,Li H,Li Q,Zhang X,Ke X,Bai B,Mao P,Hu Q,Wang H

Wed Aug 01 00:00:00 UTC 2012

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.

The Journal of general virology

Zhou P,Li H,Wang H,Wang LF,Shi Z

Wed Feb 01 00:00:00 UTC 2012

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.

The Journal of general virology

Zhou P,Li H,Wang H,Wang LF,Shi Z

Wed Feb 01 00:00:00 UTC 2012

Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.

Journal of virology

Zhu H,Zheng C,Xing J,Wang S,Li S,Lin R,Mossman KL

Tue Nov 01 00:00:00 UTC 2011

Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.

Journal of virology

Zhu H,Zheng C,Xing J,Wang S,Li S,Lin R,Mossman KL

Tue Nov 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: Interferon regulatory factor 3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3

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Gene Aliases: C920001K05Rik; IIAE7; IRF-3; IRF3

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UniProt ID: (Human) Q14653, (Mouse) P70671

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Entrez Gene ID: (Human) 3661, (Mouse) 54131

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription cofactor activity protein binding identical protein binding protein homodimerization activity regulatory region DNA binding transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter immune system process transcription, DNA-templated regulation of transcription, DNA-templated response to bacterium lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response type I interferon biosynthetic process negative regulation of interferon-beta biosynthetic process negative regulation of defense response to virus by host positive regulation of cytokine secretion defense response to virus positive regulation of type I interferon-mediated signaling pathway cellular response to lipopolysaccharide programmed necrotic cell death transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus negative regulation of type I interferon production positive regulation of type I interferon production TRIF-dependent toll-like receptor signaling pathway MDA-5 signaling pathway interferon-gamma-mediated signaling pathway type I interferon signaling pathway cellular response to dsRNA macrophage apoptotic process

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IRF3 Polyclonal Antibody

IRF3 Antibody (11312-1-AP) in ICC/IF

Product Details

11312-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

ChIP assay (ChIP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

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