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Product Details
13124-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LNX1 Fusion Protein Ag3823 (378-728 aa encoded by BC022983)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can detect both LNX1p70 and LNX1p80, around 70-80 kDa and 80-100 kDa, respectively.
Immunogen sequence: DSFHVILNK SSPEEQLGIK LVRKVDEPGV FIFNVLDGGV AYRHGQLEEN DRVLAINGHD LRYGSPESAA HLIQASERRV HLVVSRQVRQ RSPDIFQEAG WNSNGSWSPG PGERSNTPKP LHPTITCHEK VVNIQKDPGE SLGMTVAGGA SHREWDLPIY VISVEPGGVI SRDGRIKTGD ILLNVDGVEL TEVSRSEAVA LLKRTSSSIV LKALEVKEYE PQEDCSSPAA LDSNHNMAPP SDWSPSWVMW LELPRCLYNC KDIVLRRNTA GSLGFCIVGG YEEYNGNKPF FIKSIVEGTP AYNDGRIRCG DILLAVNGRS TSGMIHACLA RLLKELKGRI TLTIVSWPGT FL (378-728 aa encoded by BC022983)
Target Information
Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is known as PDZRN2 (PDZ domain-containing RING finger 2). It is through its RING finger and PDZ domains that Lnx1 forms oligomers and interacts with some of its target proteins such as JAM4 to form multiprotein complexes. Lnx1 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Phosphotyrosine binding domain (PTB) on Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus positively regulates the Notch signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase LNX; Ligand of Numb protein X 1; Ligand of Numb-binding protein 1; Ligand of Numb-protein X 1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; Numb-binding protein 1; PDZ domain-containing RING finger protein 2; RING-type E3 ubiquitin transferase LNX
Gene Aliases: LNX; LNX1; MPDZ; PDZRN2; UNQ574/PRO1136
UniProt ID: (Human) Q8TBB1, (Mouse) O70263
Entrez Gene ID: (Human) 84708, (Rat) 360926, (Mouse) 16924
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
PDZ domain binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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