LNX1 Antibodies

Target Information

Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is known as PDZRN2 (PDZ domain-containing RING finger 2). It is through its RING finger and PDZ domains that Lnx1 forms oligomers and interacts with some of its target proteins such as JAM4 to form multiprotein complexes. Lnx1 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Phosphotyrosine binding domain (PTB) on Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus positively regulates the Notch signaling pathway.

Synonyms

E3 ubiquitin-protein ligase LNX; Ligand of Numb protein X 1; ligand of Numb-binding protein 1; Ligand of Numb-protein X 1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; LNX; Lnx1; MPDZ; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; numb-binding protein 1; PDZ domain-containing RING finger protein 2; PDZRN2; RING-type E3 ubiquitin transferase LNX; UNQ574/PRO1136