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Product Details
H00005777-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTPN6 (NP_002822.2, 1 a.a. approximately 595 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRVGDQVT HIRIQNSGDF YDLYGGEKFA TLTELVEYYT QQQGVLQDRD GTIIHLKYPL NCSDPTSERW YHGHMSGGQA ETLLQAKGEP WTFLVRESLS QPGDFVLSVL SDQPKAGPGS PLRVTHIKVM CEGGRYTVGG LETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KGKNRYKNIL PFDHSRVILQ GRDSNIPGSD YINANYIKNQ LLGPDENAKT YIASQGCLEA TVNDFWQMAW QENSRVIVMT TREVEKGRNK CVPYWPEVGM QRAYGPYSVT NCGEHDTTEY KLRTLQVSPL DNGDLIREIW HYQYLSWPDH GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ENISTKGLDC DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEVLQSQK GQESEYGNIT YPPAMKNAHA KASRTSSKHK EDVYENLHTK NKREEKVKKQ RSADKEKSKG SLKRK
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70Z-SHP; EC 3.1.3.48; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; motheaten; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTPTY-42; SH-PTP1; SHP-1; Tyrosine-protein phosphatase non-receptor type 6
Gene Aliases: 70Z-SHP; HCP; HCPH; HPTP1C; me; PTP-1C; PTP1C; PTPN6; PTPTY-42; SH-PTP1; SHP-1; SHP-1L; SHP1
UniProt ID: (Human) P29350, (Mouse) P29351
Entrez Gene ID: (Human) 5777, (Mouse) 15170
phosphotyrosine binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
protein binding
SH3 domain binding
protein kinase binding
SH2 domain binding
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
natural killer cell lectin-like receptor binding
hematopoietic progenitor cell differentiation
negative regulation of humoral immune response mediated by circulating immunoglobulin
protein dephosphorylation
apoptotic process
G-protein coupled receptor signaling pathway
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell differentiation
platelet activation
platelet formation
T cell costimulation
abortive mitotic cell cycle
positive regulation of cell adhesion mediated by integrin
peptidyl-tyrosine dephosphorylation
intracellular signal transduction
megakaryocyte development
negative regulation of T cell proliferation
natural killer cell mediated cytotoxicity
negative regulation of MAP kinase activity
regulation of B cell differentiation
negative regulation of peptidyl-tyrosine phosphorylation
B cell receptor signaling pathway
negative regulation of B cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
leukocyte migration
regulation of release of sequestered calcium ion into cytosol
regulation of type I interferon-mediated signaling pathway
regulation of ERK1 and ERK2 cascade
platelet aggregation
regulation of G1/S transition of mitotic cell cycle
signal transduction
dephosphorylation
cytokine-mediated signaling pathway
negative regulation of MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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