Product References
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer.
Journal of pharmaceutical analysis
Sun X,Zhou L,Wang Y,Deng G,Cao X,Ke B,Wu X,Gu Y,Cheng H,Xu Q,Du Q,Chen H,Sun Y
12-9392-82 was used in Flow cytometry/Cell sorting to provide new insights into the anti-tumor effects of CBD.
Sat Jul 01 00:00:00 UTC 2023
P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer.
Cancer immunology research
Ren J,Han X,Lohner H,Hoyle RG,Li J,Liang S,Wang H
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2023
Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.
Journal of experimental & clinical cancer research : CR
Zheng Y,Wang N,Wang S,Zhang J,Yang B,Wang Z
12-9392-82 was used in Flow cytometry/Cell sorting to investigate the impact of chronic psychological stress on breast cancer growth, metastasis, and pre-metastatic niche (PMN) formation.
Sat May 20 00:00:00 UTC 2023
Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors.
Journal of hematology & oncology
Yi M,Niu M,Wu Y,Ge H,Jiao D,Zhu S,Zhang J,Yan Y,Zhou P,Chu Q,Wu K
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Sat Oct 08 00:00:00 UTC 2022
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Thu Dec 01 00:00:00 UTC 2022
DNA Methylation Patterns in T Cells of Naïve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand.
Environmental health perspectives
Burke CG,Myers JR,Post CM,Boulé LA,Lawrence BP
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2021
Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone.
Cancers
Lin Q,Fang X,Liang G,Luo Q,Cen Y,Shi Y,Jia S,Li J,Yang W,Sanders AJ,Gong C,Jiang W
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Mon Nov 15 00:00:00 UTC 2021
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Mon Aug 30 00:00:00 UTC 2021
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.
Med (New York, N.Y.)
Silva-Cayetano A,Foster WS,Innocentin S,Belij-Rammerstorfer S,Spencer AJ,Burton OT,Fra-Bidó S,Le Lee J,Thakur N,Conceicao C,Wright D,Barrett J,Evans-Bailey N,Noble C,Bailey D,Liston A,Gilbert SC,Lambe T,Linterman MA
12-9392-82 was used in Flow Cytometry to show that ChAdOx1 nCoV-19 induces both cellular and humoral immunity in adult and aged mice and suggest a prime-boost strategy is a rational approach to enhance immunogenicity in older persons.
Fri Mar 12 00:00:00 UTC 2021
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.
Nature communications
Wu M,Xia X,Hu J,Fowlkes NW,Li S
12-9392-82 was used in Flow Cytometry to yield insights into the host homeostatic control of immune response and benefit the development of cancer immunotherapies.
Wed Jun 09 00:00:00 UTC 2021
NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8+ T cell responses.
iScience
Souza COS,Ketelut-Carneiro N,Milanezi CM,Faccioli LH,Gardinassi LG,Silva JS
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Fri Jun 25 00:00:00 UTC 2021
NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8+ T cell responses.
iScience
Souza COS,Ketelut-Carneiro N,Milanezi CM,Faccioli LH,Gardinassi LG,Silva JS
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Fri Jun 25 00:00:00 UTC 2021
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.
EMBO molecular medicine
Fan Z,Tian Y,Chen Z,Liu L,Zhou Q,He J,Coleman J,Dong C,Li N,Huang J,Xu C,Zhang Z,Gao S,Zhou P,Ding K,Chen L
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Mon Jun 08 00:00:00 UTC 2020
SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.
Cancer immunology research
Hu M,Lu Y,Qi Y,Zhang Z,Wang S,Xu Y,Chen F,Tang Y,Chen S,Chen M,Du C,Shen M,Wang F,Su Y,Deng Y,Wang J
12-9392-82 was used in Flow Cytometry to study the role of SRC-3 as a coactivator of T-bet in natural killer-cell biology and indicate that targeting SRC-3 may be a promising strategy to increase the tumor surveillance function of natural killer cells.
Tue Sep 01 00:00:00 UTC 2020
Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation.
Journal for immunotherapy of cancer
Wu B,Chiang HC,Sun X,Yuan B,Mitra P,Hu Y,Curiel TJ,Li R
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Sat Aug 01 00:00:00 UTC 2020
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.
eLife
Piersma SJ,Poursine-Laurent J,Yang L,Barber GN,Parikh BA,Yokoyama WM
12-9392 was used in Flow cytometry/Cell sorting to contrast anti-viral effects of MyD88 versus STING in distinct cell types that are infected with murine CMV (MCMV).
Wed Jul 29 00:00:00 UTC 2020
PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction.
Cell reports
Yin X,Zeng W,Wu B,Wang L,Wang Z,Tian H,Wang L,Jiang Y,Clay R,Wei X,Qin Y,Zhang F,Zhang C,Jin L,Liang W
12-9392 was used in Flow cytometry/Cell sorting to report that fatty acid-carrying tumor-derived exosomes (TDEs) induce immune dysfunctional DCs to promote immune evasion.
Tue Oct 20 00:00:00 UTC 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
12-9392 was used in Flow cytometry/Cell sorting to suggest a revised model for ILC differentiation that redefines the cell-fate potential of helper-ILC-restricted Zbtb16+ ILCPs.
Tue Apr 16 00:00:00 UTC 2019
GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.
Cancer cell
Mondragón L,Mhaidly R,De Donatis GM,Tosolini M,Dao P,Martin AR,Pons C,Chiche J,Jacquin M,Imbert V,Proïcs E,Boyer L,Doye A,Luciano F,Neels JG,Coutant F,Fabien N,Sormani L,Rubio-Patiño C,Bossowski JP,Muller F,Marchetti S,Villa E,Peyron JF,Gaulard P,Lemonnier F,Asnafi V,Genestier L,Benhida R,Fournié JJ,Passeron T,Ricci JE,Verhoeyen E
12-9392-82 was used in Flow Cytometry to suggest the therapeutic potential of targeting NF-κB signaling in AITL and provide a model for future AITL therapeutic investigations.
Mon Sep 16 00:00:00 UTC 2019
Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.
Cancer immunology research
Shi LZ,Goswami S,Fu T,Guan B,Chen J,Xiong L,Zhang J,Ng Tang D,Zhang X,Vence L,Blando J,Allison JP,Collazo R,Gao J,Sharma P
12-9392 was used in Flow cytometry/Cell sorting to provides a foundation of testing combinatorial therapy of ACT of CD8 T cells and dual blocking of CTLA-4 and PD-1 in patients with melanoma.
Fri Nov 01 00:00:00 UTC 2019
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Nature communications
Wang F,Meng M,Mo B,Yang Y,Ji Y,Huang P,Lai W,Pan X,You T,Luo H,Guan X,Deng Y,Yuan S,Chu J,Namaka M,Hughes T,Ye L,Yu J,Li X,Deng Y
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Mon Nov 19 00:00:00 UTC 2018
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
12-9392-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 UTC 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
12-9392 was used in Flow cytometry/Cell sorting to disclose a novel mechanism underlying the negative regulation of antitumour CD8(+) T cells during HCC progression.
Wed Nov 20 00:00:00 UTC 2019
A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.
Immunology
Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A
12-9392 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.
Mon May 01 00:00:00 UTC 2017
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Mon May 15 00:00:00 UTC 2017
NFATc1 controls the cytotoxicity of CD8+ T cells.
Nature communications
Klein-Hessling S,Muhammad K,Klein M,Pusch T,Rudolf R,Flöter J,Qureischi M,Beilhack A,Vaeth M,Kummerow C,Backes C,Schoppmeyer R,Hahn U,Hoth M,Bopp T,Berberich-Siebelt F,Patra A,Avots A,Müller N,Schulze A,Serfling E
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Mon Sep 11 00:00:00 UTC 2017
Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment.
Scientific reports
Yeku OO,Purdon TJ,Koneru M,Spriggs D,Brentjens RJ
12-9392 was used in Flow cytometry/Cell sorting to develop an armoured chimeric antigen receptor T cell capable of constitutive secretion of IL-12, and delineate the mechanism by which these cells overcome a hostile tumour microenvironment.
Tue Sep 05 00:00:00 UTC 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
12-9392 was used in Flow cytometry/Cell sorting to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 UTC 2016
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Thu Sep 01 00:00:00 UTC 2016
Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules.
Journal of leukocyte biology
Solaymani-Mohammadi S,Lakhdari O,Minev I,Shenouda S,Frey BF,Billeskov R,Singer SM,Berzofsky JA,Eckmann L,Kagnoff MF
12-9392 was used in Flow cytometry/Cell sorting to identify the role of the programmed death-1 receptor in early host microbial defence at the intestinal mucosa.
Tue Mar 01 00:00:00 UTC 2016
IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ.
Journal of immunology (Baltimore, Md. : 1950)
Guo Y,Luan L,Rabacal W,Bohannon JK,Fensterheim BA,Hernandez A,Sherwood ER
Tue Sep 01 00:00:00 UTC 2015
CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis.
Oncotarget
Concepcion AR,Salas JT,Sáez E,Sarvide S,Ferrer A,Portu A,Uriarte I,Hervás-Stubbs S,Oude Elferink RP,Prieto J,Medina JF
12-9392 was used in Flow cytometry/Cell sorting to study the behaviour of intrahepatic T cells during different stages of life within Ae2a,b(-/-) mice.
Tue Oct 06 00:00:00 UTC 2015
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
Published figure using Perforin monoclonal antibody (Product # 12-9392-82) in Flow Cytometry
Mon Jul 06 00:00:00 UTC 2015
Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.
Cancer research
Riese MJ,Wang LC,Moon EK,Joshi RP,Ranganathan A,June CH,Koretzky GA,Albelda SM
12-9392 was used in Flow cytometry/Cell sorting to investigate whether activation of T cells using chimeric antigen receptor can be enhanced by deletion of negative regulators, showing that deletion of dgk enhanced cytokine production and were effective at limiting growth of implanted tumours.
Sat Jun 15 00:00:00 UTC 2013
CD22 is required for protection against West Nile virus Infection.
Journal of virology
Ma DY,Suthar MS,Kasahara S,Gale M,Clark EA
12-9392 was used in Flow cytometry/Cell sorting to elucidate the immunological requirements for an antibody response following West Nile virus infection.
Fri Mar 01 00:00:00 UTC 2013
2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury.
Toxicology and applied pharmacology
Fullerton AM,Roth RA,Ganey PE
12-9392 was used in Flow cytometry/Cell sorting to investigate whether 2,3,7,8-tetrachlorodibenzo-p-dioxin pretreatment exacerbates the hepatotoxicity caused by concanavalin A.
Tue Jan 15 00:00:00 UTC 2013
Reduced immunosuppressive properties of axitinib in comparison with other tyrosine kinase inhibitors.
The Journal of biological chemistry
Stehle F,Schulz K,Fahldieck C,Kalich J,Lichtenfels R,Riemann D,Seliger B
12-9392 was used in Flow cytometry/Cell sorting to investigate the reduced immunosuppressive properties of axitinib in comparison with other tyrosine kinase inhibitors.
Fri Jun 07 00:00:00 UTC 2013
Development of murine hepatic NK cells during ontogeny: comparison with spleen NK cells.
Clinical & developmental immunology
Wu X,Chen Y,Wei H,Sun R,Tian Z
12-9392 was used in Flow cytometry/Cell sorting to investigate the phenotype of developing liver NK cells compared to spleen NK cells.
Tue Apr 24 00:00:00 UTC 2012
Regulatory role of Vγ1 γδ T cells in tumor immunity through IL-4 production.
Journal of immunology (Baltimore, Md. : 1950)
Hao J,Dong S,Xia S,He W,Jia H,Zhang S,Wei J,O'Brien RL,Born WK,Wu Z,Wang P,Han J,Hong Z,Zhao L,Yin Z
12-9392 was used in Flow cytometry/Cell sorting to establish a negative regulatory role of Vγ1 γδ T cells in Vγ4 γδ T cell-mediated antitumor immunity through cell contact-independent and IL-4-mediated mechanisms.
Tue Nov 15 00:00:00 UTC 2011
Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure.
Journal of immunology (Baltimore, Md. : 1950)
Zou Y,Chen T,Han M,Wang H,Yan W,Song G,Wu Z,Wang X,Zhu C,Luo X,Ning Q
12-9392 was used in Immunocytochemistry to reveal a pivotal role for liver natural killer cells in the pathogenesis of virus-induced fulminant hepatic failure and acute-on-chronic liver failure.
Fri Jan 01 00:00:00 UTC 2010
CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration.
Journal of virology
Thapa M,Carr DJ
12-9392 was used in Flow cytometry/Cell sorting to study the relevance of CXCR3 for optimal T-cell activation and the induction of regulatory transcription factors relative to host immune defence against herpes simplex virus type 2 infection.
Tue Sep 01 00:00:00 UTC 2009
Dendritic cells are required for optimal activation of natural killer functions following primary infection with herpes simplex virus type 1.
Journal of virology
Kassim SH,Rajasagi NK,Ritz BW,Pruett SB,Gardner EM,Chervenak R,Jennings SR
12-9392 was used in Flow Cytometry to provide evidence that functional DCs are required for optimal IFN-gamma expression and cytolytic function by NK cells following HSV-1 infection.
Wed Apr 01 00:00:00 UTC 2009
CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses.
PloS one
Lai YP,Lin CC,Liao WJ,Tang CY,Chen SC
12-9392 was used in an ELISA assay to show that the activation and differentiation of CD8+ T cells require IL-2 provided by activated CD4+ T cells at the initial priming stage within 0-2.5 hours after stimulation.
Tue Nov 10 00:00:00 UTC 2009
Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation.
International immunology
Jin GH,Hirano T,Murakami M
12-9392 was used in Flow cytometry/Cell sorting to identify the cell populations that mediate the anti-tumour effect of combination treatment with IL-2 and anti-IL-2 mAbs.
Sun Jun 01 00:00:00 UTC 2008
A direct comparison of rejection by CD8 and CD4 T cells in a transgenic model of allotransplantation.
Archivum immunologiae et therapiae experimentalis
Porrett PM,Lee MK,Lian MM,Wang J,Caton AJ,Deng S,Markmann JF,Moore DJ
12-9392 was used in Flow cytometry/Cell sorting to confirm functional similarity between CD4 and CD8 T cells and provide insight into the redundancy of T cell mechanisms mediating allograft rejection.
Wed Sep 03 00:00:00 UTC 2008
Evaluation of T-cell responses to peptides with MHC class I-binding motifs derived from PE_PGRS 33 protein of Mycobacterium tuberculosis.
Journal of medical microbiology
Chaitra MG,Shaila MS,Nayak R
12-9392 was used in Flow cytometry/Cell sorting to study how PE_PGRS 33 has access to the MHC class I processing pathway, and how short peptide fragments of this protein can be presented to CD8+ T cells.
Sun Apr 01 00:00:00 UTC 2007
