Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
Securin / PTTG1 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
18040-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Securin / PTTG1 Fusion Protein Ag12670 (1-202 aa encoded by BC101834)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATLIYVDK ENGEPGTRVV AKDGLKLGSG PSIKALDGRS QVSTPRFGKT FDAPPALPKA TRKALGTVNR ATEKSVKTKG PLKQKQPSFS AKKMTEKTVK AKSSVPASDD AYPEIEKFFP FNPLDFESFD LPEEHQIAHL PLSGVPLMIL DEERELEKLF QLGPPSPVKM PSPPWESNLL QSPSSILSTL DVELPPVCCD IDI (1-202 aa encoded by BC101834)
Target Information
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Esp1-associated protein; ESP1-associated protein 1; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; Securin; Tumor-transforming protein 1
Gene Aliases: AW555095; C87862; EAP1; HPTTG; PTTG; PTTG1; Pttg3; TUTR1
UniProt ID: (Human) O95997, (Mouse) Q9CQJ7, (Rat) P97613
Entrez Gene ID: (Human) 9232, (Mouse) 30939, (Rat) 64193
DNA repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
mitotic nuclear division
spermatogenesis
negative regulation of endopeptidase activity
anaphase-promoting complex-dependent catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
homologous chromosome segregation
chromosome organization
cell division
regulation of cell growth
cellular response to DNA damage stimulus
cell cycle
chromosome segregation
negative regulation of cell proliferation
cellular process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support