Preimplantation genetic testing – aneuploidy (PGT-A) is a rapidly growing area of fertility research commonly incorporated into IVF research workflows. PGT-A findings can determine chromosome presence and frequency in embryo biopsies, which provides scientific insight into reducing the time to pregnancy and decreasing miscarriage rates. Ion ReproSeq PGS kits for PGT-A leverage the speed and reliability of Ion Torrent next-generation sequencing (NGS) to offer important insight for future reproductive decisions.
Key benefits
Versatile and comprehensive—detect whole-chromosome, mosaic, and small copy number events, from just 6 pg of DNA from single or multiple cells
Scalable throughput—multiple kit configurations to analyze from 16 to 192 samples in a single run
Rapid, end-to-end NGS workflow—cells to results in less than 10 hours* and minimized user error, with <2 hours* hands-on time
Enhanced interpretation of results—mosaicism detection, gender masking, and improved data plotting (for easier data interpretation)
Premium quality controls—Deliver enhanced PGT-A results with checks for triploidy, maternal contamination, and sibling identification
Product guide: Perform PGT-A with confidence with Ion ReproSeq PGS Kits
Deliver premium PGT-A analysis with SNP-based quality controls
Confidently identify triploidy 69, XXX, assess potential maternal contamination, and track sibling samples with the new Ion AmpliSeq Polyploidy Panel, now available as an optional add-on to Ion ReproSeq PGS Kits.
Learn about PGT from key opinion leaders in the field
IVF and genomics: positioning ourselves for the future with Ion ReproSeq PGS
Catherine Welch, MBA, TS (ABB)
Founder and Managing Partner of Sequence46
PGT-A simplified -- Comparison of leading
NGS solutions: Ion ReproSeq
PGS and VeriSeq PGS
Adam Goodman
Director of Preimplantation Genetics, NxGen MDx
Simple, rapid workflow from single cell to aneuploidy detection
Ion ReproSeq PGS kits include all materials for library construction, template preparation, and sequencing on Ion Torrent NGS systems for cell to analysis in as little as 10 hours.* Simple cartridge-loaded reagents, straightforward user interface, and automated template preparation minimize user errors and facilitate rapid implementation of PGT research into your lab.
The Genexus workflow (blue) leverages the flexible design of GX5 chips, which can run from 24 to 48 samples per lane. Each lane can be run independently, for a total of 96 or 192 samples per chip.
For the Ion GeneStudio S5 System workflow (purple), the Ion sequencing chips (Ion 510 Chip, Ion 520 Chip, and Ion 530 Chip) provide sample throughput flexibility and scalability to match your needs and enable cost-effective analysis of 16, 24, or 96 samples in a single sequencing run.
*Turnaround time for the Ion ReproSeq PGS Kit with Ion 510 Chips (16 samples/run) is less than 10 hours with less than 2 hours of hands on time
Video: Ion ReproSeq workflow—preimplantation genetic testing made simple
ReproSeq PGS kits for reliable and rapid aneuploidy detection
Ordering information
Resources
For Research Use Only. Not for use in diagnostic procedures.