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Invitrogen
Human KLHL26 (aa 527-598) Control Fragment Recombinant Protein
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Product Details
RP-93615
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESF
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-54688. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
KLHL26, part of the Kelch-like family member 26, is a protein-coding gene located on chromosome 19. It has been associated with various cellular functions due to its structural components, particularly the BTB/POZ domain at the N-terminus which spans about 115 amino acids. This domain plays crucial roles in forming E3 ubiquitin ligases by facilitating interactions with Cullin3 and enabling KLHL protein homodimerization. The significance of KLHL26 extends to its potential involvement in familial genetic conditions, as evidenced by the identification of a novel damaging variant, which was validated through Sanger sequencing in affected family members. Moreover, the Kelch motif within the KLHL proteins underlines their diverse roles in cellular morphology, gene expression regulation, and interaction with extracellular entities, including possible implications in actin binding and virus interactions post-infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kelch-like 26; kelch-like family member 26; Kelch-like protein 26
Gene Aliases: KLHL26
UniProt ID: (Human) Q53HC5
Entrez Gene ID: (Human) 55295
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