KLHL26 Proteins

Protein Information

KLHL26, part of the Kelch-like family member 26, is a protein-coding gene located on chromosome 19. It has been associated with various cellular functions due to its structural components, particularly the BTB/POZ domain at the N-terminus which spans about 115 amino acids. This domain plays crucial roles in forming E3 ubiquitin ligases by facilitating interactions with Cullin3 and enabling KLHL protein homodimerization. The significance of KLHL26 extends to its potential involvement in familial genetic conditions, as evidenced by the identification of a novel damaging variant, which was validated through Sanger sequencing in affected family members. Moreover, the Kelch motif within the KLHL proteins underlines their diverse roles in cellular morphology, gene expression regulation, and interaction with extracellular entities, including possible implications in actin binding and virus interactions post-infection.

Synonyms

C630013N10Rik; kelch like family member 26; kelch-like 26; kelch-like family member 26; kelch-like protein 26; Klhl26; Klkl26; RGD1312034