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Invitrogen
Human REPIN1 (aa 1-89) Control Fragment Recombinant Protein
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Product Details
RP-95769
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
MLERRCRGPLAMGLAQPRLLSGPSQESPQTLGKESRGLRQQGTSVAQSGAQAPGRAHRCAHCRRHFPGWVALWLHTRRCQARLPLPCPE
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (72%), Rat (72%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57498. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Replication initiator 1 (REPIN1) is a gene encoding a zinc-finger protein that plays a critical role in various metabolic processes. Located on chromosome 7 in humans, REPIN1 is prominently expressed in liver and adipose tissues. It is associated with the regulation of body weight and triglyceride levels, as evidenced by its locus within a quantitative trait locus (QTL) related to these metabolic traits. The REPIN1 protein is involved in enhancing DNA bending, which is crucial for replication initiation. Studies have shown that deleting REPIN1 in the liver can lead to improved insulin sensitivity and altered lipid metabolism, with secondary effects on adipose tissue. Additionally, REPIN1 is implicated in iron metabolism and apoptosis regulation, further underscoring its multifaceted role in cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60 kDa origin-specific DNA-binding protein; 60 kDa replication initiation region protein; ATT-binding protein; DHFR oribeta-binding protein RIP60; DNA-binding protein REPIN1; H_DJ0584D14.12; replication initiation region protein (60kD); Zinc finger protein 464; zinc finger protein 464 (RIP60); zinc finger protein AP4
Gene Aliases: AP4; REPIN1; RIP60; Zfp464; ZNF464
UniProt ID: (Human) Q9BWE0
Entrez Gene ID: (Human) 29803
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