REPIN1 Proteins

Protein Information

Replication initiator 1 (REPIN1) is a gene encoding a zinc-finger protein that plays a critical role in various metabolic processes. Located on chromosome 7 in humans, REPIN1 is prominently expressed in liver and adipose tissues. It is associated with the regulation of body weight and triglyceride levels, as evidenced by its locus within a quantitative trait locus (QTL) related to these metabolic traits. The REPIN1 protein is involved in enhancing DNA bending, which is crucial for replication initiation. Studies have shown that deleting REPIN1 in the liver can lead to improved insulin sensitivity and altered lipid metabolism, with secondary effects on adipose tissue. Additionally, REPIN1 is implicated in iron metabolism and apoptosis regulation, further underscoring its multifaceted role in cellular processes.

Synonyms

60 kDa origin-specific DNA-binding protein; 60 kDa replication initiation region protein; AP4; ATT-binding protein; DHFR oribeta-binding protein RIP60; H_DJ0584D14.12; REPIN1; replication initiation region protein (60kD); replication initiator 1; RIP60; Zfp464; Zinc finger protein 464; zinc finger protein 464 (RIP60); zinc finger protein AP4; ZNF464