IEX-1 Proteins

Protein Information

IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappa-B/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.

Synonyms

AI663993; anti-death protein; cAMP inducible gene 3; cI-3; DADB-118P11.5; DIF2; DIF-2; Differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; gly96; gly96, mouse, homolog of; Ier3; IEX1; IEX-1; IEX-1L; Immediate early protein GLY96; immediate early response 3; Immediate early response 3 protein; immediately early gene X-1; Ler3; PACAP-responsive gene 1 protein; PRG1; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1