Life science electron microscopy webinars and seminars
Stay connected with the latest discoveries, EM solutions, and resources with our Ask the Expert series, EM community webinars, and find us at scientific conferences throughout the year.
These interactive Q&A sessions offer you the chance to stay connected to the latest science through conversations on unique topics. Register for upcoming EM Ask the Experts webinars or view sessions on-demand.
The Ask the Experts series focuses on various electron microscopy topics. Every month we invite experts in the field to join us for an interactive discussion on electron microscopy applications and techniques.
See more at 100 kV with the new Falcon C Direct Electron Detector
Wednesday, November 08, 2023
8:00 AM PT| 11:00 AM ET | 05:00 PM CET
Join our upcoming Ask the Experts webinar to learn how the new Thermo Scientific Falcon C Direct Electron Detector and the Thermo Scientific Tundra Cryo-TEM can help you see even challenging proteins clearly.
Register to:
- See exciting new data showing the impact of improved resolution when combining the new Falcon C Detector with the Tundra Cryo-TEM
- Learn how the entire Tundra Cryo-TEM workflow facilitates rapid adoption of cryo-EM with its user-friendly interface and biologically relevant structure determination capabilities
- Strengthen your justification for adding a Tundra Cryo-TEM to your lab
Stay informed on the latest scientific breakthroughs using electron microscopy. Check back often to find webinars of interest to your research and join in live or watch on-demand.
Join us in community hosted virtual webinars throughout the year on a variety of scientific topics.
Insights into plant respiration using cryo-EM
Thursday, October 26th, 2023
10:00 AM EDT | 4:00 PM CET
Respiration is a key metabolic process driving most life of Earth, yet the biochemical and structural details of respiratory complexes have remained unknown outside of a handful of mammals, yeast and bacteria. Drs. Letts and Maldonado will discuss how they obtained high-resolution cryo-EM structures of these complexes from plants using partial biochemical purifications from natural sources followed by in-silico purification. The structures and biochemical characterization of respiratory complexes from plants and other under-studied organisms expand the understanding of respiration across the tree of life, reveal unexpected diversity and generate new mechanistic hypotheses for this core metabolic process.
In situ cryo-EM of tau filaments in brain extracellular vesicles in Alzheimer’s disease
Tuesday, October 31st, 2023
9:00 AM EDT | 2:00 PM CET
The assembly of tau protein in the brain underlies many neurodegenerative diseases, including Alzheimer's disease (AD). Evidence suggests that extracellular vesicles (EVs) facilitate assembled tau clearance and transfer between neurons. However, the molecular mechanisms are unknown. Here, using cryo-electron tomography and subtomogram averaging, Behr and colleagues directly visualised tau paired helical filaments (PHFs) and straight filaments (SFs) within the lumen of EVs from AD patient brain. This revealed that PHFs and SFs associate with one another and are tethered to the EV limiting membrane at their ends. Single particle cryo-electron microscopy revealed that the PHFs contain additional negatively-charged molecules compared to PHFs within neuronal inclusions, resulting in a more compact filament fold. Their findings will inform strategies to target the clearance and spread of assembled tau in AD and other neurodegenerative diseases. This work paves the way for further in situ structural studies of neurodegenerative disease-associated filaments in near-native conditions in human brain.
Machine Learning Approach to Cellular Cryo-Tomography
Wednesday, November 01, 2023
11:00 AM ET | 03:00 PM London
Image dynamic protein complexes within cells at nanometer resolution and beyond with an open-source machine-learning approach for reconstructing and visualizing biomolecular structures from in situ cryo-electron tomography sub-tomograms.
In this webinar, you will learn:
- How cryo-tomography can visualize cellular architecture in three dimensions at nanometer resolution
- An overview of computational processing of 3D tomograms that can further resolve structures at sub-nanometer resolution
- Why cryoDRGN-ET avoids extensive classification and masking.
- What do dynamic protein complexes look like inside the cell?
Cryo-EM Insights into TnpB, the Tiny Yet Powerful Genome Editor
Wednesday, November 15th, 2023
8:00 AM PT| 11:00 PM ET | 17:00 CET
In this webinar, Dr. Giedrius Sasnauskas will discuss how he used cryo-electron microscopy to determine structures of the Deinococcus radiodurans TnpB–reRNA complex in DNA-bound and -free forms. Collectively, the structures and structure-guided biochemical experiments demonstrated that TnpB represents the minimal structural and functional core of the Cas12 protein family, providing a framework for developing TnpB-based genome editing tools. He will also delve into technical intricacies of the study, specifically addressing the challenge posed by the preferred orientation of the TnpB-RNA-DNA ternary complex.
Getting Started in Cryo-EM: Basics of data processing for single particle analysis
Wednesday, December 13th, 2023
8:00 AM PT | 11:00 AM ET | 17:00 CET
Cryo-electron microscopy (cryo-EM) is rapidly becoming the method of choice for structural biologists and biochemists around the world. Using the technique, they’re able to visualize molecular details and protein structures in 3D to better understand protein function and disease mechanisms, which in turn facilitates effective drug design.
In this webinar, you will learn about considerations for data processing in the cryo-TEM, including information about single particle analysis and data reconstruction. Register today to learn how scientists are using innovative cryo-EM techniques to accelerate their research and expand their 3D structure determination capabilities.
Join us in booth demonstrations of the latest innovations in electron microscopy for the life sciences or hear one of our sponsored talks.
Meet us in-person at local events and international scientific conferences.
Life science electron microscopy seminar recordings
Single particle cryo-electron microscopy webinars
Single particle analysis is a cryo-EM technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.
Cryo-electron tomography webinars
Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins and their spatial arrangements within the cell. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis. Watch now to see how cryo-ET is opening literal windows into cells.
Micro-electron diffraction webinars
Micro electron diffraction (MicroED) is an exciting new technique with applications in the structural determination of small molecules and proteins. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture. Learn how MicroED is transforming structural determination.
Integrative structural biology webinars
Integrative structural biology uses structural and functional information from various techniques, including mass spectrometry and cryo-EM, to arrive faster at a more complete picture of the protein and its function. See how integrating data helps you to understand structure-function relationships.
Connect with us
For Research Use Only. Not for use in diagnostic procedures.