SMAD1/SMAD5 Antibodies

Antibodies that detect SMAD1/SMAD5 can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, Flow Cytometry and ELISA. These antibodies target SMAD1/SMAD5 in Human, Mouse and Rat samples. Our SMAD1/SMAD5 polyclonal,... Antibodies that detect SMAD1/SMAD5 can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, Flow Cytometry and ELISA. These antibodies target SMAD1/SMAD5 in Human, Mouse and Rat samples. Our SMAD1/SMAD5 polyclonal, recombinant monoclonal and monoclonal antibodies are... Antibodies that detect SMAD1/SMAD5 can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, Flow Cytometry and ELISA. These antibodies target SMAD1/SMAD5 in Human, Mouse and Rat samples. Our SMAD1/SMAD5 polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit. These antibodies have been verified by Cell treatment to confirm specificity to SMAD1/SMAD5. Find the SMAD1/SMAD5 antibody that fits your needs. Choose from 1 of 5 SMAD1/SMAD5 antibodies, which have been validated in experiments with 15 publications and 18 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other... Antibodies that detect SMAD1/SMAD5 can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, Flow Cytometry and ELISA. These antibodies target SMAD1/SMAD5 in Human, Mouse and Rat samples. Our SMAD1/SMAD5 polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit. These antibodies have been verified by Cell treatment to confirm specificity to SMAD1/SMAD5. Find the SMAD1/SMAD5 antibody that fits your needs. Choose from 1 of 5 SMAD1/SMAD5 antibodies, which have been validated in experiments with 15 publications and 18 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

The Smad family of proteins are functioning in the transmission of extracellular signals in the TGF-beta signaling pathway. Binding of a TGF-beta superfamily ligands to extracellular receptors triggers phosphorylation of Smad2 at a Serine-Serine-Methionine-Serine (SSMS) motif at its C-terminus. Phosphorylated Smad2 is then able to form a complex with Smad4. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression. In mammals, eight Smad proteins have been identified to date. The Smad family of proteins can be divided into three functional groups: the receptor-activated Smads (R-Smads), common mediator Smads (Co-Smads), and the inhibitory Smads (I-Smads). The R-Smads are directly phosphorylated by the activated type I receptors on their C-terminal Ser-Ser-X-Ser (SSXS) motif and include Smad1, Smad2, Smad3, Smad5, and Smad8. Smad2 and Smad3 are phosphorylated in response to TGF-beta and activin, whereas Smad1, Smad5, and Smad8 are phosphorylated in response to BMP (Bone Morphogenetic Protein). This C-terminal phosphorylation allows R-Smad binding to Co-Smad, Smad4, and translocation to the nucleus where they regulate TGF-beta target genes. Smad6 and Smad7 belong to the I-Smad which bind to the type I receptor or Smad4 and block their interaction with R-Smads.

Synonyms

1110051M15Rik; AI451355; AI528653; BSP1; BSP-1; dwarfin-A; Dwarfin-C; dwf-A; DWFC; Dwf-C; hSMAD1; hSmad5; JV41; JV4-1; JV5-1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog 5; MAD homolog1 (mothers against decapentaplegic, Drosophila); MAD, mothers against decapentaplegic homolog 1; MAD, mothers against decapentaplegic homolog 5; Madh1; Madh5; Madr1; mad-related protein 1; Mlp1; mMad1; mothers against decapentaplegic homolog 1; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; mothers against DPP homolog 1; mothers against DPP homolog 5; mothers-against-DPP-related 1; Msmad5; MusMLP; OTTHUMP00000223331; SMA- and MAD-related protein 5; SMAD; Smad 1; SMAD 5; SMAD family member 1; SMAD family member 5; SMAD, mothers against DPP homolog 1; SMAD, mothers against DPP homolog 5; SMAD1; SMAD5; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1

SMAD1/SMAD5 Antibodies

Target Information

Synonyms

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