The Falcon 4i Direct Electron Detector is the ideal solution for both single particle and cryo-tomography applications. With its unique combination of high image quality, high throughput, efficient lossless data compression enabled via electron-event representation (EER), and a streamlined solution for data management and quality monitoring, the Falcon 4i Electron Detector offers productivity and a performance boost over other detectors. 

Energy filtering is essential for cryo-EM acquisition conditions that generate a large amount of noise through interfering inelastic electron scattering. This can be the result of two main factors: sample thickness and accelerating voltage. Sample thickness is especially important for cryo-tomography applications, as there is an inevitable increase in the travel path at larger tilt angles. Notably, this means that energy filtering on a 200 kV instrument will have an inherently greater impact than on 300 kV tools, where there is less inelastic scattering. Narrow slit width and stable slit (position) is another key requirement for high-quality energy filtering. The narrower the width, the less of the unfiltered signal is sampled, and the less data is needed to produce high-quality results. With the Selectris Energy Filter, extremely narrow slit widths are possible (<10 eV) with low slit drift (less than ±1.5 eV in 24 hours).